scholarly journals Design and development of experimental models for textile structures integrated in wound dressings applied in curative therapy of inflammatory skin diseases, using specific instruments of descriptive statistics

2021 ◽  
Vol 72 (05) ◽  
pp. 579-584
Author(s):  
CARMEN MIHAI ◽  
CRISTINA GROSU ◽  
LAURA CHIRILA ◽  
SABINA OLARU ◽  
ALINA POPESCU

Wound dressing is a key factor of the wound management system, having as main objective the stimulation of the healing process for a variety of inflammatory skin diseases. To maximize the therapeutic effects, innovative medical devices with integrated drug delivery system become of real interest during the last decade. For the realization of the optimal woven fabrics used as a substrate for various active principles, such as propolis and cinnamon essential oil, the multivariate linear regression analysis was used to elaborate the conceptual models on the basis of which the experimental models of the textile supports were designed. Using as input data the characteristics of the selected yarns (breaking force, elongation at break, torsion/twist, hygroscopicity), one can predict the structural parameters of the woven fabrics (raw materials, yarn density, lengths of the underlaps) and also the assembly and adjusting parameters for the machinery from weaving preparation and weaving sectors (advance and height of the drum, reed width, drawing-in, input/output of the gripper, cross unevenness reed, stationary in maximum open lease, the moment of the grippers opening, impulse time, the moment of the shaft smoothening, etc.). The validation of the elaborated conceptual models it was confirmed by the registered yields in the range of 88–96 %, during the weaving process

2019 ◽  
Vol 21 (1) ◽  
pp. 80
Author(s):  
Ilja L. Kruglikov ◽  
Philipp E. Scherer

Caveolin-1 is strongly expressed in different dermal and subdermal cells and physically interacts with signaling molecules and receptors, among them with transforming growth factor beta (TGF-β), matrix metalloproteinases, heat shock proteins, toll-like and glucocorticoid receptors. It should therefore be heavily involved in the regulation of cellular signaling in various hyperproliferative and inflammatory skin conditions. We provide an overview of the role of the caveolin-1 expression in different hyperproliferative and inflammatory skin diseases and discuss its possible active involvement in the therapeutic effects of different well-known drugs widely applied in dermatology. We also discuss the possible role of caveolin expression in development of the drug resistance in dermatology. Caveolin-1 is not only an important pathophysiological factor in different hyperproliferative and inflammatory dermatological conditions, but can also serve as a target for their treatment. Targeted regulation of caveolin is likely to serve as a new treatment strategy in dermatology.


Author(s):  
Petra Staubach ◽  
Natascha Plavic‐Radeka ◽  
Adriane Peveling‐Oberhag ◽  
Anna Sohn ◽  
Sebastian Zimmer ◽  
...  

2021 ◽  
Vol 141 (9) ◽  
pp. B18
Author(s):  
P. Mande ◽  
S. Borthakur ◽  
D. Rios ◽  
P. Halvey ◽  
A. Boisvert ◽  
...  

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