scholarly journals PENGARUH SENAM AEROBIK INTENSITAS SEDANG DAN TINGGI TERHADAP TEKANAN INTRAOKULER WANITA DEWASA NON GLAUKOMA

2013 ◽  
Vol 4 (2) ◽  
Author(s):  
Jimmy F Rumampuk ◽  
Wenny Supit ◽  
Djon Wongkar
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Intraocular Pressure ◽  
Aerobic Fitness ◽  
High Intensity ◽  
The Body ◽  
Arterial Pulse ◽  
Inclusion Criteria ◽  
Adult Females ◽  
Significant Difference

Abstract: The influence of aerobic fitness to certain physiologic changes of the body, in this case a decrease of intraocular pressure (IOP), has not been elucidated yet. This study aimed to examplify the influence of medium and high intensity aerobic fitness to the IOPs of non-glaucomatous adult females by involving 30 subjects (n=30) in accordance with the inclusion criteria. Prior to doing the aerobic fitness, body weight (BW), height (H), body mass index (BMI), and the arterial pulse were measured. The IOPs were measured by using a Schiotz Tonometer. Aerobic fitness was conducted under the supervision of a fitness instructor. Subjects in the treatment group carried out aerobic fitness on a regular basis. A mild intensity aerobic fitness was carried out for 30 minutes and a high intensity one for 15 minutes. There was a significant difference between the IOP values of post-aerobic fitness in the mild intensity group and the high intensity group (P < 0.05). This is shown by the average IOP value of post-aerobic fitness in the mild intensity group 15.37±1.261 mmHg, and the average IOP value of post-aerobic fitness in the high intensity group decreasing to 12.92±1.111 mmHg. Conclusion: aerobic fitness can decrease the IOP.Keywords: intra-ocular, aerobic fitness, female, non-glaucomatousAbstrak: Pengaruh senam aerobik dalam mengakibatkan perubahan fisiologik tubuh berupa penurunan tekanan intraokuler (TIO) belum jelas diketahui. Penelitian ini bertujuan untuk mengetahui pengaruh senam aerobik intensitas sedang dan tinggi terhadap TIO wanita dewasa non-glaukoma dengan mengikutsertakan 30 subyek (n=30) yang sesuai dengan kriteria inklusi. Sebelum melakukan senam aerobik, dilakukan pengukuran berat badan (BB), tinggi badan (TB), Indeks Massa Tubuh (IMT), serta denyut nadi. TIO diukur dengan menggunakan Tonometer Schiotz. Kegiatan senam aerobik dibimbing oleh seorang instruktur senam. Kelompok perlakuan melaksanakan aktifitas senam aerobik secara berkesinambungan. Senam aerobik intensitas sedang dilakukan selama 30 menit dan senam aerobik intensitas tinggi dilakukan selama 15 menit. Terdapat perbedaan nilai TIO yang bermakna sesudah senam aerobik intensitas sedang dengan sesudah senam aerobik intensitas tinggi (P < 0,05). Hal ini terlihat pada hasil rerata TIO pada kelompok perlakukan sesudah senam aerobik intensitas sedang sebesar 15,37±1,261 mmHg dan sesudah senam aerobik intensitas tinggi menurun menjadi 12,92±1,111. Simpulan: senam aerobik dapat menurunkan TIO.Kata kunci: intraokuler, senam aerobik, wanita, non-glaukoma

scholarly journals TRAUMATIC DISEASE PECULIARITIES COURSE, ITS DIAGNOSTICS AND TREATMENT AT POLYTRAUMA IN SUFFER OBESE PATIENTS

2019 ◽  
Vol 43 (4) ◽  
pp. 47-53
Author(s):  
S.D. Khimich ◽  
O. M. Chemerys
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Overweight And Obesity ◽  
The Body ◽  
Obese Patients ◽  
Prognostic Features ◽  
Normal Body ◽  
Significant Difference ◽  
Normal Body Weight

Abstract Introduction. It’s known that the issue of polytrauma is one of the most urgent problems of surgery, and among injured patients a special approach is required for patients with overweight and obesity of varying degrees. Purpose of the study. To study prognostic features of traumatic disease course and to improve the results of diagnostics and surgical treatment of patients with polytrauma suffer obesity. Materials and methods. Clinical material was made up of 106 patients with combined body trauma, which were divided into three groups according to body mass index. Results. The results of the research showed a significant difference in the course of traumatic disease in patients with normal body weight and obesity. In particular, in the process of diagnostics of blunt chest and abdominal trauma the frequency of application of interventional methods of diagnostics was directly proportional to the increase of body mass index. The course of traumatic disease in the obese patients had a number of characteristic features that formed the basis for the development of diagnostics and differential program of treatment. Conclusions. The results of the research showed that the course of traumatic disease in combined injury obese patients is directly proportional to the body mass index and has certain features that differentiate them from patients with normal body weight. Keywords: polytrauma, obesity, traumatic disease, diagnostics, treatment.

scholarly journals Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110110
Author(s):  
Wiraphol Phimarn ◽  
Bunleu Sungthong ◽  
Hiroyuki Itabe
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Body Mass ◽  
The Body ◽  
Current Evidence ◽  
Diabetic Patients ◽  
Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

Specific Susceptibility to HCN and the amount of HCN recovered from Fumigated Insects

1951 ◽  
Vol 42 (2) ◽  
pp. 399-418 ◽  
Author(s):  
S. Pradhan ◽  
S. C. Bhatia
Keyword(s):  
Body Weight ◽  
Water Content ◽  
Relative Position ◽  
Surface Resistance ◽  
Internal Resistance ◽  
Effective Resistance ◽  
The Body ◽  
Effective Dosage ◽  
Adult Females ◽  
The Dead

The relationship was studied between susceptibility of a number of different species of insects to HCN fumigation and the recovery of HCN from them immediately after fumigation.The test insects used were Tribolium castaneum, seventh stage caterpillars of Corcyra cephalonica, first-and second-instar nymphs of Drosicha sp., third-and fourthinstar nymphs of Drosicha sp. and adult females of Drosicha sp.The apparatus and methods used in the fumigation and in the recovery of HCN from the fumigated insects are fully described.Preliminary expsriments showed that the processes of distillation and redistillation did not affect the recovery of HCN but that the result obtained for recovery from distillation could be affected if some volatile reducing substance were produced and carried over to the distillate. It was found that this did actually take place in the case of one of the test insects—T. castaneum—but that redistillation got rid of the impurity.In the main experiments it was shown that, on the assumption that the concentration of HCN to which insects are exposed is the effective dosage, the susceptibility of the test insects varied in the following descending order : firstand second-stage nymphs of Drosicha sp. > third- and fourth-stage nymphs of Drosicha sp.>C. cephalonica> T. castaneum>the adult females of Drosicha sp.When the same insects were arranged in descending order of the quantities of HCN recovered per 100 gm. of body weight, the order was identical except for the nymphs of Drosicha sp. which occupied a different relative position. The two categories of nymphs of Drosicha sp. were found to occupy a different relative position again with regard to the other three test insects when exposed to a superlethal concentration and assessed for recovery of HCN per 100 gr. body weight.Parallel batches of T. castaneum and C. cephalonica were fumigated and the HCN was recovered from the dead and survivors. More HCN was recovered from the dead insects than from those that survived.Both recovery and sorption of HCN were estimated separately in parallel batches of insects (adult females of Drosicha sp. and C. cephalonica). Recovery was found to be less than sorption showing that a part of the HCN absorbed is converted into a non-recoverable state. Further, that the weight of HCN sorbed per gram body weight of adult females of Drosicha sp. is much less than in the case of C. cephalonica under similar conditions of fumigation and that the amount of HCN converted into non-recoverable products is less in Drosicha adults than in C. cephalonica.A comparison of the water content of T. castaneum, C. cephalonica and Drosicha sp. (adults) showed that there was a positive correlation between water content and higher susceptibility to HCN and greater recovery of HCN was also indicated. It is suggested that this may be a factor in the “ Surface Resistance ” of an insec to a fumigant.The observations of previous workers that larger amounts are sorbed by or recovered (after fumigation) from more susceptible species than for those less susceptible was corroborated by the results obtained with C. cephalonica, T. castaneum and adult females of Drosicha sp. but not with those from nymphs of Drosicha sp.When dosage-mortality graphs were prepared by taking the amount of HCN recovered per gram body weight as an index of internal dose, the order of resistance of different test insects based on this new criterion was found to be entirely different from that based on the usual criterion of the concentration of HCN in the fumatorium being the index of effective dosage.These apparently anomalous observations may be explained by assuming that the resistance shown by an insect in an actual fumigation operation, i.e., to the concentration of HCN to which it is exposed (external dose) is what may be called the total “ Effective Resistance ” and that this “ Effective Resistance ” is the resultant of (a) “ Surface Resistance ” to the entry of fumigant and (b) “ Internal Resistance ” to the amount of HCN which actually gains entry into the body in some way or other. Thus the “Effective Resistance ” of an insect may be due to a combination either of low “ Surface Resistance ” and high “ Internal Resistance ”, giving a very low “ Effective Resistance ” as in the case of C. cephalonica, or vice versa giving the maximum “ Effective Resistance ” as in adult females of Drosicha sp. The lower recovery of HCN from the nymphs of Drosicha sp., although they were more susceptible to fumigation than C. cephalonica, is explained by their higher “ Surface Resistance ” combined with a very much lower “ Internal Resistance ”, leading to a lower “ Effective Resistance ”.

A study on the safety evaluation of buphrenorphine administered through an autoinjector compared with manual injection using haematological and biochemical variables in rats

2016 ◽  
Vol 36 (9) ◽  
pp. 901-909 ◽  
Author(s):  
D Sheela ◽  
R Vijayaraghavan ◽  
S Senthilkumar
Keyword(s):  
Body Weight ◽  
Research Work ◽  
Safety Evaluation ◽  
Weight Ratio ◽  
The Body ◽  
Control Group ◽  
Body Weight Ratio ◽  
Significant Difference ◽  
Manual Group ◽  
Significant Change

Buprenorphine drug cartridge was made for autoinjector device for use in emergency and critical situations to reduce the morbidity and mortality. Water-filled cartridges were prepared and buprenorphine was injected aseptically in the cartridge, to make 0.05 and 0.10 mg/mL. Rats were injected intraperitoneally, buprenorphine (0.3 and 0.6 mg/kg), repeatedly with the autoinjector and compared with manual injection (7 days and 14 days) using various haematological and biochemical parameters. No significant change was observed in the body weight, organ to body weight ratio and haematological variables in any of the experimental groups compared with the control group. Except serum urea and aspartate aminotransferase, no significant change was observed in glucose, cholesterol, triglycerides, bilirubin, protein, albumin, creatinine, uric acid, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase. The autoinjectors deliver the drugs with spray effect and force for faster absorption. In the present study, the autoinjector meant for intramuscular injection was injected intraperitoneally in rats, and the drug was delivered with force on the vital organs. No significant difference was observed in the autoinjector group compared to the manual group showing tolerability and safety of the buphrenorphine autoinjector. This study shows that buprenorphine autoinjector can be considered for further research work.

scholarly journals Morphometric characteristics of the patellar tendon

2016 ◽  
Vol 69 (suppl. 1) ◽  
pp. 53-58
Author(s):  
Milodrag Vranjes ◽  
Ivan Vukasinovic ◽  
Mirko Obradovic ◽  
Mile Bjelobrk ◽  
Zlatko Budinski ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Body Weight ◽  
Body Mass ◽  
Patellar Tendon ◽  
Cruciate Ligament ◽  
The Body ◽  
Professional Athletes ◽  
Morphometric Characteristics ◽  
Significant Difference ◽  
Anterior Cruciate

Introduction. The most common injuries of the knee joint are injuries of the anterior cruciate ligament. The golden standard in reconstruction of this ligament is graft bone - patellar tendon - bone. Knowing the morphometric characteristics of these ligaments is crucial for anterior cruciate ligament reconstruction. This study was aimed at determining morphometric characteristics of the patellar tendon in vivo, measured intraoperatively, and at defining the correlation between the obtained values and body weight, height, gender and sport activity among different groups of athletes. Material and Methods. This study included 184 patients suffering from anterior cruciate ligament injuries who were admitted to the Clinical Center of Vojvodina, Department of Orthopedics and Traumatology. Results. The patellar tendon width ranged from 28 mm to 43 mm, averaging at 32.02 mm. The length of the patellar tendon ranged from 35 mm to 62 mm, averaging at 46.34 mm. The thickness of the patellar tendon ranged from 3 mm to 6 mm, averaging at 3.78 mm. The measured results were positively and statistically relevant with the body mass, height and body mass index. Discussion and Conclusion. The patellar tendon was thicker, longer and wider in persons with higher values of body weight and height. Men have statistically longer, thicker and wider patellar tendon than women. There was no statistically significant difference between morphometric characteristics of the patellar tendon among professional athletes and recreational athletes, neither was there one in the obtained geometric data of the patellar tendon among tested groups of professional athletes.

scholarly journals Comparison between Vinorelbine–Carboplatin and Vinorelbine–Cisplatin in Stage III–IV EGFR Mutations-Negative NSCLC

2021 ◽  
Author(s):  
Laksmi Wulandari ◽  
Gatot Soegiarto ◽  
Anna Febriani ◽  
Farah Fatmawati ◽  
Wirya Sastra Amran
Keyword(s):  
Lung Cancer ◽  
Body Weight ◽  
Evaluation Criteria ◽  
Growth Factor Receptor ◽  
The Body ◽  
Stage Iii ◽  
Egfr Mutations ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Abstract Introduction There are a substantial number of lung cancer patients with negative mutations in Indonesia. This type of cancer is deemed to be the major contributor of lung cancer patient’s death. However, reseaerch related to therapy using vinorelbine combined with platinum-based compounds is still scarce in Indonesia. The aim of this study was to compare the efficacy and tolerability between vinorelbine and carboplatin with vinorelbin and cisplatin in stage III-IV epidermal growth factor receptor (EGFR) mutations-negative non-small cell lung cancer (NSCLC). Methods The participants were divided into two groups—group I(vinorelbine–carboplatin) and group II (vinorelbine–cisplatin). The participants were assessed based on several measurement criteria. Not only Eq-5D was performed, but the body weight and response evaluation criteria for solid tumors (RECIST) were also examined. The participants received chemotherapy for four cycles (1 cycle = 21 days). Results The quality of life was considered stable in 60% of group I and 60% of group II (p=0.255). In both groups, 46.67% of participants had an increased body weight, while the other 20.00% was stable (p = 1.000). In terms of RECIST evaluation after the second cycle, 80.00% of group I and 86.67% of group II were considered to have a stable disease, with 20% of group I and none of group II had partial response (p = 0.027). However, after the fourth cycle, there were no significant difference between the groups (p = 0.734). Conclusion In EGFR mutation-negative NSCLC patients, the combination of vinorelbine and carboplatin showed comparable outcomes to vinorelbine and cisplatin chemotherapy with no significant differences.

scholarly journals The Relationship of Perceived Body Image, Body Mass Index and Physical Activity with Weight Status among Students at King Abdulaziz University Hospital

2021 ◽  
pp. 218-227
Author(s):  
Futoon S. Alobiri ◽  
Roaa A. Alharbi ◽  
Mohammed R. Algethami ◽  
Raghdah H. Ateeq ◽  
Aseel M. Badurayq ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Image ◽  
Body Weight ◽  
Body Mass ◽  
Body Satisfaction ◽  
Weight Status ◽  
Rating Scale ◽  
Significant Difference ◽  
King Abdulaziz University

Aim: Identify the relation between poor esteem for body image and weight-related behaviors. The results will help increase awareness and improve students’ lifestyles to have a better body image and achieve ideal body weight. Methods: A cross-sectional study was conducted among King Abdulaziz University medical students (n= 460) between July to the end of August 2019. Data was collected using the International physical activity questionnaire (IPAQ), figure rating scale (FRS) and analyzed using SPSS software. Result: The results showed that the average Body Mass Index (BMI) was 24.80 ± 11.89. Participant sex was an important factor influencing the prevalence of obesity; male students were more obese than female students with a significant difference (p<0.001). The level of body satisfaction was also affected by gender. Students in preclinical years were more likely to gain weight more than clinical years students. Conclusion: The results show a significant relationship between body satisfaction and gender (P<0.0001) despite having diverse BMIs. Overweight and obese males and females' participants had the lowest body satisfaction. Females who were too thin and had low BMIs described themselves as normal, while males describe themselves as too thin. Conversely, females with high BMIs described themselves as too fat, while males described themselves as normal. This could be due to different factors. Also, underweight females and males have high body satisfaction, which can lead to dangerous behaviors to maintain low body weight which cause negative health consequences.

scholarly journals CORRELAÇÃO ENTRE OBESIDADE/SOBREPESO E PRESSÃO ARTERIAL ELEVADA EM ESCOLARES DE UMA CIDADE DO INTERIOR DE SÃO PAULO

2019 ◽  
Vol 11 (1) ◽  
pp. 51-56
Author(s):  
Marcelo José Alves ◽  
Victor Hugo Santos Zangirolamo ◽  
Carlos Augusto Carvalho Filho ◽  
Everton Alex Carvalho Zanuto ◽  
Diane de Vasconcelos Barrionuevo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Standard Deviation ◽  
Physical Inactivity ◽  
Pediatric Population ◽  
The Body ◽  
Chronological Age ◽  
Hemodynamic Variables

Currently the Brazilian pediatric population has been exposed to risk factors caused by physical inactivity and poor diet, resulting in an increase in the Body Mass Index (BMI), which can lead to vascular problems even in childhood. The objectivewasto verify the influence of BMIon pressure levels. The sample consisted of 61 children of both sexes, chronological age between six and seven years and regularly enrolled/attending school. These children were evaluated in their hemodynamic variables (systolic -SBP and diastolic –DBP blood pressure), body weight, and height. Mean and standard deviation of participants' ages were 7±0.3 years, SBP had 89.4±10 and DBP of 57±6.9, eutrophic patients had 88.7±1.1 for SBP and 56±5 for DBP,and for those with overweight/obesityof109±5 for SBP and 70.7±8.2 for PAD(p=0.0001).Pearson's correlation for BMI with SBP and DBP was moderate for both, but with beta of 1.53 in linear regression for SBP and 0.96 for DBP. It was concluded thatBMI directly influences systolic and diastolic blood pressure levels and the control of overweight / obesity is necessary at the initial ages of life

scholarly journals Penggunaan Hasil Fermentasi Bungkil Kedelai Dalam Ransum Terhadap Pertumbuhan Ayam Pedaging

2001 ◽  
Vol 2 (2) ◽  
pp. 26-31
Author(s):  
Al Qudri
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Soybean Oil ◽  
Energy Content ◽  
Body Weight Gain ◽  
The Body ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Fermented Soybean ◽  
Significant Difference

ABSTRACT. Tempe of soybean is fermented soybean with Rhizopus ologosporus fungus. From a result of researchers, it is the fact that tempe can increase valuable of nutrion and digest capacity and also produce antibiotic . Utilization of abtibiotic in chiken food as stimulus growth in not recommended because it can cause resistance a certain germ and it is presume there are antibiotic residu in egg and chiken meat. It is hope that the use of fermented soybean oil meal can increase nutrient value and digest capacity as well as produce antibiotic, so that it can get a better growth and over come a problem of using antibiotic in chiken food. The study was conducted to evaluate the effect of fermented soybean oil meal utilization in the ration on body weight gain, feed consumption, feed conversion and mortality. The study use 80 unsex day old chick broiler CP-707 and conducted at Poulty Laboratory Product Agriculture Faculty, Syiah Kuala University. Chiken were putting in 27 houses unit, each unit contain of four chiken. The design of experiment was Completely Randomized Design, four treatments and five replication. The treatments were ration contained 0%, 5%, 10% and 15% fermented soybean oil meal as replace the use of soybean oil meal. The protein and energy content of all dietary treatments were equally composed from six weeks investigation, were body weight gain, feed consumption, feed conversion and mortality. The result of the study indicated that up to 10% graded of fermented soybean oil meal in ration were significant difference influenced increase the body weight gain and decrease the feed conversion. The fermented soybeanoil meal) utilization more than 10% were significant difference decrease the body weight gain and increase the feed conversion. If the inclusion was increase the feed consumption would tendency decline. In this study there were no mortality in all treatment. In can be advised from this study that fermented soybean oil meal could be used in broiler ration or in all poulty ration.

scholarly journals The effect of red-fleshed pitaya (Hylocereus polyrhizus) on heat shock protein 70 and cortisol expression in strenuous exercise induced rats

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 130
Author(s):  
Novita Sari Harahap ◽  
Aznan Lelo ◽  
Ambrosius Purba ◽  
Awaluddin Sibuea ◽  
Rina Amelia ◽  
...  
Keyword(s):  
Body Weight ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
The Body ◽  
Male Rats ◽  
Strenuous Exercise ◽  
Hsp70 Expression ◽  
Average Weight ◽  
Significant Difference

Background: Oxidative stress from exercise can contribute to damaging cells, increasing heat shock protein 70 (HSP70) and suppressing the immune system in the body. This research aimed to determine the antioxidant potential of red-fleshed pitaya extract on HSP70 and cortisol expression in rats which were subjected to strenuous exercise. Methods: The subjects of this research were 32 Sprague Dawley male rats, aged 3 months, with an average weight of 200 g. Red-fleshed pitaya extract was obtained from methanol extraction process; a maceration technique was performed and the extract was concentrated using an air-drying method. Rats were randomly divided into four groups. Group 1 were subjected to strenuous exercise and treated with distilled water only; while Groups 2, 3 and 4 were subjected to strenuous exercise and treated with 100 mg/kg body weight, 200 mg/kg body weight and 300 mg/kg body weight of red-fleshed pitaya extract, respectively. Strenuous exercises in rats was performed by intense swimming of 20 min/day, 3 days a week for 3 weeks. HSP70 expression and cortisol were measured with Enzyme-Linked Immune Sorbent Assay (ELISA) method. Results: There was a significant reduction of HSP70 (p=0.000) and cortisol expression (p=0.000) between the groups. Also, there was a significant difference in the average decreasing of HSP70 expression between group 4 and either groups 1 or 2 (p=0.000). However, a significant difference between groups 4 and 3 was not observed (p=0.813). Lastly, a significant difference was found in the average decrease of cortisol expression between groups 4 and 1 (p=0.000), 2 (p=0.000), and 3 (p=0.000) respectively. Conclusion: Red-fleshed pitaya is potential to be utilized as antioxidant to decrease the HSP70 and cortisol expression.

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