scholarly journals Opioids Inhibit Angiogenesis in a Chorioallantoic Membrane Model

2017 ◽  
Vol 2 (20;2) ◽  
pp. sE11-sE21 ◽  
Keyword(s):  
Medical Center ◽  
Academic Medical Center ◽  
Chorioallantoic Membrane ◽  
Negative Control ◽  
Patients With Cancer ◽  
Model Study ◽  
Academic Medical ◽  
High Concentrations ◽  
High Doses

Background: Angiogenesis is an important characteristic of cancer. Switching from the avascular phase to the vascular phase is a necessary process for tumor growth. Therefore, research in cancer treatment has focused on angiogenesis as a drug target. Despite the widespread use of opioids to treat pain in patients with cancer, little is known about the effect of these drugs on vascular endothelium and angiogenesis. Objectives: We aimed to investigate the efficacies of morphine, codeine, and tramadol in 3 different concentrations on angiogenesis in hens’ eggs. Study Design: This is a prospective, observational, controlled, in-vivo animal study. Setting: Single academic medical center. Methods: This study was conducted on the chorioallantoic membrane (CAM) of fertilized hens’ eggs. The efficacies of morphine, codeine, and tramadol in 3 different concentrations were evaluated on angiogenesis in a total of 165 hens’ eggs. Results: Statistically significant differences were found between drug-free agarose used as a negative control and concentrations of morphine of 10 µM and 1 µM, a concentration of tramadol of 10 µM, and concentrations of codeine of 10 µM and 1 µM. Concentrations of morphine of 10 µM and 1 µM showed strong antiangiogenic effects. While codeine had strong antiangiogenic effects at high concentrations, at 0.1 µM it was shown to have weak antiangiogenic effects. However, tramadol at a concentration of 10 µM had only weak antiangiogenic effects. Limitations: This is just a CAM model study. Conclusion: In this study, we tested the effects of 3 different opioid drugs on angiogenesis in 3 different concentrations, and we observed that morphine was a good anti-angiogenic agent, but tramadol and codeine only had anti-angiogenic effects at high doses. Key Words: Morphine, codeine, tramadol, opioid, bevacizumab, chorioallantoic membrane (CAM), angiogenesis

Dialysate Markers of Peritoneal Tissue during Peritonitis and in Stable CAPD

1995 ◽  
Vol 15 (3) ◽  
pp. 217-225 ◽  
Author(s):  
Marja M. Pannekeet ◽  
Désirée Zemel ◽  
Ger C.M. Koomen ◽  
Dick G. Struijk ◽  
Raymond T. Krediet
Keyword(s):  
Peritoneal Dialysis ◽  
Medical Center ◽  
Academic Medical Center ◽  
Ca 125 ◽  
Cancer Antigen ◽  
Dialysis Unit ◽  
Peritoneal Tissue ◽  
Academic Medical ◽  
Second Peak

Objective To investigate whether dialysate concentrations of substances that are locally produced within the peritoneal cavity can be used to study the effects of inflammation on peritoneal tissue. Design We followed the appearance rates (AR) of concentrations of cancer antigen (CA) 125, phospholipids (PHL), hyaluronan (HA), and the procollagen peptides PICP (procollagen 1 C-terminal) and PIIINP (procollagen 3 N-terminal) in dialysate during peritonitis (8 consecutive days) and after recovery. Data were compared with the stable situation. Setting CAPD (continuous ambulatory peritoneal dialysis) unit in the Academic Medical Center in Amsterdam. Patients Twelve CAPD patients with a total of 16 episodes of peritonitis and 10 clinically stable CAPD patients were studied. Results All substances showed temporal increments in dialysate during peritonitis compared to control. No difference was found between the control day of peritonitis and the stable patients. Maximum AR were reached in the acute phase of peritonitis for CA 125, PHL, and HA and on day 4 for both PICP and P111NP. A second increment in CA125 occurred on days 4 to 6. These findings indicate acute damage to the mesothelium (CA 125) and other cells (PHL) by the infection. HA may reflect stromal changes. Subsequently, peritoneal healing (PICP, PIIINP) and remesothelialization (second peak CA125) are likely to occur. Conclusions Dialysate concentrations of these substances can be used as markers for the effects of peritonitis on the peritoneum of CAPD patients in vivo. The similarity between the marker concentrations in the effluent after recovery from peritonitis and those in stable CAPD patients implies that complete peritoneal healing is likely to occur after uncomplicated peritonitis.

Dialysate Markers of Peritoneal Tissue during Peritonitis and in Stable Capd

1995 ◽  
Vol 15 (6_suppl) ◽  
pp. 217-225 ◽  
Author(s):  
Marja M. Pannekeet ◽  
Désirée Zemel ◽  
Ger C.M. Koomen ◽  
Dick G. Struijk ◽  
Raymond T. Krediet
Keyword(s):  
Peritoneal Dialysis ◽  
Medical Center ◽  
Academic Medical Center ◽  
Ca 125 ◽  
Cancer Antigen ◽  
Dialysis Unit ◽  
Peritoneal Tissue ◽  
Academic Medical ◽  
Second Peak

Objective To investigate whether dialysateconcentrations of substances that are locally produced within the peritoneal cavity can be used to study the effects of inflammation on peritoneal tissue. Design We followed the appearance rates (AR) of concentrations of cancer antigen (CA) 125, phospholipids (PHL), hyaluronan (HA), and the procollagen peptides PICP (procollagen 1 C-terminal) and PIIINP (procollagen 3 N-terminal) in dialysate during peritonitis (8 consecutive days) and after recovery. Data were compared with the stable situation. Setting CAPD (continuous ambulatory peritoneal dialysis) unit in the Academic Medical Center in Amsterdam. Patients Twelve CAPD patients with a total of 16 episodes of peritonitis and 10 clinically stable CAPD patients were studied. Results All substances showed temporal increments in dialysate during peritonitis compared to control. No difference was found between the control day of peritonitis and the stable patients. Maximum AR were reached in the acute phase of peritonitis for CA 125, PHL, and HA and on day 4 for both PICP and P111NP. A second increment in CA125 occurred on days 4 to 6. These findings indicate acute damage to the mesothelium (CA 125) and other cells (PHL) by the infection. HA may reflect stromal changes. Subsequently, peritoneal healing (PICP, PIIINP) and remesothelialization (second peak CA125) are likely to occur. Conclusions Dialysate concentrations of these substances can be used as markers for the effects of peritonitis on the peritoneum of CAPD patients in vivo. The similarity between the marker concentrations in the effluent after recovery from peritonitis and those in stable CAPD patients implies that complete peritoneal healing is likely to occur after uncomplicated peritonitis.

Validity of the screener and opioid assessment for patients with pain-revised (SOAPP-R) in patients with cancer

2019 ◽  
Vol 15 (4) ◽  
pp. 272-274
Author(s):  
Junaid T. Yasin, MPH ◽  
Amy E. Leader, DrPH, MPH ◽  
Alison Petok, MSW, MPH ◽  
Gregory Garber, MSW ◽  
Britainy Stephens, MSW ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Medical Center ◽  
Academic Medical Center ◽  
Opioid Prescription ◽  
Care Clinic ◽  
Current Form ◽  
Patients With Cancer ◽  
Opiate Abuse ◽  
Academic Medical ◽  
Urine Drug

Objective: To determine the utility of the screener and opioid assessment for patients with pain-revised (SOAPP-R) for patients with cancer-related pain. Design: The authors performed a retrospective analysis of cancer patients screened with the SOAPP-R. Opiate abuse was determined using a combination of urine drug screens and analysis of patients’ electronic medical records.Setting/Patients: Patients who were seen at a palliative care clinic presenting with pain or needing an opioid prescription at an academic medical center with any type of cancer were screened using the SOAPP-R (N = 69).Outcome measures: Aberrant opioid-related behavior was determined using a combination of provider notes and urine drug screens.Results: A positive SOAPP-R score (≥18) was observed in 27 participants (39.1 percent). The sensitivity and specificity of the SOAPP-R in the study population was 0.75 and 0.80, respectively.Conclusions: The SOAPP-R, in its current form, may have value in screening patients with cancer for substance abuse. Incorporation of the screening tool in palliative and oncology settings may help reduce opioid abuse in cancer patients.

Nurses' perceptions of depression in patients with cancer

2014 ◽  
Vol 13 (4) ◽  
pp. 849-858
Author(s):  
Wadih Rhondali ◽  
Tanguy Leprince ◽  
Anne Chirac ◽  
Jean-Louis Terra ◽  
Marilène Filbet
Keyword(s):  
Cancer Patients ◽  
Medical Center ◽  
Academic Medical Center ◽  
Daily Practice ◽  
Systematic Screening ◽  
Patients With Cancer ◽  
Academic Medical ◽  
Nurses Perceptions ◽  
Knowledge Of Depression ◽  
Video Education

AbstractObjective:Our study aimed at examining nurses' perceptions of depression in cancer patients and their role in its management.Method:We employed questionnaire-based semi-directed interviews. Participants were asked to classify 22 symptoms (related and specific to depression in cancer patients, related but not specific, and unrelated) as “very important,” “important,” “less important,” or “not important” for the diagnosis of depression in cancer patients at two different timepoints (baseline and after a video education program). They were also asked to complete a questionnaire exploring their perceptions about depression and of their role in its systematic screening. We recruited nurses caring for cancer patients from four different departments (palliative care unit, hematology, medical oncology, and thoracic oncology) at an academic medical center.Results:We interviewed 18 nurses and found that they had a good general knowledge of depression in cancer patients, with the majority of them being able to distinguish specific and important symptoms from nonspecific symptoms. Some nurses considered depression as a second-line symptom, and most did not employ a screening tool in their daily practice. All considered that they had a role to play in the management of depression, even as they acknowledged lacking specific training for that task.Significance of results:Our results suggest that limited resources—especially lack of training—affects nurses' ability to correctly manage depression in their cancer patients.

Gender differences in career progress and satisfaction in an academic medical center

2002 ◽  
Vol 2 (3) ◽  
pp. 95-104 ◽  
Author(s):  
JoAnn Manson ◽  
Beverly Rockhill ◽  
Margery Resnick ◽  
Eleanor Shore ◽  
Carol Nadelson ◽  
...  
Keyword(s):  
Gender Differences ◽  
Medical Center ◽  
Academic Medical Center ◽  
Academic Medical ◽  
Career Progress
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