scholarly journals Protective Effect of Ethanol Extract of Roots of Tetracera akara (Burm. f.) Merr., on Carbon Tetrachloride-induced Hepatic Injury in Wistar Rats

2019 ◽  
Vol 81 (5) ◽  
Author(s):  
R. R. Nair ◽  
S. R. Suja ◽  
V. Vilash ◽  
A. L. Aneeshkumar ◽  
S. Rajasekharan ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Wistar Rats ◽  
Hepatic Injury ◽  
Ethanol Extract

scholarly journals Protective effect of apricot (Prunus armeniacaL.) on hepatic steatosis and damage induced by carbon tetrachloride in Wistar rats

2009 ◽  
Vol 102 (12) ◽  
pp. 1767-1775 ◽  
Author(s):  
Feral Ozturk ◽  
Mehmet Gul ◽  
Burhan Ates ◽  
I. Cetin Ozturk ◽  
Asli Cetin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Hepatic Steatosis ◽  
Wistar Rats ◽  
Liver Steatosis ◽  
Radical Scavenging ◽  
Hepatic Necrosis ◽  
Control Group ◽  
Cytoplasmic Matrix

The present study was planned to investigate the protective effect of 10 % and 20 % apricot-containing feed on carbon tetrachloride (CCl4)-induced hepatic steatosis and damage. Adult male Wistar rats (n42) were divided into six groups of seven each, as follows: control group; CCl4group; CCl4+10 % apricot group; CCl4+20 % apricot group; 10 % apricot group; 20 % apricot group. All apricot groups were fed with 10 % or 20 % apricot-containing feed for 5 months. CCl4injections were applied to the CCl4groups at the dose of 1 mg/kg for 3 d at the end of 5 months. In the CCl4group, vacuolated hepatocytes and hepatic necrosis were seen, especially in the centrilobular area. Hepatocytes showed an oedematous cytoplasmic matrix, large lipid globules and degenerated organelles. The area of liver injury was found significantly decreased with apricot feeding. Malondialdehyde and total glutathione levels and catalase, superoxide dismutase and glutathione peroxidase activities were significantly changed in the CCl4group and indicated increased oxidative stress. Apricot feeding decreased this oxidative stress and ameliorated histological damage. We concluded that apricot feeding had beneficial effects on CCl4-induced liver steatosis and damage probably due to its antioxidant nutrient (β-carotene and vitamin) contents and high radical-scavenging capacity. Dietary intake of apricot can reduce the risk of liver steatosis and damage caused by free radicals.

The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities

2009 ◽  
Vol 122 (3) ◽  
pp. 555-560 ◽  
Author(s):  
Xiangchun Shen ◽  
Yuping Tang ◽  
Ruihui Yang ◽  
Li Yu ◽  
Taihui Fang ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Hepatic Injury ◽  
Jujube Fruit ◽  
Zizyphus Jujube

Protective Effect of Cornuside against Carbon Tetrachloride-Induced Acute Hepatic Injury

2011 ◽  
Vol 75 (4) ◽  
pp. 656-661 ◽  
Author(s):  
Shun Zong SONG ◽  
Yun Ho CHOI ◽  
Guang Yu JIN ◽  
Guang Zhao LI ◽  
Guang Hai YAN
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Hepatic Injury ◽  
Acute Hepatic Injury

scholarly journals COMPARATIVE STUDY OF ALCOHOLIC AND AQUEOUS EXTRACTS OF SYZYGIUM CUMINI ON CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN WISTAR RATS

2016 ◽  
Vol 9 (9) ◽  
pp. 182
Author(s):  
Shweta Sharma ◽  
Mehta Bk
Keyword(s):  
Alkaline Phosphatase ◽  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Hepatic Injury ◽  
Total Bilirubin ◽  
Ethanolic Extract ◽  
Aqueous Extracts ◽  
Syzygium Cumini ◽  
Standard Drug ◽  
Ethanolic Extracts

ABSTRACTObjective: In this investigation, the comparative hepatoprotective effect of aqueous and ethanolic extracts of Syzygium cumini (AESC and EESC,respectively) was studied on carbon tetrachloride (CCl4)-induced hepatic injury in rats. These findings were also compared with the standardhepatoprotective drug silymarin.Methods: Hepatotoxicity was induced by a single dose of CCl4 to healthy Wistar rats. Standard drug (100 mg/kg) and test extracts (500 mg/kg forboth) were given orally for 10 days; the effects were observed using different biochemical and histological methods.Results: In most of the studied parameters test extracts exhibited significant hepatoprotection, these were comparative to standard. Histologicalanalysis also revealed the protective nature of both the extracts.Conclusion: These results suggest that the SC extracts can ameliorate CCl4 induced hepatic injury. However, its ethanolic extract was found to berelatively less effective than aqueous extract. Indicated, some hydrophilic active compound of SC might work here.Keywords: Hepatoprotective, Carbon tetrachloride, Silymarin, Syzygium cumini, Alkaline phosphatase, Total bilirubin.

scholarly journals Protective Effect of Repeatedly Preadministered Brazilian Propolis Ethanol Extract against Stress-Induced Gastric Mucosal Lesions in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Tadashi Nakamura ◽  
Yoshiji Ohta ◽  
Kumiko Ikeno ◽  
Koji Ohashi ◽  
Takeyuki Ikeno
Keyword(s):  
Protective Effect ◽  
Restraint Stress ◽  
Wistar Rats ◽  
Water Immersion ◽  
Ethanol Extract ◽  
Neutrophil Infiltration ◽  
Gastric Mucosal Lesions ◽  
Male Wistar Rats ◽  
Mucosal Lesions ◽  
Brazilian Propolis

The present study was conducted to clarify the protective effect of Brazilian propolis ethanol extract (BPEE) against stress-induced gastric mucosal lesions in rats. The protective effect of BPEE against gastric mucosal lesions in male Wistar rats exposed to water-immersion restraint stress (WIRS) for 6 h was compared between its repeated preadministration (50 mg/kg/day, 7 days) and its single preadministration (50 mg/kg). The repeated BPEE preadministration attenuated WIRS-induced gastric mucosal lesions and gastric mucosal oxidative stress more largely than the single BPEE preadministration. In addition, the repeated BPEE preadministration attenuated neutrophil infiltration in the gastric mucosa of rats exposed to WIRS. The protective effect of the repeated preadministration of BPEE against WIRS-induced gastric mucosal lesions was similar to that of a single preadministration of vitamin E (250 mg/kg) in terms of the extent and manner of protection. From these findings, it is concluded that BPEE preadministered in a repeated manner protects against gastric mucosal lesions in rats exposed to WIRS more effectively than BPEE preadministered in a single manner possibly through its antioxidant and anti-inflammatory actions.

scholarly journals Assessment of changes in energy metabolism parameters provoked by carbon tetrachloride in Wistar rats and the protective effect of white grape juice

2015 ◽  
Vol 2 ◽  
pp. 645-653 ◽  
Author(s):  
Tatiane Gabardo ◽  
Clarice M. Peripolli ◽  
Rodrigo Binkowski de Andrade ◽  
Tanise Gemelli ◽  
Juliana D.O. Lima ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Wistar Rats ◽  
Grape Juice

Protective effect of chrysin on carbon tetrachloride (CCl4)—induced tissue injury in male Wistar rats

2011 ◽  
Vol 27 (10) ◽  
pp. 923-933 ◽  
Author(s):  
Kalaiselvi Velayutham Anand ◽  
Ramalingam Anandhi ◽  
Murugesan Pakkiyaraj ◽  
Pitchairaj Geraldine
Keyword(s):  
Carbon Tetrachloride ◽  
Vitamin C ◽  
Protective Effect ◽  
Wistar Rats ◽  
Tissue Injury ◽  
Protective Action ◽  
Intraperitoneal Administration ◽  
Serum Levels ◽  
Male Wistar Rats ◽  
The Mean

Chrysin, a natural flavonoid has been reported to possess potent anti-inflammatory, anti-cancer and antioxidation properties. In the present study, we aimed to evaluate the putative protective effect of chrysin, an isoflavone, on carbon tetrachloride (CCl4)-induced toxicity in male Wistar rats. Intraperitoneal administration of CCl4 (2 ml/kg) to rats for 4 days resulted in significantly elevated ( p < 0.05) serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), when compared to normal rats. In addition, the tissues (liver, kidney and brain) and haemolysate samples showed considerable increase in levels ( p < 0.05) of malondialdehyde (MDA) and lowered levels ( p < 0.05) of reduced glutathione (GSH), vitamin C and E when compared to values in normal rats. Quantitative analysis of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (Gpx) exhibited lower activities of these antioxidant enzymes in the tissues and haemolysate of CCl4-administered rats. The protective action of chrysin on CCl4-induced rat was demonstrated with SGPT, SGOT, ALP and LDH resuming to near normal levels, while the mean levels of GSH and of vitamin C and E were elevated, the mean activities of CAT, SOD and Gpx were enhanced and the mean level of MDA was lowered in the tissue and haemolysate samples when compared to the CCl4-exposed untreated rats. The expression of the iNOS gene appeared to be up-regulated in the liver and kidney samples of CCl4-exposed untreated rats, whereas in CCl4-exposed chrysin-treated rats, the mRNA transcript levels of iNOS approximated normal levels. These results strongly suggest that chrysin is able to prevent the oxidative damage induced by CCl4 in the liver, brain, kidney and haemolysate of male Wistar rats.

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