scholarly journals Effects of Osteocyte Apoptosis on Bone Cell Proliferation and Recruitment

2014 ◽  
Vol 35 (1) ◽  
pp. 23-34
Author(s):  
이희수 ◽  
Seong-Hee Ko
Keyword(s):  
Cell Proliferation ◽  
Bone Cell ◽  
Osteocyte Apoptosis ◽  
Bone Cell Proliferation

Effects of osteocyte apoptosis on bone cell proliferation and recruitment

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S146
Author(s):  
S.H. Kim ◽  
J.H. Lee ◽  
H.S. Lee ◽  
S.-H. Ko
Keyword(s):  
Cell Proliferation ◽  
Bone Cell ◽  
Osteocyte Apoptosis ◽  
Bone Cell Proliferation

Effects of parathyroid hormone and agonists of the adenylyl cyclase and protein kinase C pathways on bone cell proliferation

Bone ◽  
1996 ◽  
Vol 18 (1) ◽  
pp. 59-65 ◽  
Author(s):  
M. Sabatini ◽  
C. Lesur ◽  
M. Pacherie ◽  
P. Pastoureau ◽  
N. Kucharczyk ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase C ◽  
Parathyroid Hormone ◽  
Protein Kinase ◽  
Adenylyl Cyclase ◽  
Bone Cell ◽  
Kinase C ◽  
Bone Cell Proliferation

Magnetoelectric 3D scaffolds for enhanced bone cell proliferation

2019 ◽  
Vol 16 ◽  
pp. 290-300 ◽  
Author(s):  
Fajer Mushtaq ◽  
Harun Torlakcik ◽  
Queralt Vallmajo-Martin ◽  
Erdem Can Siringil ◽  
Jianhua Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bone Cell ◽  
3D Scaffolds ◽  
Bone Cell Proliferation

Superparamagnetic nano-composite scaffolds for promoting bone cell proliferation and defect reparation without a magnetic field

RSC Advances ◽  
2012 ◽  
Vol 2 (33) ◽  
pp. 13007 ◽  
Author(s):  
Kuilin Lai ◽  
Wen Jiang ◽  
James. Z. Tang ◽  
Yao Wu ◽  
Bin He ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Cell Proliferation ◽  
Bone Cell ◽  
Composite Scaffolds ◽  
Nano Composite ◽  
Bone Cell Proliferation

Progesterone and promegestone stimulate human bone cell proliferation and insulin-like growth factor-2 production

1992 ◽  
Vol 126 (4) ◽  
pp. 329-337 ◽  
Author(s):  
Florence A Tremollieres ◽  
Donna D Strong ◽  
David J Baylink ◽  
Subburaman Mohan
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Bone Formation ◽  
Conditioned Medium ◽  
Bone Cell ◽  
Human Bone ◽  
Osteoblastic Cells ◽  
Human Bone Cell ◽  
Bone Cell Proliferation ◽  
Human Osteoblastic Cells

Recent clinical studies suggest that progesterone may be involved in the regulation of bone turnover and could promote bone formation. This study was undertaken to evaluate whether progesterone and promegestone (a 19 nor-PG derivative) may have a direct effect on human bone cells and, if so, whether growth factor production could be involved in promoting this effect. The osteosarcoma cell line TE85 and untransformed normal human osteoblastic cells derived from iliac crest were used as in vitro model systems. Progesterone and promegestone were found to significantly increase [3H]thymidine incorporation in TE8 5 cells in a dose-dependent manner at concentrations ranging from 10−12to 10−8 mol/l after four days of cultivation (p<0.01, ANOVA). Consistent with this response in the TE85 cells, progesterone and promegestone increased cell number in human osteoblastic cells after six days of treatment (p<0.05. ANOVA). To determine whether this effect on cell proliferation was mediated by the insulin-like growth factor (IGF) regulatory system, the levels of IGF-1, IGF-2 and IGF binding protein (IGFBP) were measured in the conditioned media of both TE85 and human osteoblast cells. While no significant changes in IGF-1 levels were found in the conditioned media of progesterone and promegestone treated cultures, progesterone and promegestone at the concentration of 5 nmol/l significantly increased IGF-2 levels 2.4 and 1.5-fold respectively, at 48 h in the conditioned medium of TE8 5 cells as compared to control. Similarly, a 4.1 and 1.9-fold increase in IGF-2 levels was found upon treatment with progesterone and promegestone in human osteoblastic cells. Consistent with the increased secretion of IGF-2 into the conditioned medium, IGF-2 mRNA levels were found to be increased in TE85 cells. A 4.9 kb transcript was increased 2.7 and 3.7-fold respectively after 6 h of exposure to 5 nmol/l of progesterone and promegestone as compared to control. Western ligand blot analysis of conditioned medium collected from TE85 and human osteoblast cell cultures treated with progesterone and promegestone revealed no changes in the levels of IGFBP-3 and IGFBP-4 after 48 h of treatment. Consistent with these results, the IGFBP-4 mRNA level was unaffected. These data suggest that both progesterone and promegestone stimulate human bone cell proliferation and that the mechanism may in part involve increased IGF-2 secretion. Because IGF-2 has been proposed to play a potential role in the coupling of bone formation to bone resorption, it follows that progesterone deficiency may be involved in the uncoupling that occurs in postmenopause. In any case, the findings that progesterone and promegestone have direct effects on bone formation could have physiological implications.

Vanadate Stimulates Bone Cell Proliferation and Bone Collagen Synthesisin Vitro*

Endocrinology ◽  
1988 ◽  
Vol 123 (6) ◽  
pp. 2858-2867 ◽  
Author(s):  
K.-H. WILLIAM LAU ◽  
HIROMICHI TANIMOTO ◽  
DAVID J. BAYLINK
Keyword(s):  
Cell Proliferation ◽  
Bone Cell ◽  
Bone Collagen ◽  
Bone Cell Proliferation

bFGF enhances human bone cell proliferation in bone allografts in vitro

Bone ◽  
1996 ◽  
Vol 19 (3) ◽  
pp. 140
Author(s):  
C. Fölsch ◽  
A. Brink ◽  
A. Battmann ◽  
A. Schulz
Keyword(s):  
Cell Proliferation ◽  
Bone Cell ◽  
Human Bone ◽  
Human Bone Cell ◽  
Bone Allografts ◽  
Bone Cell Proliferation
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