scholarly journals Nanofibres made from biocompatible and biodegradable polymers, with potential application as medical textiles

2018 ◽  
Vol 69 (01) ◽  
pp. 55-58 ◽  
Author(s):  
SUBTIRICA ADRIANA-IOANA ◽  
BANCIU CRISTINA ANTONELA ◽  
CHIVU ANDREEA ANA-MARIA ◽  
LAURENTIU CHRISTIAN DINCA
Keyword(s):  
Biodegradable Polymers ◽  
Textile Industry ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Electrospinning Process ◽  
High Porosity ◽  
Medical Textiles ◽  
Small Pore

An important and growing part of the textile industry is the medical and related healthcare and hygiene sector. Recently, ultrafine fiber webs made from biocompatible and biodegradable polymers have been obtained by the electrospinning process. Their unique properties such as high surface area-to-volume ratio, small pore sizes, high porosity, and the possibility of incorporation therapeutic compounds into the electrospun nanofibers has attracted the researcher’s attention lately. This paper presents the obtaining of PEO and PVA nanofibers.

scholarly journals Electrospun Nanofibers for Sensing and Biosensing Applications—A Review

2021 ◽  
Vol 22 (12) ◽  
pp. 6357
Author(s):  
Kinga Halicka ◽  
Joanna Cabaj
Keyword(s):  
High Surface ◽  
High Surface Area ◽  
Toxic Metal ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Clinical Diagnostics ◽  
Loading Capacity ◽  
Electrospun Nanofiber ◽  
Sensing Platforms ◽  
Different Types

Sensors and biosensors have found applications in many areas, e.g., in medicine and clinical diagnostics, or in environmental monitoring. To expand this field, nanotechnology has been employed in the construction of sensing platforms. Because of their properties, such as high surface area to volume ratio, nanofibers (NFs) have been studied and used to develop sensors with higher loading capacity, better sensitivity, and faster response time. They also allow to miniaturize designed platforms. One of the most commonly used techniques of the fabrication of NFs is electrospinning. Electrospun NFs can be used in different types of sensors and biosensors. This review presents recent studies concerning electrospun nanofiber-based electrochemical and optical sensing platforms for the detection of various medically and environmentally relevant compounds, including glucose, drugs, microorganisms, and toxic metal ions.

Preparation of Electrospun PLA Nanofiber Scaffold and the Evaluation In Vitro

2005 ◽  
Vol 288-289 ◽  
pp. 139-142 ◽  
Author(s):  
Xian Tao Wen ◽  
Hong Song Fan ◽  
Yan Fei Tan ◽  
H.D. Cao ◽  
H. Li ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
High Surface ◽  
Volume Ratio ◽  
Electrospinning Process ◽  
High Porosity ◽  
Electrospun Scaffold ◽  
Nanofiber Scaffold ◽  
Soft Tissue Engineering

A electrospinning process to prepare soft tissue engineering scaffold was introduced in this study. This kind of scaffold was composed with ultrathin fiber and characterized with high porosity, well-interconnected pores and high surface-to-volume ratio. Biodegradable polylaticacid (PLA) was used to spin the scaffold and the scaffold was evaluated in vitro by analysis the microscopic structure, porosity, mechanical property, especially cytocompatibility. The results indicated that the electrospun PLA scaffold showed good cytocompatibility and the tensile property of electrospun scaffold was similar to human’s soft tissue. It could be expected that the electrospun scaffold would be potential in soft tissue engineering or soft tissue repair.

scholarly journals Research Progress on the Applications of Electrospun Nanofibers in Catalysis

Catalysts ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 9
Author(s):  
M. Olga Guerrero-Pérez
Keyword(s):  
Low Cost ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Internal Diffusion ◽  
Research Progress ◽  
Bibliographic Analysis ◽  
Low Resistance ◽  
Electro Catalysis

During the last two decades, electrospinning has become a very popular technique for the fabrication of nanofibers due to its low cost and simple handling. Nanofiber materials have found utilization in many areas such as medicine, sensors, batteries, etc. In catalysis, these materials also present important advantages, since they present a low resistance to internal diffusion and a high surface area to volume ratio. These advantages are mainly due to the diameter–length proportion. A bibliographic analysis on the applications of electrospun nanofibers in catalysis shows that there are two important groups of catalysts that are being investigated, based on TiO2 and in carbon materials. The main applications found are in photo- and in electro-catalysis. The present study contributes by reviewing these catalytic applications of electrospun nanofibers and demonstrating that they are promising materials as catalysts, underlining some works to prove the advantages and possibilities that these materials have as catalysts. On one hand, the possibilities of synthesis are almost infinite, since with coaxial electrospinning quite complex nanofibers with different layers can be prepared. On the other hand, the diameter and other properties can be controlled by monitoring the applied voltage and other parameters during the synthesis, being quite reproducible procedures. The main advantages of these materials can be grouped in two: one related to their morphology, as has been commented, relative to their low resistance and internal diffusion, that is, their fluidynamic behavior in the reactor; the second group involves advantages related to the fact that the active phases can be nanoscaled and dispersed, improving the activity and selectivity in comparison with conventional catalytic materials with the same chemical composition.

scholarly journals Nanotechnology and Its Applications to Medicine: an over view

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H Ibrahim
Keyword(s):  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrospinning Process ◽  
Nano Particles ◽  
High Production Rate ◽  
Nano Fiber ◽  
Nano Medicine ◽  
Bio Compatibility

Abstract Nowadays there are more interesting with nanotechnology and its applications in several sectors specially in medicine for diagnoses, therapeutic and research biomedical tools. It can be defined as any process or technique used to produce material in nano-scale structure with particle size ranged from 1-100 nm. The utilization of nanotechnology in human health benefits known as nano medicine. So that nanotechnology has firmly entered the drug delivery realm to maximize drug therapeutic activity and minimize its undesirable side effects. Herein we deal with both nanoparticles and nano-fibers and their applications in medical field. Nano-particles have unique properties from its small size with high surface area therefore it provides larger than particle numbers from that prepared with convention methods. In addition, nanoparticles can be used to improve various drug bio-availability from its biodegradability and bio-compatibility. Nano-fibers have huge surface area to volume ratio which increase its performance in several applications. Nano-fiber produced via electrospinning process (simple and have high production rate). It can be used in many applications such as water filtration, tissue engineering scaffold, wounds, fiber composites, drug release and protective clothes.

Apatite Forming Ability of a Non-Woven Silica Fabric Containing Calcium

2007 ◽  
Vol 330-332 ◽  
pp. 699-702 ◽  
Author(s):  
Sang Hoon Rhee ◽  
Il Yong Chung ◽  
Yong Keun Lee ◽  
Bum Soon Lim ◽  
Yang Jo Seol
Keyword(s):  
Electric Field ◽  
Bone Grafting ◽  
Salt Water ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
High Porosity ◽  
Heat Treated ◽  
High Voltage Supply ◽  
Low Crystalline

Non-woven silica fabric was made by electro-spinning method for the potential application as a bone grafting material. The silica gel, the source material for electro-spinning, was prepared by the hydrolysis of tetraethyl orthosilicate in the presence of calcium salt, water, hydrochloric acid and ethanol. It was transferred to a syringe, which was connected to the high voltage supply generating a high electric field between the spinneret and the ground collecting drum. The silica fibers containing calcium were spun under the electric field of 2 KV/cm. Their diameters were in the range from about 0.3 μm to 8 μm. It was heat-treated at 300 oC for 3 hours. After soaking in the SBF for 1 week, low crystalline apatite crystals were observed to occur on their surfaces. From the results, it can be concluded that the non-woven silica fabric containing calcium made by electro-spinning method and then heat-treated has a bioactivity. It means it has a potential to be used as a bone grafting material because of its apatite-forming ability, high surface area to volume ratio and high porosity.

scholarly journals Perspective on Nanofiber Electrochemical Sensors: Design of Relative Selectivity Experiments

Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3706
Author(s):  
Stanley G. Feeney ◽  
Joelle M. J. LaFreniere ◽  
Jeffrey Mark Halpern
Keyword(s):  
Electrochemical Sensors ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrochemical Sensing ◽  
High Porosity ◽  
Specific Recognition ◽  
Materials Used ◽  
New Applications ◽  
Speed And Accuracy

The use of nanofibers creates the ability for non-enzymatic sensing in various applications and greatly improves the sensitivity, speed, and accuracy of electrochemical sensors for a wide variety of analytes. The high surface area to volume ratio of the fibers as well as their high porosity, even when compared to other common nanostructures, allows for enhanced electrocatalytic, adsorptive, and analyte-specific recognition mechanisms. Nanofibers have the potential to rival and replace materials used in electrochemical sensing. As more types of nanofibers are developed and tested for new applications, more consistent and refined selectivity experiments are needed. We applied this idea in a review of interferant control experiments and real sample analyses. The goal of this review is to provide guidelines for acceptable nanofiber sensor selectivity experiments with considerations for electrocatalytic, adsorptive, and analyte-specific recognition mechanisms. The intended presented review and guidelines will be of particular use to junior researchers designing their first control experiments, but could be used as a reference for anyone designing selectivity experiments for non-enzymatic sensors including nanofibers. We indicate the importance of testing both interferants in complex media and mechanistic interferants in the selectivity analysis of newly developed nanofiber sensor surfaces.

scholarly journals Applications of electrospun nanofibers in the biomedical field

SURG Journal ◽  
2012 ◽  
Vol 5 (2) ◽  
pp. 63-73 ◽  
Author(s):  
Nishath Khan
Keyword(s):  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Ease Of Use ◽  
The Past ◽  
Wide Range ◽  
Novel Method ◽  
Biomedical Field ◽  
Highly Porous

Electrospinning is a technology that has been widely used as a novel method for the generation of nano scale fibres. Electrospun fibres are used in a wide range of applications from electronics to textile. The viability and popularity of this technology can be evidenced by its ease of use and the simplicity of the science behind building the electrospinning machine. The generated fibres have a high surface area- to- volume ratio, the fibrous mats are highly porous and display excellent mechanical properties when compared to other materials of the same scale. In the past decade, this technology has taken off with the use of biocompatible and biodegradable polymers. This review is a summary of the different ways in which electrospinning can be used in the biomedical field. This article analyzes the recent advances of this technology in tissue engineering, drug delivery and in enzyme immobilisation, which once again showcases the versatility of the electrospinning procedure.

scholarly journals Electrospun nanofibers: A nanotechnological approach for drug delivery and dissolution optimization in poorly water-soluble drugs

ADMET & DMPK ◽  
2020 ◽  
Author(s):  
Luis Castillo-Henríquez ◽  
Rolando Vargas-Zúñiga ◽  
Jorge Pacheco-Molina ◽  
Jose Vega-Baudrit
Keyword(s):  
Drug Delivery ◽  
High Surface ◽  
High Surface Area ◽  
Electrospun Nanofibers ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Small Pore ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Surface Morphologies

<p class="ADMETabstracttext">Electrospinning is a novel and sophisticated technique for the production of nanofibers with high surface area, extreme porous structure, small pore size, and surface morphologies that make them suitable for biomedical and bioengineering applications, which can provide solutions to current drug delivery issues of poorly water-soluble drugs. Electrospun nanofibers can be obtained through different methods asides from the conventional one, such as coaxial, multi-jet, side by side, emulsion, and melt electrospinning. In general, the application of an electric potential to a polymer solution causes a charged liquid jet that moves downfield to an oppositely charged collector, where the nanofibers are deposited. Plenty of polymers that differ in their origin, degradation character and water affinity are used during the process. Physicochemical properties of the drug, polymer(s), and solvent systems need to be addressed to guarantee successful manufacturing. Therefore, this review summarizes the recent progress in electrospun nanofibers for their use as a nanotechnological tool for dissolution optimization and drug delivery systems for poorly water-soluble drugs.</p>

scholarly journals Size Also Matters in Biodegradable Composite Microfiber Reinforced by Chitosan Nanofibers

2014 ◽  
Vol 1621 ◽  
pp. 59-69
Author(s):  
Elisabete D. Pinho ◽  
Albino Martins ◽  
José V. Araújo ◽  
Rui L. Reis ◽  
Nuno M. Neves
Keyword(s):  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Electrospun Nanofibers ◽  
Butylene Succinate ◽  
Biodegradable Composite ◽  
Biological Performance ◽  
Different Diameters ◽  
Kinetics Of

ABSTRACTPioneer works on nanocomposites were focused in carbon nanofibers or nanotubes dispersed in epoxy matrix, a viscous liquid facilitating the compounding stage. The interest in developing new composites aimed for biomedical applications led us to design new nanocomposites based in biodegradable polymers with demonstrated biological performance.We report herein the development of micro-nano composites by extruding poly(butylene succinate) (PBS) microfibers with two different diameters, 200 and 500 µm, reinforced with electrospun chitosan nanofibers. Analysis of the microfibers showed high levels of alignment of the reinforcing phase and excellent distribution of the nanofibers in the composite. Its geometry facilitates the development of orthotropy, maximizing the reinforcement in the axial fiber main axis.The biodegradable microfiber composites show an outstanding improvement of mechanical properties and of the kinetics of biodegradation, with very small fractions (0.05 and 0.1 wt.%) of electrospun chitosan nanofibers reinforcement. The high surface area-to-volume ratio of electrospun nanofibers combined with the increased water uptake capability of chitosan justify the accelerated kinetics of biodegradation of the composite as compared with the unfilled synthetic polymer.

scholarly journals Electrospinning Nanotechnology-A Robust Method for Preparation of Nanofibers for Medicinal and Pharmaceutical Application.

2020 ◽  
Vol 8 (3) ◽  
pp. 176-184
Author(s):  
Bhadarge Meghana ◽  
Dhas Umesh ◽  
Shirode Abhay ◽  
Kadam Vilasrao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Delivery Systems ◽  
Successful Implementation ◽  
Theoretical Principle ◽  
High Porosity ◽  
Pharmaceutical Application

Nanotechnology has evolved as a preferred choice in current research arena due to the advantages offered by it. The current research in pharmaceutical development is all about exploring and/or adopting different approaches for preparation of nanostructured drug delivery systems. Electrospinning nanotechnology has made its mark as a technology of choice for preparation of nanofibers for different applications. Electrospinning is a novel, robust and efficient fabrication process that is widely accepted and used to assemble nanofibers with distinct features such as length of several kilometers and diameter less than 300 nm. One of the most striking features of nanofibers is that they provide exceptionally high surface area-to-volume ratio and high porosity, making them a robust and attractive candidate for many advanced applications. Many researchers working on development of medicinal and pharmaceutical product design and development have reported their studies indicating successful implementation of electrospinning nanotechnology for preparation of nanofibers with distinct medicinal and pharmaceutical drug delivery applications. Authors of this article aims to provide a comprehensive review of electrospinning method for preparation of nanofibers with respect to theoretical principle, mechanics of electrospinning, critical process parameters, polymers and drug loaded nanofibers incorporated in different drug delivery systems for various pharmaceutical application.  

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