An Analysis of Clinical Spectrum, Laboratory Profile, and Outcome of Scrub Typhus Cases in a Tertiary Care Hospital

2020 ◽  
Vol 23 (19) ◽  
Author(s):  
Pavithra Muthusamy ◽  
Ramya SG ◽  
Nelliaiappa Ganesan SK
Keyword(s):  
Scrub Typhus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Spectrum ◽  
Care Hospital ◽  
Laboratory Profile

scholarly journals CLINICAL SPECTRUM OF SCRUB TYPHUS IN A TERTIARY CARE HOSPITAL AT EASTERN INDIA

2018 ◽  
Vol 11 (5) ◽  
pp. 351 ◽  
Author(s):  
Srikant Kumar Dhar ◽  
Sobhitendu Kabi ◽  
Chandan Das ◽  
Swati Samant ◽  
Debasmita Tripathy ◽  
...  
Keyword(s):  
Scrub Typhus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Gastrointestinal Symptoms ◽  
Unknown Origin ◽  
Immunoglobulin M ◽  
Care Hospital ◽  
Diagnostic Features ◽  
Laboratory Findings ◽  
Pyrexia Of Unknown Origin

 Objective: Our hospital, tertiary care hospital in the capital of the state of Odisha, had been witnessing pyrexia of unknown origin, associated with breathlessness, renal, and liver impairment, which did not respond to high antibiotics but to doxycycline; therefore, the present study was undertaken to identify whether scrub typhus is the etiological agent, and thereafter, their characteristic features were further evaluated as an effort in supporting its diagnoses and treating patients accordingly.Methods: A total of 65 adult patients (age >15 years) admitted with pyrexia between April 2015 and October 2017 were evaluated. Immunoglobulin M (IgM) scrub typhus test was done in all these patients. IgM scrub typhus test positive samples were included in the study and various clinical parameters analyzed.Results: Of the 65 patients included in the study, all were found to be positive for IgM antibodies against Orientia tsutsugamushi. The cases were seen mainly in the months between September and November. The common symptoms found were fever, myalgia, breathlessness, rash, and abdominal pain and rarely altered sensorium. The diagnostic features like eschar were found in 23% patients. Nearly, two-thirds of patients had fever more than 7 days and myalgia (76.92%), headache (58.46%). The most common complications were renal failure (20%) followed by pneumonia (10.76%). Laboratory findings of high C-reacting protein (89.23%) and leukocytosis are found in 35.38%.Conclusion: Our results showed that scrub typhus should be considered in the differential diagnosis of pyrexia of unknown origin associated with breathlessness, myalgia, rash, gastrointestinal symptoms, hepatorenal syndrome, or acute respiratory distress syndrome. Empirical treatment with doxycycline may be given in the cases with strong suspicion of scrub typhus.

scholarly journals Clinical spectrum of melioidosis at a tertiary care hospital in South India

2016 ◽  
Vol 45 ◽  
pp. 470
Author(s):  
S.V.S. Malladi ◽  
L. Vemu ◽  
N.C. Chandra ◽  
M. Shetty ◽  
K.P. Adiraju ◽  
...  
Keyword(s):  
South India ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Spectrum ◽  
Care Hospital

Scrub typhus in a tertiary care hospital in the eastern part of Odisha

2015 ◽  
Vol 12 (1) ◽  
pp. 2-6 ◽  
Author(s):  
Suneeta Sahu ◽  
Sudhi Ranjan Misra ◽  
Prasant Padhan ◽  
Samir Sahu
Keyword(s):  
Scrub Typhus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

scholarly journals Clinical Profile and Predictors of Outcome for Pediatric Scrub Typhus at a Tertiary Care Hospital

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Kiruthika Muthukrishnan ◽  
Shruthi Tarikere ◽  
Rajakumar Padur Sivaraman ◽  
Shuba Sankaranarayanan ◽  
Krithika Prabaharan ◽  
...  
Keyword(s):  
Scrub Typhus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Enzyme Linked Immunosorbent Assay ◽  
Care Hospital ◽  
Emerging Infections ◽  
Predictors Of Outcome ◽  
Altered Sensorium ◽  
Elevated Liver Enzymes

Background: Scrub typhus is an important cause of acute undifferentiated fever. It is currently one of the most covert re-emerging infections and the most common rickettsial infection caused by Orientia tsutsugamushi. Untreated cases can have mortality rates as high as 30-35%. Objectives: This study was done to study demographical data, clinical profile, and predictors of outcome for scrub typhus in children who were admitted to our institution, a tertiary care hospital in south India. Methods: In this retrospective study, children diagnosed with scrub typhus based on IgM enzyme-linked immunosorbent assay (ELISA), between January 2012 and June 2019 were included. Detailed history, clinical examination findings, laboratory profile, complications, and outcome were analyzed. Results: A total of 120 patients were identified, of whom 84 (42 males- and 42 females) cases satisfied the inclusion criteria and were analyzed. About 80 (95%) cases had a complete recovery, whereas 4 patients (5%) died of multiple complications. Hypotension, hypoxia, altered sensorium, hypoalbuminemia, elevated liver enzymes, azotemia, and deranged coagulation on admission were considered as poor predictors of outcome for scrub typhus. Conclusions: Pediatric scrub typhus is a common infection and should be suspected in cases with fever for more than 5 days and non-specific signs and symptoms. Early detection and timely management lead to a higher recovery rate. Hypotension, hypoxia, azotemia, altered sensorium, and bleeding manifestations on admission were associated with unfavorable outcomes.

Sign in / Sign up

Export Citation Format

Share Document