IS TUMOUR SIZE AN INDEPENDENT PREDICTOR FOR AXILLARY LYMPH NODE METASTASIS IN INFILTRATING DUCT CARCINOMA BREAST IN T2 AND T3 TUMOURS : PROSPECTIVE REVIEW OF 256 CASES

2021 ◽  
pp. 12-14
Author(s):  
Nimisha C. R. ◽  
Ravindran Chirukandath ◽  
Sharath K Krishnan ◽  
Sancia Roy Fernandez ◽  
Remani Remani ◽  
...  
Keyword(s):  
Lymph Node ◽  
Tumor Size ◽  
Axillary Lymph Node ◽  
Ductal Carcinoma ◽  
Tumour Size ◽  
Axillary Lymph Node Metastasis ◽  
Nodal Status ◽  
Axillary Lymph ◽  
Duct Carcinoma ◽  
Node Metastasis

Background: As breast cancer remains a major fraction of cancer cases worldwide, the options for minimalizing postoperative morbidity and mortality remain an area for ardent research and improvement. The ability to identify patients at low risk of axillary metastases, would be of great value in limiting extensive axillary dissection which causes signicant morbidity, thereby improving the postoperative quality of life amongst patients. We conducted a study to identify characteristics of primary tumors highly associated with axillary lymph node metastases by comparing various demographic and tumor characteristics against nodal status. Methodology: 288 cases of the axillary dissection specimens of all inltrating duct carcinoma cases who underwent MRM in Government Medical College, Thrissur for 5 consecutive years were studied (n=256). Pathology was interpreted by a select group of Pathologists and then reanalyzed by another set to avoid bias. Various other aspects were studied including age distribution, histology, tumour size and nodal status. Analysis was done using SPSS 26 software. Results: The mean age of the study population was 50.58 years. The most common histopathological type encountered was Invasive ductal carcinoma – NOS (89.58%). Most of the patients (78.29%) belonged to T2 stage, with most patients (76.39%) having 1- 3 nodes involved. On analysis, a signicant association between T status ( T2 ,T3 ) and N status (p = 0.001) was found. However, there was no signicant correlation between age against tumor size or nodal status (p = 0.528, and p = 0.614 respectively). Conclusions: This study found that while tumor size is independently can predict the amount of axillary lymph node metastasis especially in T2 and T3 tumors , there is no signicant predictor value for age in predicting the nodal status or tumor size in invasive ductal carcinoma. However, the factors which modifying tumor behavior like the grade, ER status, Her2 neu status and Cerb 2 will have an inuence on the prediction of Axillary Lymph node involvement that offers further scope of prospective research

scholarly journals Mammary adenoid cystic carcinoma presenting with Ductal carcinoma in situ and axillary lymph node metastasis

2020 ◽  
Vol 2020 (2) ◽  
Author(s):  
Chairat Burusapat ◽  
Naphan Buarabporn ◽  
Kittisak Wongchansom ◽  
Pongsit Chanapai ◽  
Parinya Parinyanut ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Axillary Lymph Node ◽  
Ductal Carcinoma ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Breast Cancers ◽  
Node Metastasis ◽  
Adenoid Cystic

Abstract Mammary adenoid cystic carcinoma (ACC) is extremely rare tumors, comprising <0.1% of all breast cancers. Moreover, lymph node metastasis is <2% of mammary ACC. Here, we report a case of 51-year-old female presented with painful mass on her left breast and left axillary lymph node enlargement. Core needle biopsy revealed invasive ductal carcinoma. Left lumpectomy and axillary lymph nodes dissections were performed. The final pathological report showed triple-negative mammary ACC arising with high grade ductal carcinoma in situ (DCIS) and axillary lymph node metastasis. Immunohistochemistry study is useful in confirming a diagnosis. Given the rarity of this cancer, natural history of disease is still not clearly understood. Complete surgical excision is the mainstay of treatment. To our best knowledge, mammary ACC presenting with DCIS and axillary lymph node metastasis has never been reported and should be considered in the differential diagnosis of breast cancers.

scholarly journals Association of Histopathological Parameters and Axillary Lymphnode Metastasis in Primary Breast Carcinoma

2021 ◽  
Vol 6 (4) ◽  
pp. 379-382
Author(s):  
Manjula K Purushotham ◽  
Pradeep Mitra Venkatesh
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Size ◽  
Axillary Lymph Node ◽  
Inflammatory Infiltrate ◽  
Axillary Lymph Node Metastasis ◽  
Axillary Lymph ◽  
Node Metastasis ◽  
T Stage ◽  
Common Malignancy

Introduction: The most common malignancy worldwide among females is breast carcinoma and the second most common malignancy in India, next to cervical cancer. A wide range of potential prognostic features have been studied in breast cancer and are mainly divided into two groups i.e. Histopathological and Molecular. The histological features are cost-effective and provide reliable diagnostic and prognostic information in these tumors. Axillary Lymph node status is one of the most important prognostic factors and greatly affects the morbidity and mortality of the patient. Materials and Methods: All breast cancer specimens received in the Department of Pathology over a period of five years. The following histopathological parameters were carefully studied like Tumor size, Histological type, Grade, Presence of necrosis, Inflammatory cell infiltrate, Lymphatic invasion, Blood vessel invasion, Perineural invasion, and other Stromal changes were studied in detail, and association of these histopathological parameters with axillary lymph node metastasis were analyzed. Results: A total of 100 cases were studied, and most of the patients were over the age of 50. The maximum number of cases was in the T2 stage (55%). Infiltrating ductal carcinoma (88%) was the most common type of tumor encountered in the study. The majority of the cases were Grade I tumors. Skin Invasion was seen in 14% and Lymphovascular Invasion was seen in 17% of cases respectively. There was a statistically significant association between the size of the tumor, T stage, Grade of the tumor, necrosis, and inflammatory infiltrate on further analysis. Conclusion: There was a statistically significant correlation between Tumor size, pathological T stage, Grade of the tumor, Necrosis and inflammatory infiltrate with axillary Lymph node metastasis in the present study. Increased tumor size, T stage, higher grade, presence of necrosis and low inflammatory infiltrate are associated with increased axillary Lymph node metastasis.

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