scholarly journals An Innovative Mucoadhesive Thermosensitive In situ Gelling Liquid Suppository of Metoclopramide Hydrocloride for Treatment of Nausea and Vomiting Associated with Diseases

2020 ◽  
Vol 82 (4) ◽  
Author(s):  
Z. D. SALMAN ◽  
A.T. ALHAMDANY ◽  
N. Z. YOUSIF
Keyword(s):  
Nausea And Vomiting ◽  
In Situ Gelling ◽  
Liquid Suppository

Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository

1998 ◽  
Vol 165 (1) ◽  
pp. 33-44 ◽  
Author(s):  
Han-Gon Choi ◽  
Jae-Hee Jung ◽  
Jei-Man Ryu ◽  
Sung-June Yoon ◽  
Yu-Kyoung Oh ◽  
...  
Keyword(s):  
In Situ Gelling ◽  
Liquid Suppository

Trials of in situ-gelling and mucoadhesive acetaminophen liquid suppository in human subjects

1998 ◽  
Vol 174 (1-2) ◽  
pp. 201-207 ◽  
Author(s):  
Chong-Kook Kim ◽  
Sa-Won Lee ◽  
Han-Gon Choi ◽  
Mi-Kyung Lee ◽  
Zhong-Gao Gao ◽  
...  
Keyword(s):  
Human Subjects ◽  
In Situ Gelling ◽  
Liquid Suppository

scholarly journals Thermally Reversible In Situ Gelling Carbamazepine Liquid Suppository

Drug Delivery ◽  
2006 ◽  
Vol 13 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Amal El-Kamel ◽  
Mona El-Khatib
Keyword(s):  
In Situ Gelling ◽  
Liquid Suppository

New formulation of in situ gelling Metolose-based liquid suppository

2010 ◽  
Vol 37 (1) ◽  
pp. 1-7 ◽  
Author(s):  
E. Pásztor ◽  
Á. Makó ◽  
G. Csóka ◽  
Zs. Fenyvesi ◽  
R. Benko ◽  
...  
Keyword(s):  
New Formulation ◽  
In Situ Gelling ◽  
Liquid Suppository

Novel Formulation Development and Evaluation of Nanoparticles Based in Situ Gelling System for The Ophthalmic Delivery of Ciprofloxacin Hydrochloride

2015 ◽  
Vol 5 (4) ◽  
Author(s):  
Kranti Singh ◽  
Surajpal Verma ◽  
Shyam Prasad ◽  
Indu Bala
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Drug Loading ◽  
In Vitro Release ◽  
Formulation Development ◽  
Ciprofloxacin Hydrochloride ◽  
Potential Value ◽  
The Mean ◽  
In Situ Gelling

Ciprofloxacin hydrochloride loaded Eudragit RS100 nanoparticles were prepared by using w/o/w emulsification (multiple emulsification) solvent evaporation followed by drying of nanoparticles at 50°C. The nanoparticles were further incorporated into the pH-triggered in situ gel forming system which was prepared using Carbopol 940 in combination with HPMC as viscosifying agent. The developed nanoparticles was evaluated for particle size, zeta potential value and loading efficiency; nanoparticle incorporated in situ gelling system was evaluated for pH, clarity, gelling strength, rheological studies, in-vitro release studies and ex-vivo precorneal permeation studies. The nanopaticle showed the mean particle size varying between 263.5nm - 325.9 nm with the mean zeta potential value of -5.91 mV to -8.13 mV and drug loading capacity varied individually between 72.50% to 98.70% w/w. The formulation was clear with no suspended particles, showed good gelling properties. The gelling was quick and remained for longer time period. The developed formulation was therapeutically efficacious, stable and non-irritant. It provided the sustained release of drug over a period of 8-10 hours.

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