scholarly journals A STUDY OF SERUM URIC ACID LEVELAND RISK FOR ACUTE ISCHEMIC NONEMBOLIC STROKE IN ELDERLY SUBJECTS

2020 ◽  
pp. 1-3
Author(s):  
Somnath Ghosh ◽  
Apurba Bikash Pramanik ◽  
Shampa Maity ◽  
Pulakesh Sinha ◽  
Debarshi Jana
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Ischemic Stroke ◽  
Statistical Analysis ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Case Control ◽  
Elderly Subjects ◽  
Cross Sectional ◽  
Medical College

The study is conducted to determine the association between serum uric acid (SUA) and acute non embolic ischemic stroke and to assess its risk factor potential using statistical analysis. The observational, cross-sectional, case control, retrospective was conducted in the N.R.S. Medical College and Hospital, Kolkata. Study was done from 1st February 2017 to 30th September 2018 i.e., through one and half year period. About 200 patients(100cases & 100 controls). It was also found that serum uric acid was also independent risk factor for causing acute ischemic non embolic stroke. It is also suggested that further studies are required to assess whether lowering of SUA level with drugs can actually reduce the risk of ischemic stroke.

scholarly journals Study of Serum Uric Acid Level as an Independent Risk Factor in Acute Ischemic Stroke

2020 ◽  
Vol 7 (9) ◽  
pp. 442-445
Author(s):  
Chandrashekhar K ◽  
Mohammed Anwar Hussain ◽  
Ishwar S. Hasabi ◽  
Suryakanth Suryakanth ◽  
Chethan K. Ganteppanavar
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Independent Risk Factor ◽  
Serum Uric Acid Level

Abstract P146: Uric Acid is an Independent Risk Factor for Developing Hypertension From Prehypertension: A 5-year Japanese Cohort Study

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Masanari Kuwabara ◽  
Shigeko Hara ◽  
Koichiro Niwa ◽  
Minoru Ohno ◽  
Ichiro Hisatome
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Risk Factor ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Drinking Habits

Objectives: Prehypertension frequently progresses to hypertension and is associated with cardiovascular diseases, stroke, excess morbidity and mortality. However, the identical risk factors for developing hypertension from prehypertension are not clarified. This study is conducted to clarify the risks. Methods: We conducted a retrospective 5-year cohort study using the data from 3,584 prehypertensive Japanese adults (52.1±11.0 years, 2,081 men) in 2004 and reevaluated it 5 years later. We calculated the cumulative incidences of hypertension over 5 years, then, we detected the risk factors and calculated odds ratios (ORs) for developing hypertension by crude analysis and after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid. We also evaluated whether serum uric acid (hyperuricemia) provided an independent risk for developing hypertension. Results: The cumulative incidence of hypertension from prehypertension over 5 years was 25.3%, but there were no significant differences between women and men (24.4% vs 26.0%, p=0.28). The cumulative incidence of hypertension in subjects with hyperuricemia (n=726) was significantly higher than those without hyperuricemia (n=2,858) (30.7% vs 24.0%, p<0.001). After multivariable adjustments, the risk factors for developing hypertension from prehypertension were age (OR per 1 year increased: 1.023; 95% CI, 1.015-1.032), women (OR versus men: 1.595; 95% CI, 1.269-2.005), higher body mass index (OR per 1 kg/m 2 increased: 1.051; 95% CI 1.021-1.081), higher baseline systolic blood pressure (OR per 1 mmHg increased: 1.072; 95% CI, 1.055-1.089) and diastolic blood pressure (OR per 1 mmHg increased: 1.085; 95% CI, 1.065-1.106), and higher serum uric acid (OR pre 1 mg/dL increased: 1.149; 95% CI, 1.066-1.238), but not smoking and drinking habits, diabetes mellitus, dyslipidemia, and chronic kidney diseases. Conclusions: Increased serum uric acid is an independent risk factor for developing hypertension from prehypertension. Intervention studies are needed to clarify whether the treatments for hyperuricemia in prehypertensive subjects are useful.

scholarly journals Serum uric acid is an independent risk factor for cardiovascular disease and mortality in hypertensive patients

2012 ◽  
Vol 35 (11) ◽  
pp. 1087-1092 ◽  
Author(s):  
Tatsuo Kawai ◽  
Mitsuru Ohishi ◽  
Yasushi Takeya ◽  
Miyuki Onishi ◽  
Norihisa Ito ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Hypertensive Patients

scholarly journals Serum Uric Acid Is Not an Independent Risk Factor for Premature Coronary Artery Disease

2013 ◽  
Vol 3 (4) ◽  
pp. 246-253 ◽  
Author(s):  
Sara Zand ◽  
Akbar Shafiee ◽  
Mohammadali Boroumand ◽  
Arash Jalali ◽  
Younes Nozari
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

scholarly journals Association between serum uric acid and carotid disease in patients with atherosclerotic acute ischemic stroke

Vascular ◽  
2018 ◽  
Vol 27 (1) ◽  
pp. 19-26 ◽  
Author(s):  
José Carlos Arévalo-Lorido ◽  
Juana Carretero-Gómez ◽  
Nicolás Roberto Robles Pérez-Monteoliva
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Pearson Correlation ◽  
Vascular Wall ◽  
Carotid Disease ◽  
Cross Sectional ◽  
Stroke Registry ◽  
Media Thickness

Aim The role of serum uric acid in ischemic stroke is controversial. On the one hand, it has a role as neuroprotectant in acute phase, but on the other hand, it may promote atherosclerosis in carotid arteries. Our aim is to investigate the association of serum uric acid levels at admission of acute ischemic stroke patients with carotid disease. Methods Cross-sectional study of patients admitted due to acute ischemic stroke. Clinical and laboratory variables were recorded. The carotid disease was defined based on the findings of carotid echography intima to media thickness and stenosis. Patients were grouped according to these findings. Robust statistical methods were applied into analysis. Results A total of 245 patients were recruited through a stroke registry. Their values of serum uric acid were related to both carotid intima to media thickness and stenosis showing a positive relationship between serum uric acid levels and intima to media thickness by Pearson correlation ( p < 0.05). Similarly, after adjusting for all potential confounders, eGFR, glucose, age and serum uric acid levels, (OR 1.26 (95% CI 1.04 −1.52, p¼0.01), were identified as independent predictors for having a intima to media thickness ≥1 mm. Similarly, by grouping patients in tertiles of the serum uric acid distribution, we found a predominantly greater carotid disease in the tertile with the highest levels of serum uric acid ( p < 0.005). Conclusion Our study supports the hypotheses that serum uric acid levels have different roles in the case of ischemic stroke. Its effects on the vascular wall contribute to the development of atherosclerosis and carotid disease.

scholarly journals Study of prevalence and impact of hyperuricemia in a patient of hypertension

2017 ◽  
Vol 4 (2) ◽  
pp. 367
Author(s):  
Rizwan N. Ansari ◽  
Rina V. Gandhi ◽  
M. N. Saiyed ◽  
Kaushal D. Jain
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Risk Factor ◽  
Essential Hypertension ◽  
Cardiovascular Risk ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Biochemical Marker ◽  
Direct Relation ◽  
Stage 1

Background: The association of raised serum uric acid levels with various cardiovascular risk factors has often led to the debate of whether raised serum uric acid levels could be an independent risk factor in essential hypertension. Hence we carried out a study to examine the possibility of hyperuricemia causing hypertension, to see if there is a relationship between the serum uric acid levels and severity and duration of hypertension.Methods: The study was carried out in Smt. SCL Hospital, Saraspur, Ahmedabad, India, the study period from September 2012 to June 2014, a total of 100 patients were studied. The patients were included if they satisfied the JNC VII criteria for hypertension. They were excluded if they were having any other condition known to cause raised serum uric acid levels and secondary hypertension.Results: With the result based on the study carried out we concluded that there can be a direct relation between hyperuricemia and hypertension. Also the study showed that the SUA levels were significantly increased in patient with stage 2 hypertension in comparasion with those with stage 1 hypertension, showing that the severity of hypertension also related to the SUA levels.Conclusions: Based on the study carried out we concluded that SUA can be used as an early biochemical marker to determine the severity and duration of hypertension.

Mechanistic Insights of Soluble Uric Acid-related Kidney Disease

2020 ◽  
Vol 27 (30) ◽  
pp. 5056-5066 ◽  
Author(s):  
Pan Jing ◽  
Min Shi ◽  
Liang Ma ◽  
Ping Fu
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Elevated Serum ◽  
Tubulointerstitial Fibrosis ◽  
Renal Diseases ◽  
Glomerular Hypertrophy ◽  
Progression Of Kidney Disease

Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent risk factor was common in patients during the causation and progression of kidney disease. Uric acid is a soluble final product of endogenous and dietary purine metabolism, which is freely filtered in kidney glomeruli where approximately 90% of filtered uric acid is reabsorbed. Considerable studies have demonstrated that soluble uric acid was involved in the pathophysiology of renal arteriolopathy, tubule injury, tubulointerstitial fibrosis, as well as glomerular hypertrophy and glomerulosclerosis. In the review, we summarized the mechanistic insights of soluble uric acid related renal diseases.

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