scholarly journals ETIOLOGY AND CLINICAL PROFILE OF FEVER OF UNKNOWN ORIGIN IN CHILDREN-A PROSPECTIVE OBSERVATIONAL STUDY IN PEDIATRICS DEPARTMENT OF DMCH, LAHERIASARAI, BIHAR

2020 ◽  
pp. 1-3
Author(s):  
Raman Paswan ◽  
Ashok KUMAR ◽  
Debarshi Jana
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Fever Of Unknown Origin ◽  
Urine Analysis ◽  
Complete Blood Count ◽  
Unknown Origin ◽  
Tuberculin Test ◽  
Test Results ◽  
Indian Children ◽  
Peripheral Smear

Background: Fever of unknown origin (FUO) is an important cause of morbidity and mortality in children, especially in tropical countries with varied aetiology and clinical presentation. Aim of this study is to determine the aetiology and outcome of FUO in Indian children. Study design is Prospective, observational study. Methods: We enrolled 75 children aged 1 to 12 years who were admitted with fever >8 days to the pediatric department of DMCH, Laheriasarai, Bihar from November 2019 to June 2020. Initial evaluation included complete blood count, peripheral smear, urine analysis, chest radiography, blood culture and tuberculin test. Results: In 72 children (96%), a definitive diagnosis could be established, whereas 3 children (4%) remained undiagnosed. Most common aetiology of FUO was infectious disease (90.6%) followed by malignancy (4%) and collagen vascular disease (1.3%). Among the infections group, scrub typhus was found to be the commonest aetiology (52%). Conclusions: Infections were the most common etiological factor for FUO in children aged 1-12 years of our region.

scholarly journals Fever in the tropics: aetiology and clinical profile of fever of unknown origin in children-a prospective observational study in a tertiary care hospital in South India

2019 ◽  
Vol 6 (5) ◽  
pp. 1834
Author(s):  
Ramachandran Sumathisri ◽  
Karuppiah Pandi ◽  
Sadagopan Srinivasan
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Fever Of Unknown Origin ◽  
Urine Analysis ◽  
Complete Blood Count ◽  
Tertiary Care ◽  
Unknown Origin ◽  
Tuberculin Test ◽  
Care Hospital ◽  
Indian Children

Background: Fever of unknown origin (FUO) is an important cause of morbidity and mortality in children, especially in tropical countries with varied aetiology and clinical presentation. Aim of this study is to determine the aetiology and outcome of FUO in Indian children. Study design is Prospective, observational study.  Methods: We enrolled 75 children aged 1 to 12 years who were admitted with fever >8 days to the paediatric department from January 2015 to August 2016. Initial evaluation included complete blood count, peripheral smear, urine analysis, chest radiography, blood culture and tuberculin test.  Results: In 72 children (96%), a definitive diagnosis could be established, whereas 3 children (4%) remained undiagnosed. Most common aetiology of FUO was infectious disease (90.6%) followed by malignancy (4%) and collagen vascular disease (1.3%). Among the infections group, scrub typhus was found to be the commonest aetiology (52%).Conclusions: Infections were the most common etiological factor for FUO in children aged 1-12 years of our region.

scholarly journals Prevalence of Connective Tissue Diseases in Egyptian Patients Presenting with Fever of Unknown Origin

2011 ◽  
Vol 4 ◽  
pp. CMAMD.S6763 ◽  
Author(s):  
Mohamad S. Abdelbaky ◽  
Howaida E. Mansour ◽  
Shafika I. Ibrahim ◽  
Iman A. Hassan
Keyword(s):  
Connective Tissue ◽  
Fever Of Unknown Origin ◽  
Urine Analysis ◽  
Complete Blood Count ◽  
Connective Tissue Diseases ◽  
Unknown Origin ◽  
Medical Problem ◽  
Advanced Technology ◽  
Diagnostic Tools ◽  
History Taking

Objective To estimate the prevalence of connective tissue diseases in patients presenting with fever of unknown origin (FUO). Patients and Methods In this study thirty patients diagnosed as FUO (Group 1), in 2008, were included in an observational study and diagnostic workup. Additionally, retrospective analysis of seventy patients’ files (Group 2), for patients who presented with prolonged unexplained pyrexia to the same hospital in the previous two years, was performed. Patients were subjected to: full clinical assessment including full history taking, thorough clinical examination, laboratory investigations including the basic investigations for patients with prolonged fever, complete blood count, erythrocytes sedimentation rate, urine analysis and culture, blood culture, sputum culture and plain chest X ray. Further diagnostic work up and/or procedures were requested according to the potential diagnostic clues (PDC) present in every patient. Results Out of 100 FUO patients, 50% were found to have infectious diseases, 24% were found to have connective tissue diseases, 8% miscellaneous causes and 7% neoplastic diseases ( P < 0.05). In 11 patients no definite cause for FUO could be identified. Connective tissue patients were: eight systemic lupus patients (33.3%), five patients with familial mediterranean fever (20.8%), four patients with rheumatoid arthritis (16.6%), three patients (12.5%) with Still's disease and Rheumatic fever and one patient with Behçet syndrome/Crohn's disease (4.3%), ( P < 0.05). Conclusions Despite the advanced technology, FUO remains a challenging medical problem. Infections were the most common cause of FUO in Egypt, confirming the trends found in other parts of the world. There was an increased prevalence of connective tissue patients presented with prolonged unexplained fever. A keen clinical eye, meticulous history taking and repeated physical examination remained the most important diagnostic tools in FUO patients.

scholarly journals Clinical and Microbiological Characteristics of Visceral Leishmaniasis Outbreak in a Northern Italian Nonendemic Area: A Retrospective Observational Study

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
E. Franceschini ◽  
C. Puzzolante ◽  
M. Menozzi ◽  
L. Rossi ◽  
A. Bedini ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Observational Study ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Mediterranean Area ◽  
Retrospective Observational Study ◽  
Attributable Mortality ◽  
Microbiological Characteristics ◽  
The One ◽  
Bone Marrow Blood

Background. Visceral leishmaniasis (VL) caused byLeishmania infantumis endemic in the Mediterranean area. In the last decades a northward spread of the parasite has been observed in Italy. This paper describes a VL outbreak in Modena province (Emilia-Romagna, Northern Italy) between 2012 and 2015.Methods. Retrospective, observational study to evaluate epidemiological, microbiological characteristics, and clinical management of VL in patients referring to Policlinico Modena Hospital.Results. Sixteen cases of VL occurred in the study period. An immunosuppressive condition was present in 81.3%. Clinical presentation included anemia, fever, leukopenia, thrombocytopenia, and hepatosplenomegaly. Serology was positive in 73.3% of cases, peripheral blood PCR in 92.3%, and bone marrow blood PCR in 100%. Culture was positive in 3/6 cases (50%) and all the isolates were identified asL. infantumby ITS1/ITS2 sequencing. The median time between symptom onset and diagnosis was 22 days (range 6–131 days). All patients were treated with liposomal amphotericin b. 18.8% had a VL recurrence and were treated with miltefosine. Attributable mortality was 6.3%.Conclusions. VL due toL. infantumcould determine periodical outbreaks, as the one described; thus it is important to include VL in the differential diagnosis of fever of unknown origin, even in low-endemic areas.

Clinical spectrum of fever of unknown origin among Indian children

2008 ◽  
Vol 28 (4) ◽  
pp. 261-266 ◽  
Author(s):  
N. Joshi ◽  
K. Rajeshwari ◽  
A. P. Dubey ◽  
T. Singh ◽  
R. Kaur
Keyword(s):  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Clinical Spectrum ◽  
Indian Children

scholarly journals Prospective observational study to evaluate the performance of the BioSure HIV Self-Test in the hands of lay users

2017 ◽  
Vol 94 (3) ◽  
pp. 169-173 ◽  
Author(s):  
John Saunders ◽  
Nataliya Brima ◽  
Marzena Orzol ◽  
Laura Phillips ◽  
Ana Milinkovic ◽  
...  
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Evaluation Study ◽  
Test Results ◽  
Valid Result ◽  
Sexual Health Service ◽  
Self Test ◽  
Test Outcomes ◽  
Result Interpretation ◽  
Test Result

ObjectivesIn order to assess whether the BioSure HIV Self-Test could be reliably performed by users at home and to determine whether they were able to perform and correctly interpret the test, we carried out an evaluation study among attendees at a sexual health service.MethodsA prospective observational study of clinic attendees to determine their ability to follow the instructions, complete the test on themselves and correctly interpret the results. The evaluation included interpretation of three dummy (contrived) devices, chosen at random from a sample of 12 devices, to ensure that a sufficient number of all possible test outcomes were included.ResultsTwo hundred participants were recruited. 97.0% (95% CI 93.5 to 98.9) conducted the test so as to achieve a valid result. 99.5% correctly identified the test result. Participants correctly interpreted the result of 94.0% (95% CI 91.4 to 95.9) of 586 contrived devices.ConclusionsThe majority of participants were able to follow the instructions and perform the test in order to get a valid result. Interpretation of the test results was good and the majority of participants were able to correctly read the result of their own and contrived tests. The availability of HIV self-tests will provide another option to increase access to testing particularly for those who may not wish or are unable to access clinical services.

scholarly journals Hypophosphataemia in severe acute malnutrition: a prospective observational study

2018 ◽  
Vol 121 (3) ◽  
pp. 306-311 ◽  
Author(s):  
Rana Chanchal ◽  
Sarika Gupta ◽  
Chandra Kanta ◽  
Kalpana Singh ◽  
Sciddhartha Koonwar
Keyword(s):  
Observational Study ◽  
Prospective Observational Study ◽  
Severe Acute Malnutrition ◽  
Tertiary Care ◽  
Uttar Pradesh ◽  
North India ◽  
Acute Malnutrition ◽  
Indian Children ◽  
Mortality And Morbidity ◽  
Growth Standards

AbstractSevere acute malnutrition (SAM) is a major cause of child mortality and morbidity. Children treated for SAM are at risk of refeeding hypophosphataemia (HP). The study was done to find out the incidence and various predictors of moderate/severe HP in SAM among North Indian children. This prospective observational study was conducted from August 2014 to July 2015 in the inpatients’ department of Department of Paediatrics at King George’s Medical University, Lucknow, Uttar Pradesh, North India, a tertiary care teaching hospital. Before inclusion, ethical approval and written informed consent was obtained. Included in the study were sixty-five children aged 6–59 months of age, who were admitted to the hospital with SAM as per the WHO guidelines. SAM was defined as a mid-upper arm circumference <115 mm and/or weight-for-height/length <–3z-scores of the WHO growth standards and/or have bilateral oedema. Serum P levels were measured on admission and for five consecutive days after starting feed. HP was defined as mild, moderate and severe with a cut-off of 1·19–0·65, 0·65–0·32 and <0·32 mmol/l, respectively. About 60 % children had HP, with 20 % having moderate/severe HP at admission. The proportion of HP increased to 83·1 %, with 38·5 % having moderate/severe HP on day 3 after feeding. It was concluded that HP is a common biochemical abnormality in SAM. Considering its impact on the health of the child, serum P levels should be monitored in patients with SAM who are treated with enteral feeding.

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