scholarly journals Treatment strategy of type 2 diabetes used in Czech Republic after metformin therapy failure

2017 ◽  
Vol 63 (10) ◽  
pp. 647-657
Author(s):  
Štěpán Svačina ◽  
Petra Ovesná ◽  
Matyáš Kuhn ◽  
Martina Nováčková
Keyword(s):  
Type 2 Diabetes ◽  
Czech Republic ◽  
Treatment Strategy ◽  
Therapy Failure ◽  
Metformin Therapy

227-OR: The Effect of Dietary Fiber in Combination with Metformin Therapy in Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 227-OR
Author(s):  
FLAVIA TRAMONTANA ◽  
ERNESTO MADDALONI ◽  
SARA GRECI ◽  
GIUSEPPE DEFEUDIS ◽  
ROCKY STROLLO ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Fiber ◽  
Metformin Therapy

Cognitive and Functional Influences of Vildagliptin, a DPP-4 Inhibitor, Added to Ongoing Metformin Therapy in Elderly with Type 2 Diabetes

2013 ◽  
Vol 13 (3) ◽  
pp. 256-263 ◽  
Author(s):  
Ilker Tasci ◽  
Mehmet Naharci ◽  
Ergun Bozoglu ◽  
Umut Safer ◽  
Aydogan Aydogdu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metformin Therapy

Adding Noninsulin Antidiabetic Drugs to Metformin Therapy for Type 2 Diabetes—Reply

JAMA ◽  
2010 ◽  
Vol 304 (4) ◽  
pp. 405
Author(s):  
Craig I. Coleman ◽  
Olivia J. Phung ◽  
Jennifer M. Scholle
Keyword(s):  
Type 2 Diabetes ◽  
Antidiabetic Drugs ◽  
Metformin Therapy

Metformin regulates TRPM6, a potential explanation for magnesium imbalance in type 2 diabetes patients

2020 ◽  
Vol 98 (6) ◽  
pp. 400-411 ◽  
Author(s):  
Hacene Bouras ◽  
Sara R. Roig ◽  
Steef Kurstjens ◽  
Cees J.J. Tack ◽  
Mohamed Kebieche ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cell Surface ◽  
Fine Tuning ◽  
Metformin Treatment ◽  
Long Term Effects ◽  
Short Term ◽  
Metformin Therapy ◽  
Diabetes Patients

Metformin therapy is associated with lower serum magnesium (Mg2+) levels in type 2 diabetes patients. The TRPM6 channel determines the fine-tuning of Mg2+ (re)absorption in intestine and kidney. Therefore, we aimed to investigate the short- and long-term effects of metformin on TRPM6. Patch clamp recordings and biotinylation assays were performed upon 1 h of incubation with metformin in TRPM6-transfected HEK293 cells. Additionally, 24 h of treatment of mDCT15 kidney and hCaco-2 colon cells with metformin was applied to measure the effects on endogenous TRPM6 expression by quantitative real-time PCR. To assess Mg2+ absorption, 25Mg2+ uptake measurements were performed using inductively coupled plasma mass spectrometry. Short-term effects of metformin significantly increased TRPM6 activity and its cell surface trafficking. In contrast, long-term effects significantly decreased TRPM6 mRNA expression and 25Mg2+ uptake. Metformin lowered TRPM6 mRNA levels independently of insulin- and AMPK-mediated pathways. Moreover, in type 2 diabetes patients, metformin therapy was associated with lower plasma Mg2+ concentrations and fractional excretion of Mg2+. Thereby, short-term metformin treatment increases TRPM6 activity explained by enhanced cell surface expression. Conversely, long-term metformin treatment results in downregulation of TRPM6 gene expression in intestine and kidney cells. This long-term effect translated in an inverse correlation between metformin and plasma Mg2+ concentration in type 2 diabetes patients.

scholarly journals The Efficacy and Safety of Saxagliptin When Added to Metformin Therapy in Patients With Inadequately Controlled Type 2 Diabetes With Metformin Alone

Diabetes Care ◽  
2009 ◽  
Vol 32 (9) ◽  
pp. 1649-1655 ◽  
Author(s):  
R. A. DeFronzo ◽  
M. N. Hissa ◽  
A. J. Garber ◽  
J. Luiz Gross ◽  
R. Yuyan Duan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Efficacy And Safety ◽  
Metformin Therapy
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