scholarly journals A rare lesion of cervical lymph nodes: Angiomyomatous hamartoma

2021 ◽  
Vol 8 (3) ◽  
pp. 187-188
Author(s):  
Mecdi Gurhan Balci ◽  
Mahir Tayfur
Keyword(s):  
Smooth Muscle ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Smooth Muscle Cells ◽  
Histopathological Examination ◽  
Muscle Cells ◽  
Cervical Region ◽  
Pathology Laboratory ◽  
Cervical Lymph Nodes ◽  
Vascular Structures

Objective: Angiomyomatous hamartomas are extremely rare, tumor-like lesions of the lymph nodes. They are usually seen in the inguinal region lymph nodes. They are rarely seen in the lymph nodes of the cervical region. Histopathologically, fibrous tissues, smooth muscle cells, and vascular structures are seen in the lymph node structure. It is important to distinguish it from benign and malignant lesions of the lymph node. Case: A 1 cm diameter lymph node excision material removed from the cervical region of a 26-year-old male patient was sent to the pathology laboratory with a pre-diagnosis of lymphadenitis. 4- micron sections were taken from the paraffin blocks prepared from the tissues belonging to the lesion. The samples were examined by staining Hematoxylin-Eosin. In histopathological examination, it was found that almost all of the lymph node structure consisted of vascular structures and smooth muscle cells located on a fibrous ground. The case was reported as angiomyomatous hamartoma. Conclusion: Angiomyomatous hamartomas are extremely rare lesions of the cervical lymph nodes and their consideration in differential diagnosis will reduce the risk of possible diagnostic error.

scholarly journals Histopathological Evaluation of Lymph Node Biopsies: A Hospital Based Study

2012 ◽  
Vol 2 (1) ◽  
pp. 8-14
Author(s):  
Md Atiqur Rahman ◽  
Md Mamun Ali Biswas ◽  
Syeda Tasfia Siddika ◽  
Abdul Mannan Sikder
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Histopathological Examination ◽  
Age Groups ◽  
The Body ◽  
Cross Sectional ◽  
Cervical Lymph Nodes ◽  
Female Ratio ◽  
Histopathological Evaluation

Background: Lymphadenopathy is a common manifestation of a large variety of disorders,both benign and malignant. It is essential to define the pattern of disorders presenting primarily as lymph node enlargement in a particular environment. Histopathological examination of the lymph node biopsies is a gold standard test in the distinction between reactive and malignant lymphoid proliferations as well as for detailed subtyping oflymphomas. We designed this study in our population for histopathological evaluation of lymph nodes that might be helpful for clinical management of these lesions. Objective: Histopathological evaluation of lymphadenopathy from excised specimen, in relation to ageand sex of the patients, and distribution of the lymph nodes. Materials and Methods: It was a retrospective cross sectional study conducted in the department of Pathology, Enam MedicalCollege & Hospital, Savar, Dhaka during the period from January 2006 to December 2010. Lymph node biopsies of all patients of both sexes and all age groups were included.Metastatic lymph nodes associated with evidence of primaries elsewhere in the body were excluded from the study. Total 191 lymph node biopsies were selected for histopathological evaluation. Among these 90 (47.12%) were from males and 101 (52.88%) were from females with male to female ratio being 1:2.1. The age of the patients ranged from 2 to 85 years with a mean age of 35.73 ± 18 years. Results: Cervical lymph nodes were the most common (56%) biopsied group. Of the 191 cases 59 cases (30.89%) were reactive lymphadenitis, 64 cases (33.5%) were tuberculosis, 2 cases (1.05%) were non-caseous granuloma, 11 cases (5.76%) were Hodgkin lymphoma, 22 cases (11.52%) were non-Hodgkin lymphoma, 24 cases (12.57%) were metastatic neoplasm and 9 cases (4.7%) were other lesions.Conclusion: Tuberculosis was the most common cause of lymphadenopathy, followed by reactive lymphadenitis and the cervical group of lymph nodes was most frequently affected. DOI: http://dx.doi.org/10.3329/jemc.v2i1.11915 J Enam Med Col 2012; 2(1):8 -14

scholarly journals Postoperative recurrence with right cervical lymph node metastasis in hepatocellular carcinoma: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kiyonori Tanoue ◽  
Yota Kawasaki ◽  
Yoichi Yamasaki ◽  
Satoshi Iino ◽  
Masahiko Sakoda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Metastatic Lymph Node ◽  
Cervical Region ◽  
Cervical Lymph Nodes ◽  
Lymph Node Recurrence ◽  
Metastatic Lymph ◽  
The Right

Abstract Background Hepatocellular carcinoma (HCC) patients with metastases to the cervical lymph nodes are extremely rare, and its clinical course is characterized by rapidly progressive disease. Hence, there have been no reports of metastatic cervical lymph node recurrence indicated after a long postoperative surveillance period. Case presentation The patient was a 63-year-old male who underwent right hepatectomy for HCC of the right upper lobe. Three years after resection, metastatic lymph node recurrence was detected in the subdiaphragm, superior mediastinum, and right cervical lymph nodes. The patient underwent excisional biopsy of the cervical lymph node, followed by molecular-targeted therapy and radiation therapy. Lenvatinib reduced the size of all metastatic lymph nodes and the patient survived for a relatively long period of 43 months after the recurrence was detected. Conclusions After resection of HCC in the right upper lobe, there is the possibility of metastatic lymph node recurrence in unusual sites, including the cervical region, and lenvatinib may be effective in those recurrences.

scholarly journals Intranodal Palisaded Myofibroblastoma in a Submandibular Lymph Node

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Leila Bouhajja ◽  
Raja Jouini ◽  
Olfa Khayat ◽  
Wafa Koubâa ◽  
Chiraz Mbarek ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Spindle Cell ◽  
Cell Tumor ◽  
Spindle Cell Tumor ◽  
Cervical Lymph Nodes ◽  
Histological Features ◽  
Submandibular Lymph Node ◽  
Intranodal Palisaded Myofibroblastoma

Intranodal palisaded myofibroblastoma (IPM), also known as “intranodal hemorrhagic spindle cell tumor with amianthoid fibers,” is a rare benign mesenchymal tumor originating from smooth muscle cells and myofibroblasts, often with the presence of amianthoid fibers. Usually IPM affects inguinal lymph nodes, but three cases have been described in the submandibular and cervical lymph nodes. We report a new case of a 44-year-old women with submandibular mass. Cervical ultrasound showed a suspect right submandibular adenomegaly. The patient underwent an excision of the submandibular mass. Histological features of the tumor include an encapsulated fusocellular proliferation, with nuclear palisading, amianthoid fibers, hemosiderin pigment, and extravasated erythrocytes. In the light of these results, we made the diagnosis of IPM. No recurrence was found 5 years after surgery.

scholarly journals Glucocorticoids stimulate the contractile activity of lymphatic vessels and lymph nodes

2017 ◽  
Vol 16 (4) ◽  
pp. 73-79
Author(s):  
G. I. Lobov ◽  
D. V. Unt
Keyword(s):  
Smooth Muscle ◽  
Lymph Nodes ◽  
Smooth Muscle Cells ◽  
Contractile Function ◽  
Contractile Activity ◽  
Lymphatic Vessels ◽  
Muscle Cells ◽  
Mechanisms Of Action ◽  
Genomic Effects ◽  
Antigen Presenting

Objective. The lymphatic network participates in the launch and development of an immune response. From an immunological point of view, the lymph flow, provided by active contractions of the lymphatic vessels, is the process of delivering antigens and antigen-presenting cells to the lymph nodes. The purpose of this study is to study the non-genomic effects and mechanisms of action of glucocorticoids, which are natural immunomodulators, on the transport function of lymphatic vessels and lymph nodes. Materials and methods. Bovine mesenteric afferent lymphatic vessels 1.2-1.5 mm in diameter and lymph nodes were used for the study. The contractile activity of isolated lymphatic vessels and capsules of lymph nodes under the action of glucocorticoids in vitro were studied. Agonists and antagonists of signaling pathways were used to determine the mechanisms of action of glucocorticoids on smooth muscle cells. Results and their discussion. Glucocorticoids in therapeutic concentrations increase the tone of lymphatic vessels and lymph nodes, increase in frequency and a decrease the amplitude of phase contractions. It is shown that glucocorticoids stimulate α-adrenoreceptors of smooth muscle cells due to the increase in their affinity. Glucocorticoids activate in the smooth muscle cells the RhoA / ROCK signaling pathway and inhibit the synthesis of endothelial vasodilators - NO and prostacyclin. The revealed changes in the contractile function of lymphatic vessels and lymph nodes under the action of glucocorticoids underlie the modulation of glucocorticoid transport of lymph and the speed of delivery to the lymph nodes of antigens and antigen-presenting cells, i.e. regulation of immune responses. Conclusions. Non-genomic effects and mechanisms of action of glucocorticoids on the contractile function of lymphatic vessels and nodes have been studied. Glucocorticoids activate smooth muscle cells of lymphatic vessels and nodes by stimulating α-adrenoreceptors, and also inhibit the production of NO and prostacyclin.

Immunogold localization of HMB-45 antigen in pulmonary lymphangiomyomatosis

1995 ◽  
Vol 53 ◽  
pp. 998-999
Author(s):  
J.M. Minda ◽  
E. Dessy ◽  
G. G. Pietra
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Room Temperature ◽  
Osmium Tetroxide ◽  
Muscle Cells ◽  
Ultrastructural Localization ◽  
Reproductive Age ◽  
Thin Sections ◽  
Smooth Muscle Proliferation ◽  
Hmb 45

Pulmonary lymphangiomyomatosis (PLAM) is a rare disease occurring exclusively in women of reproductive age. It involves the lungs, lymph nodes and lymphatic ducts. In the lungs, it is characterized by the proliferation of smooth muscle cells around lymphatics in the bronchovascular bundles, lobular septa and pleura The nature of smooth muscle proliferation in PLAM is still unclear. Recently, reactivity of the smooth muscle cells for HMB-45, a melanoma-related antigen has been reported by immunohistochemistry. The purpose of this study was the ultrastructural localization of HMB-45 immunoreactivity in these cells using gold-labeled antibodies.Lung tissue from three cases of PLAM, referred to our Institution for lung transplantation, was embedded in either Poly/Bed 812 post-fixed in 1% osmium tetroxide, or in LR White, without osmication. For the immunogold technique, thin sections were placed on Nickel grids and incubated with affinity purified, monoclonal anti-melanoma antibody HMB-45 (1:1) (Enzo Diag. Co) overnight at 4°C. After extensive washing with PBS, grids were treated with Goat-anti-mouse-IgG-Gold (5nm) (1:10) (Amersham Life Sci) for 1 hour, at room temperature.

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