scholarly journals EVALUASI PENGGUNAAN OBAT PADA PASIEN ASMA DI INSTALASI RAWAT INAP RSUP PROF. DR. R. D. KANDOU MANADO

PHARMACON ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 613
Author(s):  
Gerry S. Alotia ◽  
Weny I. Wiyono ◽  
Deby A. Mpila

ABSTRACTAsthma is a disease in the top five causes of death in the world, which varies between 5-10%. Drug use accuracy in this study was that patients who received treatment were evaluated for accuracy based on the category of indication, drug, patient and the correct dose. This study aims to identify the characteristics and presentation of the accuracy of drug use in asthma patients. This study is a descriptive study with retrospective data collection from 59 medical records of asthma patients for the period January - December 2017. The results of the study based on the characteristics of asthma patients show the number of female patients more than men, namely 33 patients (55.93%) and the highest number of patients age is in the 56 - 65 years for 10 patients (16.95%). Endocrine diseas, nutritional and metabolic disorders were the most common comorbidities was found in 13 patients (17.33%) and 3-4 drugs were prescribed more, namely 28 patients (47.46%). The accuracy percentage of drug use consisted of 81.36% right indication, 74.58% right drug, 94.92% right patient, and 86.44% correct dose. Keywords: Inpatient Asthma, Drug evaluation  ABSTRAKPenyakit asma merupakan penyakit lima besar penyebab kematian di dunia yang bervariasi antara 5 - 10%. Ketepatan penggunaan obat dalam penelitian ini adalah pasien menerima pengobatan yang kemudian di evaluasi ketepatannya berdasarkan kategori tepat indikasi, tepat obat, tepat pasien, dan tepat dosis. Penelitian ini bertujuan untuk mengidentifikasi karakteristik dan presentasi ketepatan penggunaan obat pada pasien asma. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif dari 59 catatan rekam medik pasien asma periode Januari - Desember 2017. Hasil penelitian berdasarkan karakteristik pasien asma menunjukkan jumlah pasien perempuan lebih banyak dibanding laki-laki yaitu sebesar 33 pasien (55,93%) dan jumlah pasien terbanyak pada kelompok usia 56 - 65 tahun sebesar 10 pasien (16,95%). Penyakit endoktrin, nutrisi dan gangguan metabolik merupakan penyakit penyerta terbanyak yang ditemukan pada 13 pasien (17,33%) dan 3 - 4 obat diresepkan lebih banyak yaitu pada 28 pasien (47,46%). Persentase ketepatan penggunaan obat terdiri dari tepat indikasi 81,36%, tepat obat 74,58%, tepat pasien 94,92%, dan tepat dosis 86,44%. Kata Kunci: Asma rawat inap, Evaluasi obat

PHARMACON ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 630
Author(s):  
Rochmat Hidayat Hathasary ◽  
Weny Wiyono ◽  
Deby Afriani Mpila

ABSTRACTChronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease characterized by limited airflow in the airways that is not completely reversible and is progressive. The accuracy of drug use in this study is that patients receive treatment which is then evaluated for its accuracy based on the right category of indication, right drug, right patient, and right dose. This study aims to identify the characteristics and presentation of the accuracy of drug use in COPD patients. This study is a descriptive study with retrospective data collection from 30 medical records of  COPD patients for the period July - September 2020. The results of the study based on the characteristics of COPD patients showed that the number of male patients was greater than that of women, namely 23 patients (76.67%) and The highest number of patients was in the 56-65 years age group of 13 patients (43.33%). Diseases of the digestive system were the most common comorbidities found in 2 patients (6.67%) and 3-4 drugs were prescribed more, namely in 16 patients (53.34%). The percentage of accuracy of drug use consisted of 93.33% right indication, 53.33% right drug, 100% correct patient, and 96.67% correct dose. Keywords: drug evaluation , COPD, outpatient  ABSTRAKPenyakit Paru Obstruksi Kronik (PPOK) adalah penyakit paru kronik yang ditandai dengan keterbatasan aliran udara di dalam saluran napas yang tidak sepenuhnya reversible dan bersifat progresif. Ketepatan penggunaan obat dalam penelitian ini adalah pasien menerima pengobatan yang kemudian di evaluasi ketepatannya berdasarkan kategori tepat indikasi, tepat obat, tepat pasien, dan tepat dosis.Penelitian ini bertujuan untuk mengidentifikasi karakteristik dan presentasi ketepatan penggunaan obat pada pasien PPOK. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif dari 30 catatan rekam medik pasien PPOK periode Juli - September 2020. Hasil penelitian berdasarkan karakteristik pasien PPOK menunjukkan jumlah pasien laki-laki lebih banyak dibanding perempuan yaitu sebesar 23 pasien (76,67%) dan jumlah pasien terbanyak pada kelompok usia 56-65 tahun sebesar 13 pasien (43,33%). Penyakit pada sistem pencernaan merupakan penyakit penyerta terbanyak yang ditemukan pada 2 pasien (6,67%) dan 3-4 obat diresepkan lebih banyak yaitu pada 16 pasien (53,34%). Persentase ketepatan penggunaan obat terdiri dari tepat indikasi 93,33%, tepat obat 53,33%, tepat pasien 100%, dan tepat dosis 96,67%. Kata kunci: Evaluasi Obat, PPOK, rawat jalan


PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 498
Author(s):  
Febryan Gultom ◽  
Weny I. Wiyono ◽  
Heedy Tjitrosantoso

ABSTRACT Malaria is an infectious disease caused by the Plasmodium parasite (class of Sporozoa) that attacks red blood cells. In indonesia, there are 4 (four) species of malaria parasites, namely Plasmodium falciparum as the cause of tropical malaria which often causes brain malaria with death, Plasmodium vivax as the cause of malaria tertiana, Plasmodium malariae as the cause of malaria quartana and Plasmodium ovale as the cause of ovale malaria. This study aims to determine the patient characteristics and treatment patterns in malaria patients at the inpatient installation of the Mimika District Hospital in period June – December 2018. This study was a descriptive study with retrospective data collection against 68 medical records of malaria patients who were hospitalized inclusion criteria. There were  more men group than women, 41 patiensts (60,29%). Most of malaria patients are in the 0 – 5 year age group with 30 patients (44,12%). The most common type of malaria is uncomplicated vivax malaria 21 patients (33,82%). The most drug use of patients was Primaquin as many as 57 (83,82%) of 68 patients. The exact percentage of drug use for patients is 100%, right drug 89.71%, right dose 92.65%, timely 97.06% and right route 100%. Keywords : Malaria, Drug Utilization Study, Hospitalization.  ABSTRAK Malaria merupakan penyakit menular disebabkan oleh parasit Plasmodium (kelas Sporozoa) yang menyerang sel darah merah. Di Indonesia dikenal 4 (empat) macam spesies parasit malaria yaitu Plasmodium falciparum sebagai penyebab malaria tropika yang sering menyebabkan malaria otak dengan kematian, Plasmodium vivax sebagai penyebab malaria tertiana, Plasmodium malariae sebagai penyebab malaria quartana dan Plasmodium ovale sebagai penyebab malaria ovale. Penelitian ini bertujuan untuk mengetahui karakteristik pasien dan pola pengobatan penyakit malaria pada pasien malaria di instalasi rawat inap RSUD Kabupaten Mimika periode bulan Juni – Desember 2018. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif terhadap 68 data rekam medik pasien malaria rawat inap yang memenuhi kriteria inklusi. Jumlah pasien laki-laki lebih banyak dibandingkan perempuan yaitu sebanyak 41 pasien (60,29%). Pasien Malaria kebanyakan berada pada kelompok usia 0-5 tahun sebanyak 30 pasien (44,12%). Jenis malaria yang paling sering terjadi adalah Malaria vivax tanpa komplikasi sebanyak 23 pasien (33,82%). Penggunaan obat pasien paling banyak yaitu Primakuin sebanyak 57 (83,82%) dari total 68 pasien. Persentase ketepatan penggunaan obat yang tepat pasien 100%, tepat obat 89,71%, tepat dosis  92.65%, tepat waktu 97,06% dan tepat rute 100%. Kata kunci : Malaria, Studi Penggunaan Obat, Rawat Inap.


Crisis ◽  
2016 ◽  
Vol 37 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Jin Kim ◽  
Han Joon Kim ◽  
Soo Hyun Kim ◽  
Sang Hoon Oh ◽  
Kyu Nam Park

Abstract. Background: Previous suicide attempts increase the risk of a completed suicide. However, a large proportion of patients with deliberate self-wrist cutting (DSWC) are often discharged without undergoing a psychiatric interview. Aims: The aims of this study were to investigate the differences in the characteristics and outcomes of patients with DSWC and those with deliberate self-poisoning (DSP) episodes. The results of this study may be used to improve the efficacy of treatment for DSWC patients. Method: We retrospectively reviewed the medical records of 598 patients with DSWC and DSP who were treated at the emergency department of Seoul Saint Mary's Hospital between 2008 and 2013. We assessed sociodemographic information, clinical variables, the reasons for the suicide attempts, and the severity of the suicide attempts. Results: A total of 141 (23.6%) patients were included in the DSWC group, and 457 (76.4%) were included in the DSP group. A significantly greater number of patients in the DSWC group had previously attempted suicide (p = .014). A total of 63 patients (44.7%) in the DSWC group and 409 patients (89.5%) in the DSP group underwent psychiatric interviews. Conclusion: More DSWC patients had previously attempted suicide, but fewer of them underwent psychiatric interviews compared with the DSP patients.


2021 ◽  
Vol 15 (1) ◽  
pp. 11
Author(s):  
Lianda Siregar ◽  
Imelda Maria Loho ◽  
Agus Sudiro Waspodo ◽  
Siti Nadliroh ◽  
Rahmanandhika Swadari ◽  
...  

Background: There is currently no data regarding the efficacy of prophylactic telbivudine in hepatitis B patients undergoing chemotherapy. This study aims to describe the results of preemptive telbivudine and lamivudine to prevent chemotherapy-related HBV reactivation.Methods: The medical records of all patients with HBsAg positive or HBs-Ag negative, anti-HBc positive, who were referred to the hepatology clinic between May 2014 and December 2016, were retrospectively reviewed. As this is a descriptive study, no statistical analysis was done.Results: A total of 52 patients with prophylactic telbivudine or lamivudine therapy were included, with 26 patients in each group. Rituximab-based treatment was given in nine and five patients in the telbivudine and lamivudine group, respectively. The number of patients who completed antiviral treatment up to six months after chemotherapy was 17 patients in each group. There was less incidence of HBV reactivation in the telbivudine group (2 of 17 patients, 11.8%) than in the lamivudine group (7 of 17 patients, 41.2%). Delayed reactivation was noticed in 1 of 2 patients in the telbivudine group and 3 of 7 patients in the lamivudine group. The median log10[HBV DNA] at reactivation was 4.52 (1.70 – 8.35) IU/mL. Severe hepatitis was observed in two patients in the lamivudine group and one patient in the telbivudine group. Of 34 patients who completed antiviral treatment, two patients died due to primary cancer. No interruption of chemotherapy or mortality due to hepatitis was noticed in both groups.Conclusions: Preemptive telbivudine or lamivudine in HBsAg positive or HBsAg negative, anti-HBc positive patients seems to be a good treatment option.


Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3119 ◽  
Author(s):  
Shin-Hye Kim ◽  
Kwang-Jin Kim ◽  
Hyeon Kang ◽  
Young-Jin Son ◽  
Sik-Won Choi ◽  
...  

The number of patients with bone metabolic disorders including osteoporosis is increasing worldwide. These disorders often facilitate bone fractures, which seriously impact the patient’s quality of life and could lead to further health complications. Bone homeostasis is tightly regulated to balance bone resorption and formation. However, many anti-osteoporotic agents are broadly categorized as either bone forming or anti-resorptive, and their therapeutic use is often limited due to unwanted side effects. Therefore, safe and effective therapeutic agents are needed for osteoporosis. This study aims to clarify the bone protecting effects of oat bran water extract (OBWE) and its mode of action. OBWE inhibited RANKL (receptor activator of nuclear factor-κB ligand)-induced osteoclast differentiation by blocking c-Fos/NFATc1 through the alteration of I-κB. Furthermore, we found that OBWE enhanced BMP-2-stimulated osteoblast differentiation by the induction of Runx2 via Smad signaling molecules. In addition, the anti-osteoporotic activity of OBWE was also evaluated using an in vivo model. OBWE significantly restored ovariectomy-induced bone loss. These in vitro and in vivo results showed that OBWE has the potential to prevent and treat bone metabolic disorders including osteoporosis.


2015 ◽  
Vol 31 (7) ◽  
pp. 1505-1516 ◽  
Author(s):  
Ana Rita Barbieri ◽  
Crhistinne Cavalheiro Maymone Gonçalves ◽  
Maria de Fátima Meinberg Cheade ◽  
Cristina Souza ◽  
Daniel Henrique Tsuha ◽  
...  

The increasing incidence of chronic renal failure in Brazil and the consequential expansion of hemodialysis as a choice for treatment in final stage have to be taken into account to guarantee access to those in need. The ecological study conducted in Mato Grosso do Sul State, Brazil, in 2012, using data from the Brazilian Health Informatics Department (DATASUS) and from the analysis of medical records in 12 clinics, identified and mapped patients on hemodialysis, the distance they travelled and the estimated number of patients. The prevalence of hemodialysis patients in Mato Grosso do Sul State, about 55 per 100,000 inhabitants, is similar to the national average. The analyses indicated concentration of patients in counties with clinics and also geographical gaps that generate displacement of over 100km for more than 16% of patients. The results point to the necessity of strengthening public policies that consider, for decision-making, the decentralization of service, the expansion of home care and the follow-up education for professionals.


e-CliniC ◽  
2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Muhammad F. Bazmul ◽  
Eka Y. Lantang ◽  
Barry I. Kambey

Abstract: Emergency Department provides first emergency services to patients with threats of death and disability in an integrated manner involving multi disciplines. Patients who come to the Emergency Department are always assessed as 3 priorities, namely priorities 1, 2 and 3. Priority 1 is case/disease with life-threatening emergency or severe emergency; Priority 2 is case/disease with mild emergency; and Priority 3 is non-emergency case/disease. This study was aimed to obtain the Triage profile of patients at Emergency Department of Prof. Dr. R. D. Kandou Hospital Manado. This was a retrospective descriptive study using patients’ medical records. Samples were all patients treated at the Emergency Department of Prof. Dr. R. D. Kandou Hospital from January 2018 until July 2018. The results showed that there were 19,229 patients as samples. Based on sex, most patients were male, meanwhile based on age most were 51-70 years, with the highest number of patients in March 2018. There were 6,913 patients (35.9%) in the orange or emergency category (Priority 2) and 6,130 patients (31.8%) in the yellow category (Priority 3). Conclusion: Based on the Start Triage in Emergency Department, the majority of patients were in Priority 2 category, followed by Priority 3 category.Keywords: Emergency Department, Start Triage Abstrak: Instalasi Gawat Darurat (IGD) memberikan pelayanan pertama yang bersifat emergency pada pasien dengan ancaman kematian dan kecacatan secara terpadu dengan melibatkan multi disiplin ilmu. Pasien yang datang di IGD selalu dinilai kegawatannya menja-di 3 prioritas, yaitu prioritas 1, 2, dan 3. Prioritas 1 yaitu kasus/penyakit dengan kegawat-daruratan yang mengancam jiwa atau gawat darurat berat. Prioritas 2 untuk kasus/penyakit dengan gawat darurat ringan. Prioritas 3 untuk kasus/penyakit yang bukan gawat darurat. Penelitian ini bertujuan untuk mengetahui profil skala Triase pasien yang masuk di IGD RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deskriptif-retrospektif, menggunakan data rekam medis pasien. Sampel penelitian ialah seluruh pasien yang dirawat di IGD RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2018 sampai Juli 2018. Hasil penelitian mendapatkan data pasien yang masuk ke Ruang IGD RSUP Prof. Dr. R. D. Kandou Manado terhitung sejak Januari hingga Juli 2018 sebanyak 19.229 orang. Distribusi pasien terbanyak berdasarkan jenis kelamin ialah laki-laki, dan berdasarkan usia ialah 51-70 tahun, dengan jumlah pasien terbanyak pada bulan Maret 2018. Pasien IGD terbanyak ialah kategori jingga yaitu emergency (Prioritas 2) berjumlah 6.913 orang (35,9%) serta kategori kuning (Prioritas 3) berjumlah 6.130 orang (31,8%). Simpulan: Berdasarkan skala Triase di IGD, pasien terbanyak ialah Prioritas 2, disusul dengan Prioritas 3.Kata kunci : Instalasi Gawat Darurat, skala Triase


2021 ◽  
Vol 22 (21) ◽  
pp. 11629
Author(s):  
Jorge Gutiérrez-Cuevas ◽  
Arturo Santos ◽  
Juan Armendariz-Borunda

Obesity is now a worldwide epidemic ensuing an increase in comorbidities’ prevalence, such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty liver disease (MAFLD), nonalcoholic steatohepatitis (NASH), hypertension, cardiovascular disease (CVD), autoimmune diseases, and some cancers, CVD being one of the main causes of death in the world. Several studies provide evidence for an association between MAFLD and atherosclerosis and cardio-metabolic disorders, including CVDs such as coronary heart disease and stroke. Therefore, the combination of MAFLD/NASH is associated with vascular risk and CVD progression, but the underlying mechanisms linking MAFLD/NASH and CVD are still under investigation. Several underlying mechanisms may probably be involved, including hepatic/systemic insulin resistance, atherogenic dyslipidemia, hypertension, as well as pro-atherogenic, pro-coagulant, and pro-inflammatory mediators released from the steatotic/inflamed liver. MAFLD is strongly associated with insulin resistance, which is involved in its pathogenesis and progression to NASH. Insulin resistance is a major cardiovascular risk factor in subjects without diabetes. However, T2D has been considered the most common link between MAFLD/NASH and CVD. This review summarizes the evidence linking obesity with MAFLD, NASH, and CVD, considering the pathophysiological molecular mechanisms involved in these diseases. We also discuss the association of MAFLD and NASH with the development and progression of CVD, including structural and functional cardiac alterations, and pharmacological strategies to treat MAFLD/NASH and cardiovascular prevention.


Author(s):  
Krystyna Piskorz-Ogórek ◽  
Krzysztof Narkun

Aim: Present a model of RRTs system and the effects of its implementation in child care. Material and methods: The medical staff survey (n = 97) analysis and complete analysis of the medical records of patients (document analysis; n = 1020) were performed. The variables such as: the number and the type of RRTs interventions, the number of patients admitted to the intensive care unit (ICU) and the hospital mortality rate were analysed. These were compared with the variables obtained before the implementation of RRTs (from 1st November 2018 to 31st August 2019 vs. 1st November 2017 to 31st August 2018). Results and discussion: RRTs made 626 surveillance visits to patients with serious conditions staying at hospital wards, 266 scheduled visits to 89 patients transferred from the ICU to other wards and 126 interventions in response to calls from different wards. The number of patients transferred from the hospital wards to the ICU decreased from 125 to 90. The number of deaths in the ICU decreased from 20 to 13. Conclusions: The evaluation of the 10-month implementation period for this project encourages to keep RRTs operational. The interviewed staff admitted that the safety of inpatient care increased along with more meticulous supervision over patients needing intensive care.


2016 ◽  
Vol 97 (1) ◽  
pp. 124-130
Author(s):  
A M Tulenkov ◽  
E V Dyuzheva ◽  
K A Romanov

Aim. To assess tendency in medico-demographic indicators of persons held in prisons of Volga Federal District in the period of the penal system modern reforming (2006-2014).Methods. Assessment of the studied contingent quantitative and qualitative medico-demographic indicators dynamics, the most relevant for the prisons for the 2006-2014. Forecasting of studied indicators for the period up to 2017 was conducted. Intensive and extensive indicators calculation and their dynamic comparison were performed.Results. Changes of demographic indicators for the 2006-2014 period involve the total number of prisoners reduction, the proportion of women increase and the proportion of teenagers decrease, reduction the punishment serving duration, migration processes intensification. The studied contingent, which was held in the prisons of the Volga Federal District, in the vast majority (91.0%) was presented by male persons. The mean age of convicted is 30.9 years. The mean term of punishment in prisons is 7.6 years. During the 2006-2014, the constant tendency of the studied contingent mortality increase due to the continuing increase in the number of patients with socially significant diseases amid decrease of the total number of persons held in prisons was registered. In 2014, the mortality rate was 7.1‰, which is 36.5% higher than in 2006 (5.2‰). The leading causes of death were infectious and parasitic diseases (37.1%). Studied medico-demographic indicators changes had significant regional features.Conclusion. Revealed significant changes in the medico-demographic indicators of studied contingent, definitely affecting the penalty system medical service activity, dictate the necessity of considering them when adopting the strategy of medical care organization in prisons.


Sign in / Sign up

Export Citation Format

Share Document