scholarly journals Effect of Vitamin C to The Plasma Level of Interleukin-6, Plasma MDA and Length of Hospitalization of COPD Exacerbation Patient

2018 ◽  
Vol 38 (1) ◽  
pp. 24-32
Author(s):  
Fadlia Yulistiana ◽  
Suradi Suradi ◽  
Reviono Reviono

Background: Exacerbation is an acute condition characterized by worsening of symptoms that require a change in therapy. Increased inflammation of the airways and lungs during exacerbations causes an increase in plasma IL-6 and MDA levels and causes most patients needed treatment at the hospital. Vitamin C is an antioxidant vitamin that has anti-inflammatory and antioxidant effects so that it can be added to COPD exacerbations therapy. This study aims to determine the effect of vitamin C on plasma IL-6, plasma MDA levels and length of hospitalization of acute exacerbation of COPD patients. Methods: This research is an experimental study with pre-test and post-test design. Subjects consisted of 33 patients with exacerbation of COPD were treated at the Soehadi Pridjonegoro Hospital Sragen in October-November 2015 which were selected by purposive sampling. Subjects were divided into two groups, the treatment group (n=16) received vitamin C therapy 1x1000 mg/day and the control group (n=17) received 5 mL of NaCl 0.9%. Levels of IL-6 plasma and plasma MDA was measured on admission and at discharge criteria are met. Length of hospitalization is calculated based on the number of days’ patients in hospital. Results: There was no statistically significant difference to decreased of IL-6 plasma level (P=0.379), MDA plasma level (P=0.27) and length of hospitalization (P=0.24) between treatment and control group. Conclucions: The addition of vitamin C 1x1000 mg/day during hospitalization is not helpful to decreased in levels of plasma IL-6, plasma MDA and length of hospitalization in this study. (J Respir Indo 2018; 38(1): 24-32)

2015 ◽  
Vol 37 (1) ◽  
pp. 14
Author(s):  
Enikarmila Asni ◽  
Ismawati Ismawati ◽  
Bulqis Vellaya Arlem

AbstrakPemanasan berulang pada minyak dengan suhu tinggi mengakibatkan proses oksidasiyang akan meningkatkan oksidan tubuh jika termakan. Penelitian ini menentukan pengaruhlama konsumsi makanan yang digoreng dengan minyak kelapa sawit pemanasan 40 kaliterhadap kadar malondialdehid (MDA) plasma. Desain penelitian ini adalah post test onlycontrol group dengan menggunakan hewan coba tikus sebagai sampel.Tikus dibagi 4 kelompokyang terdiri dari 2 kelompok perlakuan 14 dan 28 hari yang diberikan kentang yang digorengdengan minyak tanpa pemanasan berulang serta 2 kelompok perlakuan 14 dan 28 hari denganpemanasan berulang 40 kali. MDA diukur dengan metode Wills. Hasil penelitian menunjukkanbahwa MDA plasma pada kelompok dengan pemanasan berulang berbeda bermakna(p=0,004) jika dikonsumsi selama 28 hari, namun tidak berbeda bermakna (p=0,749) jikadikonsumsi selama 14 hari jika dibandingkan dengan kelompok tanpa pemanasan berulang.Durasi konsumsi selama 14 dan 28 hari tidak mengakibatkan perbedaan MDA plasma yangbermakna (p=0,766). Kesimpulan, pemberian makanan yang digoreng dengan minyakkelapa sawit yang dipanaskan berulang 40 kali selama 14 dengan 28 hari tidak menimbulkanperbedaan bermakna kadar MDA plasma.AbstractRe-heated process of oil could increase oxidative products, resulting in the increase ofoxidant level if consumed. This research investigated the influence of long term consumptionof food fried in 40 times re-heated palm oil on plasma malondialdehyde (MDA) level. This waspost test only control group research. This research used rat as experimental models whichwere divided into 4 groups. Two groups were given potatoes fried in non re-heated palm oilfor 14 and 28 days, and 2 groups were given potatoes fried in 40 times re-heated palm oilfor 14 and 28 days. MDA levels were measured by Wills methods. Result showed that MDAplasma level in re-heated group was significantly different (p=0.004) if consumed for 28 dayscompared to non re-heated group, but was not significantly different (p=0.749) if consumedfor 14 days. There was no significant difference on MDA plasma level between the durationof consumption for 14 days and 28 days (0.766). As conclusion, consumption of food fried in40 times re-heated palm oil for 14 and 28 days did not cause significant differences on MDAplasma level.


2019 ◽  
Vol 38 (4) ◽  
pp. 192-8
Author(s):  
Aslani Threestiana Sari ◽  
Suradi Suradi ◽  
Jatu Aphridasari

Background: COPD exacerbations is an acute condition with worsening symptoms and require more intensive treatment changes. Increased inflammatory exacerbations marked increase in plasma levels of IL-8, exacerbation of clinical symptoms and risk of hospitalization. Ginseng extracts have anti inflammatory so it can be used as an additional drug in COPD exacerbations. Method: This study aimed to analyze the effect of ginseng extract on plasma levels of IL-8, CAT scores, and length of hospitalization of patients with COPD exacerbations. Clinical trials of experimental with pre test and post test design was conducted on 34 patients with COPD exacerbation in Dr. Moewardi Hospital Surakarta and Dr. Ario Wirawan Lung Hospital Salatiga from August until September 2016. Samples were taken by consecutive sampling were divided into two groups. The treatment group (n = 17) received standard therapy and ginseng extracts 2x100mg/day and the control group received only standard therapy (n = 17). Clinical improvement measured in CAT score and length of stay. Plasma levels of IL-8, CAT scores, and longer hospitalization time measured at entry and discharge criteria are met. Length of stay based on the number of days of care in hospitals. Results: There were significant difference (p=0.000) towards decreased of of IL-8 plasma level between treatment group (-12.38 ± 10,35pg/ml) and control group (0.65 ± 7,92pg/ml), towards decrease of CAT score (p=0.000) between treatment group (-16.53 ± 1.28) and control group (-12.59 ± 2.87), and length of stay (p = 0.004) between treatment group (4.29 ± 1.45) and control group (5.76 ± 1.20). Conclusions: The addition of ginseng extract 2x100 mg/day during hospitalization was significantly lowered plasma levels of IL-8, CAT scores, and shortening the length of stay. (J Respir Indo. 2018; 38: 192-8)


2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Geri W. Setiawan ◽  
Damajanty H. C. Pangemanan ◽  
Hedison Polii

Abstract: Vitamin C is a water soluble antioxidant. Vitamin C can prevent tissue damage by reducing the production of oxidants. Supplementation of vitamin C is reported to have a protective effect against muscle injury induced by physical exercise. Physical exercise can trigger oxidative stress caused by tissue injury. Neutrophils play an active role in the process of phagocytosis of bacteria, microorganisms, and clean up the damaged tissue caused by tissue injury. The purpose of this research is to know the effect of vitamin C on neutrophil count after physical exercise. The study was a field experimental with pre post test control group design. To test the significance of this research, the statistical test such as Mann Whitney U with a standard error of 5% or α = 0.05. Physical exercise such as futsal for 60 minutes conducted by 30 male respondents were divided into 2 groups: treatment and control. The levels of neutrophils measured after physical exercise and after the administration of vitamin C 500 mg. There was no significant effect of vitamin C on levels of neutrophils after physical exercise where significant value 0.378. Conclusion: In this research vitamin C had no effect on levels of neutrophils after physical exercise.Keywords: vitamin c, neutrophil, physical exercise, oxidative stressAbstrak: Vitamin C adalah antioksidan yang larut dalam air. Vitamin C dapat mencegah kerusakan jaringan dengan mengurangi produksi oksidan. Suplementasi vitamin C dilaporkan memiliki efek protektif terhadap cedera otot yang diinduksi latihan fisik. Latihan fisik dapat memicu stres oksidatif yang disebabkan oleh cedera jaringan. Neutrofil berperan aktif dalam proses fagositosis bakteri, mikroorganisme, dan membersihkan sisa jaringan rusak yang disebabkan oleh cedera jaringan. Tujuan penelitian ini yaitu untuk mengetahui pengaruh vitamin C terhadap kadar neutrofil setelah latihan fisik. Jenis penelitian ini adalah eksperimental lapangan dengan rancangan pre post test control group design. Untuk menguji signifikansi dari penelitian ini maka dilakukan uji statistik Mann Whitney U test dengan taraf kesalahan yaitu 5 % atau α = 0,05. Latihan fisik berupa olahraga futsal selama 60 menit dilakukan oleh 30 responden laki-laki yang dibagi dalam 2 kelompok yaitu perlakuan dan kontrol. Kadar neutrofil diukur setelah latihan fisik dan setelah pemberian vitamin C 500 mg. Tidak terdapat pengaruh signifiakan pemberian vitamin C terhadap kadar neutrofil setelah latihan fisik dimana nilai signifikannya 0,378. Simpulan: Pada penelitian ini vitamin C tidak berpengaruh terhadap kadar neutrofil setelah latihan fisik.Kata kunci: vitamin c, neutrofil, latihan fisik, stres oksidatif


2017 ◽  
Vol 1 (2) ◽  
pp. 138
Author(s):  
Mekar Dwi Anggraeni ◽  
Lutfatul Latifah ◽  
Aprilia Kartikasari ◽  
Ima Rismawati

Background and purpose: The earlier development of the attitude toward exclusive breastfeeding produces the longer exclusive breastfeeding duration. Considering the first marriage age among Indonesian, the attitude toward exclusive breastfeeding should be developed at the adolescence age. The purpose of this study was to examine the effect of the attitude toward breastfeeding concept based comic on the adolescent's attitude toward exclusive breastfeeding. Method: This was a quasy experimental posttest only with control group study. The respondents were provided an comic. The respondent's attitude toward exclusive breastfeeding was measured using The Breastfeeding Attitude Questionnaire. Data were analyzed using independent and dependent t test. Results: The majority of respondents were aged 17 years old in both intervention (70%) and control grup (63%), first child in both intervention (23,3%) and control grup (26,7%), and had a nuclear family in both intervention (80%) and control grup (90%). The independent t test showed that there was a significant difference between post-test scores among the intervention and control groups (t = 5,602, p < 0,01). Conclusion and recommendation: Nurses may use the Attitude Toward Breastfeeding based comic to increase the Adolescence's attitude toward breastfeeding.Keywords: Comic, Attitudes Toward Exclusive Breastfeeding, Adolescence


2019 ◽  
Vol 1 (33) ◽  
pp. 693-714
Author(s):  
. Muntaha Sabbar Jebur

          Peer teaching is a strategy that allows the students to teach the new content to each other, and they must be accurately guided by instructors.     The researcher proposes that the use of students peer teaching  may promote students' achievement  and ensure the engagement of all the students in the learning process. Therefore, the researcher employs it as a teaching method aiming at investigating its  effect on Iraqi EFL students' achievement in the course of Library and Research Work .      The study hypothesizes that there is no significant difference between the students' achievement who are taught library and research work by students peer teaching  and that of the students taught by the traditional way. The experimental design of the study is Parallel Groups, Random Assignment, posttest. Each group consists of 35 students, chosen randomly from the Third Year Students at the Department of English in the College of Basic Education. Both groups were matched in terms of their age and parents' education. The experiment was fulfilled in the first course for 15 weeks during the academic year 2016-2017.       The same materials were presented to both groups. This included   units from Writing Research Paper by Lester D. . Post-test was constructed and exposed  The t-test for  independent samples was used to analyze the results and it is found out that there is a statistical difference between the two groups in their achievement because the calculated t- value 2.635 is bigger than the tabulated t- value which is 2.000, and also shown the superiority of the experimental group. The results indicate that the experimental group, who was taught Library and Research Work by peer teaching   was better than the control group, who was taught according to the traditional way. So, the null hypothesis is rejected. Finally, some recommendations and suggestions are presented in the light of the study findings. to a jury of experts to verify its validity and it was administered to both groups.


Author(s):  
Rajwinder Kaur

The purpose of the study was to study the Effect of Web based instructions on achievement in Social Studies. The sample consisted of 100 students from Grade 8th of schools affiliated to C.B.S.E of Ferozepur and were randomly split into two groups-control (taught by traditional method) and experimental (taught by Web based instruction) groups. Firstly pre-test was administered on both the groups; then the students in the control group were taught by conventional method while experimental group was taught by Web based instructions. Then post-test was administrated on both the groups. The Statistical techniques were then employed to data collected and analysis and interpretation of the data was done. The result of the study implied that there exists significant difference in achievement in Social Studies based on Web based instructions and conventional method. The study also revealed that there exist significant gender differences in achievement in Social Studies with Web based instructions.


Author(s):  
Shamsa Hashmi ◽  
Tanveer Akhtar ◽  
Maniha Hashmi

AbstractPresent study was aimed at investigating the role of Physical, Environmental, Task, Timing, Learning, Emotion and Perspective (PETTLEP) Imagery technique in the improvement of skill precision level of hockey drag flickers. For this purpose, both male (83) and female (38) hockey drag flickers (n=121) of age ranged between 17 and 27 years were selected from different hockey teams belonging to clubs, colleges, universities, departments, regional and national academies of Pakistan. Participants were made to undergo a Pretest-Intervention-Posttest research design consisted of 20 drag flicks and filling of SIAQ questionnaire. Drag Flick Precision Measurement Test (DFPMT) along with Sports Imagery Ability Questionnaire (SIAQ) were used to measure their skill precision levels and their imagery ability. The participants were classified into three categories as per their skill precision levels (Point-based), ranging from 48 Novice (upto12 points), 42 Intermediate (13–18 points) and 31 Elite (19 points and above), and were randomly assigned to one of four intervention groups; Physical Practice (PP), PETTLEP Imagery Practice (IP), Physical Practice+PETTLEP Imagery Practice Combination (CP), and No Practice (NP) Control group. Each group performed their respective tasks for 10 weeks through specially designed physical training programs aided by Imagery scripts. Paired sample t test analysis showed that all groups improved significantly (p<0.05) from pre- to post-test, and the CP group improved more with average improvement value of 8.32 for DFPMT and 5.39 for SIAQ (p<0.05) than the IP, PP and NP groups. However, there was no significant difference found between the PP (Sig. 0.73) and NP (Sig. 0.44) groups in SIAQ. Result extend prior research findings and suggests that PETTLEP Imagery practice used in combination with Physical practice has substantial impact on improving performance of complex motor skills, Present findings showed that PETTLEP imagery model was found to improve player’s precision skill levels, especially when it was combined with physical practice. However, further studies in this connection are needed.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tria Astika Endah Permatasari ◽  
Fauza Rizqiya ◽  
Walliyana Kusumaningati ◽  
Inne Indraaryani Suryaalamsah ◽  
Zahrofa Hermiwahyoeni

Abstract Background Almost one-third of children under 5 years old in Indonesia suffer from stunting. Stunting can be prevented optimally during pregnancy as the initial phase of the first 1000 days of life. This study aims to determine the effect of nutrition and reproductive health education of pregnant women in Bogor Regency, Indonesia. Methods A quasi-experimental study was conducted among 194 pregnant women from August to November 2019. The pregnant women were randomly selected from four different villages in Bogor Regency. The intervention group (n = 97) received 2 h of nutrition and reproductive health education in small groups (four or five mothers per group) every 2 weeks for 3 consecutive months. This interactive education was given by facilitators using techniques such as lectures, role-playing, simulation, and games. The control group (n = 97) received regular health care services. A structured questionnaire was applied to collect data consisting of maternal characteristics, nutritional and reproductive health knowledge, attitudes, and practices in the intervention and control groups. Data were analysed using t-test and chi-square analysis. Results Pregnant women in the intervention group indicated a significant increase in knowledge, attitudes, and practices regarding nutrition and reproductive health after receiving education. The pre-test and post-test mean scores in the intervention group were 55.1 and 83.1 for overall knowledge, 40.2 and 49.0 for attitudes, and 36.2 and 40.2 for practices, respectively. In the control group, there was no significant difference between the pre-test and post-test mean scores for these three variables. There was a significant difference (P < 0.001) in the post-test mean between the intervention group and the control group, but the difference was not significant (P > 0.05) in the pre-test. Conclusion Providing nutrition and reproductive health education through small groups with interactive methods improves the knowledge, attitudes, and practices of pregnant women. This intervention has the potential to be replicated and developed for large-scale implementation by optimising collaboration between government, non-governmental organizations, and maternal and child health service providers.


2020 ◽  
Vol 2 (1) ◽  
pp. 32
Author(s):  
Ahmad Farham Majid ◽  
Ismail Ismail ◽  
Mardhiah Mardhiah ◽  
Fitriani Nur

AbstrakPenelitian ini bertujuan untuk mengetahui kemampuan komunikasi matematis siswa yang menggunakan metode silih tanya berbantuan kartu model dan metode make a match. Jenis penelitian ini adalah quasi eksperimen dengan desain penelitian non equivalent pretest-posttest control group design. Populasi dalam penelitian ini adalah seluruh siswa kelas VII SMPN 4 Sungguminasa Kab. Gowa berjumlah 351 siswa dan total sampel berjumlah 64 siswa dengan teknik pengambilan sampel purposive sampling. Instrumen yang digunakan dalam penelitian ini adalah tes yang terdiri dari pretest dan posttest dan non tes berupa lembar observasi. Berdasarkan hasil analisis data nilai siswa menggunakan statistik deskriptif rata-rata nilai kemampuan komunikasi matematis siswa yang diajar menggunakan metode silih tanya berbantuan kartu model adalah 86,84 dengan kategori sedang dan yang diajar menggunakan metode make a match adalah 77,78 dengan kategori sedang. Berdasarkan analisis statistik inferensial bahwa terdapat perbedaan yang signifikan antara kemampuan komunikasi matematis siswa yang menggunakan metode silih tanya berbantuan kartu model dengan yang menggunakan metode make a match pada kelas VII SMPN 4 Sungguminasa Kab. Gowa. AbstractThis study aims to determine the mathematical communication ability of students who use card-assisted questions method and make a match method. This type of research is a quasi-experimental research with nonequivalent pretest-posttest control group design. The population in this study were all VII grade students of SMPN 4 Sungguminasa, Gowa Regency with 351 students and a total sample of 64 students with purposive sampling techniques. The instrument used in this study was a test consisting of pre-test and post-test and non-test that is observation sheet. Based on the data analysis results that average the value of students’ mathematical communication skills who were taught using the card-assisted questions was 86.84 in the medium category and those who taught using make a match method were 77.78 in the medium category. The results of inferential statistical analysis that there is a significant difference between the mathematical communication abilities of students who use card-assisted questions and using the make a match method in class VII of SMPN 4 Sungguminasa, Gowa Regency.


Author(s):  
Brij Bhushan Singh ◽  
Shubi Mirja ◽  
Samiya Husain

The purpose of this study was to investigate the effects of yogic practices on cardio-vascular efficiency. Material and methods: Total Forty (40) subject’s boys/girls were selected as the sample of the study through the random sampling and their age ranged between 20 to 25 years from the Department of Physical Education, Aligarh Muslim University, Aligarh. The subjects were divided into two groups comprising 20 subjects in each group, namely group “A” (the experimental group) performs yogic practices (Asanas, Pranayamas and Kriyas) and group “B” (the control group) served as control. Statistical technique: for the assessment of the cardiovascular efficiency through Harvard step test pre and post-test was conducted and t-test was applied for the analysis. Result: revealed that there exist a significant difference between group A and group B, at .05 level of significance. On the basis of the pre and post-test among experimental and control group, experimental group found better than the control group on cardiovascular efficiency and significant result were found in this study.


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