A CASE OF ACUTE LIVER FAILURE DUE TO HEPATITIS E

2021 ◽  
pp. 1-2
Author(s):  
Mansi. Makwana ◽  
Jaydev Mod
Keyword(s):  
Hepatitis B ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Viral Hepatitis ◽  
Medical History ◽  
Hepatitis E ◽  
Fulminant Liver Failure ◽  
Liver Impairment ◽  
Viral Hepatitis B

We report the case of a 20 year old male who came to the hospital because of jaundice and a fever. His symptoms were associated with signicant liver impairment and a necroinammatory pattern due to viral hepatitis B although he had no relevant medical history. His symptoms developed rapidly until death. We present the factors that may have inuenced his progression to fulminant liver failure as described in the literature.

scholarly journals Circulating proteomic panels for diagnosis and risk stratification of acute-on-chronic liver failure in patients with viral hepatitis B

Theranostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 1200-1214 ◽  
Author(s):  
Zeyu Sun ◽  
Xiaoli Liu ◽  
Daxian Wu ◽  
Hainv Gao ◽  
Jing Jiang ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Risk Stratification ◽  
Liver Failure ◽  
Viral Hepatitis ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Viral Hepatitis B

High levels of circulating HMGB1 as a biomarker of acute liver failure in patients with viral hepatitis E

2013 ◽  
Vol 33 (9) ◽  
pp. 1341-1348 ◽  
Author(s):  
Manasi Majumdar ◽  
Radhakanta Ratho ◽  
Yogesh Chawla ◽  
Mini P. Singh
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Viral Hepatitis ◽  
Hepatitis E

scholarly journals Role of formalin fixed paraffin embedded liver tissues in the diagnosis of viral hepatitis E in patients with undiagnosed acute liver failure

VirusDisease ◽  
2019 ◽  
Vol 30 (2) ◽  
pp. 302-306
Author(s):  
Radha Kanta Ratho ◽  
Vikram Thakur ◽  
Manasi Majumdar ◽  
Mini P. Singh ◽  
Ashim Das ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Viral Hepatitis ◽  
Hepatitis E ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Formalin Fixed ◽  
Liver Tissues

Acute liver failure and misdiagnosis: Do not forget viral hepatitis E

2019 ◽  
Vol 38 (1) ◽  
pp. 73-75 ◽  
Author(s):  
Thomas Laumon ◽  
Hélène Dietrich ◽  
Laurent Muller ◽  
Claire Roger
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Viral Hepatitis ◽  
Hepatitis E

scholarly journals Systematic review of the global epidemiology of viral-induced acute liver failure

BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e037473
Author(s):  
Jenna Patterson ◽  
Hannah Sophia Hussey ◽  
Sheetal Silal ◽  
Liz Goddard ◽  
Mashiko Setshedi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Hepatitis B ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis E Virus ◽  
Hepatitis A ◽  
Parvovirus B19 ◽  
Hepatitis E ◽  
Virus Hepatitis ◽  
Global Epidemiology

ObjectivesThe aetiology and burden of viral-induced acute liver failure remains unclear globally. It is important to understand the epidemiology of viral-induced ALF to plan for clinical case management and case prevention.ParticipantsThis systematic review was conducted to synthesize data on the relative contribution of different viruses to the aetiology of viral-induced acute liver failure in an attempt to compile evidence that is currently missing in the field. EBSCOhost, PubMed, ScienceDirect, Scopus and Web of Science were searched for relevant literature published from 2009 to 2019. The initial search was run on 9 April 2019 and updated via PubMed on 30 September 2019 with no new eligible studies to include. Twenty-five eligible studies were included in the results of this review.ResultsThis systematic review estimated the burden of acute liver failure after infection with hepatitis B virus, hepatitis A virus, hepatitis C virus, hepatitis E virus, herpes simplex virus/human herpesvirus, cytomegalovirus, Epstein-Barr virus and parvovirus B19. Data were largely missing for acute liver failure after infection with varicella-zostervirus, human parainfluenza viruses, yellow fever virus, coxsackievirus and/or adenovirus. The prevalence of hepatitis A-induced acute liver failur was markedly lower in countries with routine hepatitis A immunisation versus no routine hepatitis A immunisation. Hepatitis E virus was the most common aetiological cause of viral-induced acute liver failure reported in this review. In addition, viral-induced acute liver failure had poor outcomes as indicated by high fatality rates, which appear to increase with poor economic status of the studied countries.ConclusionsImmunisation against hepatitis A and hepatitis B should be prioritised in low-income and middle-income countries to prevent high viral-induced acute liver failure mortality rates, especially in settings where resources for managing acute liver failure are lacking. The expanded use of hepatitis E immunisation should be explored as hepatitis E virus was the most common cause of acute liver failure.RegistrationPROSPERO registration number: CRD42017079730.

scholarly journals HEV-related Liver Disease in India : Why is the Disease Stormy?

2018 ◽  
Vol 54 (01) ◽  
pp. 054-061
Author(s):  
Premashis Kar
Keyword(s):  
Developing Countries ◽  
Viral Load ◽  
Mortality Rate ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Pregnant Women ◽  
Viral Hepatitis ◽  
High Viral Load ◽  
Hepatitis E ◽  
Women And Girls

ABSTRACTHepatitis E virus (HEV) is an important cause of epidemic and sporadic acute viral hepatitis (AVH) in many developing countries, including India. Hepatitis E, a positive-sense single-stranded RNA virus approximately 7.2 kb in length had been classified provisionally into the Caliciviridae family from 1988 to 1998 but HEV is currently placed in the genus Hepevirus and is the only member of the family Hepeviridae. Pregnant women with jaundice and AVH caused by HEV infection have worse fetal and obstetric outcome and higher maternal mortality compared to other types of viral hepatitis. Studies from various developing countries have shown that the incidence of HEV infection in pregnancy is high and a significant proportion of pregnant women can progress to fulminant hepatitis with a mortality rate varying from 30% to 100%. The incidence of hepatitis B virus (HBV) related acute liver failure is known widely in comparison to hepatitis C virus (HCV) infection in which acute liver failure (ALF) is rare. But the severe course of HEV infection causing ALF during pregnancy is unique to this virus with chronicity occurring in recipients of solid organ transplants.Various factors have been suggested to be associated with the mortality rate of the HEV in pregnant women along with the abortion of the fetus. Steroid hormones play a significant role in the viral replication through their effects on viral regulatory elements. The NF-κB signaling pathway regulating at the transcriptional level through p50 subunits has been suggested to correlate with the severe liver damage, leading to multiple organ failure and the death of both the mother and the fetus. Pregnant women in Asia suffer from folate deficiency reducing the immunocompetence to greater risk of multiple viral infections and higher viral load. The viral load of HEV was found to be significantly higher (P < 0.05) in pregnant patients compared to the non-pregnant and the viral copies of HEV with fulminant hepatic failure (FHF) in pregnant women were comparatively higher when compared to the pregnant women with AVH, which may be related to the severity of the disease in these patients. Besides, reduced expression of progesterone and progesterone induced-blocking factor and the high viral load of HEV have been regarded as a cause of poor pregnancy outcome in hepatitis E infection. Vertical transmission of the HEV infection has been reported. There are published reports of abortion, death of the fetus in utero, premature delivery or death of the baby soon after birth in patients with icteric hepatitis or with ALF caused by HEV. However, studies in Europe and United States have shown the course of viral hepatitis during pregnancy resembling with the non-pregnant women. In contrast, various reports carried out in India, Iran, Africa, and Middle East have reported the incidence of ALF to be higher during pregnancy.Data on the viral load of HEV during pregnancy are limited. The study was designed to determine the viral load of HEV and its association with the disease severity in patients with ALF. A total HEV related 163 patients with ALF which included 105 pregnant, 46 non-pregnant women and girls, 12 men, and 730 patients with AVH which comprised of 220 pregnant women; 282 non-pregnant women and girls, and 228 men were included. Viral load was measured by real-time PCR. Comparison was made between the pregnant and non-pregnant women. HEV RNA was detectable in 265 patients (142 pregnant; 75 non-pregnant and 48 men) and 104 patients with ALF (64 pregnant, 34 non-pregnant and 6 men). The viral load of HEV in pregnant women with ALF and AVH was significantly higher 129,984.0±103,104.17 and 768.92±1,105.40 copies/ml, respectively compared to the non-pregnant women which was 189.2±225 and 12.73±7.8 copies/ml (P < 0.0001). The viral load of HEV was also significantly higher in the pregnant patients with ALF compared to the pregnant women with AVH and also men (P < 0.0001). High viral load of HEV during pregnancy could be one of the factors responsible for the severity of the infection during pregnancy.

scholarly journals Acute viral hepatitis B complicated by acute pancreatitis.

2017 ◽  
Vol 16 (3) ◽  
pp. 455-457
Author(s):  
Mohammad Mushtaque Ahmad ◽  
Praveen Kumar Malik ◽  
Abhinav Jain ◽  
Shridhar Dwivedi
Keyword(s):  
Acute Pancreatitis ◽  
Hepatitis B ◽  
Liver Failure ◽  
Viral Hepatitis ◽  
Acute Viral Hepatitis ◽  
Medical Science ◽  
Radiological Features ◽  
Severe Pancreatitis ◽  
Acute Hepatitis B ◽  
Viral Hepatitis B

Majority of acute viral hepatitis cases resolve spontaneously in due course of time. Few cases that develop acute liver failure are prone to develop various complications, including acute pancreatitis. However, development of acute pancreatitis in patients with uncomplicated acute viral hepatitis is very rare and extremely rare in case of Acute Hepatitis B. In this case, a young boy with acute non-fulminant hepatitis B developed acute moderately severe pancreatitis, diagnosed by clinical, enzymatic and radiological features. He was managed conservatively and improved. Acute pancreatitis must be considered in patients with acute viral hepatitis who develop abdominal pain.Bangladesh Journal of Medical Science Vol.16(3) 2017 p.455-457

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