scholarly journals Antihypertensive drug prescription trends in Shahrekord, Iran

2021 ◽  
Vol 11 (1) ◽  
pp. e13-e13
Author(s):  
Ahmadreza Maghsoudi ◽  
Maryam Dehghani Mobarakeh ◽  
Ali Momeni ◽  
Alireza Nematollahi ◽  
Shahin Asgari ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Antihypertensive Drugs ◽  
Beta Blockers ◽  
Angiotensin Receptor Blockers ◽  
Drug Prescription ◽  
Angiotensin Receptor ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
The Status ◽  
Receptor Blockers

Introduction: Hypertension is one of the most leading causes of death worldwide. It is an important risk factor for ischemic heart disease (IHD), chronic kidney disease (CKD) and cerebrovascular diseases. Objectives: The aim of the study was evaluation of the status of blood pressure control and trends in prescribed antihypertensive medication usage among hypertensive patients in Shahrekord, Iran. Patients and Methods: In a cross-sectional descriptive study 250 hypertensive patients were enrolled. The patients were evaluated based on the status of blood pressure (BP) control and the prescription trends and efficacy of antihypertensive drugs. The data were also evaluated in subgroups of diabetics or non-diabetics, smokers or non-smokers, patients with or without CKD, patients with or without IHD. Results: A total of 250 patients (149 women and 101 men) were enrolled in this study. The mean age of participants was 66.22±13.58 years. Mean systolic and diastolic BP were 143.4±29.4 mm Hg and 85.8±12.5 mm Hg respectively. Poor controlled BP was seen in 106 patients. The more common prescribed antihypertensive drugs were angiotensin receptor blockers (46%), diuretics (33.6%) and beta-blockers (32.8%). Conclusion: The study showed that most of the patients had poor controlled BP and physicians increasingly prescribe angiotensin receptor blockers.

scholarly journals Blood Pressure Control: Stroke and Stroke Prevention

2005 ◽  
Vol 6 (1_suppl) ◽  
pp. S8-S11
Author(s):  
Hans-Christoph Diener
Keyword(s):  
Blood Pressure ◽  
Stroke Prevention ◽  
Antihypertensive Drugs ◽  
Angiotensin Receptor Blockers ◽  
Antihypertensive Agents ◽  
Pressure Control ◽  
Angiotensin Receptor ◽  
Risk Of Death ◽  
Pressure Lowering ◽  
Receptor Blockers

Hypertension is the most important modifiable risk factor for primary and secondary stroke prevention. All antihypertensive drugs are effective in primary prevention: the risk reduction for stroke is 30—42%. However, not all classes of drugs have the same effects: there is some indication that angiotensin receptor blockers may be superior to other classes of antihypertensive drugs in stroke prevention. Seventy-five percent of patients who present to hospital with acute stroke have elevated blood pressure within the first 24—48 hours. Extremes of systolic blood pressure (SBP) increase the risk of death or dependency. The aim of treatment should be to achieve and maintain the SBP in the range 140—160 mmHg. However, fast and drastic blood pressure lowering can have adverse consequences. The PROGRESS trial of secondary prevention with perindopril + indapamide versus placebo + placebo showed a decrease in numbers of stroke recurrences in patients given both active antihypertensive agents, more impressive for cerebral haemorrhage.There were also indications that active treatment might decrease the development of post-stroke dementia.

scholarly journals An observational cross-sectional study to determine the effect of telmisartan on reducing microalbuminuria in diabetic hypertensive patients in tertiary care teaching hospital, Central India

2017 ◽  
Vol 6 (8) ◽  
pp. 2082
Author(s):  
Santenna Chenchula ◽  
Rupesh Gupta ◽  
Balakrishnan S. ◽  
Akash Vishwe ◽  
Pushparaj Gour ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Angiotensin Receptor Blockers ◽  
Tertiary Care ◽  
Channel Blockers ◽  
Angiotensin Receptor ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Urine Albumin ◽  
Receptor Blockers

Background: There are many groups of drugs to decrease microalbuminuria like angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs), calcium channel blockers and direct vasodilators. Among these, ACEI and ARBs are commonly used for this purpose. If side effects occur, ACEI are replaced with ARBs. Many ARBs have been studied for their effect on reducing microalbuminuria, but data on telmisartan with its additional unique properties are scarce in Indian population.Methods: This cross sectional observational study was carried out in a tertiary care centre. We first measured base line urine albumin levels in included patients, 3 months after treatment with telmisartan using ‘hemocue urine albumin analyser’. We collected and compared both baseline and after treatment data of microalbuminuria and analysed in descriptive statistics.Results: A total of 110 patients participated in this study; out of which 10 patients were excluded from the study because they were not available for follow up. As compared to baseline, urine albumin level decreased by 30.42% after 12 weeks treatment with telmisartan (P <0.001).Conclusions: Microalbuminuria is one of the leading cause of end stage renal disease and coronary heart diseases in diabetic hypertensive patients. Drugs like ACE inhibitors, Angiotensin receptor blockers, Calcium channel blockers and direct vasodilators are used to prevent these complications. In this present study, we concluded that telmisartan decreases urine albumin excretion around 30.42% from baseline after 12 weeks of treatment.

scholarly journals Genetic Variants of C-5312TRENIncreased Renin Levels and Diastolic Blood Pressure Response to Angiotensin Receptor Blockers

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Mohammad Saifur Rohman ◽  
Ika Arum Dewi Satiti ◽  
Nashi Widodo ◽  
Mifetika Lukitasari ◽  
Hidayat Sujuti
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Diastolic Pressure ◽  
Blood Pressure Response ◽  
Angiotensin Receptor Blockers ◽  
Pressure Response ◽  
Angiotensin Receptor ◽  
Hypertensive Patients ◽  
Renin Level ◽  
Receptor Blockers

Renin catalyzes the cleavage of angiotensinogen into angiotensin I. Genetic variant C-5312T of renin enhancer has been reported to increase in vitro renin gene transcription. However, no obvious in vivo study was performed to see the renin level in C-5312T when treated with angiotensin receptor blockers (ARB). Therefore, this study aimed to investigate the serum renin level and blood pressure response in ARB treated hypertensive patients. Single nucleotide polymorphism (SNP) of C-5312T was identified in 55 hypertensive patients by using multiplex PCR and renin serum level was assayed by ELISA. The data showed that the increase of serum renin levels after 5 months of ARB treatment was significantly higher in patients with CT/TT genotype (10 pg/mL) than those with CC genotype (4.08 pg/mL) (P= 0.025). Hypertensive patients with CT/TT genotypes also showed less diastolic pressure reduction than CC genotypes in hypertensive patients with valsartan treatment (P= 0.04) or telmisartan treatment (P= 0.03). Finally, these findings suggested that SNP of C-5312TRENenhancer might contribute to higher increased renin serum levels and less diastolic blood pressure response to ARB treatment.

scholarly journals Management of Hypertension in the Elderly Patient at Abidjan Cardiology Institute (Ivory Coast)

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
K. E. Kramoh ◽  
E. Aké-Traboulsi ◽  
C. Konin ◽  
Y. N'goran ◽  
I. Coulibaly ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Enzyme Inhibitors ◽  
Antihypertensive Drugs ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
The Elderly ◽  
Converting Enzyme ◽  
Angiotensin Receptor ◽  
Converting Enzyme Inhibitors ◽  
Receptor Blockers

Background. Since the treatment of hypertension is beneficial for the elderly, we have undertaken this study that aims to evaluate the management of hypertension in elderly patient in Côte d'Ivoire.Methods. A retrospective study was conducted among 854 hypertensive elderly patients of Abidjan Cardiology Institute who were followed for a minimum of one year, between January 2000 and December 2009.Results. The patients mean age was years, and 59% were women. At the first presentation, it was mostly systolic-diastolic hypertension (51.8%) and isolated systolic hypertension (38.5%). Mean blood pressure was  mmHg for systolic,  mmHg for diastolic, and  mmHg for pulse pressure. Pulse pressure was ≥60 mmHg in 80.4%. According to the European Guidelines stratification of the cardiovascular risk-excess attributable to high blood pressure, 82.1% of the sample had a very high added risk. The pharmacological therapy was prescribed in 93.5%. More than 66% of patients were receiving ≥2 antihypertensive drugs including fixed-dose combination drugs. The most common agents used were diuretics (63.5%) followed by angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in 61.3%. The most common agents used for monotherapy were calcium antagonists. When ≥2 drugs were used, diuretics and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were the most common. Blood pressure control was achieved in 42.6%.Conclusion. The control of elderly hypertension can be effective in Sub-Saharan Africa. He required at least two antihypertensive drugs to meet the recommended blood pressure target.

scholarly journals Gambaran Pola Penggunaan Obat Antihipertensi Pada Pasien Rawat Inap di RSUD Panembahan Senopati

2020 ◽  
Vol 1 (2) ◽  
pp. 73
Author(s):  
Anis Febri Nilansari ◽  
Nanang Munif Yasin ◽  
Diah Ayu Puspandari
Keyword(s):  
Ace Inhibitor ◽  
Antihypertensive Drugs ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Receptor ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Use Patterns ◽  
Long Run ◽  
Drug Use Patterns ◽  
Receptor Blockers

ABSTRAKHipertensi hingga kini masih menjadi masalah kesehatan di dunia. Terapi yang diberikan kepada pasien hipertensi biasanya dilakukan dalam jangka panjang. Pengobatan hipertensi yang dilakukan sesuai dengan kondisi pasien. Penelitian ini bertujuan untuk mengetahui gambaran pola penggunaan obat antihipertensi pada pasien rawat inap di RSUD Panembahan Senopati. Penelitian dirancang dengan metode deskriptif crosssectional. Subyek penelitian ialah pasien hipertensi rawat inap yang memenuhi kriteria inklusi. Objek pada penelitian ini adalah rekam medis pasien rawat inap hipertensi periode bulan Oktober 2016- Juli 2017. Hasil penelitian menunjukkan bahwa dari 53 pasien yang memenuhi kriteria inklusi, sebanyak 38 pasein (71,8 %) menjalani pengobatan antihipertensi secara politerapi, sedangkan hanya 15 pasien (28,2 %) menjalani pengobatan monoterapi. Pengobatan monoterapi yang paling banyak dipakai golongan diuretik yaitu Furosemid sebanyak 6 pasien (11,3%), sedangkan penggunakan obat politerapi yang paling banyak dipakai yaitu Valsatan+ Amlodipin sebanyak 13 pasien ( 24,5%). Secara keseluruhan, golongan obat yang paling banyak digunakan adalah golongan Calcium Chanel Blocker dengan jenis terbanyak adalah Amlodipin, dilanjutkan golongan Diuretik yaitu Furosemid, dan golongan ARB yaitu Valsartan. Penelitian ini disimpulkan bahwa penggunaan obat sebagian besar politerapi dan secara umum penggunaan obat antihipertensi yang dipakai terdiri dari 6 golongan obat yaitu diuretik, ACE inhibitor, Angiotensin Receptor Blocker, ẞ- blocker. Kata kunci: Pola Penggunaan Obat; Antihipertensi; Rawat Inap. ABSTRACTHypertension is a health problem in the world. Therapy given to hypertensive patients is usually done in the long run. Hypertension treatment is carried out according to the patient's condition. This study aims to determine the pattern of the use of antihypertensive drugs in inpatients at Panembahan Senopati Hospital. The study was designed using descriptive cross sectional method. The subjects of the study were hypertensive inpatients who met the inclusion criteria. The object of this study was the medical record of hypertensive inpatients for the period October 2016-July 2017. The results showed that of 53 patients, 38 patients (71.8%) used antihypertensive treatment by polytherapy, whereas only 15 patients (28.2%) used monotherapy treatment. The most used monotherapy treatment of diuretics is Furosemide with 6 patients (11.3%), while the most used polytherapy drugs are Valsatan + Amlodipin with 13 patients (24.5%). Overall, the most used group of drugs is the Calcium Chanel Blocker with the most types, Amlodipine, followed by the Diuretic group, Furosemide, and the ARB group, Valsartan. This study concluded that the use of drugs is mostly polytherapy and in general the use of antihypertensive drugs used consists of 6 classes of drugs namely diuretics, ACE inhibitors, Angiotensin Receptor Blockers, ẞ-blockers. Keywords: Drug Use Patterns; Anti-hypertension; Inpatient. 

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