scholarly journals An effect of single high dose of vitamin D3 on the risk of nosocomial infections, hospitalization time and mortality in hospitalized elderly population. A preliminary report

2020 ◽  
Vol 2 (2) ◽  
pp. 1-5
Author(s):  
Dorota Leszczyńska ◽  
Agata Tuszyńska ◽  
Magdalena Zgliczyńska ◽  
Wojciech Zgliczyński ◽  
Waldemar Misiorowski
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Vitamin D3 ◽  
Nosocomial Infections ◽  
Control Group ◽  
High Dose ◽  
Single High Dose ◽  
Hospital Acquired Infections ◽  
Hospital Acquired ◽  
The Impact

Introduction: Observational studies indicate a significant impact of serum 25(OH)D concentration on incidence of hospital-acquired infections. However, we did not find any interventional study assessing the effect of vitamin D3 administration at the admission on the course of further hospitalization in internal medicine departments. Objective of the paper: Investigation of the impact of one-time high-dose vitamin D3 administration in elderly patients on the day of urgent admission to the hospital, on hospital-acquired infections. Materials and methods: A randomized, two-arms, open pilot study in 97 adults aged 60-100. A study group was given a single dose of 60,000 IU vitamin D3 and a control group was not subject to any intervention. Serum 25(OH)D and calcium were measured at the baseline and after 7 days. Results: 77.32% of studied patients were vitamin deficient, and among those, in 28.87% severe vitamin D deficiency was found. After single administration of 60,000 IU of vitamin D3, only 4 patients achieved recommended serum 25(OH)D concentration. The highest increase in serum 25(OH)D was observed in patients with severe deficiency. Numbers of observed nosocomial infections such as flu, hospital-acquired pneumonia or Klebsiella pneumoniae MBL+ infection did not differ significantly between study and control group, however there was a trend close to significance for lower incidence of Clostridium difficile infection in the vitamin D3 group. Conclusions: Preliminary results of the presented research indicate possible protective effect of single high dose of vitamin D3 against Clostridium difficile infection during hospitalization. Further research on larger group of patients, using higher dose of vitamin D3 is necessary.

scholarly journals Does a single high dose of vitamin D3 have an effect on fracture healing? Animal study

2016 ◽  
Vol 2 (4) ◽  
pp. 260
Author(s):  
Ahammed Zakir Hussain ◽  
N. Jambu ◽  
Kevin Lourdes
Keyword(s):  
Vitamin D ◽  
Fracture Healing ◽  
Vitamin D3 ◽  
Test Group ◽  
Maximum Load ◽  
Mean Value ◽  
Control Group ◽  
High Dose ◽  
Single High Dose

<p class="abstract"><strong>Background:</strong> Vitamin D has an important role in the regulation of calcium by stimulating intestinal absorption of calcium and phosphorous and osteoclastic resorption of bone thus being critical building bone. Given the high prevalence, severity, and cost of osteoporotic fractures, prevention strategies that are effective, low in cost and well tolerated are needed. One promising prevention strategy may be vitamin D supplementation. This animal study was done in order to establish the role of Vitamin D in fracture healing among rabbits.</p><p class="abstract"><strong>Methods:</strong> 8 rabbits were involved in the study with 4 in the control group &amp; 4 in the test group. A fracture was surgically induced on both the groups following which a single high dose of vitamin D was administered intra muscular injection to the test group and normal saline for the control group. Biomechanical properties of the fractured bones such as energy absorbed until fracture (EAUF), maximum load (N) and diameter at the fracture site (D) were assessed 12 weeks later.<strong></strong></p><p class="abstract"><strong>Results:</strong> Mean value of EAUF for test group was 401.8 N-mm and control group was 404 N-mm. Mean value of maximum load in control group is 228.8 N and for test group is 186.9 N.</p><strong>Conclusions:</strong>From the above results, the authors did not find any significant improvement in fracture healing in test group. Hence, further investigations are to be needed to prove the role of vitamin D3 in fracture healing.

scholarly journals Single High-Dose Vitamin D Supplementation as an Approach for Reducing Ultramarathon-Induced Inflammation: A Double-Blind Randomized Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1280
Author(s):  
Jan Mieszkowski ◽  
Andżelika Borkowska ◽  
Błażej Stankiewicz ◽  
Andrzej Kochanowicz ◽  
Bartłomiej Niespodziński ◽  
...  
Keyword(s):  
Vitamin D ◽  
Inflammatory Marker ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Oncostatin M ◽  
Control Group ◽  
High Dose ◽  
Double Blind ◽  
Single High Dose ◽  
High Dose Vitamin

Purpose: A growing number of studies indicate the importance of vitamin D supplementation for sports performance. However, the effects of a single high-dose vitamin D supplementation on ultramarathon-induced inflammation have not been investigated. We here analyzed the effect of a single high-dose vitamin D supplementation on the inflammatory marker levels in ultramarathon runners after an ultramarathon run (maximal run 240 km). Methods: In the study, 35 runners (amateurs) were assigned into two groups: single high-dose vitamin D supplementation group, administered vitamin D (150,000 IU) in vegetable oil 24 h before the start of the run (n = 16); and placebo group (n = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Results: Serum 25(OH)D levels were significantly increased after the ultramarathon in both groups. The increase was greater in the vitamin D group than in the control group. Based on post-hoc and other analyses, the increase in interleukin 6 and 10, and resistin levels immediately after the run was significantly higher in runners in the control group than that in those in the supplementation group. Leptin, oncostatin M, and metalloproteinase tissue inhibitor levels were significantly decreased in both groups after the run, regardless of the supplementation. Conclusions: Ultramarathon significantly increases the serum 25(OH)D levels. Attenuation of changes in interleukin levels upon vitamin D supplementation confirmed that vitamin D has anti-inflammatory effect on exercise-induced inflammation.

scholarly journals HOSPITAL ACQUIRED INFECTIONS

2010 ◽  
Vol 17 (02) ◽  
pp. 168-173
Author(s):  
SHAZIA QAYYUM ◽  
BUSHRA Waqas ◽  
ABDUL SATTAR
Keyword(s):  
Nosocomial Infections ◽  
Hospital Staff ◽  
Prevention Study ◽  
Basic Step ◽  
Hospital Acquired Infections ◽  
Different Types ◽  
Study Population ◽  
Study Designs ◽  
Hospital Acquired ◽  
Surgical Unit

Nosocomial infections may be defined as the infections which develop within hospital. There are different types of microorganisms which are involved along with other agents for the spread of these infections. Knowledge about the spread and prevention of these infections is the basic step for control. Hospital staff especially the doctors should be aware about the precautions to control the spread of there infections. Objectives: To assess the knowledge of doctors about hospital acquired infections and its prevention. Study designs: descriptive study Settings and period: In surgical unit of Allied Hospital Faisalabad from 15th June 2006 15th July 2006. Materials and methods: Study population was consisted on 71 doctors including Consultants, Medical Officers and House Officers. Data was collected with the help of questionnaires. Results: Results showed that majority of doctors were aware about nosocomial infections (N.I) but have weak knowledge about their routes of transmission and common types of N.I. Conclusions: The study revealed that doctors have sufficient knowledge regarding N.I and its prevention but certain weakness were observed.

scholarly journals HOSPITAL ACQUIRED INFECTIONS

2010 ◽  
Vol 17 (02) ◽  
pp. 168-173
Author(s):  
SHAZIA QAYYUM ◽  
BUSHRA WAQAS ◽  
ABDUL SATTAR
Keyword(s):  
Nosocomial Infections ◽  
Hospital Staff ◽  
Prevention Study ◽  
Basic Step ◽  
Hospital Acquired Infections ◽  
Different Types ◽  
Study Population ◽  
Study Designs ◽  
Hospital Acquired ◽  
Surgical Unit

Nosocomial infections may be defined as the infections which develop within hospital. There are different types of  microorganisms which are involved along with other agents for the spread of these infections. Knowledge about the spread and prevention of these infections is the basic step for control. Hospital staff especially the doctors should be aware about the precautions to control the spread of there infections. Objectives: To assess the knowledge of doctors about hospital acquired infections and its prevention. Study designs: descriptive study Settings and period: In surgical unit of Allied Hospital Faisalabad from 15th June 2006 15th July 2006. Materials and methods: Study population was consisted on 71 doctors including Consultants, Medical Officers and House Officers. Data was collected with the help of questionnaires. Results: Results showed that majority of doctors were aware about nosocomial infections (N.I) but have weakknowledge about their routes of transmission and common types of N.I. Conclusions: The study revealed that doctors have sufficient knowledge regarding N.I and its prevention but certain weakness were observed.

scholarly journals Nosocomial infections in the Intensive care unit: global problem of modern medicine

2018 ◽  
Vol 1 (2) ◽  
pp. 5-19
Author(s):  
Zara Vezirova
Keyword(s):  
Nosocomial Infections ◽  
Metastatic Cancer ◽  
Intensive Therapy ◽  
Treatment Modalities ◽  
Critical Conditions ◽  
Special Treatment ◽  
Surgical Interventions ◽  
Hospital Acquired Infections ◽  
The Us ◽  
Hospital Acquired

Increased volume of surgical interventions, improvement of efficiency of special treatment modalities and modes of respiratory support, as well as development of new generation antibiotic medications has led to significant improvement of clinical outcomes of intensive therapy for critical conditions. At the same time, introduction of innovative and largely invasive interventions resulted in the emergence of new disease entities. Presently, the development of hospital-acquired infections (HAI) has become one of the riveting and serious problems of modern hospitals. These infections often lead to prolonged hospital stay, which in turn adds to the morbidity and mortality, worsen patient quality of life and also has significant economic consequences [1-5]. There are number of varying definitions of infections related to medical care [6]. According to the WHO, infections that develop 48 hours after hospitalization, excluding the incubation period, are called hospital-acquired or nosocomial infections. Some authors also include here infections that develop 4 weeks after patient’s discharge from hospital or 30 days after surgical interventions are also included in this category. Infections that develop within 30 days after last chemotherapy in patients with metastatic cancer are also included as additional criteria according to a medical literature [7]. Other authors conclude that readmission of patients with established infection that was the result of previous hospitalization as well as any infectious diseases of hospital employee that develops secondary to the work in the hospital, irrespective to the time of onset of symptoms (during or after the hospital visit or stay) shall also be regarded as the hospital-acquired infections (HAI) [8-10]. The average prevalence of HAI is around 3.5-10.5% or 9.0-91.7 cases per 1000 patient-days [11]. It is estimated that the probability of infectious complications increases after five days of hospitalization [12]. According to the modern medical knowledge, the prevalence of HAI of various causes among the hospitalized patients in North America and Europe is around 5-10% and those in Latin America and Asia is around 40% [13,14]. The mortality among patients with HAI is seven times higher than among other patients aligned based on age, sex, main disease and comorbidities and severity of disease. According to the official statistics, HAIs are fourth most common cause of mortality in the US leading to 90.000 deaths annually. Annual economic burden and additional costs associated with the treatment of HAIs in the US is about 2.4-4.5 billion US dollars [15-17].

scholarly journals Highly sensitive detection of Staphylococcus aureus by a THz metamaterial biosensor based on gold nanoparticles and rolling circle amplification

RSC Advances ◽  
2020 ◽  
Vol 10 (45) ◽  
pp. 26824-26833 ◽  
Author(s):  
Ke Yang ◽  
Wenjing Yu ◽  
Guorong Huang ◽  
Jie Zhou ◽  
Xiang Yang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Rolling Circle Amplification ◽  
Rolling Circle ◽  
Hospital Acquired Infections ◽  
Food Borne ◽  
Highly Sensitive ◽  
Food Borne Illness ◽  
Highly Sensitive Detection ◽  
Hospital Acquired ◽  
The Impact

A highly sensitive method for detecting Staphylococcus aureus (S. aureus) is urgently needed to reduce the impact and spread of hospital-acquired infections and food-borne illness.

scholarly journals Probiotics to Reduce Clostridium difficile Infection: Clinical Experience in a Tertiary Care Center

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S384-S384
Author(s):  
Maggie Box ◽  
Kristine Ortwine ◽  
Keyword(s):  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Primary Outcome ◽  
Care Center ◽  
Tertiary Care ◽  
Concomitant Administration ◽  
Antibiotic Exposure ◽  
Time Period ◽  
Probiotic Preparation ◽  
Hospital Acquired

Abstract Background There is conflicting clinical data regarding the efficacy of probiotics to prevent Clostridium difficile infection (CDI). The goal of this study is to compare rates of hospital acquired Clostridium difficile infection (HA-CDI) among patients receiving antibiotics with or without concomitant administration of probiotics. Methods This retrospective, cohort study compares hospitalized patients who received antibiotics alone vs. antibiotics plus a multi-strain probiotic preparation of lactobacillus over a six month time period. Probiotics were given at the discretion of the physician. The primary outcome was incidence in HA-CDI (defined as onset after hospital day three) between groups. Results A total of 1,576 patients met selection criteria, with 927 patients receiving antibiotics alone and 649 patients receiving antibiotics plus probiotics. HA-CDI rates were 0.9% and 1.8% (P = 0.16), respectively. In a subgroup analysis of patients in the antibiotic only group, patients who received similar antibiotic exposure as the probiotics group (n = 284) had no difference in rates of HA-CDI (1.8% vs. 1.8%; P = 1.0). Conclusion Probiotic administration did not decrease rates of HA-CDI in our institution. We recommend prioritizing resources to other CDI reduction measures such as decreasing antibiotic exposure and preventing transmission. Disclosures All authors: No reported disclosures.

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