scholarly journals The Relationship Between Serum Vitamin D Level and Type 2 Diabetes Mellitus

2021 ◽  
Vol 8 (2) ◽  
pp. 79-85
Author(s):  
Habibe İnci ◽  
Fatih İnci
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Risk Factor ◽  
Control Group ◽  
Healthy Individuals ◽  
The Relationship

Objective: Vitamin D (VD) could play a role in pathogenesis of Type 2 Diabetes Mellitus (T2DM) by affecting either insulin sensitivity or pancreatic β-cell function. This article is about the relationship between T2DM and VD levels. Material and Methods: The 4678 individuals were included in the study. Of these, 1764 were T2DM patients and 2914 were healthy individuals. Correlation analysis was carried out between VD, age, Body Mass Index (BMI), Hemoglobin A1c (HbA1c), and duration of illness in the T2DM patients. Logistic regression analysis was used to determine the independent predictors. Results: VD levels were significantly lower in the T2DM patients compared to the control group. The VD level of T2DM patients with HbA1c >7% was lower than those with HbA1c <7%. The VD level of T2DM patients using insulin was found to be significantly lower compared to those not using insulin. Among the T2DM patients, VD level was found to be the highest in those without complications and the lowest in those with nephropathy. The cut-off value for VD was calculated as 16.95 ng/mL. According to the logistic regression test, low serum VD levels were found to be an independent risk factor for the development of T2DM and its complications. Conclusion:  VD deficiency may be a risk factor for the development of T2DM. In our study, VD levels were significantly lower in the T2DM patients and those having complications of T2DM than the healthy individuals.

scholarly journals Correlation between OSAHS and Early Peripheral Atherosclerosis Indices in Patients with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xin Zhao ◽  
Xiaofeng Yu ◽  
Sixu Xin ◽  
Wei Zhang ◽  
Xiaomei Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Risk Factor ◽  
Lower Extremity ◽  
Control Group ◽  
Multivariate Logistic Regression ◽  
Early Atherosclerosis

Objective: To analyze the differences of early atherosclerosis indices in type 2 diabetes mellitus (T2DM) patients with different degrees of obstructive sleep apnea-hypopnea syndrome (OSAHS) and explore the correlation between them, so as to provide a new clinical basis for the prevention and treatment of early atherosclerosis in patients with T2DM and OSAHS. Methods. A prospective study was conducted in 312 patients with T2DM and snoring who were hospitalized in the Department of Endocrinology, Peking University International Hospital from January 2017 to January 2020. According to the monitoring results, 312 patients were divided into 4 groups including the control group (208 cases), mild OSAHS group (18 cases), moderate OSAHS group (38 cases), and severe OSAHS group (48 cases). Multivariate logistic regression analysis was used to analyze the early atherosclerosis indices including brachial-ankle pulse wave velocity (PWV) and ankle-brachial index (ABI) in patients with T2DM coexistence with different degrees of OSAHS. Results. (1) As the degree of OSAHS increased, ABI decreased gradually and was lower than that in the control group, but PWV increased and was higher than that in the control group ( p < 0.05 , respectively). (2) The apnea-hypopnea index (AHI) positively correlated with PWV ( r = 0.36 , p < 0.05 ) and negatively correlated with ABI ( r = − 0.37 , p < 0.05 ). (3) Multivariate logistic regression showed that after adjusting for age, gender, duration, BMI, blood pressure, blood glucose, blood lipid, and other factors, OSAHS was a risk factor of lower extremity arterial disease (LEAD) in patients with T2DM. With the increase of degree of OSAHS, the risk of lower extremity atherosclerosis gradually increased. Conclusion. OSAHS is an independent risk factor of LEAD in patients with T2DM, and with the increase of AHI, the ABI and PWV have changed, which provides a new clinical basis for the prevention and the treatment of early atherosclerosis in patients with T2DM and OSAHS.

scholarly journals The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Celil Alper Usluogullari ◽  
Fevzi Balkan ◽  
Sedat Caner ◽  
Rifki Ucler ◽  
Cafer Kaya ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Microvascular Complications ◽  
The Relationship

scholarly journals Hubungan Antara kadar Vitamin D dengan HbA1c pada Pasien Diabetes Mellitus Tipe 2 di Laboratorium Klinik Thamrin Medan Tahun 2019

2020 ◽  
Vol 2 (1) ◽  
pp. 8-12
Author(s):  
Desi Novita ◽  
Meida Nugrahalia ◽  
Ida Fauziah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Clinical Laboratory ◽  
Glucose Binding ◽  
Vitamin D Levels ◽  
Sugar Levels ◽  
The Relationship

Vitamin D as an immunomodulator play an important role in controlling glycemic levels and reducing the risk of diabetes. HbA1c as a substance formed from glucose binding with hemoglobin which has a good relationship with average blood sugar levels of fasting, daily and 3 months. This research was conducted to determine the relationship between vitamin D levels and HbA1c in patients with type 2 diabetes mellitus. This research used descriptive methods and the research samples were all patients who suffer from type 2 diabetes mellitus in the clinical laboratory of Thamrin Medan. Data were obtained by checking vitamin D and HbA1c levels in patients blood serum. The number of samples in this research were 47 people. The results of this research indicate that there is a very weak relationship between vitamin D levels and HbA1c, with r = 0,225 and R = 5,1%, therefore, it was clearly presented that effect of vitamin D on HbA1c is 5,1%.

scholarly journals High Prevalence of Hypovitaminosis D in Postmenopausal Women with Type 2 Diabetes Mellitus

2016 ◽  
Vol 117 (1) ◽  
pp. 5-17 ◽  
Author(s):  
Ivan Raška ◽  
Mária Rašková ◽  
Vít Zikán ◽  
Jan Škrha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Postmenopausal Women ◽  
Fasting Glucose ◽  
Hypovitaminosis D ◽  
Control Group ◽  
Total Body

The link between vitamin D and type 2 diabetes mellitus (T2DM) is intensively studied. This study aims to define the serum concentration of 25-hydroxyvitamin D (25-OH D) and to investigate the relationship between 25-OH D status, glycated hemoglobin (HbA1c) and body composition in postmenopausal women with T2DM and in non-diabetic controls. In this cross-sectional study, 75 women with T2DM and 32 control subjects were selected. Serum 25-OH D, intact parathyroid hormone (PTH), calcium, fasting glucose and HbA1c, were measured. The mean 25-OH D level was 21.4 ± 11.4 ng/ml (range 4.1–50.7 ng/ml) in diabetic women and 30.3 ± 9.4 ng/ml (range 10.8–54.2 ng/ml) in control group (p<0.001). The prevalence of hypovitaminosis D (< 30 ng/ml) was higher in vitamin D3 non-supplemented T2DM women (89% vs. 63% controls); the difference diminished in vitamin D3 (500–1000 IU per day) supplemented subgroups (45% diabetics vs. 42% controls). In T2DM women, 25-OH D levels were not associated to HbA1c, duration of diabetes, fasting glucose and PTH levels, however, 25-OH D levels negatively associated with body mass index (p=0.011), total body fat mass (p=0.005) and total body lean mass (p=0.004). The prevalence of hypovitaminosis D is higher in non-supplemented postmenopausal women with T2DM than in non-diabetic controls (89% vs. 63%). Obesity is a risk factor for vitamin D insufficiency in T2DM postmenopausal women. Further studies evaluating relationships between fat, muscle, bone and vitamin D metabolism in T2DM patients are warranted.

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