scholarly journals CORRELATION BETWEEN HRCT SCORE AND SERUM FERRITIN IN COVID-19 PATIENTS WITH PNEUMONIA IN TERTIARY CARE HOSPITAL, MGM HOSPITAL AURANGABA

2021 ◽  
pp. 52-54
Author(s):  
Saurabh Govind Pad ◽  
Devidas Dahiph ◽  
Saurabh Kakani ◽  
Vimal Dugad
Keyword(s):  
Serum Ferritin ◽  
Pearson Correlation ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
The Social ◽  
Severe Group ◽  
Positive Correlations ◽  
Age Range

This study was aimed to correlate the HRCT score and serum ferritin in diagnosed cases of COVID19 patients with pneumonia.During the pandemic of COVID-19,there was sudden surge in the numbers of HRCT chest scans and along with this amongst the various laboratory investigations serum ferritin was done to observe the role of cytokines which helps in disease progression.The main purpose of this study was to correlate the severity of disease on HRCT chest scan with serum ferritin levels. Aim:To correlate the HRCT score and serum ferritin in diagnosed cases of COVID19 patients with pneumonia. Materials and methods: We included 59 patients (38 men, 21 women age range 18-78years) with documented COVID19 were reviewed. All patients underwent RTPCR tests and had a noncontrast HRCT scan done at presentation. Estimation of serum ferritin was analyzed by using chemiluminescence method.The subjects were divided into three groups:mild,moderate and severe on the basis of HRCT score. Each group's HRCT score correlated with serum ferritin. The details were recorded on a prestructured proforma. The Pearson correlation coefficient test was used for correlations, and p value less than 0.05 was defined as statistically significant.The data was analyzed using Statistical Package for the Social Sciences (SPSS). Results: Out of 59 patients,21 patients were included in the mild group,31 were included in the moderate group and 7 were included in the severe group.CT severity score was found to be positively correlated with ferritin levels (p < 0.001). Strong positive correlations were found between CT scores and serum ferritin in mild (r = 0.84),Moderate (r = 0.92) and severe group (r = 0.082)

scholarly journals Comparative study of serum ferritin and vitamin D in thalassemia patients with healthy controls

2018 ◽  
Vol 6 (2) ◽  
pp. 693 ◽  
Author(s):  
Shweta Gombar ◽  
Kiran Parihar ◽  
Mamta Choudhary
Keyword(s):  
Vitamin D ◽  
Serum Ferritin ◽  
Genetic Disorder ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
Globin Chains ◽  
Bony Landmarks ◽  
High Level

Background: Thalassemia is the most common genetic disorder in humans; they are encountered among all ethnic groups and in almost every country around the world. Mostly occur in the regions surrounding the Mediterranean sea, hence the name. These are a group of hereditary haemolytic disorders characterized by impairment in the synthesis of globin chains of Hb. The present study aimed to find out the serum ferritin and vitamin D level in thalassemic children in the tertiary care hospital in Bikaner, western Rajasthan, India.Methods: In this study 50 (27 male and 23 female) adult skulls were investigated to determine the type of asterion, its distance from important bony landmarks and also the nearby venous sinuses were measured.Results: Level of serum ferritin was significantly high and vitamin D was significantly low (p-value<0.0001 for both) in thalassemic children.Conclusions: In this study the role of serum ferritin and vitamin D has been explored. The extremely high level of ferritin was found due to the regular blood transfusion and consequent iron overload and low vitamin D was found due to impairment in liver functions among thalassemic children.

scholarly journals Frequency of familial short stature identified in children presenting with short stature at a Tertiary Care Hospital in Multan, Pakistan.

2021 ◽  
Vol 28 (7) ◽  
pp. 993-996
Author(s):  
Waqas Imran Khan ◽  
◽  
Asia Noreen ◽  
Summera Tabasum ◽  
◽  
...  
Keyword(s):  
Short Stature ◽  
Tertiary Care ◽  
Female Gender ◽  
P Value ◽  
Care Hospital ◽  
Pediatric Endocrinology ◽  
Multicenter Studies ◽  
Study Population ◽  
Age Range ◽  
Study Setting

Objectives: The objective of my study was to determine the frequency of familial short height in children aged 3 to 14 years with short height. Study Design: Descriptive study. Setting: Department of Pediatric Endocrinology at The Children Hospital & Institute of Child health Multan (CH& ICH). Period: 1st November 2018 to 31st October 2019. Material & Methods: Eighty four patients were enrolled after taking informed consent from parents/guardians. Heights of all patients, parental heights, mid parental heights were plotted on CDC growth charts. Patients having familial short stature were noted down. Results: Out of 84 patients, 59 (70.2%) were males and 25 (29.85%) were females. Age range was 3-14 years. Mean age of the population was 8.68 ± 3.42 years and mean height and weight were 114.29 ± 24.62cm and 28.95±10.01 kg, respectively. Mean height for mother and father of the patients were 154.39 ±4.56cm and 171.10 ± 3.52cm, respectively. Out of 84 children, 21 (25%) patients had FSS. In our study population FSS was more seen in children < 8 years of age, female gender and families with income of > 20K/months with p value of 0.879, 0.129 and 0.592 respectively. Conclusion: Majority of children presenting with short stature have FSS and CDG and do not have an endocrine disorder. In our study, frequency of familial short stature in children aged 3 to 14 years was 25%. The results should be validated in multicenter studies.

scholarly journals Quality of life in epilepsy

2017 ◽  
Vol 5 (2) ◽  
pp. 452 ◽  
Author(s):  
Prem Singh ◽  
Achyut Kumar Pandey
Keyword(s):  
Quality Of Life ◽  
Pearson Correlation ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
Lower Education Level ◽  
One Year ◽  
Patients With Epilepsy ◽  
The Impact

Background: The quality of life (QOL) evaluation is a relatively new measure to evaluate the outcome of epilepsy. Many factors influence the quality of life of people with epilepsy, including seizure severity, stigma, fear, and the presence of cognitive or psychiatric problems. QOL is influenced by biological factors as well as cultural, social and religious beliefs and values. This study was planned to find out the impact of epilepsy on quality of life of epileptic patients.Methods: The study was conducted in the epilepsy clinic of department of neurology at a tertiary care hospital over a period of one year.101 patients were included after fulfilling the inclusion criteria. All the patients seeking treatment in the OPD were screened, assessed and then all procedures were fully explained to them. History regarding name, age sex, socio-demographic profile and detailed history regarding seizure disorder was taken from both the patient and the reliable informant. Bengali version of QOLIE-9 was used to assess the quality of life.Results: One hundred and one patients with epilepsy consisting of 70 men (69.3%) and 31 women (30.7%) were included. Their ages ranged from 15 to 52, the mean age being 26.17 (SD = 7.84). Out of the 101 patients, 65 patients (64.4%) were suffering from partial epilepsies and 36 patients (35.6%) were suffering from generalized epilepsies. Mean QOLIE-9 total scores were 16.66, 19.74, 20.13 and 24.00 in married, widows, unmarried and separated individuals respectively. The differences in the means were statistically significant on ANOVA (p value 0.002). Mean QOLIE-9 total scores were 27.75, 19.64, 19.65, 18.14 and 18.00 in primary, secondary, higher secondary, graduate and postgraduate individuals respectively. The differences were highly significant statistically on ANOVA (p value<0.001). Frequency of seizures per month was positively correlated with QOLIE-9 total scores (Pearson Correlation 0.622) and was highly statistically significant (p value<0.001).Conclusions: Frequent seizures, lower education level and single status are associated with lower quality of life in persons with epilepsy.

scholarly journals Distribution of HPV Genotypes in Patients with a Diagnosis of Anal Cancer in an Italian Region

2020 ◽  
Vol 17 (12) ◽  
pp. 4516 ◽  
Author(s):  
Narcisa Muresu ◽  
Giovanni Sotgiu ◽  
Laura Saderi ◽  
Illari Sechi ◽  
Antonio Cossu ◽  
...  
Keyword(s):  
Anal Cancer ◽  
Tertiary Care ◽  
Scale Up ◽  
Anal Carcinoma ◽  
Detection Methods ◽  
P Value ◽  
Care Hospital ◽  
Significant Difference ◽  
Hpv Genotypes

Objectives: Anal cancer is a rare disease. However, its incidence is increasing in some population groups. Infection caused by Human Papillomavirus (HPV) is strongly associated with the risk of anal cancer, whose variability depends on samples, histology, and HPV detection methods. The aim of the study was to assess prevalence and distribution of HPV genotypes in patients diagnosed with anal carcinoma. Methods: An observational, retrospective study was carried out in a tertiary care hospital in North Sardinia, Italy. Specimens of anal cancer diagnosed from 2002–2018 were selected. Demographic, epidemiological, and clinical variables were collected to assess their relationship with the occurrence of anal cancer. Results: The overall HPV positivity was 70.0% (21/30), with HPV-16 being the predominant genotype (~85%). The highest prevalence of anal cancer was in patients aged ≥55 years. HPV positivity was higher in women (p-value > 0.05) and in moderately differentiated samples (G2) (p-value < 0.05). p16INK4a and E6-transcript positivity were found in 57% and 24% of the HPV positive samples, respectively. The OS (overall survival) showed a not statistically significant difference in prognosis between HPV positive sand negatives (10, 47.6%, vs. 4, 44.4%; p-value = 0.25). Conclusions: HPV-DNA and p16INK4a positivity confirmed the role of HPV in anal carcinoma. Our findings could support the implementation and scale-up of HPV vaccination in males and females to decrease the incidence of HPV-associated cancers. Further studies are needed to better clarify the prognostic role of HPV/p16 status.

Association of Inflammatory Markers with the Severity of COVID-19 in a Tertiary Care Hospital in Bagalkot, India - A Cross-Sectional Study

2021 ◽  
Vol 8 (28) ◽  
pp. 2520-2525
Author(s):  
Sunil Baragi ◽  
Pavani Mallikarjun Dyavannavar
Keyword(s):  
Serum Ferritin ◽  
Inflammatory Markers ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
Prediction Of Mortality ◽  
Severe Group ◽  
D Dimer

BACKGROUND A novel coronavirus was identified as being responsible for a cluster of pneumonia cases worldwide. With an upward trajectory of (corona virus disease-19) COVID-19 cases and its numerous presentations, there is an urgent requirement of identifying initial signs of decline of quality and an adequate response in order to shift a patient to specialized intensive care units (ICU) for those who progress morbidly to severe or critical categories. It has been reported that various acute phase reactants like erythrocyte sedimentation rate (ESR), ferritin, C-reactive protein (CRP), lactate dehydrogenase (LDH) and D-dimer are raised much more in severe and critical patients than in the mild cases. These markers might have a role to predict mortality. The present study was done to assess the relationship of serum ferritin, and CRP levels at admission with in-hospital mortality among patients with COVID-19 infection and to determine cut-off values of the best prediction of mortality. METHODS A cross-sectional study of 109 reverse transcription polymerase chain reaction (RTPCR) confirmed COVID-19 patients admitted in our hospital was done. The outcome of cases was categorized into mild, moderate and severe grades. RESULTS Out of 109, 80(73.4 %) were males and 29 (26.6 %) were females. Majority patients of both genders were having severe disease with 30 males and females 10 (P - value = 0.066). Among 109 patients, mild cases (33), moderate case (36), severe case (40). Serum ferritin value severe group (n = 49) 422.45 ng/mL, moderate group (n = 33) 563.64 ng/mL, mild group (n = 27) 529.63 ng/mL. Mean ESR value in severe group 98.37, moderate group 100, mild group 100. Mean CRP in severe group 242.86 mg/L, moderate group 248.48 mg/L, mild group 307.41 mg/L. Mean d-dimer in severe group 971.43 ng/mL, moderate group 803.03 ng/mL, mild group 811.11 ng/mL. CONCLUSIONS Our study showed higher levels of markers like ferritin, D-dimer, CRP and ESR in severe patients as compared to mild and helped in forecasting the advancement of mild cases to severe. Also, the blood levels of CRP and ferritin and the duration to complete symptomatic relief all demonstrated a substantial statistical link thus aiding for monitoring of patients at home and in hospitals. KEYWORDS Covid-19, Inflammatory Markers

scholarly journals A RETROSPECTIVE STUDY OF ROLE OF SERUM FERRITIN AS A PROGNOSTIC MARKER IN COVID-19 PATIENTS, IN A TERTIARY CARE CENTRE IN INDORE DISTRICT, STATE M.P.

2021 ◽  
Vol 5 (5) ◽  
Author(s):  
Sakar Saxena ◽  
Romi Srivastava ◽  
Shubhi Pandey
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Serum Ferritin ◽  
Tertiary Care ◽  
Chronic Obstructive ◽  
P Value ◽  
Positive Polymerase Chain Reaction ◽  
Severe Group

Background: Ferritin is a key mediator of immune dysregulation, especially under extreme hyperferritinemia, via direct immune-suppressive and pro-inflammatory effects, contributing to the cytokine storm. In several studies, it was found that individuals with severe and very severe COVID-19 exhibited increased serum ferritin level, being serum ferritin in the very severe COVID-19 group significantly higher than in the severe COVID-19 group Method: All patients had a positive polymerase chain reaction (PCR) test results.  Patients with the history of comorbidities such as Hypertension (HTN), Diabetes Mellitus (DM), Chronic obstructive pulmonary disease (COPD), Asthama, Heart failure, Chronic renal Failure (CRF) were included. The clinical and laboratory findings including haemoglobin, wbc counts, differential counts, liver function tests, c-reactive protein (CRP), ferritin and interleukin -6 (IL-6) were obtained from the database. Results: A total of 38 patients were included in the study. The median age of study population was 52.5 years (13-90) and 65% of patients were male. Patients in the severe group were significantly older and had a higher frequency of hypertension, diabetes mellitus, coronary heart disease, heart failure and chronic renal failure as compared to the patients with the mild group. In addition frequency of dyspnea was higher in the severe group. It was observed that the serum ferritin levels of those patients who fell in the serious category were found significantly raised. P value for Serum Ferritin and Category (serious/mild) is 0.048 which is less than < 0.05. Conclusion: Hence it was concluded that there was a strong association between increased serum ferritin levels and the severity of the disease. Early analysis of ferritin levels in patients with covid 19 might effectively define the severity of disease. Keywords: Serum, Ferritin, Covid & Marker.

scholarly journals ROLE OF OCTREOTIDE ON OUTCOME OF PATIENTS WITH ACUTE PANCREATITIS

1969 ◽  
Vol 5 (1) ◽  
pp. 639-643
Author(s):  
AJMAL KHAN ◽  
SAMIULLAH ◽  
MANZOOR ALI ◽  
SAIFUREHMAN
Keyword(s):  
Acute Pancreatitis ◽  
Hospital Stay ◽  
Pain Control ◽  
Tertiary Care ◽  
P Value ◽  
Care Hospital ◽  
P Values ◽  
Group A ◽  
Group B

BACKGROUND: acute pancreatitis is a multisystem disease carrying broad spectrum of clinicalpresentation and complications. The objective of this study was to determine the positive role ofoctreotide in the out come of patients suffering from acute pancreatitis.OBJECTIVE: The objective of this study was to assess the role of octreotide in patients having acutepancreatitis.PATIENTS AND METHODS: This is a descriptive, comparative, prospective study. The study wasconducted in the department of surgery Saidu Group of Teaching hospital Saidu Sharif Swat fromJanuary 2011 to June 2014. Total of seventy consecutive patients having acute pancreatitis wasrandomized in a prospective trail for the treatment, at tertiary care hospital in Malakand division SwatKPK Pakistan. The data of patients were recorded on a purposely prepared proforma for this study. Thediagnosis of patients was established on basis of biochemical (serum amylase, WCC, C-reactive protein)and radiological (USG, CT- scan) investigations. The patients were divided into two groups, A and B.Group A, had received octreotide along with fluids, omeprazole, analgesic. Group B received fluids,omeprazole, analgesic without octreotide. Ages of the Group A and B were matched (±5 years). Datawas analyzed using SPSS version 16 employing chi-square test (X" test). A p-value below 0.05 wasconsidered statistically significant.RESULTS: In this prospective, comparative study two groups, each of 35 consecutive patients wereselected. The mean age in Group A was 37 ±12.41 years and in Group B 40±10.32 years (p DO.364).There were 12 males and 23 females in group A, while 14 males and 21 females in group B. Both thegroups were comparable. All the patients in octreotide group A and non-octreotide group B weresurvived. No major complications were noted in either group. As far as mean hospital stay was 7 ±2.10days in group A, while it was 9±3.14 days in group B (p<0.032). All the P- values for the criteria ofstudy were calculated. P-values were significant when we consider pain control and hospital stay intwo groups.CONCLUSION: In our study we found that octreotide was more effective in the final outcome ofpatients with acute pancreatitis. There is clear cut beneficial effect of octreotide on hospital stay andreduced need of analgesics in patients having acute pancreatitis.KEYWORDS: Acute Pancreatitis, Octreotide, Hospital Stay, pain control.

scholarly journals Effect of thalidomide in patients with β–thalassemia major

2018 ◽  
Vol 6 (6) ◽  
Author(s):  
Shahzad Ali Jiskani ◽  
Sumair Memon
Keyword(s):  
Serum Ferritin ◽  
Ferritin Level ◽  
Treatment Options ◽  
Tertiary Care ◽  
Thalassemia Major ◽  
Hereditary Disease ◽  
P Value ◽  
Care Hospital ◽  
Female Ratio ◽  
Before And After

Introduction: Thalassemia is among the common hereditary disease, caused by synthesis of defective haemoglobin, leading to ineffective erythropoiesis, chronic haemolytic anaemia and certain clinical complications. Various treatment options are available for treatment of β–thalassemia major including regular blood transfusion, iron chelation therapy and hydroxyurea. Although complications and poor survival is still major problem in these patients. So treatment with alternative drugs can be helpful in management of these patients. Methods and materials: Prospective study, conducted at a tertiary care hospital. Study included 70 known cases of transfusion dependant thalassemia major. Age, gender, haemoglobin and serum ferritin levels were analyzed before and after treatment with thalidomide. All data were collected and analyzed in SPSS 21.0. P–value of <0.05 was considered as statistically significant. Results: Among 70 patients, 46 were males and 24 were females (male to female ratio=1.9:1). Mean age of the patients was 10.31±1.24years. Before and after treatment with thalidomide, mean haemoglobin was 8.93±1.04g/dL and 10.54±1.18g/dL respectively (p=0.011). Before and after treatment, mean serum ferritin level was 3125±143.51ng/mL and 1241±135.94ng/mL (p>0.001). Conclusion: Thalidomide proved to increased haemoglobin levels and reducing ferritin levels in patients with β–thalassemia major.

scholarly journals Correlation of decayed, missing and filled teeth with risk factors for dental caries in children attending outpatient department in tertiary care hospital

2019 ◽  
Vol 6 (4) ◽  
pp. 1510
Author(s):  
V. Arunagirinathan ◽  
P. Venkatesh
Keyword(s):  
Risk Factors ◽  
Oral Health ◽  
Dental Caries ◽  
Pearson Correlation ◽  
Tertiary Care ◽  
Outpatient Department ◽  
Deciduous Teeth ◽  
P Value ◽  
Care Hospital ◽  
Increased Risk

Background: Oral health is of vital importance to humans’ general health. Despite the marked improvement in oral health, caries occurs in both developed and developing countries worldwide. The patient’s age is important for determining caries risk. Special attention must be paid to children’s oral health when deciduous teeth start erupting and occlusion has formed in 2 to 3-year-old children. To assess the correlation of decayed, missing and filled teeth (dmft/DMFT) with risk factors for dental caries in children and with knowledge, attitude, and practices of parents regarding dental caries.Methods: Cross-sectional study included 96 children with dental caries attending paediatric outpatient department of Government Stanley Medical College, Chennai, Tamil Nadu, India between 2018 March to November. Clinical evaluation, dmft score, and knowledge, attitude and practices of parents were assessed using pre-formed questionnaire.Results: Patients with high dmft score were found to have low practice score with the Pearson correlation coefficient(r) value -0.41 and P value was 0.01. Corresponding values of knowledge and attitude were not statistically significant. Children who nap/sleep with bottle/pacifier have increased risk (P value-0.01).Conclusions: An oral health risk assessment should be done periodically by Paediatrician who has regular contact with children for early identification of dental caries, to impart healthy oral practices and make them aware of preventive measures.

scholarly journals The role of neutrophil/lymphocyte ratio in predicting the severity of sepsis in a tertiary care hospital in South India: a retrospective study

2020 ◽  
Vol 8 (5) ◽  
pp. 1624
Author(s):  
Alfy Ann George ◽  
Teju P. Thomas ◽  
Abdul Gaffoor
Keyword(s):  
Tertiary Care ◽  
Clinical Manifestations ◽  
Organ Involvement ◽  
P Value ◽  
Risk Category ◽  
Care Hospital ◽  
Chi Square ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio

Background: Sepsis, a syndrome of dysregulated host response to infection leading to life-threatening organ dysfunction, is having a substantial burden in health system. The outcome in sepsis is often time dependent. None of the clinical manifestations nor the age-old markers like ESR, CRP, etc. have proven diagnostic or prognostic of sepsis. This study aims to assess the role of neutrophil: lymphocyte ratio (NLR) in assessing the severity of sepsis within the initial 24 hrs of admission.Methods: Authors did a retrospective observational study in 208 sepsis patients admitted in the MDICU. The NLR was calculated and the study population was grouped into those with an NLR of more than or equal to 5 and those with less than 5. The patients were also grouped based on the number of organs impaired due to sepsis. The association between these groups were then assessed.Results: 46 patients (60.5%) with single organ involvement had NLR <5; 30 patients (39.5%) had NLR >5; 27 patients (42.2%) with two organ involvement had NLR <5 and 37 patients (57.8%) had NLR >5. Among patients with more than two organ involvement, 8 patients (21.6%) had NLR <5 and 29 patients (78.4%) had NLR >5. It was found that there is statistically significant association between increase in number of organs involved and NLR more than 5. The chi square test value was 15.691 with a p value was less than 0.001.Conclusions: In the current study, we have evaluated the role of NLR in sepsis. NLR calculated on the day of admission is a simple parameter that helps to stratify patients into severe risk category. A significant association was found with higher NLR and the number of organs impairment in sepsis.

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