scholarly journals Effect of Addition of Epidural Ketamine to Steroid in Lumbar Radiculitis: One-Year Follow-Up

2011 ◽  
Vol 5;14 (5;9) ◽  
pp. 475-481
Author(s):  
Yasser Mohamed Amr

Background: Treating sciatica with epidural steroid injection has been a common practice worldwide. N-methyl-D-aspartate (NMDA) receptors are an important component of pain pathways. Objectives: The aim of this study was to evaluate the safety and efficacy of epidurally administered NMDA receptor antagonists (ketamine) for the treatment of chronic low back pain secondary to radiculopathy and its effect on patients’ quality of life. Study Design: Randomized, double blind controlled trial. Setting: Hospital outpatient setting. Methods: Two hundred participants aged 25 to 50 years old with a diagnosis of lumbar radiculopathic pain secondary to disc herniation were randomized into 2 equal groups. Group I received 80 mg of triamcinolone (2 mL) and 0.25% bupivacaine (3 mL) plus 30 mg (3 mL) of preservative free ketamine. Group II received 80 mg of triamcinolone (2 mL) and 0.25% bupivacaine (3 mL) plus 3 mL of 0.9% saline. Pain scores were obtained before injection, immediately after injection, one week, one month, 3 months, 6 months , 9 months and one year post injection. The Oswestry Low Back Pain Disability Questionnaire was used at baseline and at one month, 3, 6, 9, and 12 months after injection for assessment of quality of life. Patients were asked to report any side effects, particularly those related to ketamine, including nausea, vomiting, visual or auditory hallucinations, and delirium. Results: Immediately after injection there was no statistically significant difference between Group I and II regarding pain scale scores. After one week of injection, pain relief was significantly better in Group I compared to Group II and then at all evaluation times. The Oswestry Low Back Pain Disability Questionnaire score decreased significantly (P < 0.05) from 72 (range 62- 83) and 70 (range 57- 82) to 8 (range 2 – 12) and 17 (range 9 – 27) at one month; 6 (range 4 – 12) and 18 (range 14 – 22) at 3 months; 12 (range 9 – 16) and 28 (range 22 – 34) at 6 months; 17 (range 9 – 24) and 31 (range 21 – 35) at 9 months; and 17 (range 8 – 22) and 33 (range 20 – 37) at 12 months in the groups, respectively. Six patients in the ketamine group showed short-lasting delusions lasting for 45 ± 12 minutes after injection. Limitations: The limitations include a lack of placebo control. Conclusion: Epidurally administrated ketamine seems to be a safe and useful adjunct to epidural corticosteroid therapy in chronic lumbar radicular pain. Key words: Ketamine, epidural, radiculopathic, pain, steroid

2018 ◽  
Vol 58 (1) ◽  
Author(s):  
Josielli Comachio ◽  
Mauricio Oliveira Magalhães ◽  
Ana Paula de Moura Campos Carvalho e Silva ◽  
Amélia Pasqual Marques

2021 ◽  
Vol 38 (1) ◽  
pp. 28-35
Author(s):  
AC Kanitz ◽  
B Machado ◽  
D Rodrigues ◽  
G Zambelli ◽  
A Ivaniski ◽  
...  

Objective: The present study aimed to verify the influence of training intensity in the aquatic environment on pain, disability, physical capacity, and quality of life in patients with chronic low back pain. Design/Setting: A randomized clinical trial. Subjects: Twenty-two patients with chronic low back pain of both sexes (13 women and 9 men) participated in the study. Material and method: One group performed deep-water walking/running training at moderate intensity (MIT) and a second group performed deep-water walking/running training at high intensity (HIT). Pain, disability, peak oxygen uptake (VO2peak), and quality of life were assessed before and after an intervention. Results: Decreases in pain and disability were observed within both groups, without differences in these parameters between training groups. VO2peak did not change in either group after the training intervention. The results of the HIT group showed more significant improvements in quality of life than that of the MIT group, highlighting the social domain, psychological domain, and general quality of life. Both groups presented significant improvements in the physical and environmental domains of quality of life. Conclusions: Deep-water aerobic exercise training seems to be effective for improving pain symptoms and reducing the disability of people with chronic low back pain. These improvements seem to be independent of the intensity at which the training is performed. In addition, improving pain and disability does not directly reflect all areas of quality of life. In this case, the group that performed the intervention at high intensity achieved more significant improvements in quality of life.


Author(s):  
Sameed Liaqat ◽  
Muhammad Jawad ◽  
Wardah Rauf ◽  
Mehak Hamna Zahra Gilani

Automobile mechanic work is an extensive and physically hard job. Consequently, the automobile workers suffer from ergonomic risk factors including Low Back Pain (LBP) as a major.Objective: To find out the prevalence of Low Back pain (LBP) and disability among automobile mechanics in Lahore.Methodology:The study was cross-sectional and included 180 automechanics of Lahore. Oswestry Low Back Pain Disability Questionnaire (OLBPDQ) was used to measure the disability caused by pain. Pain was measured by Visual Analog Scale (VAS). Data was collected from 180 auto mechanics from auto repair shops of Lahore.Results:Out of 180 individuals, 125 subjects reported LBP with average age of 30±5.3 years. 87 individuals (69.6%) were minimally disabled and 31 individuals (24.8%) experienced moderate disability, whereas only 7 individuals (5.6%) experienced severedisability in activities of daily living (ADLs).Conclusions:LBP is highly frequent among automobile mechanics. Majority of the individuals suffering from LBP had minimal disability. The rate of moderate disability was also noticeable but number of individuals with severe disability was very low. Overall, LBP disturbed the quality of life.


Spine ◽  
2004 ◽  
Vol 29 (2) ◽  
pp. 206-210 ◽  
Author(s):  
Francisco M. Kovacs ◽  
Víctor Abraira ◽  
Javier Zamora ◽  
María Teresa Gil del Real ◽  
Joan Llobera ◽  
...  

2017 ◽  
Vol 5 (6) ◽  
pp. 859-862 ◽  
Author(s):  
Daljit Singh ◽  
◽  
Akshav Aggarwal ◽  
Sandeep Kumar ◽  
Smati Sambyal ◽  
...  

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