scholarly journals Acute Ocular Manifestations and Long-term Ocular Complications of Stevens Johnson Syndrome Pattern in Thammasat University Hospital

2020 ◽  
Vol 15 (2) ◽  
Author(s):  
Wimolwan Tangpagasit ◽  
Duangmontree Rojdamrongratana ◽  
Grobgarn Wichitnark
Keyword(s):  
University Hospital ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Ocular Manifestations ◽  
Johnson Syndrome ◽  
Syndrome Pattern

scholarly journals Preventable Blindness due to Ankyloblepharonin Stevens- Johnson Syndrome–A Case Report

2017 ◽  
Vol 6 (2) ◽  
pp. 136-138
Author(s):  
Manash Kumar Goswami ◽  
Md Asaduzzaman
Keyword(s):  
Case Report ◽  
Dry Eye ◽  
Stevens Johnson Syndrome ◽  
Bulbar Conjunctiva ◽  
Ocular Complications ◽  
Johnson Syndrome ◽  
Department Of Ophthalmology ◽  
Corneal Opacities ◽  
Preventable Blindness

Stevens-Johnson syndrome (SJS) is common, having long term ocular complications ranging from dry eye to loss of vision due to ankyloblepharon or corneal opacities. Proper medical management and separating the bulbar conjunctiva from palpebral regularly by a glass rod during the acute phaseof the diseases can prevent the development of ankyloblepharonand symblepharon. Here we present a case of ankyloblepharon after SJS which was repaired after 6 months in the department of ophthalmology, BIRDEM General Hospital.Birdem Med J 2016; 6(2): 136-138

Stevens-Johnson Syndrome and toxic epidermal necrolysis in children: a retrospective study at Srinagarind Hospital, Khon Kaen, Thailand 1992–2012

2017 ◽  
Vol 9 (2) ◽  
pp. 193-196
Author(s):  
Watuhatai Paipool ◽  
Leelawadee Sriboonnark
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Drug Exposure ◽  
Length Of Hospital Stay ◽  
Retrospective Chart Review ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Common Mean ◽  
Johnson Syndrome ◽  
Acute Complications

Abstract Background Stevens–Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening skin conditions with an etiology of drug exposure or infections. Objectives To determine the cause, treatments, complications, and outcomes of SJS/TEN in children admitted to Srinagrind Hospital during 1992–2012. Methods Retrospective chart review. A diagnosis of SJS and TEN was confirmed by pediatric dermatologists. Results A total of 38 patients was recorded. They consisted 31 (82%) SJS patients and 7 (18%) TEN patients. Mean age 6.6 years (range 1 to 14 years). Male to female was 1.1:1. Most cases (30 or 79%) were caused by drug exposure. Three cases (8%) by infection, and 5 cases (13%) were of unknown cause. The antiepileptic drug group was the most common cause. Systemic corticosteroids were used in 33 cases (87%). Intravenous immunoglobulin was used in one TEN patient (3%). There were 18 cases (47%) with acute complications. Ocular complications (7 cases, 39%), septicemia (4 cases, 22%), and secondary skin infections (3 cases, 17%) were the most common. Mean difference in length of hospital stay between those with and without acute complications was 12.3 days (P < 0.01, 95% CI 5.9–18.6). Ocular complications were the only long-term complications at 1-year follow up, and included symblepharon, corneal pannus, and dry eyes. Two patients (5%), both having cases of TEN, died. Conclusions Antiepileptic drugs were the most common causes of SJS/TEN in our study. Good ophthalmologic care of the prevalent acute eye complications in these patients is needed to prevent long-term ophthalmic complications.

Long-term Progression of Ocular Surface Disease in Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis

Cornea ◽  
2020 ◽  
Vol 39 (6) ◽  
pp. 745-753
Author(s):  
Yamato Yoshikawa ◽  
Mayumi Ueta ◽  
Hideki Fukuoka ◽  
Tsutomu Inatomi ◽  
Isao Yokota ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Ocular Surface ◽  
Ocular Surface Disease ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome

scholarly journals Human leukocyte antigen B*0702 is protective against ocular Stevens–Johnson syndrome/toxic epidermal necrolysis in the UK population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gibran F. Butt ◽  
Ali Hassan ◽  
Graham R. Wallace ◽  
Shigeru Kinoshita ◽  
Sajjad Ahmad ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Toxic Epidermal Necrolysis ◽  
Human Leukocyte ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Leukocyte Antigen ◽  
Asian Populations ◽  
Risk Alleles ◽  
Johnson Syndrome ◽  
The Uk

AbstractStevens–Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) are part of a disease continuum of vesiculobullous mucocutaneous reactions affecting the skin and mucous membranes including the ocular surface. Manifestations of disease range from mild dry eye to progressive conjunctival cicatrisation, limbal epithelial stem cell failure and corneal blindness. In Far Eastern and South East Asian populations where SJS/TEN is prevalent, numerous human leukocyte antigen (HLA) gene variants at the A, B and C loci have been identified as risk factors for developing SJS/TEN with severe ocular complications (SOC). By contrast, the incidence of SJS/TEN with SOC in European countries is relatively low. To date, ocular SJS/TEN risk altering alleles have not been widely investigated in European populations. In this study, we analysed the association of HLA -A, -B and -C alleles with SJS/TEN in 33 patients residing in the UK with age matched controls. The data showed statistically significant novel negative allele association with HLA-B*0702 and a trend with HLA-C*0702 in the patient group, indicating these alleles are protective. Further characterisation of protective and risk alleles in other ethnic groups is required to fully elucidate the putative role of these alleles in the susceptibility of SJS/TEN with or without severe ocular complications in patients in the UK.

New Grading System for the Evaluation of Chronic Ocular Manifestations in Patients with Stevens–Johnson Syndrome

Ophthalmology ◽  
2007 ◽  
Vol 114 (7) ◽  
pp. 1294-1302 ◽  
Author(s):  
Chie Sotozono ◽  
Leonard P.K. Ang ◽  
Noriko Koizumi ◽  
Hisayo Higashihara ◽  
Mayumi Ueta ◽  
...  
Keyword(s):  
Stevens Johnson Syndrome ◽  
Grading System ◽  
Ocular Manifestations ◽  
Johnson Syndrome

scholarly journals Toxic Epidermal Necrolysis/Stevens-Johnson Syndrome at A University Hospital in Saudi: Causative Factors and Outcomes

2022 ◽  
Author(s):  
Amal A Kokandi
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Small Sample Size ◽  
Intravenous Immunoglobulins ◽  
Small Sample ◽  
University Hospital ◽  
Stevens Johnson Syndrome ◽  
Johnson Syndrome ◽  
Causative Agents ◽  
Life Threatening ◽  
King Abdulaziz University

Abstract Introduction:Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare, life-threatening conditions caused mainly by drugs. Their management relies on the withdrawal of the culprit medication and supportive measures. Different pharmacotherapies have varied effects. However, data related to TEN and SJS in Saudi is limited. This study aimed to identify the causative agents, associated factors, and outcomes of TEN/SJS cases admitted to a teaching hospital (King Abdulaziz University) in Jeddah during the last 10 years.Methods: We retrospectively analyzed the data of TEN/SJS patients admitted to the hospital over the last 10 years.Results: We identified 12 patients with TEN/SJS. Of these, nine survived the condition and were discharged. The culprit medication was identified in eight of them, including antibiotics in six cases and Tegretol and allopurinol in one case each. Most of the patients received systemic steroids and intravenous immunoglobulins.Conclusion: TEN/SJS is mainly caused by medications of which antibiotics are the most implicated. Consistent with other studies, the mortality rate associated with TEN/SJS in Saudi is 25%. Limitations: restricted to a single center and small sample size.

Sign in / Sign up

Export Citation Format

Share Document