scholarly journals Cause or Consequence? What is the Relationship between Cardiac Injury and COVID-19 Severity?

2021 ◽  
Vol 35 (1) ◽  
pp. 65-67
Author(s):  
Claudio Tinoco Mesquita
Keyword(s):  
Cardiac Injury ◽  
The Relationship

scholarly journals Effects of Covid-19 on Patients with Cardiovascular Diseases: A Systematic Review

2021 ◽  
pp. 130-135
Author(s):  
Naveen Sharma ◽  
Priyanka Joshi ◽  
Pawan Kumar Gupta ◽  
Parjanya Kumar Shukla ◽  
. Archna
Keyword(s):  
Cardiac Injury ◽  
Clinical Manifestations ◽  
Cardiovascular Disorders ◽  
Critical Component ◽  
Cardiac Abnormality ◽  
Cardiac Damage ◽  
Adequate Information ◽  
Corona Virus ◽  
Entire World ◽  
The Relationship

Aim of Object: During the COVID-19 pandemic, the entire world is experiencing a mortality situation; most people are battling against the corona virus, but some individuals have already suffered from cardiovascular problems. For improved patient care, adequate information and comprehension of the relationship between cardiovascular disorders and COVID-19 is required. The dominant clinical manifestations of the corona virus infection are on the respiratory system. In this instance, the acute cardiac injury is the most often reported cardiac abnormality, in which the degree of cardiac output is increased, troponin levels rise, and mostly it is found in about 8% to 12% of patients. The involvement of viral cardiomyocytes and systemic inflammation is the most prevalent mechanism for cardiac damage. The corona virus attaches itself and enters through angiotensin converting enzyme-II. Discussion and Conclusion: Recent articles on COVID-19 have revealed nothing regarding these individuals' cardiac vascular manifestations. This is a critical component of all that has a big influence on COVID-19 patients' cardiovascular systems. To fully comprehend the method and effects, more study is required.

Abstract P45: White Blood Cell Counts in Aneurysmal Subarachnoid Hemorrhage Patients as a Predictor of Cardiac Injury

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Tiffany Cheng ◽  
Joseph R Geraghty ◽  
Neil S Saini ◽  
Yonatan Hirsch ◽  
Tyler J Lung ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Cardiac Dysfunction ◽  
Leukocyte Count ◽  
Cardiac Injury ◽  
Total Leukocyte Count ◽  
Monocyte Count ◽  
Cell Counts ◽  
Leukocyte Counts ◽  
Blood Leukocyte ◽  
The Relationship

Introduction: Up to 50% of subarachnoid hemorrhage (SAH) patients develop cardiac injury. The relationship between early systemic inflammation and cardiac injury after SAH is unknown. Here we examined changes in blood leukocyte counts and their relationship to cardiac dysfunction. Methods: We reviewed the medical records of 288 SAH patients admitted to our Comprehensive Stroke Center. Patients were dichotomized based on elevated (≥0.04ng/mL) or normal (<0.04ng/mL) troponin I (TnI). Demographics and labs from admission were then compared among the two groups by Chi-Square or Mann-Whitney test. Ejection fraction (EF) was stratified into low (<50%), normal (50-70%), or high (>70%) from echocardiogram data. We performed univariate and multivariate logistic regression to establish the relationship between blood leukocyte counts and cardiac injury. Results: Of 288 SAH patients, 241 had TnI levels performed at the time of admission and 119 (49.4%) of these had elevated TnI on admission. Patients with elevated TnI were significantly older, had higher grade SAH, abnormal EF, and were more likely to have hypertension and dyslipidemia. 10 (4.1%) had low EF while 58 (24.1%) had high EF on admission echocardiogram. In univariate analysis, total leukocyte count (p<0.0001), absolute neutrophil count (p=0.037), absolute monocyte count (p=0.014), and neutrophil-lymphocyte ratio (p=0.010) were associated with elevated TnI. Multivariate analysis adjusting for covariates showed that only total leukocyte count remained a significant predictor of elevated TnI (OR = 1.104, 95% CI= 1.020 - 1.195; p=0.014). Receiver operating characteristic (ROC) analysis demonstrated that adjusted total leukocyte count distinguishes between SAH patients with normal and elevated TnI (area under the curve = 0.787, p=0.001), with the optimal cutoff being 0.521 (sensitivity of 67.0% and specificity of 80.6%). Conclusions: Blood total leukocyte count is an independent predictor of cardiac injury in SAH patients. This highlights the role of inflammation in mediating cardiac dysfunction after brain hemorrhage, and raises questions regarding the potential of anti-inflammatory therapy for cardioprotection in SAH.

scholarly journals The Covid-19 Effects on the Cardiovascular System; A Focus on Myocarditis

2021 ◽  
pp. 1-4
Author(s):  
Praise Chovwen ◽  
◽  
Ibukunoluwa Oshobu ◽  
Keyword(s):  
Cardiovascular System ◽  
Preventive Care ◽  
Cardiac Injury ◽  
Cardiovascular Effects ◽  
System A ◽  
Global Pandemic ◽  
Care And Treatment ◽  
The Relationship

The WHO declared COVID 19 a global pandemic on March 11, 2020. The effect the virus has created in various aspects of our lives has made it of primary importance that we understand its pathophysiology, complication, preventive care, and treatment. A significant number of COVID patients develop some form of cardiac injury, whether while infected or after recovery. In this article, we aim to discuss these aspects and expand further on the cardiovascular effects seen in COVID 19 infected patients, emphasizing myocarditis. We discuss the case of a patient who developed cardiac injuries while infected with COVID 19, which she contacted 18 days after receiving the first dose of the COVID mRNA vaccine. This article provides more understanding of the relationship between COVID-19 and the heart.

scholarly journals The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome

2020 ◽  
Author(s):  
Alessandro Mengozzi ◽  
Georgios Georgiopoulos ◽  
Marco Falcone ◽  
Giusy Tiseo ◽  
Nicola Riccardo Pugliese ◽  
...  
Keyword(s):  
Troponin T ◽  
Strong Predictor ◽  
Cardiac Injury ◽  
High Sensitivity ◽  
Strong Relationship ◽  
High Sensitivity Troponin T ◽  
The Relationship ◽  
D Dimer ◽  
Related Mortality

Abstract Introduction: High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk.Methods: In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. Results: hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than PaO2. Changes of hsTnT, D-dimer and CRP were related but only D-dimer was associated with mortality. Moreover, low molecular weight heparin showed attenuation of the mortality in the whole population, particularly in subjects with higher hsTnT.Conclusions: D-dimer possessed a strong relationship with hsTnT and mortality. Anticoagulation treatment showed greater benefits with regard to mortality. These findings suggest a major role of SARS-CoV-2 coagulopathy in hsTnT elevation and its related mortality in COVID-19. A better understanding of the mechanisms related to COVID-19 might pave the way to therapy tailoring in these high-risk individuals.

scholarly journals Relationship between Lactobacillus and prognosis of acute myocardial infarction patients treated by percutaneous coronary intervention and its possible mechanism

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
J.-J Cai ◽  
Y Liu ◽  
J Wang ◽  
J.-X Wang ◽  
Y Wang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Correlation Analysis ◽  
Cox Regression ◽  
Cardiac Injury ◽  
Coronary Intervention ◽  
Percutaneous Coronary ◽  
Hs Crp ◽  
The Relationship

Abstract Background Our previous study had found that the abundance of Lactobacillaceae in stool of acute coronary syndrome patients was significantly decreased. Experiments have confirmed that Lactobacillus has the effects of anti-inflammation, regulating blood lipids and improving cardiac injury after myocardial infarction. Purpose To explore the relationship between Lactobacillus and prognosis of acute myocardial infarction (AMI) patients treated by percutaneous coronary intervention (PCI) and its possible mechanism. Methods Patients with AMI who received emergency PCI from July 2017 to December 2018 in department of CCU were enrolled.Stool and blood samples were collected from all patients. The fecal 16S rDNA gene sequencing data from subjects were analyzed and subjects were categorized into Low, Medium and High level groups according to stool Lactobacillus measurements. The primary endpoints were major adverse cardiac events (MACE). Univariate and multivariate Cox regression were used to analyze the relationship between Lactobacillus and prognosis. Kaplan-Meier survival curve was used to characterize the association between the risk of MACE and Lactobacillus levels. Spearman correlation analysis and trend test were used to assess the relationship between Lactobacillus and Clinical index. Results A total of 254 patients were included in the analysis. The age was 65.90±11.56 years old,and 152 (59.84%) were male. The follow-up time was 652 (548.25, 753) days. Multivariate Cox regression showed that patients with Lactobacillus &gt;7.1 copies/g presented lower risk of MACE (HR=0.179, 95% CI 0.076–0.422, P&lt;0.001), compared to patients with Lactobacillus ≤3.6 copies/g.This difference was statistically significant in STEMI (HR=0.210, 95% CI 0.082–0.542, P=0.001). Subgroup analysis indicated that Lactobacillus was a protective factor,whereas the value was more evident for male smokers over 60 years old and whose BNP over 1000 pg/mL.Spearman correlation analysis showed that Lactobacillus was negatively correlated with WBC, NEUT, hs-CRP, TNT, CK, CK-MB and BNP, while positively correlated with LVEF. With the increasing of Lactobacillus, WBC, NEUT, hs-CRP, TNT, CK, CK-MB and BNP showed a downward trend, while LVEF had an upward trend. Conclusion Lactobacillus can significantly reduce the risk of MACE in STEMI patients treated by PCI, especially for male smokers over 60 years old. The underlying mechanism may be related to the fact that Lactobacillus can reduce inflammatory reaction, lessen cardiac injury and improve cardiac function. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): the Key Project of Scientific and Technological Support Plan of Tianjin in 2020 Correlation analysis between Lactobacill Subgroup analysis in different patients

scholarly journals Relationship Between Myocardial Injury During Index Hospitalization for SARS‐CoV‐2 Infection and Longer‐Term Outcomes

2021 ◽  
Author(s):  
Brittany Weber ◽  
Hasan Siddiqi ◽  
Guohai Zhou ◽  
Jefferson Vieira ◽  
Andy Kim ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin T ◽  
Cardiac Injury ◽  
High Sensitivity ◽  
Cardiac Biomarkers ◽  
Study Cohort ◽  
Cardiac Troponin T ◽  
Index Hospitalization ◽  
The Relationship

Background Myocardial injury in patients with COVID‐19 is associated with increased mortality during index hospitalization; however, the relationship to long‐term sequelae of SARS‐CoV‐2 is unknown. This study assessed the relationship between myocardial injury (high‐sensitivity cardiac troponin T level) during index hospitalization for COVID‐19 and longer‐term outcomes. Methods and Results This is a prospective cohort of patients who were hospitalized at a single center between March and May 2020 with SARS‐CoV‐2. Cardiac biomarkers were systematically collected. Outcomes were adjudicated and stratified on the basis of myocardial injury. The study cohort includes 483 patients who had high‐sensitivity cardiac troponin T data during their index hospitalization. During index hospitalization, 91 (18.8%) died, 70 (14.4%) had thrombotic complications, and 126 (25.6%) had cardiovascular complications. By 12 months, 107 (22.2%) died. During index hospitalization, 301 (62.3%) had cardiac injury (high‐sensitivity cardiac troponin T≧14 ng/L); these patients had 28.6%, 32.2%, and 33.2% mortality during index hospitalization, at 6 months, and at 12 months, respectively, compared with 4.1%, 4.9%, and 4.9% mortality for those with low‐level positive troponin and 0%, 0%, and 0% for those with undetectable troponin. Of 392 (81.2%) patients who survived the index hospitalization, 94 (24%) had at least 1 readmission within 12 months, of whom 61 (65%) had myocardial injury during the index hospitalization. Of 377 (96%) patients who were alive and had follow‐up after the index hospitalization, 211 (56%) patients had a documented, detailed clinical assessment at 6 months. A total of 78 of 211 (37.0%) had ongoing COVID‐19–related symptoms; 34 of 211 (16.1%) had neurocognitive decline, 8 of 211 (3.8%) had increased supplemental oxygen requirements, and 42 of 211 (19.9%) had worsening functional status. Conclusions Myocardial injury during index hospitalization for COVID‐19 was associated with increased mortality and may predict who are more likely to have postacute sequelae of COVID‐19. Among patients who survived their index hospitalization, the incremental mortality through 12 months was low, even among troponin‐positive patients.

scholarly journals Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD

2020 ◽  
Vol 8 (B) ◽  
pp. 687-691
Author(s):  
Gestina Aliska ◽  
Muhammad Fadil ◽  
Yose Ramda Ilhami ◽  
Elly Usman ◽  
Ivan Mahendra Raditya ◽  
...  
Keyword(s):  
Cardiac Injury ◽  
Cardiac Performance ◽  
Cardiac Cells ◽  
Myocardial Cells ◽  
Pathological Changes ◽  
Neuregulin 1 ◽  
Survival Factor ◽  
Epidermal Growth ◽  
The Relationship

BACKGROUND: Neuregulins (NRGs) are one of the epidermal growth factors (EGF) superfamily, which released in cellular injuries, such as neurons and myocardial cells. Neuregulin-1β (NRG-1β) could be activated when stress happens to myocardial cells, acting as a survival factor to repair the injury. Malondialdehyde (MDA) is also produced during oxidative stress in cardiac injury. In vivo study of myocardial cells in rats and dogs that got ischemic, dilated, and viral cardiomyopathy showed that NRG-1 could improve the injured cardiac performance, attenuated pathological changes, and prolonged survival of the cells. AIM: We aimed to observe NRG-1 levels in CAD patients in Indonesia, mainly focused in Minang ethnicity. This study also analyzes the relationship between NRG-1 and MDA with CAD’s severity. METHODS: We measured plasma NRG-1 in 61 nondiabetic patients within 38–82 years old range with STEMI, NSTEMI, and UAP. RESULTS: We found their plasma NRG1, respectively, was 10.3 (1.9–38.2) ng/ml, 14.3 ± 7.2 ng/ml, and 7.05 (4.5–0.4) ng/mL. Plasma NRG 1 increased in AMI patients. CONCLUSION: This study concludes that NRG1’s activated during cardiac cells injury, in any AMI.

scholarly journals The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alessandro Mengozzi ◽  
◽  
Georgios Georgiopoulos ◽  
Marco Falcone ◽  
Giusy Tiseo ◽  
...  
Keyword(s):  
Troponin T ◽  
Strong Predictor ◽  
Cardiac Injury ◽  
High Sensitivity ◽  
Strong Relationship ◽  
High Sensitivity Troponin T ◽  
The Relationship ◽  
D Dimer ◽  
Related Mortality

AbstractHigh sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk. In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than PaO2. Changes of hsTnT, D-dimer and CRP were related; but only D-dimer was associated with mortality. Moreover, low molecular weight heparin showed attenuation of the mortality in the whole population, particularly in subjects with higher hsTnT. D-dimer possessed a strong relationship with hsTnT and mortality. Anticoagulation treatment showed greater benefits with regard to mortality. These findings suggest a major role of SARS-CoV-2 coagulopathy in hsTnT elevation and its related mortality in COVID-19. A better understanding of the mechanisms related to COVID-19 might pave the way to therapy tailoring in these high-risk individuals.

Sign in / Sign up

Export Citation Format

Share Document