scholarly journals Spectrum of renal biopsies; a three-year data from a tertiary care centre of eastern India

2020 ◽  
Vol 9 (2) ◽  
pp. e20-e20
Author(s):  
Chetan Mahajan ◽  
Vaibhav Tiwari ◽  
Smita Subhash Divyaveer ◽  
Malagouda R Patil ◽  
Avinandan Banerjee ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Kidney Diseases ◽  
Tertiary Care ◽  
Rapidly Progressive Glomerulonephritis ◽  
Eastern India ◽  
Glomerular Diseases ◽  
Female Ratio ◽  
Nephritic Syndrome ◽  
Geographical Regions ◽  
Over Time

Introduction: Biopsy registries are important in studying the frequency of kidney diseases, their trends over time and allow comparison of data from different geographical regions. Objectives: We report the spectrum of biopsy-proven glomerular and tubular diseases in a single centre in Eastern India. Patients and Methods: Medical records of 1293 patients with biopsy-proven glomerular diseases (GDs) and tubular diseases over a period of three years (March 2013 to March 2016) were retrospectively analysed. All biopsy specimens were examined by the same pathologist with light and immunofluorescence microscopy. Electron microscopic (EM) analysis was performed only in selected cases. Histologic spectrum of various GDs was studied along with its correlation with the clinical and laboratory parameters. Results: The clinical diagnosis was nephrotic syndrome (NS) in 820 (63.41%), rapidly progressive glomerulonephritis in 194 (15.2%), asymptomatic urinary abnormalities (AUA) in 108 (8%), acute kidney injury (AKI)/acute nephritic syndrome in 118 (9.3%), and macroscopic hematuria (MH) in 3 (0.43%) patients. Male: Female ratio was 0.95. Around 22.42% were < 18 years, 72.2% were between 18to 59 years, and 5.3% were ≥ 60 years of age. The most common GD overall as well as primary glomerular disease (PGD) was minimal change disease (MCD) (21.6 and 83.44%). Secondary GD was present in 20.87%; most common being lupus nephritis (84.58%). Among the NS, the most common GD was MCD (33.17%), followed by FSGS (17.56%), membranous nephropathy (MN) (13.90%), lupus nephritis (LN) (9.39%), IgA-nephropathy (0.49%), and MPGN (7.32%). Thrombotic microangiopathy (TMA) constituted 24.6% of AKI presentation particularly common in pregnancy. Diffuse proliferative glomerulonephritis (DPGN) with severe renal dysfunction was present in 14% of elderly patients. Conclusion: The spectrum of GD varies according to the area of study and changes over time. Some entities which have not been reported earlier from this region that are uncommon but are significant were pregnancy associated TMA, C3 glomerulopathy (C3G) and DPGN in adults.

scholarly journals Glomerular Diseases Associated with Malignancies: Histopathological Pattern and Association with Circulating Autoantibodies

Antibodies ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 18
Author(s):  
Sophia Lionaki ◽  
Smaragdi Marinaki ◽  
Konstantinos Panagiotellis ◽  
Ioanna Tsoumbou ◽  
George Liapis ◽  
...  
Keyword(s):  
Membranous Nephropathy ◽  
Kidney Biopsy ◽  
Rapidly Progressive Glomerulonephritis ◽  
Glomerular Diseases ◽  
Transmembrane Glycoprotein ◽  
Phospholipase A2 Receptor ◽  
Nephritic Syndrome ◽  
Acute Nephritic Syndrome ◽  
Circulating Autoantibodies ◽  
End Stage

Aim: Glomerular diseases (GD) associated with malignancies (AM, GDAM) have unique features, which are important to recognize, in the light of the progress made in cancer therapy. We aimed to describe the clinical and histopathological characteristics of patients with GDAM in relation to the presence of circulating autoantibodies, pointing to potential immune pathogenic pathways connecting cancer to GD. Materials and Methods: The included patients were studied retrospectively on the basis of a kidney biopsy proving GD and a related biopsy to establish the diagnosis of AM. We recorded patients’ demographics, serological and laboratory parameters, histopathological findings, and the type of malignancy, GD, and therapy. Results: In total, 41 patients with GDAM, with a mean age of 63.1 (±10.7) years, were studied. In 28 (68.3%) cases, GD was associated with a solid tumor, and in 13 (31.7%) patients with a lymphoid malignancy. The most frequent histopathological pattern was membranous nephropathy (43.9%). Overall, at the time of GD diagnosis, 17% of the patients were positive for antinuclear antibodies (ANA), and 12.2% for antineutrophil cytoplasmic autoantibodies (ANCA), all against myeloperoxidase (MPO). In addition, 93.3% of the patients who had membranous nephropathy were negative for transmembrane glycoprotein M-type phospholipase A2 receptor (PLA2R) antibody. Sixteen patients (39.0%) presented with acute nephritic syndrome, of whom five (31.25%) developed rapidly progressive glomerulonephritis. In a mean follow-up time of 36.1 (±28.3) months, nine (21.95%) patients ended up with end-stage kidney disease, and eight (19.5%) died. Conclusion: We found that 3.2% of patients who underwent a native kidney biopsy in our institution during the past decade, for any reason, were identified as having some type of GD associated with a malignancy. Serology indicated a significant presence of ANA or MPO-ANCA antibodies in patients with nephritic syndrome and the absence of PLA2R antibodies in patients with membranous nephropathy.

scholarly journals PREVALENCE AND RISK FACTORS OF DRY EYE AMONG PATIENTS OF A TERTIARY CARE CENTRE IN EASTERN INDIA

2021 ◽  
pp. 5-7
Author(s):  
Nilesh Mohan ◽  
Vandana Parasar ◽  
Ankita Singh ◽  
Rakhi Kusumesh
Keyword(s):  
Risk Factors ◽  
Dry Eye ◽  
Tertiary Care ◽  
Office Worker ◽  
Care Centre ◽  
Eastern India ◽  
Tertiary Care Centre ◽  
Cross Sectional ◽  
Female Ratio ◽  
Ocular Discomfort

AIM: To determine the prevalence and risk factors of dry eye among patients of a tertiary care centre in eastern India. Symptoms of dry eye are encountered as one of the most frequent complains among the patients attending the outpatient department in ophthalmology commonly presenting as ocular discomfort, burning sensation and foreign body sensation.Prevalence of this entity is still not known in our study population due to lack of specificity of symptoms and diagnostic criteria. MATERIALS AND METHODS: A prospective, observational, cross-sectional study was conducted among patients attending ophthalmology OPD in a tertiary care teaching hospital of Bihar. 4116 (16.64%) patients with dry eye symptoms were examined after taking informed consent. RESULTS: 1620 (6.55%) patients were found to have dry eye based on McMonnies questionnaire, Schirmer's test and tear film breakup time.There were 1180 female and 440 male with dry eye.Male to female ratio was 2.7:1.Non-tribals were affected more commonly than tribals. Students, outdoor workers and office worker with professional constituted over fifty percent of dry eye cases. CONCLUSION: Prevalence of dry eye was more in females and elderly as compared to male and younger population respectively.Burning sensation and ocular discomfort was the most common presenting complains.

scholarly journals Onychomycosis: dermatophytes to yeasts: an experience in and around Mumbai, Maharashtra, India

2017 ◽  
Vol 5 (5) ◽  
pp. 1959 ◽  
Author(s):  
Rupali S. Suryawanshi ◽  
Shashir W. Wanjare ◽  
Avani H. Koticha ◽  
Preeti R. Mehta
Keyword(s):  
Tertiary Care ◽  
Local Area ◽  
Age Group ◽  
Female Ratio ◽  
Geographical Regions ◽  
Wide Range ◽  
Causative Agents ◽  
Male To Female ◽  
Nail Infection

Background: Onychomycosis is a fungal nail infection having wide range of prevalence in different geographical regions. It becomes imperative to know prevalent causative agent in local area to improve quality of life of patients. Present study was aimed to study epidemiological, clinical and laboratory aspects of onychomycosisMethods: Study was carried out prospectively at a tertiary care teaching hospital Nail scrapings of 630 clinically suspected cases of onychomycosis over a period of 5 years (January 2012 to December 2016) were subjected to KOH examination and culture.Results: Young adults in age group of 21-40 years (67.61%) were predominantly affected with male to female ratio of 1.8:1. Overall prevalence of onychomycosis of the present study is 58.41%. Yeasts were isolated in 47.86%, dermatophytes in 30.71% and non dermatophytic filamentous fungi in 21.43%Conclusions: Present study demonstrates a shift in causative agents from dermatophytes to yeasts. 

scholarly journals The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Gustavo Gomes Thomé ◽  
Talissa Bianchini ◽  
Rafael Nazario Bringhenti ◽  
Pedro Guilherme Schaefer ◽  
Elvino José Guardão Barros ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Temporal Variation ◽  
Kidney Biopsy ◽  
Systemic Vasculitis ◽  
Laboratory Data ◽  
Age Group ◽  
Glomerular Diseases ◽  
Nephritic Syndrome ◽  
Time Periods ◽  
Over Time

Abstract Background The prevalence and distribution of glomerular diseases differ among countries, and the indication to perform a kidney biopsy varies among centres. In this study, we assessed the prevalence of primary and secondary glomerulopathies based on histological diagnoses, and the correlation between glomerulopathies and demographic and clinical data was evaluated. Methods In this study, 1051 kidney biopsies were retrospectively reviewed between 2000 and 2018. Patient demographic, clinical and laboratory data were assessed. The prevalence of primary glomerulonephritis (PG) and secondary glomerulopathies (SG), as well as tubulointerstitial diseases (TIDs), hereditary nephropathies (HNs) and other diagnoses, were determined. The frequency of primary and secondary glomerulopathies was evaluated by age group, and the temporal variation in frequencies across three time periods (2000-2005, 2006-2011, and 2012-2018) was reported. Results The prevalence of SG predominated (52.4%), followed by PG (29.6%), other diagnoses (10.7%), TID (6.6%) and HN (1.1%). Among the primary forms of glomerular disease, focal segmental glomerulosclerosis (FSGS) was the most common (37.3%), followed by IgA nephropathy (IgAN, 24.4%), membranous nephropathy (MN, 18.6%) and minimal change disease (MCD, 8.4%). Lupus nephritis (LN, 41.1%) was most common in patients with SG, followed by diabetic kidney disease (DKD, 17.8%), systemic vasculitis (SV, 10.2%) and secondary FSGS (2nd FSGS, 10%). Nephrotic syndrome was the most common clinical presentation in patients with PG and also in patients with DRD and 2nd FSGS, whereas in patients with IgAN and SV, nephritic syndrome was the main presentation. For the age group between 18 and 50 years, LN, FSGS and IgAN predominated; for patients aged between 51 and 65 years, the proportion of DKD and 2nd FSGS increased, and SV was more common in patients > 65 years. The temporal variation in PG across the three time periods showed a statistically significant increase in IgAN (p = 0.001) and a reduction in FSGS over time (p < 0.001). In SG, there was a reduction in LN (p = 0.027) and an increase in DKD (p < 0.001) over time, with a tendency for 2nd FSGS to decrease over time (p = 0.053). Conclusions In the studied kidney biopsy registry, FSGS and IgAN were the most prevalent diagnoses in patients with PG, and LN and DKD were the most prevalent in patients with SG. Nephrotic syndrome was the major indication for biopsy. When comparing the temporal variation in glomerulopathies, there was a reduction in FSGS and an increase in IgAN in patients with PGs over time, and for patients with SGs, there was a reduction in LN with an increase in cases of DKD over time.

MO312MAIN TRENDS AND OUTCOMES OF KIDNEY DISEASE IN GEORGIA: THE FIRST REVIEW OF KIDNEY BIOPSY DATABASE FROM 2011 TO 2020

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Nora Sarishvili ◽  
Irma Tchokhonelidze ◽  
Tamar Tevdoradze ◽  
Tamar Kasradze ◽  
Dalakishvili Ketevan ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Kidney Biopsy ◽  
Kidney Diseases ◽  
Treatment Options ◽  
Clinical Syndrome ◽  
Current Data ◽  
Glomerular Diseases ◽  
Nephritic Syndrome ◽  
Histological Data ◽  
Registry Database

Abstract Background and Aims Kidney biopsy registry has been established in Georgia in 2011 by Dialysis, Nephrology and Kidney Transplantation Union of Georgia (DNT Union) to address the natural history of kidney disease, describe the clinical features, improve disease understanding and tracking, healthcare planning, patient care and outcomes. This report is the first review of histological data over a period of 10 years (2011-2020) covering the entire population of 3.7 million inhabitants and demonstrates the current data on trends of kidney disease in Georgia. Method 1267 ultrasound-guided kidney biopsies were performed during the 10 years. Data were extracted from the DNT Union kidney biopsy registry as of 1st of December 2020. Data on kidney function, urinalysis, treatment options and outcomes were also included in biopsy registry database. After exclusion of transplant and re-biopsies, kidney biopsies were analyzed for evaluation main trends in kidney biopsy rates and diagnosis of glomerular and non-glomerular diseases in two groups divided in 5-year time frames: the first group 2011-2015 and the second group 2016-2020. The overall treatment outcome was evaluated as complete remission (CR), partial remission (PR) and progression to ESRD. Results Final cohort consisted of 1089 patients. Mean age was 39 years [SD 13 years]. Fifty five percent of the cohort were male. The average annual biopsy incidence was 455 biopsies in the first group and 634 cases in the second group. The most common indication as clinical syndrome for performing the kidney biopsy was a decrease of glomerular filtration rate GFR (35%), followed by nephrotic syndrome (30%) and nephritic syndrome (21 %) and in lesser degree asymptomatic urinary abnormalities (14 %). The frequency of kidney biopsies increased significantly over the years (Fig.1). The distribution of major histological groups of kidney disease in both groups is shown in the Table 1. As for comparison of the major trends among various histological patterns, there was 3,6 times more heredity kidney diseases diagnosed in the second group, followed by tubulointerstitial nephritis with 3.3 times increase, acute tubular necrosis 1.5 times increase and glomerulonephritis (primary and secondary) with 1.3 times increase. There was found statistically no changes in the incidence of vascular kidney disease between two groups (p=0.005). Overall outcome demonstrates some changes during the time. PR was the most prevalent outcome in both time groups. However, proportion of PR cases increased (45%vs.64%) and proportion of CR (25% vs.17%) and ESRD (30% vs.18%) cases decreased. This change is statistically significant at p&lt;0.0001. There were no data obtained from 15% (173) of patients. The distribution of overall outcome among patients with primary glomerulonephritis (PGN) repeated the same trend. Out of total PGN patients (481 cases) 61% showed PR, 24% reached CR and 15% progressed to ESRD. The proportion of patients with PR was higher (69%) among patients diagnosed with PGN in the second group compared with the first (48%). Proportion of patients, who developed ESRD, was lower in the second group (12% vs.19%). ( Fig. 2). Conclusion The present data are an important contribution to the epidemiology of kidney disease in Georgia. The incidence of glomerulonephritis generally increased between 2011 and 2020, that may be related to changes in kidney biopsy policy. Substantial decrease in numbers of kidney biopsies were registered in 2020 due to pandemic issues. Membranous nephropathy was the most common primary glomerular disease according to the registry database. The prognosis regarding progression to ESRD has improved.

scholarly journals Epidemiological and Clinical factors associated with mortality of confirmed Covid-19 cases admitted and treated in a tertiary care hospital of Patna, Bihar

2021 ◽  
Vol 33 (1) ◽  
pp. 30-40
Author(s):  
Alok Ranjan ◽  
Sanjay Pandey ◽  
C M Singh ◽  
Pragya Kumar ◽  
Arshad Ayub ◽  
...  
Keyword(s):  
Kidney Diseases ◽  
Tertiary Care ◽  
Significant Proportion ◽  
Case Fatality ◽  
P Value ◽  
Care Hospital ◽  
Clinical Factors ◽  
Cross Sectional ◽  
Female Ratio ◽  
Factors Associated

Background: A significant proportion of the individuals having the illness of moderate to severe nature due to COVID-19 infection require immediate critical care. High incidence of mortality among elderly population or those with comorbid conditions were reported. Objectives: The study was carried out with objectives to assess the epidemiological and clinical factors associated with mortality among the COVID-19 cases admitted and treated in AIIMS, Patna. Methods: This was a hospital‑based cross‑sectional analytical study of epidemiological and clinical features of COVID‑19‑positive patients admitted and treated during the outbreak from March 20, to August 31, 2020. Results: The median age of COVID-19 cases was 51.5 years (IQR : 37-62 years) which was significantly higher (p-value = 0.001) as compared to females. Male-female ratio of cases was 2.88:1. Out of 1696 cases, the case-fatality rate was 309 (18.22%). The mean age of cases who died due to COVID-19 was significantly higher (p-value=0.001) as compared to those who survived. The odds of mortality was significantly higher in males as compared to females (Adjusted OR = 1.534, 95% CI = 1.10 – 2.13, p=0.011). The odds of mortality showed a significant increasing trend with increasing age (Mantel-Hanszel p-value for trend = 0.015). The covariates like gender, age groups 45-59, 60-74 and 75>=, breathlessness and CKD were found to be significantly associated with mortality after controlling for the confounders. Conclusions: Factors like gender, higher age, lower oxygen saturation causing breathlessness and chronic kidney diseases could be attributed to high risk of mortality in COVID-19 patients.

scholarly journals The changing clinico-demographic profile of dengue infection in children: a hospital-based study from eastern India

2020 ◽  
Vol 7 (5) ◽  
pp. 1901
Author(s):  
Radheshyam Purkait ◽  
Rajarshi Basu
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Warning Signs ◽  
Severe Dengue ◽  
Eastern India ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Study Population

Background: Many parts of India, including the eastern regions, are now endemic for the dengue infection with increased recognition of atypical neurological manifestations apart from the classical clinical features.Methods: This prospective study was conducted in the department of paediatrics in a tertiary care teaching hospital in eastern India from July 2019 to November 2019 to determine the changing trends of the clinical features in the dengue patients of this region in the recent years among paediatric populations. All the serologically confirmed dengue patients admitted during this period satisfying the inclusion criteria were enrolled in the study population and classified as per new WHO-2009 classification into: dengue fever without warning signs (DF), dengue fever with warning signs (DFWS) and severe dengue (SD). Detailed history, clinical and laboratory parameters were recorded and analysed for all children.Results: Out of the total of 110 cases, 16 cases (14.55%) were DF, 80 cases (72.73%) were DFWS and 14 cases (12.73%) were SD. The commonest age group affected (63.64 %) was between 4-<10 years. The male: female ratio of cases was 1.68:1. Besides classical clinical manifestations, we observed CNS involvement in nine cases (8.18%). Among them, five patients had dengue encephalitis, two patients had dengue encephalopathy, one patient had hypokalemic paralysis and one patient had Guillain-Barré syndrome. All the patients were treated as per standard guidelines.Conclusions: Clinician must be aware of such association during dengue outbreak because early diagnosis and appropriate supportive care can reverse this potentially fatal disease.

P0395DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS IN TURKEY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Zeki Aydin ◽  
Kultigin Turkmen ◽  
Fatih Dede ◽  
Emre Yasar ◽  
Savas Ozturk ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Interstitial Fibrosis ◽  
Rapidly Progressive Glomerulonephritis ◽  
Demographic Characteristics ◽  
Glomerular Diseases ◽  
Nephritic Syndrome ◽  
Number Of Patients ◽  
Type 3

Abstract Background and Aims Rapidly progressive glomerulonephritis (RPGN) is a clinical condition that develops due to different etiologic causes, characterized by a rapid and progressive decrease in renal function and progresses to end-stage renal failure in weeks to months if not treated. In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Method Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database between May 2009 and June 2019. Demographic characteristics such as age, sex, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. The data presented is cross-sectional and includes application data for the biopsy period. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immunocomplex related) and type 3 (immune-negative; “pauci-immune”). Results After exclusion of 46 patients with missing data, 200 patients (mean age 47.9 ± 16.7 years, 44% female) were included in the study which constitutes 5.2% of the total glomerulonephritis database (total number of patients: 3875). Hypertension was present in 62 patients (31.0%) and diabetes was present in 18 patients (9.0%). Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome (RPGN included). 80.2% of the patients' biopsies were performed in nephrology clinics and 19.8% of them were performed in radiology clinics. ANCA positivity was found in 121 (60.5%) patients (proteinase 3-ANCA was positive in 55 and myeloperoxidase-ANCA positive in 66 patients). Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. In 21 patients (10.5%), biopsy revealed RPGN with advanced chronic changes (fibrous global sclerotic glomeruli, advanced interstitial fibrosis and tubular atrophy). Mean serum creatinine was 4.2 ± 3.4 mg/dl, median glomerular filtration rate was 18 (10-37) ml/min and proteinuria 2100 (1229-3526) mg/day according to CKD-EPI formula. The mean number of glomeruli in the biopsies was 18.8 ± 10.6 and the number of crescentic glomeruli was 9.9 ± 7.7 (ratio: 52.7%) (Figure). The patients were divided into 3 groups according to their crescentic glomeruli ratios. The proportion of crescentic glomeruli is 10-50% in group 1, 50-80% in group 2, and &gt;80% in group 3. The demographic, laboratory and histopathological characteristics of the groups are given in Figure. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusion Our study provides valuable demographic, clinical, laboratory and histopathological data about RPGN in our country. Our data are generally compatible with the literature. In our study, advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival are needed.

scholarly journals GLOMERUONEPHRITIS;

2019 ◽  
Vol 26 (05) ◽  
Author(s):  
Sultan Zafar Akhtar ◽  
Humera Adeeb ◽  
Hajira Bibi ◽  
Ihsan Ullah
Keyword(s):  
Lupus Nephritis ◽  
Kidney Diseases ◽  
Case Series ◽  
Membranous Glomerulonephritis ◽  
Immunoglobulin M ◽  
Retrospective Case ◽  
Hypertensive Nephropathy ◽  
Glomerular Diseases ◽  
Male Predominance ◽  
Clinical Records

Background: The histological pattern and frequency of glomerular diseases differs according to the geographic area, race, age and indications for renal biopsy. This study was conducted to evaluate the frequency of different histological patterns of glomerulonephritis during a 10 years period at our institute. Study Design: Retrospective Case series. Period: 1st January 2007 to 31st, December 2017. Study Setting: Institute of kidney diseases, Hayatabad Medical Complex Peshawar, Pakistan. Results and Discussion: Clinical records of 415 native renal biopsies performed in patients with mean age 27.17 ± 14.98 years were included in this study. Males were 266 (64.1%) and females 149 (35.9%). Data was analysed for three age groups separately, Children (<18 years) 147 (35.5%), Adults (18-59 years) 253 (61.0%) and elderly (>60 years) 15 (3.6%). Primary GN (glomerulonephritis) was the most common (74.21%) followed by secondary GN (26.41%). Among primary glomerular diseases, Focal segmental glomerulonephritis (FSGS) was (29.6%), membranoproliferative glomerulonephritis (MPGN) also known as mesangiocapillary glomerulonephritis constituted 19.5% and Membranous glomerulonephritis (MGN) was the third most common (16.6%). Among secondary GN, acute tubular necrosis (ATN) was the most common (25.4%), followed by amyloidosis (14.7%), hypertensive nephropathy (13.7%) and lupus nephritis (12.8%) respectively. There was a slight male predominance in all types of primary GN except for focal necrotizing GN and most of the secondary types except lupus nephritis and chronic tubulointerstitial nephritis (TIN). Below 18 years, MPGN was (58.3%), focal necrotising GN (57.1%) and minimal change disease (MCD) was (52.2%). Crescentic GN (89.5%), MGN (74.5%), immunoglobulin A (IgA) nephropathy (72.7%), chronic sclerosing GN (CSGN) (64.7%) and FSGS (56%) were more common in adults. Frequency of immunoglobulin M (IgM) nephropathy (50%) was equal in children and adults. In elderly patients, the commonest GN reported was hypertensive nephropathy (28.6%), amyloidosis (6.7%) and MGN (5.9%). Conclusion: Among the wide variety of histological patterns, FSGS was the commonest GN in adults followed by MPGN and MGN. Among adults, primary GN was more common. When compared with other studies, FSGS is more common in the present study and some Indian studies, while membranous GN is more common in other regional countries.

scholarly journals Pediatric lupus nephritis – An evil cousin of its adult counterpart: A single-center based experience from a tertiary care hospital of Eastern India

2020 ◽  
Vol 63 (3) ◽  
pp. 397
Author(s):  
Keya Basu ◽  
Subhrajyoti Karmakar ◽  
Moumita Sengupta ◽  
Arpita Roychowdhury ◽  
Alakendu Ghosh ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Single Center ◽  
Eastern India ◽  
Pediatric Lupus
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