scholarly journals Clinical Characteristics and Mid-Term follow-up of Elderly Patients with Severe Aortic Stenosis not Eligible for TAVI

2021 ◽  
Author(s):  
Mariana Oliveira Rezende ◽  
Natasha Soares Simões dos Santos ◽  
Alexandre Aguiar Andrade ◽  
Mônica Serrano Francischini ◽  
Decarthon Vitor Dantas Targino ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Elderly Patients ◽  
Clinical Characteristics ◽  
Severe Aortic Stenosis

OC04 BASELINE ATRIAL STRAIN RELATES TO POST-SURGICAL FOLLOW UP IN SEVERE AORTIC STENOSIS

2018 ◽  
Vol 19 ◽  
pp. e15
Author(s):  
C. Lucarelli ◽  
L. San Biagio ◽  
A. Francica ◽  
G. Benfari ◽  
R.G. Abbasciano ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Atrial Strain

Comparison of Aortic Gradient and Ventricular Mass after Valve Replacement for Aortic Stenosis with Rapid Deployment, Sutureless, and Conventional Bioprostheses

Cardiology ◽  
2021 ◽  
pp. 1-11
Author(s):  
Rubén Taboada-Martín ◽  
José María Arribas-Leal ◽  
María Asunción Esteve-Pastor ◽  
José Abellán Alemán ◽  
Francisco Marín ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Risk Of Mortality ◽  
Echocardiographic Parameters ◽  
Rapid Deployment ◽  
The Impact ◽  
Peak Gradient

<b><i>Background:</i></b> The use of rapid deployment and sutureless aortic prostheses is increasing. Previous reports have shown promising results on haemodynamic performance and mortality rates. However, the impact of these bioprostheses on left ventricular mass (LVM) regression remains unknown. We decided to study the changes in remodelling and LVM regression in isolated severe aortic stenosis treated with conventional or Perceval® or Intuity® valves. <b><i>Method and Results:</i></b> From January 2011 to January 2016, 324 bioprostheses were implanted in our centre. The collected characteristics were divided into 3 groups: conventional valves, Perceval®, and Intuity®, and they were analysed after 12 months. There were 183 conventional valves (56%), 72 Perceval® (22%), and 69 Intuity® (21.2%). The statistical analysis showed significant differences in transprosthetic postoperative peak gradient (23 [18–29] mm Hg vs. 21 [16–29] mm Hg and 18 [14–24] mm Hg, <i>p</i> &#x3c; 0.001), ventricular mass electrical criteria regression (Sokolow and Cornell products), and 1-year survival (90 vs. 93% and 97%, log rank <i>p</i> value = 0.04) in conventional, Perceval®, and Intuity® groups. <b><i>Conclusions:</i></b> We observed differences in haemodynamic, electrocardiographic, and echocardiographic parameters related to the different types of prosthesis. Patients with the Intuity® prosthesis had the highest reduction in peak aortic gradient and the higher ventricular mass regression. Besides, patients with the Intuity® prosthesis had less risk of mortality during follow-up than the other two groups. Further studies are needed to confirm these findings.

scholarly journals Natural Progression of Low-Gradient Severe Aortic Stenosis with Preserved Ejection Fraction

2014 ◽  
Vol 41 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Antony Leslie Innasimuthu ◽  
Sanjay Kumar ◽  
Jason Lazar ◽  
William E. Katz
Keyword(s):  
Aortic Stenosis ◽  
Ejection Fraction ◽  
Severe Aortic Stenosis ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Aortic Valve Area ◽  
Ventricular Ejection Fraction ◽  
Mild Stenosis ◽  
Natural Progression

Because the natural progression of low-gradient aortic stenosis (LGAS) has not been well defined, we performed a retrospective study of 116 consecutive patients with aortic stenosis who had undergone follow-up echocardiography at a median interval of 698 days (range, 371–1,020 d). All patients had preserved left ventricular ejection fraction (&gt;0.50) during and after follow-up. At baseline, patients were classified by aortic valve area (AVA) as having mild stenosis (≥1.5 cm2), moderate stenosis (≥1 to &lt;1.5 cm2), or severe stenosis (&lt;1 cm2). Severe aortic stenosis was further classified by mean gradient (LGAS, mean &lt;40 mmHg; high-gradient aortic stenosis [HGAS], mean ≥40 mmHg). We compared baseline and follow-up values among 4 groups: patients with mild stenosis, moderate stenosis, LGAS, and HGAS. At baseline, 30 patients had mild stenosis, 54 had moderate stenosis, 24 had LGAS, and 8 had HGAS. Compared with the moderate group, the LGAS group had lower AVA but similar mean gradient. Yet the actuarial curves for progressing to HGAS were significantly different: 25% of patients in LGAS reached HGAS status significantly earlier than did 25% of patients in the moderate-AS group (713 vs 881 d; P=0.035). Because LGAS has a high propensity to progress to HGAS, we propose that low-gradient aortic stenosis patients be closely monitored as a distinct subgroup that warrants more frequent echocardiographic follow-up.

scholarly journals Surgical treatment of elderly patients with severe aortic stenosis in the modern era – review

2018 ◽  
Vol 15 (3) ◽  
pp. 188-195
Author(s):  
Anna Kwiecień ◽  
Tomasz Hrapkowicz ◽  
Krzysztof Filipiak ◽  
Roman Przybylski ◽  
Marcin Kaczmarczyk ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Aortic Stenosis ◽  
Elderly Patients ◽  
Severe Aortic Stenosis ◽  
Modern Era

scholarly journals Mortality in low-risk patients with aortic stenosis undergoing transcatheter or surgical aortic valve replacement: a reconstructed individual patient data meta-analysis

2020 ◽  
Vol 31 (5) ◽  
pp. 587-594
Author(s):  
Mevlüt Çelik ◽  
Milan M Milojevic ◽  
Andras P Durko ◽  
Frans B S Oei ◽  
Ad J J C Bogers ◽  
...  
Keyword(s):  
Data Analysis ◽  
Aortic Stenosis ◽  
Individual Patient Data ◽  
Severe Aortic Stenosis ◽  
Mortality Rates ◽  
Patient Data ◽  
Low Risk ◽  
All Cause Mortality ◽  
Risk Patients

Abstract OBJECTIVES Although the standard of care for patients with severe aortic stenosis at low-surgical risk has included surgical aortic valve replacement (SAVR) since the mid-1960s, many clinical studies have investigated whether transcatheter aortic valve implantation (TAVI) can be a better approach in these patients. As no individual study has been performed to detect the difference in mortality between these 2 treatment strategies, we did a reconstructive individual patient data analysis to study the long-term difference in all-cause mortality. METHODS Randomized clinical trials and propensity score-matched studies that included low-risk adult patients with severe aortic stenosis undergoing either SAVR or TAVI and with reports on the mortality rates during the follow-up period were considered. The primary outcome was all-cause mortality of up to 5 years. RESULTS In the reconstructed individual patient data analysis, there was no statistically significant difference in all-cause mortality between TAVI and SAVR at 5 years of follow-up [30.7% vs 21.4%, hazard ratio (HR) 1.19, 95% confidence interval (CI) 0.96–1.48; P = 0.104]. However, landmark analyses in patients surviving up to 1 year of follow-up showed significantly higher all-cause mortality at 5 years of follow-up (27.5% vs 17.3%, HR 1.77, 95% CI 1.29–2.43; P &lt; 0.001) in patients undergoing TAVI compared to patients undergoing SAVR, respectively. CONCLUSIONS This reconstructed individual patient data analysis in low-risk patients with severe aortic stenosis demonstrates that the 5-year all-cause mortality rates are higher after TAVI than after SAVR, driven by markedly higher mortality rates between 1 and 5 years of follow-up in the TAVI group. The present results call for caution in expanding the TAVI procedure as the treatment of choice for the majority of all low-risk patients until long-term data from contemporary randomized clinical trials are available.

PO621 Heart Rate Reduction Wiht Ivabradine In Severe Aortic Stenosis Rejected to Valve Replacement. Long Term Follow Up

Global Heart ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. 513
Author(s):  
G.A. Cortez Quiroga ◽  
M.C. Durán Torralba ◽  
C. Rus Mansilla ◽  
D. Fatela Cantillo ◽  
A. Fernández Suárez
Keyword(s):  
Heart Rate ◽  
Aortic Stenosis ◽  
Valve Replacement ◽  
Severe Aortic Stenosis ◽  
Heart Rate Reduction ◽  
Rate Reduction ◽  
Long Term Follow Up

Progression of aortic stenosis in elderly patients over long-term follow up

2013 ◽  
Vol 167 (4) ◽  
pp. 1226-1231 ◽  
Author(s):  
L.G. Kearney ◽  
M. Ord ◽  
B.F. Buxton ◽  
G. Matalanis ◽  
S.K. Patel ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Elderly Patients ◽  
Long Term Follow Up

Effect of Severe Aortic Stenosis on the Outcome in Elderly Patients Undergoing Repair of Hip Fracture

Gerontology ◽  
2009 ◽  
Vol 55 (3) ◽  
pp. 303-306 ◽  
Author(s):  
David Leibowitz ◽  
Gurion Rivkin ◽  
Jochanan Schiffman ◽  
David Rott ◽  
A. Teddy Weiss ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Aortic Stenosis ◽  
Elderly Patients ◽  
Severe Aortic Stenosis
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