PENGARUH PENGGUNAAN VARIASI KONSENTRASI AVICEL PH-101 PADA FORMULA TABLET PREDNISOLONE

Abstract Prednisolone is a steroid class drug that is used to treat certain types of allergies, inflammatory conditions, autoimmune disorders and cancer. Solubility of prednisolone is very difficult to dissolve in water causing problems in the absorption process so that the optimum formula is needed to form Prednisolone tablets that meet the requirements of the physical properties of tablets. The purpose of this study was to make the optimum formula with a combination of lactose excipients, avicel pH-101, and amprotab to obtain prednisolone tablets with good physical properties and dissolution. Prednisolone tablets made 7 formulas with a combination of lactose (A) Avicel PH-101 (B), and Amprotab (C), Formula I (100% A); Formula II (100% B); Formula III (100% C); Formula IV (50% A + 50% B); Formula V (50% A + 50% C); Formula VI (50% B + 50% C); Formula VII (33.33% A + 33.33% B + 33.33% C) in 2 batches. The method of making prednisolone tablets by direct printing. Testing of prednisolone tablets included the physical properties of tablets, weight uniformity, uniformity in size, hardness, friability, disintegration time, and dissolution test, and content determination. Keywords: optimization of formulas, tablets, Prednisolone, Simplex Lattice Design.

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Optimasi Formula Tablet Piroksikam Menggunakan Eksipien Laktosa, Avicel pH-101, dan Amprotab dengan Metode Simplex Lattice Design

Pharmacon Jurnal Farmasi Indonesia ◽

10.23917/pharmacon.v17i1.9176 ◽

2020 ◽

Vol 17 (1) ◽

pp. 31-44

Author(s):

Ikhwan Yuda Kusuma ◽

Rani Prabandari

Keyword(s):

Physical Properties ◽

Design Method ◽

Dominant Factor ◽

Content Uniformity ◽

Compression Tests ◽

Lattice Design ◽

Simplex Lattice Design ◽

Contour Plots ◽

Simplex Lattice ◽

Optimum Formula

Piroxicam solubility in water is very small this cause problem in the process of absorption so that it’s required an optimal formula to establish the physical properties of tablet quality for piroxicam tablets. The purpose of this research was creating formulas with the optimal combination of excipients lactose, Avicel pH 101, and piroxicam amprotab to obtain tablets with good physical properties and disolution. Seven piroxicam tablet formulas were made with a combination of lactose, avicel PH-101, and Amprotab on 2 batches. Method for making tablets piroxicam was established by direct compression. Tests included were the physical properties of piroxicam tablets tablets weight uniformity, uniformity of size, hardness, brittleness, disintegration test, as well as dissolution test, and content uniformity. Based on the simplex lattice design method, lactose is a dominant factor to improved the uniformity of tablet’s concentartions. Interaction of two components avicel PH-101 and amprotab is a dominant factor to reduced vulnerability. Interaction of three components lactose, avicel PH-101 and amprotab is a dominant factor to lowered the value coefisien variation of weight uniformity, increased hardness, decreased the disintegration, and improved dissolution of tablets. Selection of the optimum formula was determined by the method of simplex lattice design through diagrams superimposed contour plots and contour plots for obtaining the optimal proportions of each ingredient as follows: lactose (85,154–100%), avicel PH-101 (0–12,437%), and amprotab (0–5,425%).

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Tablet Formula Optimization From Helminthostachys Zaylanica Extract Using A Simplex Lattice Design

Science & Technology Indonesia ◽

10.26554/sti.2021.6.3.131-136 ◽

2021 ◽

Vol 6 (3) ◽

pp. 131-136

Author(s):

Fitrya Fitrya ◽

Najma Annuria Fithri ◽

Budi Untari ◽

Aprililianti

Keyword(s):

Physical Properties ◽

Toxicity Tests ◽

Dissolution Time ◽

Wet Granulation ◽

Disintegration Time ◽

Lattice Design ◽

Simplex Lattice Design ◽

Weight Variation ◽

Simplex Lattice ◽

Helminthostachys Zeylanica

Helminthostachys zeylanica extract has pharmacological activities such as antioxidant, antiinflamatory, and antihyerucemia. This extract is nontoxic substance from the acute and subchronic toxicity tests. This extract has a potency to be formulated into tablet dosage forms. This study aims to optimize a tablet formula from Helminthostachys zeylanica extract. Disintegrant and binder concentrations were independent variables, while physical properties and dissolution time of the tablets were dependent variables. The tablet was prepared by a wet granulation method. Formula was optimized by Simplex Lattice Design. Physicochemical propertiesof granule, physical properties and dissolution of tablet were then analyzed with One Way ANOVA (p = 0.05). Based on granule analysis, specification of physicochemical parameters, such as hausner’s ratio, compressibility index, flowability, repose angle, and water content, met standard British Pharmacopeia. In addition, the starch and PVA concentrations influenced thickness, weight variation, hardness, friability, disintegration time and dissolution of the tablets (p <0.05), except for friability (p> 0.05). Based on this study, the starch and PVA concentrations for the optimum tablet formula were 19.5% and 1.05%, respectively.

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FORMULASI TABLET EKSTRAK ANGKAK (RED YEAST RICE) DENGAN VARIASI CROSCARMELLOSE SODIUM SEBAGAI PENGHANCUR DAN LAKTOSA SEBAGAI PENGISI

Jurnal Ilmiah Manuntung ◽

10.51352/jim.v3i1.95 ◽

2017 ◽

Vol 3 (1) ◽

pp. 83

Author(s):

Adestria Resti ◽

Aris Perdana Kusuma ◽

Achmad Fudholi

Keyword(s):

Physical Properties ◽

The Body ◽

Wet Granulation ◽

Red Yeast Rice ◽

Disintegration Time ◽

Lattice Design ◽

Red Yeast ◽

Croscarmellose Sodium ◽

Simplex Lattice ◽

Optimum Formula

Angkak or better known as Red yeast rice is fermentation rice using a mold Monascus purpureus. Some studies of red yeast rice can lower cholesterol levels in the body because it contains monoakolin K or similliar with lovastatin compound. Generally in community consumption of red yeast rice only with pour in the boilling water so it can causing inconvenience for its customers. This study aims to make a formulation tablet of red yeast rice extract which varied with the levels of croscarmellose sodium 5% -1% (32mg, 26mg, 19,5mg, 13mg, 6,5mg) and lactose (75,75mg, 82.25 mg, 88,75mg , 95,25mg, 101,75mg) in order to get a best physical properties of the tablet including friability and disintegration time. Angkak extract was made by remaseration method using ethanol 75% and the manufacture of tablets using wet granulation method. Stastical test tablet extract angkak using One Way ANOVA with 95% confidence level. Optimum formula obtained by using the Simplex Lattice Design (SLD) using Design Expert version 8.0.7.1 program and statistically tested using one-sample t-test. The results from test showed the proportion of croscarmellose sodium 6.5mg and 101.75mg lactose produces tablets with the best of physical properties of red yeast rice extract.The result is indicate that the combination of croscarmellose sodium and lactose may affect response the physical properties of red yeast rice extract tablets.

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Optimasi Campuran Manitol-Sukrosa Untuk Tablet Hisap Ekstrak Daun Dewa (Gynura Procumbens (Lour) Merr)) Secara Granulasi Basah Dengan Metode Simplex Lattice Design

Jurnal Kebidanan dan Kesehatan Tradisional ◽

10.37341/jkkt.v1i1.30 ◽

2016 ◽

Vol 1 (1) ◽

Author(s):

Youstiana Dwi Rusita

Keyword(s):

Physical Properties ◽

Flow Rate ◽

Leaf Extract ◽

T Test ◽

Wet Granulation ◽

Response Characteristics ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula

Abstract: Dewa Leaves, Lozenges, Simplex Lattice Design. Dewa is an Indonesian traditional medicinal plants are efficacious among others to the tonsils. Dewa leaf extract can be prepared as lozenges because it is more practical and effective than the traditional way in the form of infusion. This study aimed to get the optimum formula mannitol - sucrose using the simplex lattice design that has more value than triall error. Dewa leaf aqueous extract obtained by maceration leaf powder dewa with 70% ethanol and then evaporated to obtain a thick extract is dried with aerosil. This study is based on the method simplex lattice design with two components, namely FI (100% mannitol), F II (100% sucrose), F III (50% mannitol: 50% sucrose). The method used in the manufacture of leaf extract lozenges Dewa was wet granulation using the binder PVP. The granules tested flow rate, compactibility and granules ditablet to test the taste responses. Of the value of the response characteristics of the granules obtained the largest total selected as the optimum formula. Furthermore ditablet and tested physical properties which include uniformity of weight, hardness and friability of tablets. Data of physical properties of the granules suction of the optimum formula theoretically and statistically tested using the t test (T-test). The results showed that the optimum formula derived from a mixture of mannitol 70% - sucrosa 30%. From the results of the t test (T-test) and compactibility flow rate did not different significantly betwen theoretical experiment. To test the taste responses acceptable 98% of respondents. Dewa leaf extract lozenges optimum formula produced meets the physical properties of the tablet.

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OPTIMASI GEL HAND SANITIZER OLEUM CITRI DENGAN KOMBINASI CARBOPOL, LIDAH BUAYA DAN TEA MENGGUNAKAN SIMPLEX LATTICE DESIGN

Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan ◽

10.36387/jiis.v6i1.569 ◽

2021 ◽

Vol 6 (1) ◽

pp. 21-28

Author(s):

Joko Santoso ◽

◽

Heru Nurcahyo

Keyword(s):

Physical Properties ◽

Design Method ◽

Aloe Vera ◽

Homogeneity Test ◽

Stabilizing Agents ◽

Hand Sanitizer ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula

Handsanitizer gel is composed of various additives such as geling agents, humectants and neutralizing / stabilizing agents. This material is certainly a basic ingredient that will affect the shape and quality of the preparation. Carbopol is very good when used, so that low levels can provide a significant viscosity response. Eleven hand sanitizer gel formulas with variations of carbomer, aloe vera and TEA were tested for their physical properties including organoleptic, homogeneity test, pH test, spreadability and adhesion test . The optimum formula is obtained by using the Simplex Lattice Design method, then the results are analyzed using an expert design software. The optimum formula for oleum citri hand sanitizer gel contains 0.944 with carbomer 0 (0.5%), aloe vera 0.471 (5.239%) and TEA 0.529 (0.576%). The t test results obtained showed insignificant differences between the response of the physical properties of the experiment results and the prediction software.

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Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin

Jurnal Kefarmasian Indonesia ◽

10.22435/jki.v10i2.2496 ◽

2020 ◽

pp. 110-119

Author(s):

Febia Arien Lestari ◽

Wahida Hajrin ◽

Nisa Isneni Hanifa

Keyword(s):

Stearic Acid ◽

Physical Properties ◽

Secondary Metabolite ◽

Test Results ◽

Design Expert ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula ◽

Selection Of

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.

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Formula Optimization of Fast Disintegrating Tablet (FDT) of Centella asiatica (L.) Urb. Ethanolic Extract

JURNAL ILMU KEFARMASIAN INDONESIA ◽

10.35814/jifi.v16i1.423 ◽

2018 ◽

Vol 16 (1) ◽

pp. 94

Author(s):

Agatha Budi Susiana Lestari ◽

Achmad Fudholi ◽

Akhmad Kharis Nugroho ◽

Erna Prawita Setyowati

Keyword(s):

Dosage Form ◽

Design Method ◽

Ethanolic Extract ◽

Centella Asiatica ◽

Disintegration Time ◽

Lattice Design ◽

Simplex Lattice Design ◽

Fast Disintegrating Tablet ◽

Simplex Lattice ◽

Optimum Formula

It has been proven that Centella asiatica (L.) Urb. herbs have an antioxidant activity that make it possible to used in preventing degenerative illness. Centella asiatica (L.) extract has been formulated to fast disintegrating tablet (FDT) dosage form. The aims of this study are to find the optimum formula of FDT of Centella asiatica (L.) Urb. The simplex lattice design method with 3 factors (which are mannitol as diluents, crospovidone as superdisintegrant and povidone as binder) and 2 levels of each was used. Centella asiatica (L.) Urb. extract was produce from maceration process using ethanol-water in ratio 75%:25% as a solvent. Direct compress method was used to produce the FDT. The results show that the optimum composition between excipients FDT formula could be reached, which fullfiled the physical properties parameter which are the hardness, friability and disintegration time of FDT.

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OPTIMIZING FORMULATION OF MINI TABLETS FLOATING RANITIDINE HCL USING FULLY PREGELATINIZED STARCH (MANIHOT ESCULENTA CRANTZ) WITH SIMPLEX LATTICE DESIGN

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i4.32657 ◽

2019 ◽

pp. 32-40

Author(s):

I Gusti Ngurah Agung Dewantara Putra ◽

RETNO MURWANTI ◽

ABDUL ROHMAN ◽

T.N SAIFULLAH SULAIMAN

Keyword(s):

Flow Rate ◽

Magnesium Stearate ◽

Lag Time ◽

Critical Parameters ◽

Dissolution Test ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Optimum Formula ◽

Functional Components

Objective: The main objective of this study was to optimize the noneffervescent floating mini tablets (NEFT) formula of ranitidine hydrochloride (ranitidine HCl) using the simplex lattice design (SLD) with parameters, granule flow rate, hardness, friability, floating lag time and ranitidine HCl dissolution test (%). Methods: The material was prepared using the SLD model was cassava starch fully pregelatinized (CSFP), hydroxypropyl methylcellulose K4M (HPMC K4M), and magnesium stearate. The formula obtained was tested for critical parameters, namely flow rate, hardness, friability, floating lag time and ranitidine HCl dissolution test (%). The dissolution test was carried out by using the USP type II method (paddle method). The beaker is immersed in the water bath of temperature 37 °C. It is filled with 900 ml of 0.1 N HCl, and the apparatus was set at 75 rpm. The samples were taken in the interval of 10 min and estimated content by a spectrophotometer at 312 nm. Results: The optimum formula based on superimposed graphs of various contour plots with SLD. From the experimental data for all test parameters, the experimental results are approaching with the results of the prediction. The condition for optimum functional components in NEFT was 80 mg for CSFP, HPMC K4M 30 mg, and 10 mg magnesium stearate to obtain a yield of 7.85 kg hardness, 0.34 % friability, 15.27 floating lag time and 91.31 % ranitidine HCl dissolved. Conclusion: It can be concluded that the optimum formula using the Design-Expert® program the SLD concept is obtained in the range of 70-80 mg CSFP, 30-40 mg HPMC K4M, 0-10 mg magnesium stearate.

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Optimization Formula of Turmeric (Curcuma longa L.) Extract Chewable with Combination of Mannitol-Lactose as Filler Based on Simplex Lattice Design

JPSCR Journal of Pharmaceutical Science and Clinical Research ◽

10.20961/jpscr.v2i01.5284 ◽

2017 ◽

Vol 2 (01) ◽

pp. 53 ◽

Cited By ~ 2

Author(s):

Dian Eka Ermawati ◽

Saifullah Sulaiman ◽

Indah Purwantini

Keyword(s):

Physical Properties ◽

Curcuma Longa ◽

Water Extract ◽

Hydroalcoholic Extract ◽

Lattice Design ◽

Simplex Lattice Design ◽

Simplex Lattice ◽

Student’S T ◽

Optimum Formula ◽

Prevention Of Atherosclerosis

<div class="WordSection1">Hydroalcoholic extract of turmeric (Curcuma longa L.) doses of 1.66 mg/kg containing 10% of curcuminoid was recommended as a supplement for prevention of atherosclerosis. This study aimed to formulate hydroalcoholic extract of turmeric into chewable which are more acceptable and practical. Mannitol-Lactose selected as a filler to make the chewable in this study. Optimum composition of filler of the mixture obtained by the Simplex Lattice Design method.Identification of turmeric rhizome has been done at Departemen of Plant Taxonomy, Faculty of Biology, Gadjah Mada University, Yogyakarta, Indonesia. The rhizome extraction carried out as re to research carried out by Quiles. The mixture between curcuminoid, ethanol and water extract made up to 25% level of curcuminoid level. Then, Extract was granulated with combination of filler mannitol-lactose to be five formulas, there are: FI (mannitol 100%), FII (mannitol-lactose 75%:25%), FIII (mannitol-lactose 50%:50%), FIV (mannitol-lactose 25%:75%), FV (lactose 100%). The granules then tested their physical properties such as flowability, compactibility, and water content. Furthermore, the granules tableted and physical tested including : weight uniformity, hardness, friability, absorption, flavor acceptance and soluble time. Determining the optimum formulation obtained from the physical properties of the granules and chewable physical properties based on SLD methods. Optimum formula of chewable then tested with kurkuminoid levels. The physical properties data of granules and chewable were analyzed statistically using student’s t-test.The result of this study was the optimum formula obtained from the mixture of mannitol-lactose fillers with a ratio of 90% mannitol: 10% lactose. The optimum formula of turmeric extract chewable produced meets the physical properties of the granules and chewable. Acceptance of flavor chewable optimum formula appreciation in the range of sweet and sour taste to sour. Percentage kurkuminoid levels in chewable after manufacture process was 76.42%.</div>

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