RHINOMAXILLARY MUCORMYCOSIS IN AN IMMUNOCOMPETENT PATIENT: A CASE REPORT

2021 ◽  
pp. 15-16
Author(s):  
Tarun Kumar Roy ◽  
Mahuya Roy ◽  
Tapan Majumdar
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Nasal Obstruction ◽  
Indian Subcontinent ◽  
Immunocompetent Patient ◽  
Immunocompromised Patients ◽  
Fatality Rate ◽  
High Fatality Rate ◽  
High Incidence ◽  
The World

Mucormycosis is an opportunistic fungal infection having a high fatality rate. Mostly it is associated with immunocompromised patients. However, mucormycosis in immunocompetent individuals has been reported in several cases throughout the world with a high incidence of such cases from the Indian subcontinent. Here, we report one such case of rhinomaxillary mucormycosis in immunocompetent patient who presented with nasal obstruction.

scholarly journals Prostatic tuberculosis: case report

2008 ◽  
Vol 126 (4) ◽  
pp. 227-228 ◽  
Author(s):  
Daniel Sáenz-Abad ◽  
Santiago Letona-Carbajo ◽  
José Luis de Benito-Arévalo ◽  
Isabel Sanioaquín-Conde ◽  
Francisco José Ruiz-Ruiz
Keyword(s):  
Computed Tomography ◽  
Mycobacterium Tuberculosis ◽  
Case Report ◽  
Urine Culture ◽  
Immunocompetent Patient ◽  
Immunocompromised Patients ◽  
Tuberculosis Case ◽  
Immunocompetent Patients

CONTEXT: Tuberculosis of the prostate has mainly been described in immunocompromised patients. However, it can exceptionally be found as an isolated lesion in immunocompetent patients. CASE REPORT: We report a case of prostatic tuberculosis in a young, healthy and immunocompetent patient with unremarkable findings from intravenous urographic examination. Computed tomography showed an abscess in the prostate and Mycobacterium tuberculosis was isolated in a urine culture. Treatment with isoniazid, rifampin and pyrazinamide was successful.

scholarly journals Primary Cutaneous Chrysosporium Infection following Ear Piercing: A Case Report

2015 ◽  
Vol 7 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Poonkiat Suchonwanit ◽  
Chayada Chaiyabutr ◽  
Vasanop Vachiramon
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Transplant Patient ◽  
Immunocompetent Patient ◽  
Immunocompromised Patients ◽  
Heart Transplant Patient ◽  
Cutaneous Injury ◽  
Ear Piercing ◽  
Large Genus ◽  
Slow Onset

Chrysosporium is a large genus of saprophytic fungi that is commonly found in the soil. Infection caused by this organism is rare in humans and typically occurs in immunocompromised patients. Primary cutaneous Chrysosporium infection is relatively rare and has been reported in a heart transplant patient. The prognosis is usually favorable, but very poor in the setting of persistent profound immunosuppression. We herein report a case of primary cutaneous Chrysosporium infection following ear piercing in an immunocompetent patient. It is important for clinicians to consider this condition in patients with slow-onset skin and soft tissue infection following cutaneous injury, even in an immunocompetent setting.

scholarly journals Pulmonary histoplasmosis: A case report

2021 ◽  
Vol 5 (5) ◽  
pp. 148-150
Author(s):  
Sunzida Arina
Keyword(s):  
Case Report ◽  
Fungal Infection ◽  
Lung Biopsy ◽  
Alcoholic Hepatitis ◽  
Histoplasma Capsulatum ◽  
Dimorphic Fungus ◽  
Systemic Fungal Infection ◽  
Pulmonary Histoplasmosis ◽  
The World ◽  
Itraconazole Treatment

Histoplasmosis is a systemic fungal infection caused by dimorphic fungus Histoplasma capsulatum. It is widely distributed throughout the world. In present study, the case of a 50-year-old male patient diagnosed as pulmonary histoplasmosis. Initially, the patient was suspected as a case of alcoholic hepatitis but subsequently the diagnosis of pulmonary histoplasmosis was confirmed by lung biopsy. The symptoms were dissuaded following amphotericin B and itraconazole treatment.

scholarly journals COVID-19 Associated Rhino-Orbital Mucormycosis Complicated by Gangrenous and Bone Necrosis—A Case Report from Honduras

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 826
Author(s):  
Elsa Yolanda Palou ◽  
María Auxiliadora Ramos ◽  
Emec Cherenfant ◽  
Adoni Duarte ◽  
Itzel Carolina Fuentes-Barahona ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Report ◽  
Early Diagnosis ◽  
Fungal Infection ◽  
Invasive Fungal Infection ◽  
Immunocompromised Patients ◽  
Bone Necrosis ◽  
Inappropriate Use ◽  
Prompt Treatment ◽  
Life Threatening

Background: Mucormycosis is a life-threatening invasive fungal infection most commonly observed in immunocompromised patients. Throughout the COVID-19 pandemic, a growing number of Mucorales associated infections, now termed COVID-19 associated mucormycosis (CAM), have been reported. Despite an increase in fatality reports, no cases of rhino-orbital CAM complicated with gangrenous bone necrosis have been described in the literature to date. Case: A 56-year-old male with a recent COVID-19 diagnosis developed rhino-orbital mucormycosis after 22 days of treatment with dexamethasone. Cultures and histopathological assessment of tissue biopsy confirmed the diagnosis. The patient survived after treatment with amphotericin B. Conclusions: Mucormycosis is an invasive fungal infection affecting mostly immunocompromised patients. Along with the COVID-19 pandemic, the inappropriate use of steroids, in addition to concurrent risk factors, such as diabetes, has led to an increase in the occurrence of these devastating mycoses, leading to the development of severe presentations and complications, as observed in many cases. Early diagnosis and prompt treatment are crucial in order to avoid dissemination and fatal outcomes.

scholarly journals Hepatitis E: A Newcomer to the Hepatitis Alphabet – Case Report and Review of the Literature

1995 ◽  
Vol 6 (1) ◽  
pp. 34-37 ◽  
Author(s):  
Karl Weiss ◽  
Louise Poirier ◽  
Sylvain Varin ◽  
Claire Beliveau ◽  
Michel Laverdière
Keyword(s):  
Developing Countries ◽  
Case Report ◽  
Hepatitis A ◽  
Hepatitis E ◽  
Fatality Rate ◽  
Review Of The Literature ◽  
High Fatality Rate ◽  
Gastrointestinal Complaints ◽  
Mode Of Transmission ◽  
Chronic Course

The first Canadian case of hepatitis E is described in a patient who travelled to Asia for a six-month period and spent most of his time in India. Hepatitis E shares some similarities with hepatitis A, notably the mode of transmission and the absence of chronic course. However, a few important differences have been noted, including a higher mortality rate and a high fatality rate in pregnant women. Hepatitis E is very common in developing countries and should be suspected more often in individuals with gastrointestinal complaints returning from endemic areas.

scholarly journals Primary malignant CNS lymphoma in an immunocompetent patient: A case report

Pulse ◽  
2011 ◽  
Vol 4 (1) ◽  
pp. 26-27
Author(s):  
A Khaled ◽  
SA Salauddin ◽  
SMQ Zaman ◽  
TA Nasir
Keyword(s):  
Case Report ◽  
Primary Cns Lymphoma ◽  
Large Cell ◽  
Immunocompetent Patient ◽  
Cns Lymphoma ◽  
Immunocompromised Patients ◽  
Cell Type ◽  
Apollo Hospital ◽  
Hiv Test ◽  
History Of

Aim and Objective: Primary malignant CNS lymphoma in otherwise healthy immunocompetent subject is relatively uncommon.They occur more frequently in immunocompromised patients. In this case report, we presented a report of an immunocompetent 48 year old male with primary CNS lymphoma.Clinical presentation: A 48 year old male was admitted in the neurosurgery department of Apollo hospital Dhaka because of continuous headache and vomiting for 15 days. There was no history of any illness, medication or head trauma. He was tested negative for HIV test. MRI revealed a periventricular mass which was confirmed as primary CNS lymphoma, diffuse large cell type by histopathology and immunohistochemical examination.Conclusion: We presented this case because of relatively uncommon occurrence and raising incidence of primary CNS lymphoma in immunocompetent subjects in last one or two decades.DOI: http://dx.doi.org/10.3329/pulse.v4i1.6960Pulse Vol.4 January 2010 p.26-27

STUDIES OF RESPIRATORY INSUFFICIENCY IN NEWBORN INFANTS

PEDIATRICS ◽  
1957 ◽  
Vol 20 (5) ◽  
pp. 817-826
Author(s):  
Herbert C. Miller
Keyword(s):  
Birth Weight ◽  
Premature Infants ◽  
Oxygen Therapy ◽  
Newborn Infants ◽  
Fatality Rate ◽  
Weight Group ◽  
Group Iii ◽  
High Fatality Rate ◽  
High Incidence ◽  
Very High

A birth weight of 1,750 grams served in the present study to separate premature infants with a good chance of survival from those confronted by grave risks. The fatality rate among infants above this weight was about 2% and for infants below this weight it was about 25%. Severe respiratory disturbances occurred in about 20% of infants with birth weights over 1,750 gm and in about 80% of infants under this weight. Initial apnea and bradypnea occurred among the heavier weight group, but the survival rate among such infants was good. In contrast, among infants in the lower weight group, initial apnea and bradypnea were associated with a high incidence of severe respiratory disturbances and a high fatality rate. Deaths in the first week of life were not observed among 248 premature infants whose respiratory rates did not increase significantly after the first hour, but death did occur in 23 of 102 premature infants who had significant increases in the respiratory rates on the first day or two after birth. Twenty-seven of sixty-one infants with birth weights from 1,001 to 1,750 gm survived without oxygen therapy; 9 of these 27 infants weighed less than 1,501 gm at birth; the smallest had a birth weight of 1,225 gm. The results suggest that oxygen therapy can be withheld with some confidence in the case of infants with birth weights from 1,001 to 1,750 gm, provided the infants (1) are free of cyanosis within a few minutes of birth, (2) initiate sustained, spontaneous respirations within 2 minutes of birth, (3) attain a respiratory rate of 40/min or more during the first hour, and (4) do not have a significant increase in respiratory rates after the first hour. No deaths occurred among 13 infants who fulfilled the above criteria; only one received oxygen therapy and this was begun on the sixth day of life because of pneumonia. The incidence of oxygen therapy, and of deaths, was very high among infants with birth weights from 1,001 to 1,750 gm who did not fulfill the above criteria. Fourteen of nineteen infants with initial apnea, and 10 of 11 infants with initial bradypnea, received oxygen therapy, and about 50% in each group died. None of the six infants who had both initial apnea and bradypnea survived, although all received oxygen therapy. There were 24 infants who did not have initial apnea or bradypnea, but did have a significant increase in the respiratory rates; 16 received oxygen therapy and 3 died. The indications for discontinuing oxygen therapy were difficult to determine for infants with birth weights less than 1,751 gm. These infants, if they belonged to respiratory Group III, often developed sudden, unexpected bradypnea and apnea after apparently recovering from the initial respiratory disturbances of the first 2 days. Late bradypnea and apnea were associated in this study with a fatality rate of about 60% among infants with birth weights under 1,751 gm. The criteria for discontinuing oxygen therapy in small premature infants will continue to be indefinite until some means is found for predicting the occurrence of late, severe bradypnea and apnea with greater accuracy than is at present available.

scholarly journals Disseminated Aspergillosis due toAspergillus nigerin Immunocompetent Patient: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ulku Ergene ◽  
Zeynep Akcali ◽  
Demircan Ozbalci ◽  
Nalan Nese ◽  
Sebnem Senol
Keyword(s):  
Case Report ◽  
Aspergillus Niger ◽  
Invasive Aspergillosis ◽  
Paranasal Sinus ◽  
Immunocompetent Patient ◽  
Antifungal Treatment ◽  
Morbidity And Mortality ◽  
Immunocompromised Patients ◽  
Disseminated Aspergillosis

Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised patients. Many cases of pulmonary, cutaneous, cerebral, and paranasal sinus aspergillosis in immunocompetent patient were defined in literature but disseminated aspergillosis is very rare. Here we present an immunocompetent case with extrapulmonary disseminated aspergillosis due toAspergillus niger, totally recovered after effective antifungal treatment with voriconazole.

scholarly journals Immunocompetent patient with Nocardia abscessus brain abscess: Case report and review of the literature

2018 ◽  
Vol 4 (1) ◽  
pp. 17
Author(s):  
Sultan Alsalmi ◽  
Abdulgadir Bugdadi ◽  
Abdu Alkhayri ◽  
Louis Chenin ◽  
Johann Peltier
Keyword(s):  
Brain Tumor ◽  
Case Report ◽  
Brain Abscess ◽  
Immunocompetent Patient ◽  
Cerebral Abscess ◽  
Immunocompromised Patients ◽  
Review Of The Literature ◽  
Surgical Evacuation

Nocardia cerebral abscess is uncommon. It accounts for 1%-2% of all cerebral abscesses. It typically occurs in immunocompromised patients but cases in immunocompetent hosts been reported. Diagnosis of Nocardia brain abscess can be difficult and misleading. In this report we report a case of Nocardia abscessus brain abscess that was misdiagnosed initially as brain tumor. The patient has been successfully managed medically along with surgical evacuation twice.

scholarly journals Nucleoside-modified mRNA vaccines protect IFNAR -/- mice against Crimean Congo hemorrhagic fever virus infection

2021 ◽  
Author(s):  
Sofia Appelberg ◽  
Lijo John ◽  
Norbert Pardi ◽  
Ákos Végvári ◽  
Sándor Bereczky ◽  
...  
Keyword(s):  
Immune Response ◽  
Global Health ◽  
Immune Responses ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Fatality Rate ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
High Fatality Rate ◽  
The World

Crimean-Congo hemorrhagic fever (CCHF), caused by Crimean-Congo hemorrhagic fever virus (CCHFV), is on the World Health Organizations’ list of prioritized diseases and pathogens. With global distribution, high fatality rate and no approved vaccine or effective treatment, CCHF constitutes a threat against global health. In the current study, we demonstrate that vaccination with nucleoside-modified mRNA-lipid nanoparticles (mRNA-LNP), encoding for the CCHFV nucleoprotein (N) or glycoproteins (GcGn) protect IFNAR -/- mice against lethal CCHFV infection. In addition, we found that both mRNA-LNP induced strong humoral and cellular immune responses in IFNAR -/- and immunocompetent mice and that neutralizing antibodies are not necessary for protection. When evaluating immune responses induced by immunization including CCHFV Gc and Gn antigens, we found the Gc protein to be more immunogenic compared to the Gn protein. Hepatic injury is prevalent in CCHF and contributes to the severity and mortality of the disease in humans. Thus, to understand the immune response in the liver after infection and the potential effect of the vaccine, we performed a proteomic analysis on liver samples from vaccinated and control mice after CCHFV infection. Similar to observations in humans, vaccination affected the metabolic pathways. In conclusion, this study shows that a CCHFV mRNA-LNP vaccine, based on viral nucleo- or glycoproteins, mediate protection against CCHFV induced disease. Consequently, genetic immunization is an attractive approach to prevent disease caused by CCHFV and we believe we have necessary evidence to bring this vaccine platform to the next step in the development of a vaccine against CCHFV infection. Importance Crimean-Congo hemorrhagic fever virus (CCHFV) is a zoonotic pathogen causing Crimean-Congo hemorrhagic fever (CCHF), a severe fever disease. CCHFV have a wide distribution and are endemic in several areas around the world. Cases of CCHF are also being reported in new areas, indicating an expansion of the disease, which is of high concern. Dispersion of the disease, high fatality rate and no approved vaccine makes CCHF a threat to global health. The development of a vaccine is thus of great importance. Here we show 100% protection against lethal CCHFV infection in mice immunized with mRNA-LNP encoding for different CCHFV proteins. The vaccination showed both robust humoral and cellular immunity. mRNA-LNP vaccines combine the ability to induce an effective immune response, the safety of a transient carrier and the flexibility of genetic vaccines. This and our results from the current study support the development of a mRNA-LNP based vaccine against CCHFV.

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