scholarly journals Relationship between administration of statins and blood serum levels of selected biochemical parameters

2021 ◽  
Vol 9 (1) ◽  
pp. 83-90
Author(s):  
Tatiana Ďurčeková ◽  
Ján Mocák ◽  
Ján Balla ◽  
Gabriela Gromanová ◽  
Katarína Boronová
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Lipoprotein Metabolism ◽  
Serum Levels ◽  
Patient Data ◽  
Biochemical Tests ◽  
Blood Samples ◽  
Software Packages ◽  
Before And After

Results of biochemical tests of 172 patient data (among them 84 men data and 88 women data, resp.) before and after administration of statins were studied. All monitored patients are characterized by lipoprotein metabolism failure or other kind of lipidaemia. The calculations were performed using several chemometrical methods pursuing visualization of most important biochemical parameters and classification of the patient blood samples by means of up-to-date software packages. The dependences of the content of most common biochemical parameters upon the treatment of patients by statins were elucidated in detail.

scholarly journals Comparison of ten biochemical laboratory tests before and after treatment by statins

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Tatiana Ďurčeková ◽  
Ján Mocák ◽  
Ján Balla ◽  
Gabriela Gromanová ◽  
Katarína Boronová
Keyword(s):  
Biochemical Parameters ◽  
Laboratory Tests ◽  
Lipoprotein Metabolism ◽  
Patient Data ◽  
Biochemical Tests ◽  
Blood Samples ◽  
Biochemical Laboratory ◽  
Before And After ◽  
Statin Drug

Results of 10 biochemical tests of 172 patient data (among them 84 men data and 88 women data, resp.) before and after administration of statins were thoroughly studied. All monitored patients are characterized by disorders of lipoprotein metabolism or other kind of dislipidaemia. The calculations were performed using four chemometrical methods facilitating quantification and visualization of the statin effect upon most important biochemical parameters, mainly lipid markers, and allowing classification of the patient blood samples taking into account whether the patient has been or has not been medicated by a statin drug.

scholarly journals Features of biochemical indices and content of enzymes in the serum of syphilis patients with viral hepatites B and C in the course of treatment

2021 ◽  
Vol 26 (3) ◽  
pp. 107-113
Author(s):  
S.V. Zakharov ◽  
V.K. Zakharov ◽  
V.V. Gorbuntsov
Keyword(s):  
Functional State ◽  
Biochemical Parameters ◽  
Early Stage ◽  
Serum Levels ◽  
Test Methods ◽  
Comprehensive Examination ◽  
Before And After ◽  
Biochemical Indices ◽  
Increased Activity ◽  
Latent Syphilis

Objective – before and after the treatment to determine the functional state of the liver, serum levels of enzymes and biochemical indices in syphilis patients with viral hepatites B and C. The results of the study are based on the data from a comprehensive examination of 35 patients with syphilis alone and 127 patients with syphilis co-infected with viral hepatites B and C before and after treatment. Test methods: hepatology, rheogeopathography, enzyme content and biochemical parameters determined in the serum. According to the results of radionuclide hepatology it has been established that disorders of the functional capacity of the liver already occur in the early stages of the disease. The most significant disorders have been in the patients with the prescription of infection for more than 12 months and in the patients co-infected with viral hepatites B and C. A disorder of pigment metabolism and increased activity of trans­aminases have been revealed in early latent syphilis. In co-infection with viral hepatites B and C an increase in total bilirubin, Lactate dehydrogenase, Alanine transaminase, Aspartate aminotransferase and albumin has been revealed. Dysproteinemia has been revealed in patients with early latent syphilis co-infected with hepatitis C. Patients with early latent syphilis treated with immunomodulators tend to normalize these indices. In patients with syphilis a disorder of the functional state of the liver have been revealed already at an early stage of the disease. The most pronounced disorder of biochemical parameters and activity of liver enzymes are observed in syphilis patients with viral hepatites B and C, as well as in patients with early latent syphilis only with the prescription of the infection for more than 12 months; in such a case it is advisable to use drugs affecting the immune system.

scholarly journals The Usefulness of Performing Biochemical Tests in the Saliva of Kickboxing Athletes in the Dynamic of Training

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Oleksandr Anatolievich Volodchenko ◽  
Leonid Vladimirovich Podrigalo ◽  
Sergii Sidorovich Iermakov ◽  
Małgorzata Teresa Żychowska ◽  
Władysław Jagiełło
Keyword(s):  
Lipid Peroxidation ◽  
Lactic Acid ◽  
Pyruvic Acid ◽  
Biochemical Parameters ◽  
Training Session ◽  
Training Experience ◽  
Biochemical Tests ◽  
Male Athletes ◽  
Correlation Matrices ◽  
Before And After

The study aimed to determine the suitability of testing the saliva of kickboxing athletes to show changes in biochemical parameters in dynamic of training. 8 elite male athletes (mean age 17.29± 0.31 years, body mass 66.82± 3.46kg, with 5.62±0.96 years of training experience) participated in the study. Indicators of lipid peroxidation and glycolysis (the concentration of lactic acid and pyruvic acid) were defined before and after a training session. Significant increases in indicators of lipid peroxidation activity indicators and the concentration of lactic acid (4-fold) were observed; analysis of correlation matrices confirms the absence of expressed changes. At the same time, significant decreases in catalase (10-fold from 3.69μkat/L to 0.39μkat/L) and pyruvic acid (from 3.92μl/l to 0.55μl/l) were observed. Our results confirm the value of using saliva to determine training load in an individual. Moreover, the study provided information on the importance of indexes reflecting a correlation of various biochemical indicators to estimate the sufficiency of training loads. The ease of sampling and informational content of saliva are reasons to use such tests in monitoring athletes’ functional state to prevent fatigue.

scholarly journals Acute long-distance trail running increases serum IL-6, IL-15, and Hsp72 levels

2019 ◽  
Vol 44 (6) ◽  
pp. 627-631 ◽  
Author(s):  
Melda Pelin Yargic ◽  
Seyma Torgutalp ◽  
Senay Akin ◽  
Naila Babayeva ◽  
Murat Torgutalp ◽  
...  
Keyword(s):  
Sandwich Elisa ◽  
Fat Metabolism ◽  
Serum Levels ◽  
Metabolic Effects ◽  
Elisa Method ◽  
Long Distance ◽  
Blood Samples ◽  
Before And After ◽  
The Mean ◽  
Trail Running

Interleukin-6 (IL-6), IL-15, and heat shock protein 72 (Hsp72) are molecules that have significant metabolic effects on glucose and fat metabolism and a cell’s stress response. The aim of this study is to determine serum levels of these molecules in runners after a long-distance trail run. Serum IL-15 levels after such endurance events have not been investigated yet. Blood samples were collected from 37 athletes (11 female, 26 male) before and after a 35-km trail run, with a total climb of 940 m. Serum was obtained from the samples, and IL-6, IL-15, and Hsp72 levels were measured from using the sandwich ELISA method. The athletes completed the race in 308.3 ± 37.4 min on average. After the race, the mean serum IL-6, IL-15, and Hsp72 concentrations increased 13.2-fold, 2.22-fold, and 1.6-fold, respectively (p < 0.001, p < 0.001, and p = 0.039, respectively). This is the first study to demonstrate the increase in serum IL-15 levels following an acute endurance exercise. In addition to IL-15, we report that IL-6 and soluble Hsp72 levels also increased significantly following a 35-km trail run. Since these molecules are involved in regulating glucose and fat metabolism, significant increases of IL-6, IL-15, and soluble Hsp72 may have health benefits that may be associated with long-distance trail runs, which are becoming more popular worldwide.

scholarly journals Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans

2005 ◽  
Vol 2005 (5) ◽  
pp. 298-303 ◽  
Author(s):  
Joanna Narbutt ◽  
Aleksandra Lesiak ◽  
Malgorzata Skibinska ◽  
Anna Wozniacka ◽  
Anna Sysa-Jedrzejowska ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Serum Levels ◽  
Cytokine Level ◽  
High Dose ◽  
Serum Cytokine Level ◽  
Serum Cytokine ◽  
Blood Samples ◽  
Before And After ◽  
Immune Impairment ◽  
Repeated Doses

The aim of our study was to compare serum concentration of IL-1β, IL-6, IL-8, IL-10, and TNF-αin 105 healthy volunteers before and after exposure to UVR: 25 subjects (10 days of UVB), 55 (10 days of UVB or solar-simulated radiation, followed by acute UVB dose), and 25 (local high dose of UVB). In all the individuals blood samples were analyzed before and after final irradiation by chemiluminescence assay. After 10 days of UVB irradiation a statistically significant increase in serum concentration only in IL-8(P<.05)and strong tendency in TNF-α(P=.05)were observed. The applied schedules of irradiation have minor impact on serum cytokine level and still a threshold dose of UVR causing systemic immune impairment is unknown.

scholarly journals Dynamics of sperm antibody levels in adolescents with left-sided varicocele

2020 ◽  
Vol 22 (5) ◽  
pp. 969-976
Author(s):  
S. V. Pichugova ◽  
I. V. Rybina ◽  
Ya. B. Beikin
Keyword(s):  
Blood Serum ◽  
Comparison Group ◽  
Seminal Fluid ◽  
Venous Blood ◽  
Blood Stasis ◽  
Serum Levels ◽  
Main Group ◽  
Childhood And Adolescence ◽  
Before And After ◽  
Sperm Antibodies

Varicocele means a varicose vein of the spermatic cord, being among the most common disorders diagnosed in childhood and adolescence, which suggests a high risk for infertility. Varicocele is considered an additional factor for immune-dependent infertility which results from damaged hemato-testicular barrier due to venous blood stasis, hyperthermia, testicular ischemia. Our objective was to determine levels of the sperm antibodies in serum and ejaculate in adolescents with left-sided varicocele, in order to assess the changing levels of sperm antibodies in blood serum at different ages during the postoperative period, depending on the degree of varicocele. For adolescents with left-sided varicocele and without varicocele, the serum levels of sperm antibodies were determined annually at the age of 14 to 17 years, as well as registration of sperm antibodies titer in seminal fluid at the age of 17 years. The levels of sperm antibodies in blood serum were traced in dynamics for the main group and comparison group, also comparing the groups with different degrees of varicocele, like as the patients before and after surgical varicocele correction. We did not reveal increased levels of the sperm antibodies over reference values in any subject under study. The level changes of sperm antibodies in serum showed an increase in these indexes at the age of 15-16 years in adolescents of both groups with a trend for a decrease in the comparison group by 17 years of age, however, without such tendency in the main group. No significant differences were found in the levels of sperm antibodies in blood serum depending on the degree of varicocele, and on the time after varicocelectomy.

scholarly journals Maternal Serum Levels of TNF-Alpha and IL-6 Long after Delivery in Preeclamptic and Normotensive Pregnant Women

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
N. Vitoratos ◽  
E. Economou ◽  
C. Iavazzo ◽  
K. Panoulis ◽  
G. Creatsas
Keyword(s):  
Pregnant Women ◽  
Serum Levels ◽  
Maternal Serum ◽  
The Other ◽  
Tnf Alpha ◽  
Blood Samples ◽  
Inflammatory Stress ◽  
Before And After ◽  
A Prospective Study ◽  
Normal Controls

Aim. To evaluate maternal TNF-alpha and IL-6 plasma levels in normotensive pregnant women, women with preeclampsia, and to examine the temporal changes in their levels from theantepartum to the postpartum period correlated with the regression of preeclampsia.Method. A prospective study was performed in the 2nd Department of Obstetrics and Gynecology, University of Athens. Blood samples were obtained: (1) antepartum at the time of clinical diagnosis of the syndrome, 2. 12-14 weeks postpartum.Results. No statistically significant differences were found in IL-6 levels, whereas a difference was found in TNF-alpha levels between preeclamptic and controls in antepartum period (0.80 pg/ml versus 0.60 pg/ml, ). Long after delivery, TNF-alpha levels were significantly higher in preeclamptic compared to normotensive controls (0.86 pg/ml versus 0.60 pg/ml, ). No difference was observed in TNF-alpha before and after delivery in both groups. No difference was noticed in IL-6 levels in women of normotensive group long after delivery compared to that before delivery. Long after delivery IL-6 levels were statistically significant higher in preeclamptic women compared to normal controls (3.53 ± 0.52 pg/ml versus 1.69 ± 0.48 pg/ml, ).Conclusion. Preeclamptic women remain under a status of increased inflammatory stress up to 12-14 weeks postpartum despite the fact that all the other signs of preeclampsia are resolved.

scholarly journals ВПЛИВ ІНТРАВАСКУЛЯРНОГО ЛАЗЕРНОГО ОПРОМІНЕННЯ НА ПОКАЗНИКИ КРОВІ У КОРІВ ЗА ЛІКУВАННЯ ГНІЙНО-ЗАПАЛЬНИХ ПРОЦЕСІВ ДИСТАЛЬНОГО ВІДДІЛУ КІНЦІВОК

2014 ◽  
pp. 134-137
Author(s):  
І. І. Юрченко
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Serum ◽  
Biochemical Parameters ◽  
Inflammatory Process ◽  
Control Group ◽  
Laboratory Results ◽  
Before And After ◽  
Inflammatory Processes ◽  
Hematological And Biochemical Parameters ◽  
Experimental Group

Висвітлені результати лабораторних дослідженькрові (сироватки) за низкою гематологічних і біохі-мічних показників від корів, хворих на гнійно-запальніпроцеси в дистальному відділі кінцівок, до та післявикористання інтраваскулярного лазерного опромі-нення крові. Встановлено, що використання ІЛОК ілокально порошку сульфату міді сприяє нормалізаціїзапального процесу. До того ж у сироватці крові ре-єструється вірогідне зниження активності аспара-гінової трансамінази та збільшення (в контрольнійгрупі) лужної фосфатази. Крім того у дослідній групівідмічали зниження, а в контрольній збільшення від-сотка лімфоцитів, а також збільшення гемоглобіну вдослідній та зменшення його в контролі. Laboratory results of blood (serum) for a range of hematological and biochemical parameters of cows sick on inflammatory processes in the distal extremities before and after use of intravascular laser irradiation of blood have been lit. It has been established that the use of locally ILOK and copper sulfate powder contributes to the normalization of the inflammatory process. In the blood serum is achieved a significant reduction of the activity of aspartic trans a minase and alkaline phosphatase is increased (in the control group).Also in the experimental group we saw a decreasing of the percentage of lymphocytes, and in control one - increasing the percentage of lymphocytes, as well as an increasing of hemoglobin in the experimental group and in control group – its reduction.

Dietary Changes in Fasting Levels of Factor VII Coagulant Activity (FVII: C) Are Accompanied by Changes in Factor VII Protein and other Vitamin K-dependent Proteins

1995 ◽  
Vol 73 (02) ◽  
pp. 239-242 ◽  
Author(s):  
E M Bladbjerg ◽  
T Tholstrup ◽  
P Marckmann ◽  
B Sandström ◽  
J Jespersen
Keyword(s):  
Fatty Acids ◽  
Vitamin K ◽  
Protein C ◽  
Saturated Fatty Acids ◽  
Factor Vii ◽  
Dietary Regimen ◽  
Blood Samples ◽  
Dietary Changes ◽  
Coagulant Activity ◽  
Before And After

SummaryThe mechanisms behind dietary effects on fasting coagulant activity of factor VII (FVII: C) are not clarified. In the present study of 15 young volunteers, two experimental diets differing in composition of saturated fatty acids (C18:0 [diet S] or C12:0 + C14:0 [diet ML]) were served for 3 weeks each. Fasting blood samples were collected before and after the dietary regimen and analysed for triglycerides, FVII:C, and protein concentrations of FVII, FII, FX, protein C, CRP, albumin, fibrinogen, and F1+2. FVII:C was significantly reduced on diet S compared with diet ML. This was accompanied by a decrease in FVII protein, F1+2 and the vitamin K-dependent proteins FII, FX, and protein C. In contrast, no changes were observed in triglycerides, FVII:C/FVII: Ag, albumin and CRP. Fibrinogen was increased on diet S compared with diet ML. Our findings suggest that the change in fasting FVII:C was part of a general change in concentrations of vitamin K-dependent proteins.

POSTOPERATIVE COMPLIANCE OF BARIATRIC SURGERY PATIENTS REGARDING THE ASSESSMENT OF SERUM LEPTIN LEVELS AND INSULIN RESISTANCE

2019 ◽  
Vol 49 (1/2019) ◽  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Serum Levels ◽  
Medical Laboratory ◽  
Leptin Resistance ◽  
Obese Patients ◽  
Laboratory Assessment ◽  
Serum Leptin ◽  
Before And After ◽  
Bariatric Patients

Background and aims: Overweight and obese patients who undergo bariatric surgery require a rigorous clinical and paraclinical assessment both before and after the surgery at 3, 6, and 12 months.The present study aims the assessment of serum leptin levels and insulin resistance status in compliant bariatric patients to scheduled medical laboratory assessment at 6 months after surgery. Material and Method: The study included 109 eligible patients selected for bariatric surgery, 48 of whom attended the scheduled visit at 6 months after the surgery. Laboratory assessing regarded the insulin resistance by determining before meal the serum levels of leptin, glucose and insulin, as well as HOMA 1 and HOMA 2 indexes. Results: Patients who underwent bariatric treatment experienced a significant decrease in insulin resistance status. A higher percentage in the preoperative group was recorded in women, feature which was also recorded in the postoperative group that attended the scheduled visit at 6 months after surgery. Age is also an important factor that significantly influences the behavioral adherence to postoperative visits. Conclusions: Insulin resistance status improved significantly in 6 months after bariatric surgery among the fully compliant patients. The percentage of attendance at scheduled visits is higher among women, and decreases with age. Keywords: obesity surgery, leptin resistance, insulin resistance, HOMA index, compliance

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