scholarly journals Our article after ten years: The practice of therapeutic mild hypothermia in cardiac arrest survivors in the Czech Republic

2020 ◽  
Vol 31 (4) ◽  
pp. 165-171
Author(s):  
R Škulec ◽  
A Truhlář ◽  
J Knor ◽  
J Šeblová ◽  
V Černý
Keyword(s):  
Cardiac Arrest ◽  
Czech Republic ◽  
Mild Hypothermia ◽  
The Czech Republic ◽  
Therapeutic Mild Hypothermia

Implementation of pre-hospital therapeutic hypothermia in post-cardiac arrest patients in the Czech Republic

Resuscitation ◽  
2012 ◽  
Vol 83 (1) ◽  
pp. e21-e22 ◽  
Author(s):  
Roman Škulec ◽  
Anatolij Truhlář ◽  
Jana Šeblová ◽  
Jiří Knor ◽  
Olga Klementová ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Czech Republic ◽  
Therapeutic Hypothermia ◽  
The Czech Republic

P1107First results of molecular autopsy examinations in sudden cardiac death drawn from nationwide multidisciplinary and multicentric collaboration in the Czech Republic

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Krebsova ◽  
P Votypka ◽  
P Peldova ◽  
K Rucklova ◽  
A Pilin ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Czech Republic ◽  
Sudden Cardiac Death ◽  
Dna Sequencing ◽  
Cardiac Death ◽  
Positive Family History ◽  
Molecular Autopsy ◽  
The Czech Republic ◽  
Pathogenic Variants ◽  
Custom Made

Abstract Funding Acknowledgements Supported by Ministry of Health of the Czech Republic, grant nr. NV18-02-00237. All rights reserved." Introduction "Molecular autopsy" in sudden cardiac death (SCD) is an important diagnostic tool for primary prevention of cardiac arrest in victim´s relatives and requires multicentric and multidisciplinary collaboration. Purpose To establish a national network for SCD diagnostics, to assess the acceptance of genetic testing in at risk relatives and to elucidate the genetic etiology of SCD in a representative Czech cohort aged below 45 years. Patients and Methods Between 2016 and 2019 we ascertained 70 SCD (50 M / 20 F), with positive family history for cardiac arrest in 8/70 cases. Only one family did not agree with molecular autopsy. Genetic counselling and cardiological screening examination was carried out in first degree relatives of SCD survivors accompanied by custom-made targeted panel massively parallel DNA sequencing comprising 100 cardiac conditions-related genes. Presence of pathogenic variants was validated by Sanger DNA sequencing and through family segregation analyses. Results According to post-mortem diagnosis most victims died of HCM (17/70), ACM (16/70), no structural heart disease was found in 15/70 cases, DCM/LVNC in 9/70, 6/70 were SIDS cases, other rare diagnoses comprised aortic dissection, or myocarditis. Most of victims died at sleep, only 9/70 victims died during strenuous activities. About 50% of SCD victims did not have cardiac complaints before death. Very likely or certain molecular etiology (i.e. based on presence of ACMG.net Class 4 to 5 variants) was disclosed in 12/70 (17%) in RYR2, FLNC, TTN, KCNH2 and KCNQ1 genes, whilst potentially causative DNA variants (Classes 3-4) were observed in 13/70 (18%) cases. In SIDS we did not find any pathogenic variants. Interestingly, the KCNE1 p.Asp85Asn (LQT 5 lite) variant, was detected in 3/70 cases as a recognized risk factor for ventricular arrhythmias. Conclusion The multidisciplinary cooperation in Czech Republic has been established, family survivors are willing to receive genetic and cardiological care, while centralised molecular genetic analysis enables reliable results which are in accordance with other multicentric studies. The molecular autopsy should, especially in SIDS, be expanded to whole exome sequencing.

scholarly journals Effect of therapeutic mild hypothermia initiated by cold fluids after cardiac arrest on haemostasis as measured by thrombelastography

Critical Care ◽  
2008 ◽  
Vol 12 (Suppl 2) ◽  
pp. P378
Author(s):  
A Spiel ◽  
A Kliegel ◽  
A Janata ◽  
T Uray ◽  
C Wandaller ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Therapeutic Mild Hypothermia

scholarly journals Therapeutic mild hypothermia improves outcome after out-of-hospital cardiac arrest

2009 ◽  
Vol 17 (10) ◽  
pp. 378-384 ◽  
Author(s):  
I. Andrade Ferreira ◽  
M. Schutte ◽  
E. Oosterloo ◽  
W. Dekker ◽  
B. W. Mooi ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Therapeutic Mild Hypothermia ◽  
Hospital Cardiac Arrest

Therapeutic hypothermia in cardiac arrest survivors: A survey of practice in the Czech Republic

Resuscitation ◽  
2008 ◽  
Vol 77 (3) ◽  
pp. 419-420 ◽  
Author(s):  
Roman Skulec ◽  
Gabriela Dostalova ◽  
Tomas Kovarnik ◽  
Ales Linhart ◽  
Jana Seblova
Keyword(s):  
Cardiac Arrest ◽  
Czech Republic ◽  
Therapeutic Hypothermia ◽  
The Czech Republic

scholarly journals A protocol of therapeutic mild hypothermia in patients developing cardiac arrest.

Cor et Vasa ◽  
2007 ◽  
Vol 49 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Roman Škulec ◽  
Jan Bělohlávek ◽  
Vladimír Dytrych ◽  
Tomáš Kovárník ◽  
Jan Horák ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Mild Hypothermia ◽  
Therapeutic Mild Hypothermia
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