scholarly journals Epidemiology of breast neoplasms at the time of organized screening program in the Czech Republic

Onkologie ◽  
2020 ◽  
Vol 14 (4) ◽  
pp. 142-147
Author(s):  
Lucie Pehalová ◽  
Denisa Krejčí ◽  
Ivana Svobodová ◽  
Ondřej Ngo ◽  
Ondřej Májek ◽  
...  
Keyword(s):  
Czech Republic ◽  
Breast Neoplasms ◽  
Screening Program ◽  
The Czech Republic ◽  
Organized Screening Program

scholarly journals PCN166 Cost-Effectiveness of Colorectal Cancer Screening Program in the Czech Republic

2020 ◽  
Vol 23 ◽  
pp. S452
Author(s):  
O. Ngo ◽  
J. Kouřil ◽  
I. Svobodová ◽  
D. Krejčí ◽  
L. Dušek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Czech Republic ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Screening Program ◽  
The Czech Republic ◽  
Cancer Screening Program

scholarly journals Detailed Phenotype of GLA Variants Identified by the Nationwide Neurological Screening of Stroke Patients in the Czech Republic

2021 ◽  
Vol 10 (16) ◽  
pp. 3543
Author(s):  
Petra Reková ◽  
Gabriela Dostálová ◽  
David Kemlink ◽  
Jaroslava Paulasová Schwabová ◽  
Zora Dubská ◽  
...  
Keyword(s):  
Czech Republic ◽  
Late Onset ◽  
Screening Program ◽  
Pathological Finding ◽  
High Risk Population ◽  
Correct Identification ◽  
The Czech Republic ◽  
Screening Programs ◽  
Pathogenic Variants ◽  
Phenotype Description

Fabry disease (FD) is a rare X-linked disorder of glycosphingolipid metabolism caused by pathogenic variants within the alpha-galactosidase A (GLA) gene, often leading to neurological manifestations including stroke. Multiple screening programs seeking GLA variants among stroke survivors lacked detailed phenotype description, making the interpretation of the detected variant’s pathogenicity difficult. Here, we describe detailed clinical characteristics of GLA variant carriers identified by a nationwide stroke screening program in the Czech Republic. A total of 23 individuals with 8 different GLA variants were included in the study. A comprehensive diagnostic workup was performed by a team of FD specialists. The investigation led to the suggestion of phenotype reclassification for the G325S mutation from late-onset to classical. A novel variant R30K was found and was classified as a variant of unknown significance (VUS). The typical manifestation in our FD patients was a stroke occurring in the posterior circulation with an accompanying pathological finding in the cerebrospinal fluid. Moreover, we confirmed that cornea verticillata is typically associated with classical variants. Our findings underline the importance of detailed phenotype description and data sharing in the correct identification of pathogenicity of gene variants detected by high-risk-population screening programs.

Social variation in size at birth and preterm delivery in the Czech Republic and Sweden, 1989-91

1998 ◽  
Vol 12 (1) ◽  
pp. 7-24 ◽  
Author(s):  
Koupilova ◽  
Vagero ◽  
Leon ◽  
Pikhart ◽  
Prikazsky ◽  
...  
Keyword(s):  
Czech Republic ◽  
Preterm Delivery ◽  
The Czech Republic ◽  
Social Variation ◽  
Size At Birth

On Geropsychology in the Czech Republic

GeroPsych ◽  
2012 ◽  
Vol 25 (3) ◽  
pp. 161-166
Author(s):  
Hana Stepankova ◽  
Eva Jarolimova ◽  
Eva Dragomirecka ◽  
Irena Sobotkova ◽  
Lenka Sulova ◽  
...  
Keyword(s):  
Czech Republic ◽  
Clinical Practice ◽  
Old Age ◽  
Cognitive Rehabilitation ◽  
The Czech Republic ◽  
Rehabilitation Research

This work provides an overview of psychology of aging and old age in the Czech Republic. Historical roots as well as recent activities are listed including clinical practice, cognitive rehabilitation, research, and the teaching of geropsychology.

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