scholarly journals Psychosomatic aspects of bronchial asthma: mechanisms of development, peculiarities of diagnostics, clinical manifestations and treatment

2009 ◽  
Vol 6 (3) ◽  
pp. 26-38
Author(s):  
Gleb Borisovich Fedoseev ◽  
V I Trofimov ◽  
M V Eliseeva ◽  
O Yu Babkina ◽  
KN Kryakunov ◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Clinical Manifestations ◽  
Disease Course ◽  
Psychosomatic Disorders ◽  
Psychosomatic Aspects ◽  
Mechanisms Of Development

Article is devoted to the role of psychosomatic disorders in onset and development of bronchial asthma, to the diagnostics and treatment of neuropsychical variant of the disease course and possibilities of psychotherapeutic correction.

scholarly journals Psychosomatic disorders: causes, development mechanisms, clinical manifestations and feasibilities of autopsychocorrection

2020 ◽  
Vol 17 (1) ◽  
pp. 101-121
Author(s):  
I. N. Semenenya
Keyword(s):  
General Practitioners ◽  
Human Population ◽  
General Scheme ◽  
Clinical Manifestations ◽  
Psychosomatic Disorders ◽  
Emotional Factor ◽  
Inhibitory Processes ◽  
Negative Thoughts ◽  
The Brain

The article reviews the information on the problem of psychosomatic disorders (PSDs) widespread in human population. Attention is drawn to the insufficient awareness of general practitioners in this field of pathology. The true-life situations are considered that the cause development of PSDs and the role of negative thoughts and an emotional factor in their development. A general scheme of the PSD pathogenesis is suggested, which is based on the shift in the balance of the excitation and inhibition processes in CNS towards the prevalence of the former ones. Suppression of the inhibitory processes results in the decrease of the excitation thresholds of different afferent systems and in the development of general hyperesthesia that causes the organism hyperreactivity to the external and internal actions, including the subthreshold ones and stimuli. This underlies the mechanism of PSD clinical manifestations. A possible role of CNS stagnant centers of excitement in the development of PSDs and their ability to migrate in the brain, which reflects the migration of PSD symptoms in the organism, are viewed. Mental, neurologic, cardiovascular, respiratory, digestive, urination, sexual and skin manifestations of PSDs are discussed. General approaches to treating PSD patients are considered. The fundamental importance of the mood factor in the PSD development and alleviation is substantiated.

scholarly journals ROLE OF KRISNADI CHURNA IN THE MANAGEMENT OF TAMAKA SWAS (BRONCHIAL ASTHMA)

2021 ◽  
Vol 9 (10) ◽  
pp. 2297-2302
Author(s):  
T. Rosylin L. Mawlong ◽  
Bishnu Prasad Sarma
Keyword(s):  
Risk Factors ◽  
Treatment Period ◽  
Respiratory Disease ◽  
Bronchial Asthma ◽  
Marked Improvement ◽  
Clinical Manifestations ◽  
Prior Consent ◽  
Ancient Times ◽  
Ethical Clearance

Since ancient times, humans are constantly threatened by diseases of respiratory disorders and Bronchial Asthma is one of them1. Ayurveda referred to Bronchial Asthma as “Tamaka Swas" which is a well-documented disease comparable to the parameters of etiopathology, risk factors, clinical manifestations and treatment principles. This study was conducted to evaluate the role of Krisnadi Churna in the management of Tamaka Swas (Bronchial Asthma). Ethical clearance was obtained from the Ethical Committee of Govt Ayurvedic College & Hospital, Gu- wahati and prior consent was taken from the patients before conducting the study The patients were given Krisnadi Churna for a period of 2 months in the Dept. of Kayachikitsa, Govt. Ayurvedic College & Hospital, Guwahati. There was a marked improvement in the symptoms as well as the Sr. IgE and AEC of the patients at the end of the treatment period. Keywords: TamakaSwas, Bronchial Asthma, Krisnadi Churna, respiratory disease

scholarly journals Expression of P-glycoprotein on blood lymphocytes and its role in development of steroid resistance in severe asthma

2007 ◽  
pp. 41-46
Author(s):  
I. V. Demko ◽  
A. B. Salmina ◽  
A. V. Morgun ◽  
N. A. Malinovskaya
Keyword(s):  
Bronchial Asthma ◽  
Peripheral Blood ◽  
Clinical Manifestations ◽  
Peripheral Blood Lymphocytes ◽  
Steroid Resistance ◽  
Blood Lymphocytes ◽  
Development Of Resistance ◽  
P Glycoprotein ◽  
Steroid Dependent

P-glycoprotein (Pgp) is a membrane transporter of hydrophobic molecules providing efflux of xenobiotics from the cytosole outside the cell. In epithelial cells, Pgp is thought to be responsible for resistance to steroids. Severe bronchial asthma (SBA) is a heterogenous disease characterized by resistance to and dependence on steroids. The goal of this study was to assess expression of Pgp on peripheral blood lymphocytes in severe bronchial asthma and to evaluate the role of Pgp in developing the resistance to glucocorticoid therapy (GC). Assessment of Pgp expression revealed difference in response to GC treatment. All the patients were susceptible to GC, however, the time of therapeutic effect appearance and the number of Pgp-immunopositive cells differed significantly. Thus, more prolonged application of GC for reducing clinical manifestations was required in patients with aspirin induced or fatal bronchial asthma. The number of Pgp-immunopositive lymphocytes per one patients was significantly higher in patients with fatal bronchial asthma and in patients with steroid dependent bronchial asthma (6.8 ± 0.1 and 7.2 ± 0.2, respectively) comparing with patients with non stable bronchial asthma being therapeutically resistant (3.2±0.2 and 3.5±0.1, respectively). Thus, our findings suggest possible pathogenic role of Pgp in development of resistance to GC therapy in patients with bronchial asthma. Detection of Pgp expression on peripheral blood lymphocytes would allow optimizing the volume and duration of intensive anti inflammatory therapy and predicting the doses of basic drugs.

Modern methods of treating rosacea

2019 ◽  
Vol 1 (7) ◽  
pp. 65-71
Author(s):  
O. A. Egorova ◽  
K. A. Novikov
Keyword(s):  
Clinical Manifestations ◽  
Treatment Method ◽  
Current Data ◽  
Trigger Factors ◽  
Laser Technology ◽  
Individual Approach ◽  
Modern Methods ◽  
Methods Of Treatment ◽  
Choice Of Therapy

Presented current data on the etiology of rosacea, the main aspects of pathogenesis, clinical forms of the disease. Reflects trigger factors leading to rosacea, as well as complicating its course. Modern methods of treatment are described, including the use of new safe preparations of ivermectin and brimonidine, providing a good, lasting effect of clinical manifestations of rosacea. The role of laser technology, actively occupying a leading place in the choice of physiotherapeutic treatment method, is noted. The need for an individual approach in the choice of therapy for each patient with rosacea is emphasized.

Papillon-Lefevre Syndrome: Challenge for Periodontal Management

2019 ◽  
Vol 3 (2) ◽  
pp. 84-86
Author(s):  
Krishna Prasad Lamichhane ◽  
Shaili Pradhan ◽  
Ranjita Shreshta Gorkhali ◽  
Pramod Kumar Koirala
Keyword(s):  
Significant Role ◽  
Autosomal Recessive ◽  
Clinical Manifestations ◽  
Autosomal Recessive Disorder ◽  
Genetic Mutations ◽  
Rare Autosomal Recessive Disorder ◽  
Diagnosis And Management ◽  
Periodontal Destruction ◽  
Palmoplantar Keratosis

Papillon-Lefèvre syndrome (PLS) is a rare autosomal recessive disorder associated with rapidly progressing periodontitis leading to premature loss of deciduous and permanent dentition and diffuse palmoplantar keratosis. Immunologic alterations, genetic mutations, and role of bacteria are some aetiologic factors. Patients present with early periodontal destruction, so periodontists play a significant role in diagnosis and management. This paper reports a case of Papillon- Lefevre syndrome with its clinical manifestations and challenges for periodontal management which was diagnosed in dental department.

Disseminated intravascular coagulation syndrome

2020 ◽  
pp. 22-40
Author(s):  
A. Kulikov
Keyword(s):  
Clinical Practice ◽  
Disseminated Intravascular Coagulation ◽  
Blood Cells ◽  
Physical State ◽  
Clinical Manifestations ◽  
Vascular Wall ◽  
Stages Of Development ◽  
Intravascular Coagulation ◽  
Hemostatic Disorder

Presented material reveals main links in the pathogenesis of hemostatic disorder. In particular, attention is paid to the role of the lungs, liver and other organs in the development of this process. Role of vascular wall and blood cells in regulation of the physical state of blood is described in detail. The most frequent factors leading to hypercoagulation are indicated. Difference between hypercoagulation and thrombophilia is shown. The latter is found in clinical practice quite often, but at the same time, it is poorly diagnosed. Such a terrible complication of hemostatic disorder as disseminated intravascular coagulation is described. Its classification, stages of development, clinical manifestations are offered to the readers.

Role of Shatyadi yoga in the management of Tamak shwasa (Bronchial Asthma)

2018 ◽  
Vol 19 (1&2) ◽  
pp. 85-87
Author(s):  
Nidhi Jain ◽  
◽  
Dinesh Kumar Goyal ◽  
Keyword(s):  
Bronchial Asthma

Monogenic Diabetes: Genetics and Relevance on Diabetes Mellitus Personalized Medicine

2020 ◽  
Vol 16 (8) ◽  
pp. 807-819 ◽  
Author(s):  
Madalena Sousa ◽  
Jácome Bruges-Armas
Keyword(s):  
Diabetes Mellitus ◽  
Complex Disease ◽  
Clinical Manifestations ◽  
Neonatal Diabetes ◽  
Monogenic Diabetes ◽  
Diabetes Genetics ◽  
Individualize Treatment

Background: Diabetes mellitus (DM) is a complex disease with significant impression in today's world. Aside from the most common types recognized over the years, such as type 1 diabetes (T1DM) and type 2 diabetes (T2DM), recent studies have emphasized the crucial role of genetics in DM, allowing the distinction of monogenic diabetes. Methods: Authors did a literature search with the purpose of highlighting and clarifying the subtypes of monogenic diabetes, as well as the accredited genetic entities responsible for such phenotypes. Results: The following subtypes were included in this literature review: maturity-onset diabetes of the young (MODY), neonatal diabetes mellitus (NDM) and maternally inherited diabetes and deafness (MIDD). So far, 14 subtypes of MODY have been identified, while three subtypes have been identified in NDM - transient, permanent, and syndromic. Discussion: Despite being estimated to affect approximately 2% of all the T2DM patients in Europe, the exact prevalence of MODY is still unknown, accentuating the need for research focused on biomarkers. Consequently, due to its impact in the course of treatment, follow-up of associated complications, and genetic implications for siblings and offspring of affected individuals, it is imperative to diagnose the monogenic forms of DM accurately. Conclusion: Currently, advances in the genetics field allowed the recognition of new DM subtypes, which until now, were considered slight variations of the typical forms. Thus, it is imperative to act in the close interaction between genetics and clinical manifestations, to facilitate diagnosis and individualize treatment.

The role of microRNA in hepatic ischemia/reperfusion injury

MicroRNA ◽  
2020 ◽  
Vol 09 ◽  
Author(s):  
Chrysanthos D. Christou ◽  
Georgios Tsoulfas
Keyword(s):  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Clinical Manifestations ◽  
Diagnostic Procedures ◽  
Clinical Tool ◽  
Hepatic Ischemia ◽  
Humoral Factors ◽  
Early Graft ◽  
Hepatic Ischemia Reperfusion

Introduction: Ischemia-reperfusion (I/R) injuries are caused by complex interrelated mechanisms and pathways. Regarding the liver, I/R injuries and their clinical manifestations are crucial for the surgical outcome. Despite its importance, there is no broadly accepted therapy either for the prevention or for the management of I/R injury. I/R injury of the liver can occur either during hepatic surgery (warm) or during the transplantation procedure (cold). MicroRNAs play a pivotal role in the mechanism of I/R injury, as they regulate the expression of the cellular participants and humoral factors associated with I/R injury. Objective: In this review, we highlight the microRNAs that are involved in the I/R injury of the liver, and the molecular pathways that they regulate. In addition, we discuss the potential role of circulating microRNAs as biomarkers and their role as pharmacological targets in the prevention, diagnosis and treatment of I/R injuries. Method: We conducted a comprehensive review of the PubMed bibliographic database regarding microRNAs and I/R injuries of the liver. Results: In diagnostics, microRNA panels could replace invasive diagnostic procedures, relieving patients of the associated complications. In therapeutics, microRNA agomirs, antagomirs and other drugs can be used to shift the balance between proapoptotic and survival pathways, to alleviate the liver damage caused by I/R. In transplantation procedures, microRNA profiling could decrease the incidence of early graft dysfunction, especially regarding marginal grafts. Conclusion: Although microRNAs seem a very promising clinical tool in the management of I/R injuries, further research is required, until microRNAs become a novel tool in the diagnosis and monitoring of an I/R injury of the liver.

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