scholarly journals Green Synthesis of Gold Nanoparticles Mediated by Garcinia Fruits andTheir Biological Applications

2020 ◽  
Vol 27 (2) ◽  
pp. 238-250
Author(s):  
Azazahemad A Kureshi ◽  
Hiral M Vaghela ◽  
Satyanshu Kumar ◽  
Raghuraj Singh ◽  
Premlata Kumari
Keyword(s):  
Gold Nanoparticles ◽  
Green Synthesis ◽  
Cell Line ◽  
Cancer Cell ◽  
Antibacterial Properties ◽  
Cancer Cell Line ◽  
Water Soluble ◽  
Aqueous Extracts ◽  
Bacterial Strains ◽  
Mcf 7

Background: Green synthesis of gold nanoparticles (AuNPs) using medicinal plant extract is an emerging area of research due to their applicability in nanomedicines. Methods: In this study, aqueous extracts prepared from fruit-pericarps of two Garcinia species, G. indica (GI) and G. cambogia (GC) fruits which are important medicinally and commercially have been utilized for the synthesis of AuNPs. Various analytical techniques were utilized to characterize the synthesized AuNPs. The synthesized AuNPs were investigated for their biological properties such as antioxidant activity using the (2,2-diphenyl-1-picrylhydrazyl) DPPH model, cytotoxicity against MCF-7 (breast) cancer cell line, and antibacterial activity against two bacterial strains viz. B. subtilis and E. coli. Results: The absorption peak of the AuNPs is observed at 541 nm using UV–Visible spectroscopy. The high resolution – scanning electron microscopy images showed spherical with a triangular shape AuNPs and their average sizes were ranging from 2 – 10 nm and it was found to be in good agreement with the particle size of 8 – 11 nm determined using X-ray diffraction analysis. Fourier-transform infrared spectroscopy revealed that water-soluble biomolecules from the aqueous extracts of the Garcinia species played a crucial role in the formation of AuNPs. The synthesized AuNPs exhibited considerable cytotoxicity with IC50 values 34.55 µg/ml (GI) and 35.69 µg/ml (GC) against the MCF-7 cancer cell line. Furthermore, synthesized AuNPs also demonstrated significant antioxidant and antibacterial properties comparable to the standards used. Conclusion: AuNPs have been synthesized using a simple green approach. The synthesized AuNPs demonstrated promising cytotoxicity, antioxidant, and antibacterial properties.

Kaempferol mediated synthesis of gold nanoparticles and their cytotoxic effects on MCF-7 cancer cell line

2015 ◽  
Vol 50 (11) ◽  
pp. 1966-1976 ◽  
Author(s):  
Bhuvanasree Srinivas Raghavan ◽  
Sindhu Kondath ◽  
Rajaram Anantanarayanan ◽  
Rama Rajaram
Keyword(s):  
Gold Nanoparticles ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cytotoxic Effects ◽  
Mcf 7

scholarly journals Cellular uptake and toxicity of gold nanoparticles in a tumor-like (hypoxic) environment

2021 ◽  
Author(s):  
Mehrnoosh Neshatian
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Drug Carrier ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell Line ◽  
Hypoxic Conditions ◽  
Hypoxic Environment ◽  
Mcf 7

Cancer cells deprived adequate oxygen tension, are called hypoxic cells. Hypoxic shows resistance to both chemotherapy and/or radiotherapy. On the other hand gold Nanoparticles (GNPs) are being used as promising agents in cancer therapy. GNPs can be used as radiosensitizer and drug carrier agents. It also has been show that uptake of GNPs in normal oxygenated (normoxic) cancer cells is maximum for 50 nm GNPs. However, it is important to know the variation in GNPs uptake and toxicity of 50 nm particles in a tumor-like (hypoxic) environment. Hence, we have investigated toxicity and uptake of 50 nm GNPs in hypoxic cancer cells. MCF-7 (breast cancer cell line) and HeLa (cervical cancer cell line), were used in this study. The results of this study showed that uptake of GNPs in hypoxic cells were dependent on the exposure duration to hypoxic conditions. Cancer cells under prolong hypoxia showed highest GNP uptake.

scholarly journals Gold Nanoparticles from Ostruthin: Green Synthesis, a Stable Mechanism, Antitumor, and Antibacterial Activity

2020 ◽  
Vol 71 (8) ◽  
pp. 220-232
Author(s):  
An Tran Nguyen Minh ◽  
Cuong Nguyen Van ◽  
Quang Nguyen Minh ◽  
Tri Mai Dinh ◽  
Alam Mahboob
Keyword(s):  
Gold Nanoparticles ◽  
Antibacterial Activity ◽  
Antitumor Activity ◽  
Cell Line ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Human Cancer Cell Lines ◽  
Human Liver Cancer ◽  
Mcf 7

The Ostruthin was extracted and identified its structure from rhizomes of Luvunga scandens located at Ta Cu Mountain, Binh Thuan province, Vietnam for the first time. Gold nanoparticles (AuNPs) were synthesized by the green method. The AuNPs acted as antitumor against breast cancer cell line (MCF-7), human liver cancer cell line (HepG2), and Non-Small Cell Lung (NCI-H460). They showed the potential antitumor activity against MCF-7 with the IC50 value of 65.47�3.09 �M. The antitumor activity of the AuNPs was also compared with the extracted constituents from the root of Luvunga Scandens in a previous article. The AuNPs were exposed to high antitumor activity against MCF-7 and Hep G2, human cancer cell lines. The AuNPs have also been tested the antibacterial activity and shown the moderate antibacterial activity on both Salmonella enterica and Bacillus subtilis at a concentration of 0.25 mM.

scholarly journals Cellular uptake and toxicity of gold nanoparticles in a tumor-like (hypoxic) environment

2021 ◽  
Author(s):  
Mehrnoosh Neshatian
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Drug Carrier ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell Line ◽  
Hypoxic Conditions ◽  
Hypoxic Environment ◽  
Mcf 7

Cancer cells deprived adequate oxygen tension, are called hypoxic cells. Hypoxic shows resistance to both chemotherapy and/or radiotherapy. On the other hand gold Nanoparticles (GNPs) are being used as promising agents in cancer therapy. GNPs can be used as radiosensitizer and drug carrier agents. It also has been show that uptake of GNPs in normal oxygenated (normoxic) cancer cells is maximum for 50 nm GNPs. However, it is important to know the variation in GNPs uptake and toxicity of 50 nm particles in a tumor-like (hypoxic) environment. Hence, we have investigated toxicity and uptake of 50 nm GNPs in hypoxic cancer cells. MCF-7 (breast cancer cell line) and HeLa (cervical cancer cell line), were used in this study. The results of this study showed that uptake of GNPs in hypoxic cells were dependent on the exposure duration to hypoxic conditions. Cancer cells under prolong hypoxia showed highest GNP uptake.

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