scholarly journals A Case Report on Red Ear Syndrome with Tinnitus Successfully Treated with Transcranial Random Noise Stimulation

2017 ◽  
Vol 1 (21;1) ◽  
pp. E199-E205 ◽  
Author(s):  
Peter M. Kreuzer
Keyword(s):  
Case Report ◽  
Therapeutic Potential ◽  
Random Noise ◽  
Temporal Cortex ◽  
Transcranial Electrical Stimulation ◽  
Clinical Effects ◽  
Compassionate Use ◽  
Transcranial Random Noise Stimulation ◽  
Red Ear Syndrome ◽  
Initial Objective

Background: The red ear syndrome represents a rare symptom complex consisting of auricular erythema associated with painful and burning sensations. It has been described in combination with tinnitus rarely. It has been hypothesized to be etiologically related to altered trigeminal afferent input, temporomandibular disorders, and thalamic dysfunction. Objectives: The initial objective of applying transcranial random noise stimulation (tRNS) in a case of red ear syndrome in combination with tinnitus was the alleviation of the phantom sounds. Study Design: This is a case report on the successful treatment of red ear syndrome with tinnitus by means of transcranial random noise stimulation (tRNS) and a short review on the published cases of this condition. Setting: We present the case of a 50-year-old woman reporting a simultaneous onset of constant left-sided tinnitus and feelings of warmth accompanied by an intermittent stabbing and/or oppressive pain stretching from the ipsilateral ear to the head/neck/shoulder region, occasionally accompanied by nausea/vomiting and dizziness. After failure of pharmacological treatment attempts, either because of lacking clinical effects (gabapentin, zolmitriptan, and indomethacin) or because of adverse reactions (pregabaline), the patient was offered an experimental neuromodulatory treatment with bitemporal tRNS primarily targeting the tinnitus complaints of the patient. Methods: tRNS was conducted in 2 – 3 day sessions (stimulation site: bilateral temporal cortex/2.0 mA/10 s on-and-off-ramp/offset 0 mA/20 min/random frequencies 101 – 640Hz / NeuroConn Eldith DC-Stimulator plus). Results: In 3 consecutive pain attacks repeated sessions of tRNS resulted in substantial alleviation of pain intensity and a prolongation of the interval between attacks. This was an expected finding as the proposed tRNS treatment was initially offered to the patient aiming at an alleviation of the tinnitus complaints (which remained unaffected by tRNS). Limitations: The reported data derive from compassionate use treatment in one single patient. Application of a sham condition would have been desirable, but is not possible in the context of compassionate use treatment. Nevertheless, we would consider it rather unlikely that the reported effects are purely unspecific as the patient did exclusively report symptom alleviation of pain-related parameters without affecting the tinnitus. Conclusions: This case report demonstrates the feasibility and therapeutic potential of applying neuromodulatory treatment approaches in red ear syndrome, a rare form of trigemino-autonomal headache. Therefore, it deserves detailed observation in clinical routine applications as well as controlled trials further investigating its neurobiological effects. Key words: Red ear syndrome, pain, trigemino-autonomal headache, chronic tinnitus, transcranial electrical stimulation, random noise stimulation

Sham transcranial electrical stimulation and its effects on corticospinal excitability: a systematic review and meta-analysis

2018 ◽  
Vol 29 (2) ◽  
pp. 223-232 ◽  
Author(s):  
Thusharika D. Dissanayaka ◽  
Maryam Zoghi ◽  
Michael Farrell ◽  
Gary F. Egan ◽  
Shapour Jaberzadeh
Keyword(s):  
Systematic Review ◽  
Electrical Stimulation ◽  
Meta Analysis ◽  
Random Noise ◽  
Corticospinal Excitability ◽  
Transcranial Electrical Stimulation ◽  
Placebo Effects ◽  
Randomized Controlled ◽  
Transcranial Random Noise Stimulation ◽  
Transcranial Alternating Current Stimulation

AbstractSham stimulation is used in randomized controlled trials (RCTs) to assess the efficacy of active stimulation and placebo effects. It should mimic the characteristics of active stimulation to achieve blinding integrity. The present study was a systematic review and meta-analysis of the published literature to identify the effects of sham transcranial electrical stimulation (tES) – including anodal and cathodal transcranial direct current stimulation (a-tDCS, c-tDCS), transcranial alternating current stimulation (tACS), transcranial random noise stimulation (tRNS) and transcranial pulsed current stimulation (tPCS) – on corticospinal excitability (CSE), compared to baseline in healthy individuals. Electronic databases – PubMed, CINAHL, Scopus, Science Direct and MEDLINE (Ovid) – were searched for RCTs of tES from 1990 to March 2017. Thirty RCTs were identified. Using a random-effects model, meta-analysis of a-tDCS, c-tDCS, tACS, tRNS and tPCS studies showed statistically non-significant pre-post effects of sham interventions on CSE. This review found evidence for statically non-significant effects of sham tES on CSE.

scholarly journals Daily high-frequency transcranial random noise stimulation of bilateral temporal cortex in chronic tinnitus – a pilot study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Peter M. Kreuzer ◽  
Timm B. Poeppl ◽  
Rainer Rupprecht ◽  
Veronika Vielsmeier ◽  
Astrid Lehner ◽  
...  
Keyword(s):  
Pilot Study ◽  
High Frequency ◽  
Random Noise ◽  
Temporal Cortex ◽  
Chronic Tinnitus ◽  
Transcranial Random Noise Stimulation ◽  
Stimulation Of

scholarly journals Investigating cognitive and therapeutic effects of transcranial electric stimulation (TES): a short guide for reproducible and transparent research

2020 ◽  
Author(s):  
Samuel James Westwood
Keyword(s):  
Random Noise ◽  
Evidence Base ◽  
Open Science ◽  
Transcranial Electrical Stimulation ◽  
Therapeutic Effects ◽  
Direct Stimulation ◽  
Causal Inferences ◽  
Science Practices ◽  
Transcranial Random Noise Stimulation ◽  
Transcranial Alternating Current Stimulation

Non-invasive brain stimulation (NIBS) is a useful tool for assisting causal inferences in cortical structure–function relationships and for developing treatment alternatives in neuropsychiatric disorders. Transcranial electrical stimulation (TES) techniques, namely transcranial direct stimulation (tDCS), transcranial alternating current stimulation (tACS), and transcranial random noise stimulation (tRNS), have grown in popularity in recent years because they are well tolerated, safe, and less costly compared to other forms of NIBS such as transcranial magnetic stimulation (TMS). The rigour and reproducibility of TES studies and their findings is therefore of key importance. However, in recent years, uncertainty has grown regarding the effectiveness of TES and the quality of its evidence base. Current recommended steps to improve the rigour and reproducibility of TES research have mainly focused on reducing variation and ambiguity in reported findings. To effectively deal with reported issues, Open Science practices provide a possible answer. The goal of this article is to give an overview of Open Science practices relevant to TES research (i.e., open materials/data, preregistration, registered reports, collaboration) and guidance in how to overcome challenges one may face in their implementation (e.g., data anonymity, costs of sharing materials/data, inappropriate incentives). The ultimate goal of this article is to instigate more engagement from TES researchers in how Open Science practices can be incorporated into standard research practice.

Delineating the low and high spatial frequency inputs to face perception using transcranial random noise stimulation

2020 ◽  
Author(s):  
Bhuvanesh Awasthi
Keyword(s):  
Spatial Frequency ◽  
High Frequency ◽  
Response Times ◽  
Random Noise ◽  
Temporal Cortex ◽  
High Spatial Frequency ◽  
Bayesian Approaches ◽  
Frequency Information ◽  
Transcranial Random Noise Stimulation ◽  
The Right

This study used high frequency transcranial Random Noise Stimulation (tRNS) to examine how low and high spatial frequency filtered faces are processed. In a response time behavioral task, healthy young adults categorized male and female faces, presented at fovea and periphery in alternate blocks, while sham and high frequency random noise was applied to occipito-parietal location on their scalp. Both the frequentist and bayesian approaches show that stimulation at the right occipito-temporal cortex significantly reduced response times to peripherally presented low spatial frequency information. This finding points to a possible plasticity in targeted regions induced by non-invasive neuromodulation of spatial frequency information in rapid perception of faces.

P197 Electroencephalographic effects of transcranial random noise stimulation of the temporal cortex

2017 ◽  
Vol 128 (3) ◽  
pp. e111
Author(s):  
M. Schecklmann ◽  
P. Kreuzer ◽  
N. Gebel ◽  
T.B. Poeppl ◽  
B. Langguth
Keyword(s):  
Random Noise ◽  
Temporal Cortex ◽  
Transcranial Random Noise Stimulation ◽  
Stimulation Of

scholarly journals Non-Invasive Neuromodulation for Tinnitus

2020 ◽  
Vol 24 (3) ◽  
pp. 113-118 ◽  
Author(s):  
Berthold Langguth
Keyword(s):  
Random Noise ◽  
Transcranial Electrical Stimulation ◽  
Somatosensory Stimulation ◽  
Non Invasive ◽  
Transcutaneous Vagus Nerve Stimulation ◽  
Transcranial Random Noise Stimulation ◽  
Pilot Trials ◽  
Valuable Treatment ◽  
Further Development ◽  
The Brain

Tinnitus is a prevalent disorder that has no cure currently. Within the last two decades, neuroscientific research has facilitated a better understanding of the pathophysiological mechanisms that underlie the generation and maintenance of tinnitus, and the brain and nerves have been identified as potential targets for its treatment using non-invasive brain stimulation methods. This article reviews studies on tinnitus patients using transcranial magnetic stimulation, transcranial electrical stimulation, such as transcranial direct current stimulation, alternating current stimulation, transcranial random noise stimulation as well as transcutaneous vagus nerve stimulation and bimodal combined auditory and somatosensory stimulation. Although none of these approaches has demonstrated effects that would justify its use in routine treatment, the studies have provided important insights into tinnitus pathophysiology. Moreover bimodal stimulation, which has only been developed recently, has shown promising results in pilot trials and is a candidate for further development into a valuable treatment procedure.

scholarly journals Transcranial random noise stimulation for the acute treatment of depression: a randomized controlled trial

2019 ◽  
Author(s):  
Stevan Nikolin ◽  
Angelo Alonzo ◽  
Donel Martin ◽  
Veronica Gálvez ◽  
Sara Buten ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Controlled Trial ◽  
Electrical Stimulation ◽  
Controlled Trial ◽  
Random Noise ◽  
Transcranial Electrical Stimulation ◽  
Depression Severity ◽  
Randomized Controlled ◽  
Transcranial Random Noise Stimulation ◽  
Treatment Of Depression

AbstractBackgroundTranscranial electrical stimulation has broad potential as a treatment for depression. Transcranial random noise stimulation (tRNS), which delivers randomly fluctuating current intensities, may have greater cortical excitatory effects compared to other forms of transcranial electrical stimulation. We therefore aimed to investigate the antidepressant efficacy of tRNS.MethodsDepressed participants were randomly assigned by computer number generator to receive 20 sessions of either active or sham tRNS over four weeks in a double-blinded, parallel group randomized-controlled trial. tRNS was delivered for 30mins with a direct current offset of 2mA and a random noise range of 2mA. Primary analyses assessed changes in depression severity using the Montgomery-Asperg Depression Rating Scale (MADRS). Neuroplasticity, neuropsychological, and safety outcomes were analysed as secondary measures.Results69 participants were randomised, of which three discontinued treatment early leaving 66 (sham n = 34, active n = 32) for per-protocol analysis. Depression severity scores reduced in both groups (MADRS reduction in sham = 7.0 [95%CI 5.0-8.9]; and active = 5.2 [95%CI 3.2-7.3]). However, there were no differences between active and sham groups in the reduction of depressive symptoms, or the number of participants meeting response (sham = 14.7%; active = 3.1%) and remission criteria (sham = 5.9%; active = 0%). Erythema, paraesthesia, fatigue, and dizziness/light-headedness occurred more frequently in the active tRNS group. Neuroplasticity, neuropsychological and acute cognitive effects were comparable between groups.ConclusionOur results do not support the use of tRNS with the current stimulation parameters as a therapeutic intervention for the treatment of depression.Clinical trial registration at clinicaltrials.gov/NCT01792414.Significance StatementThis is the first randomized sham-controlled clinical trial of a four-week course of transcranial random noise stimulation (tRNS) for the treatment of depression. tRNS is a relatively novel form of non-invasive electrical stimulation that uses mild, randomly fluctuating currents to constrain homeostatic mechanisms and increase brain excitability. We investigated effects across multiple validated mood outcomes and comprehensively assessed cognitive, neurophysiological, and physical side effects to examine the safety of tRNS. We found no differences between active and sham conditions for all mood outcomes, and are thus unable to lend support for tRNS as an effective treatment for depression. We found tRNS to be well-tolerated with no adverse acute cognitive, neuropsychological or severe phyisical side effects, suggesting a course of 20 repeated sessions can be delivered safely.

scholarly journals Transcranial Random Noise Stimulation for the Acute Treatment of Depression: A Randomized Controlled Trial

2020 ◽  
Vol 23 (3) ◽  
pp. 146-156 ◽  
Author(s):  
Stevan Nikolin ◽  
Angelo Alonzo ◽  
Donel Martin ◽  
Veronica Gálvez ◽  
Sara Buten ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Electrical Stimulation ◽  
Rating Scale ◽  
Controlled Trial ◽  
Random Noise ◽  
Transcranial Electrical Stimulation ◽  
Depression Severity ◽  
Randomized Controlled ◽  
Transcranial Random Noise Stimulation ◽  
Treatment Of Depression

Abstract Background Transcranial electrical stimulation has broad potential as a treatment for depression. Transcranial random noise stimulation, which delivers randomly fluctuating current intensities, may have greater cortical excitatory effects compared with other forms of transcranial electrical stimulation. We therefore aimed to investigate the antidepressant efficacy of transcranial random noise stimulation. Methods Depressed participants were randomly assigned by computer number generator to receive 20 sessions of either active or sham transcranial random noise stimulation over 4 weeks in a double-blinded, parallel group randomized-controlled trial. Transcranial random noise stimulation was delivered for 30 minutes with a direct current offset of 2 mA and a random noise range of 2 mA. Primary analyses assessed changes in depression severity using the Montgomery-Asperg Depression Rating Scale. Neuroplasticity, neuropsychological, and safety outcomes were analyzed as secondary measures. Results Sixty-nine participants were randomized, of which 3 discontinued treatment early, leaving 66 (sham n = 34, active n = 32) for per-protocol analysis. Depression severity scores reduced in both groups (Montgomery-Asperg Depression Rating Scale reduction in sham = 7.0 [95% CI = 5.0–8.9]; and active = 5.2 [95% CI = 3.2–7.3]). However, there were no differences between active and sham groups in the reduction of depressive symptoms or the number of participants meeting response (sham = 14.7%; active = 3.1%) and remission criteria (sham = 5.9%; active = 0%). Erythema, paresthesia, fatigue, and dizziness/light-headedness occurred more frequently in the active transcranial random noise stimulation group. Neuroplasticity, neuropsychological, and acute cognitive effects were comparable between groups. Conclusion Our results do not support the use of transcranial random noise stimulation with the current stimulation parameters as a therapeutic intervention for the treatment of depression. Clinical trial registration at clinicaltrials gov/NCT01792414.

Treatment of Major Depressive Disorder by Transcranial Random Noise Stimulation: Case Report of a Novel Treatment

2012 ◽  
Vol 72 (4) ◽  
pp. e9-e10 ◽  
Author(s):  
Herng-Nieng Chan ◽  
Angelo Alonzo ◽  
Donel M. Martin ◽  
Michael Player ◽  
Philip B. Mitchell ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Case Report ◽  
Depressive Disorder ◽  
Random Noise ◽  
Major Depressive ◽  
Novel Treatment ◽  
Transcranial Random Noise Stimulation
Sign in / Sign up

Export Citation Format

Share Document