scholarly journals Satisfactory Control for Glucose Profile by Combined Agents of Xultophy with A Small Dose

2021 ◽  
Vol 3 (2) ◽  
pp. 23-29
Author(s):  
Hiroshi Bando ◽  
Hiroko Ogawa ◽  
Shinji Nagahiro ◽  
Miwako Nakanishi ◽  
Osami Watanabe
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Social History ◽  
Glucose Monitoring ◽  
Glucose Variability ◽  
Social Benefit ◽  
Insulin Degludec

The patient was a 74-year-old female with type 2 diabetes mellitus (T2DM) treated on Humalog mix 25 twice a day. As social history, she has worked long years for growing and harvesting lotus roots. It gives physically heavy loading, which brings unstable glycemic daily control. She had to titrate minute regulation every time. For stable glucose variability, the treatment was changed to Xultophy, which is a specific combined agent of Insulin Degludec and Liraglutide (IDeg/Lira) once a day. Then, detailed glucose monitoring showed a better daily profile of blood glucose, irrespective of heavy or light work. It showed the bio-psycho-social benefit of Xultophy.

scholarly journals Reduced Glucose Variability With Glucose-Dependent Versus Glucose-Independent Therapies Despite Similar Glucose Control and Hypoglycemia Rates in a Randomized, Controlled Study of Older Patients With Type 2 Diabetes Mellitus

2018 ◽  
Vol 12 (6) ◽  
pp. 1184-1191
Author(s):  
Richard E. Pratley ◽  
Julio Rosenstock ◽  
Simon R. Heller ◽  
Alan Sinclair ◽  
Robert J. Heine ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Older Patients ◽  
Glucose Monitoring ◽  
Glycemic Variability ◽  
Glucose Variability ◽  
Controlled Study ◽  
Glucagon Like Peptide 1

Background: Few studies have evaluated continuous glucose monitoring (CGM) in older patients with type 2 diabetes mellitus (T2DM) not using injectable therapy. CGM is useful for investigating hypoglycemia and glycemic variability, which is associated with complications in T2DM. Methods: A CGM substudy of Individualized treatMent aPproach for oldER patIents in a randomized trial in type 2 diabetes Mellitus (IMPERIUM)) was conducted. Patients were vulnerable (moderately ill and/or frail) older (≥65 years) individuals with suboptimally controlled T2DM. Strategy A comprised glucose-dependent therapies (n = 26) with a nonsulfonylurea oral antihyperglycemic medication (OAM) and a glucagon-like peptide-1 receptor agonist as the first injectable. Strategy B comprised non-glucose-dependent therapies (n = 21) with sulfonylurea as the preferred OAM and insulin glargine as the first injectable. Primary endpoints were duration and percentage of time spent with blood glucose (BG) ≤70 mg/dL over 24 hours at week 24. Results: Duration and percentage of time spent with hypoglycemia at ≤70 mg/dL were similar for Strategy A and Strategy B; glycemic control improved similarly in both arms (LSM change in HbA1c at week 24; A = −1.2%, B = −1.4%). Duration and percentage time spent with euglycemia and hyperglycemia were also similar in both arms. However, Strategy A was associated with lower within-day (21.1 ± 1.2 vs 25.1 ± 1.4, P = .046) and between-day (5.4 ± 1.0 vs 9.1 ± 1.3, P = .038) BG variability (coefficient of variance [LSM ± SE]) at week 24. Conclusions: This CGM substudy in older patients with T2DM showed lower within- and between-day BG variability with glucose-dependent therapies but similar HbA1c reductions and hypoglycemia duration with glucose-independent strategies.

scholarly journals The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM)

2021 ◽  
Author(s):  
Mike Stedman ◽  
Rustam Rea ◽  
Christopher J. Duff ◽  
Mark Livingston ◽  
Katie McLoughlin ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Glucose Monitoring ◽  
Blood Glucose Monitoring

scholarly journals The association of diurnal blood glucose variability with subclinical cardiac disease in patients with type 2 diabetes mellitus

2020 ◽  
Vol 32 (4) ◽  
pp. 490-497
Author(s):  
Walid Shehab-Eldin ◽  
Ahmed Al-ashmawy ◽  
Mahmoud Kamel ◽  
Nesrin Elhelbawy ◽  
Alaaeldin Dawood ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Cardiac Disease ◽  
Glucose Variability ◽  
Blood Glucose Variability
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