A case of drug-induced hypersensitivity syndrome manifesting as toxic epidermal necrolysis-like skin lesions and severe liver injury

2020 ◽  
Keyword(s):  
Liver Injury ◽  
Toxic Epidermal Necrolysis ◽  
Hypersensitivity Syndrome ◽  
Skin Lesions ◽  
Severe Liver ◽  
Drug Induced

scholarly journals A case of drug-induced toxic epidermal necrolysis complicated with severe liver injury.

Kanzo ◽  
1988 ◽  
Vol 29 (7) ◽  
pp. 949-955 ◽  
Author(s):  
Kazuhiro MATSUEDA ◽  
Yoshiko MATSUOKA ◽  
Motowo MIZUNO ◽  
Toshihiro HIGASHI ◽  
Minoru UKIDA ◽  
...  
Keyword(s):  
Liver Injury ◽  
Toxic Epidermal Necrolysis ◽  
Severe Liver ◽  
Drug Induced

Drug-induced hypersensitivity syndrome and toxic epidermal necrolysis. Treatment with N-acetylcysteine

1997 ◽  
Vol 136 (4) ◽  
pp. 645-646 ◽  
Author(s):  
P. Redondo ◽  
I. de Felipe ◽  
A. de la Pena ◽  
J.M. Aramendia ◽  
V. Vanaclocha
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Hypersensitivity Syndrome ◽  
Drug Induced

scholarly journals Drug-induced liver injury associated with stevens-Johnson syndrome/toxic epidermal necrolysis: Patient characteristics, causes, and outcome in 36 cases

Hepatology ◽  
2015 ◽  
Vol 63 (3) ◽  
pp. 993-999 ◽  
Author(s):  
Harshad Devarbhavi ◽  
Sujata Raj ◽  
Venu H. Aradya ◽  
Vijaykumar T. Rangegowda ◽  
Girish P. Veeranna ◽  
...  
Keyword(s):  
Liver Injury ◽  
Toxic Epidermal Necrolysis ◽  
Patient Characteristics ◽  
Stevens Johnson Syndrome ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Johnson Syndrome

scholarly journals Sorafenib-Induced Liver Failure: A Case Report and Review of the Literature

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Anneleen Van Hootegem ◽  
Chris Verslype ◽  
Werner Van Steenbergen
Keyword(s):  
Liver Failure ◽  
Lung Metastases ◽  
Hypersensitivity Syndrome ◽  
Phase Iii ◽  
Severe Liver ◽  
Drug Induced ◽  
Randomized Controlled ◽  
Phase Iii Trials ◽  
Severe Liver Dysfunction ◽  
Type Of Injury

In patients with hepatocellular carcinoma characterized by vascular invasion and/or extrahepatic disease, Sorafenib is considered treatment of choice. Although mild liver test abnormalities were reported in less than 1% of the patients in the two large randomized, controlled phase III trials, four cases of severe acute Sorafenib-induced hepatitis have been described. One of these four cases died from liver failure. In this paper, a patient with HCC with lung metastases developed high fever and a severe hepatitis that rapidly evolved into liver coma and death, two weeks after the initiation of Sorafenib. Biochemical parameters pointed to a hepatocellular type of injury. Clinical and biochemical presentations were compatible with a drug-induced hypersensitivity syndrome such as it has mainly been described for aromatic anticonvulsants, sulphonamides, and allopurinol. We hypothesize that an underlying cytochrome P450 dysfunction with the presence of reactive drug metabolites might lead to this potentially fatal Sorafenib-induced severe liver dysfunction.

A Case of Drug-induced Hypersensitivity Syndrome with the Features of Toxic Epidermal Necrolysis

2009 ◽  
Vol 71 (6) ◽  
pp. 584-588 ◽  
Author(s):  
Kenji HIROSE ◽  
Yoshihiro MATSUDATE ◽  
Yasutoshi HIDA ◽  
Shin-ichi ANSAI ◽  
Yoshiaki KUBO ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Hypersensitivity Syndrome ◽  
Drug Induced

The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda

Lupus ◽  
2018 ◽  
Vol 27 (8) ◽  
pp. 1383-1386 ◽  
Author(s):  
B Sunkara ◽  
D Roofeh ◽  
S Silver ◽  
T LeBleu Pearson ◽  
M Ettel ◽  
...  
Keyword(s):  
Liver Injury ◽  
Lupus Erythematosus ◽  
Porphyria Cutanea Tarda ◽  
Cutaneous Lupus Erythematosus ◽  
Antibody Test ◽  
Skin Lesions ◽  
Drug Induced ◽  
Naive Patient ◽  
Drug Induced Liver Injury ◽  
Cutaneous Lupus

A 29-year-old woman with a 1.5 year history of photosensitive skin lesions on her hands presented with a malar rash, bullous lesions on her hands, and was diagnosed with subacute lupus erythematosus after serologies revealed a positive antinuclear antibody test (1:2560), and antibodies to Ro/SSA and dsDNA. Hydroxychloroquine (400 mg/day) was prescribed and the patient developed severe drug-induced liver injury. Biopsy of her bullous skin lesions was consistent with porphyria cutanea tarda, as were her serological and urinary exams. She was successfully treated with therapeutic phlebotomy. This case identifies porphyria cutanea tarda as an important differential diagnosis for the rheumatologist to consider when evaluating patients with bullous skin lesions. Hydroxychloroquine in lower doses is an effective treatment for porphyria cutanea tarda; at doses used to treat systemic lupus erythematosus and subacute cutaneous lupus, there is a potentially life-threatening complication of hepatotoxicity.

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