scholarly journals Effect of Q10 supplementation on exercise-induced response of leukocytes, hepatic damage and anti-inflammatory indicators in male runners

2020 ◽  
Vol 42 (5) ◽  
pp. 556-563
Author(s):  
Mostafa Armanfar ◽  
Afshar Jafari ◽  
Amir Shakib
Keyword(s):  
Coenzyme Q10 ◽  
Leukocyte Count ◽  
The Body ◽  
Hepatic Damage ◽  
Induced Response ◽  
Short Term ◽  
Before And After ◽  
Anti Inflammatory ◽  
Exercise Induced ◽  
Coenzyme Q10 Supplementation

Background: Occurrence of cellular damage in various tissues of the body and inflammatory response is evident during intense sporting competitions, such as half-endurance running racing. Therefore, the aim of this study was to determining the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, anti-inflammatory, muscle and hepatic damage indicators response in elite male runners. Methods: In quasi-experimental study, eighteen elite male middle-distance runners (aged 20.45±2.48 years, and body fat 7.4 ±1.63 % and VO2max 60.85 ± 3.96) in a randomized and double-blind design were allocated in two equal groups: supplement group (n=9, Coenzyme Q10: 5 mg/kg/day) and placebo group (n=9, Dextrose: 5 mg/kg/day). Before and after supplementation acute and 14-day period, all subjects were participated in a training like running a competitive 3000 meters. Leukocyte count, serum Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) and interleukin-10 (IL-10) concentration were analyzed before and after two like competitive running 3000 meters and supplementation protocols. Data were analyzed by repeated measure ANOVA, Bonferroni and independent t test, with a <0.05 significance level. Results: The short-term coenzyme Q10 supplementation attenuated the exercise-induced increase in response of ALT and AST and Leukocyte count (p<0.05). However, acute supplementation had no significant effect on any of the parameters. Also, short-term supplementation had no significant effect on baseline and exercise-induced response of IL-10. Conclusion: Based on the results, Short-term supplementation of coenzyme Q10 may reduce markers of liver damage and muscle response to competitive and exhaustive exercise.

Effects of Coenzyme Q10 Supplementation on Exercise Performance, VO2max, and Lipid Peroxidation in Trained Cyclists

1991 ◽  
Vol 1 (4) ◽  
pp. 353-365 ◽  
Author(s):  
Barry Braun ◽  
Priscilla M. Clarkson ◽  
Patty S. Freedson ◽  
Randall L. Kohl
Keyword(s):  
Lipid Peroxidation ◽  
Coenzyme Q10 ◽  
Cycling Performance ◽  
Physiological Parameters ◽  
Significant Difference ◽  
Before And After ◽  
Intense Training ◽  
Exercise Induced ◽  
Coenzyme Q10 Supplementation ◽  
Physiological And Biochemical

The effects of dietary supplementation with Coenzyme Q10 (CoQlO), a reputed performance enhancer and antioxidant, on physiological and biochemical parameters were examined. Ten male bicycle racers performed graded cycle ergometry both before and after being given 100 mg per day CoQlO or placebo for 8 weeks. Analysis of variance showed a significant difference between groups for postsupplementation serum CoQ10. Although both groups demonstrated training related improvements in all physiological parameters over the course of the study, there were no significant differences between the two groups (p>.05). Both groups showed a 21 % increase in serum MDA (an index of lipid peroxidation) after the presupplementation exercise test. After 8 weeks this increase was only 5 % , and again was identical for both groups. Supplementation with CoQlO has no measurable effect on cycling performance,, submaximal physiological parameters, or lipid peroxidation. However, chronic intense training seems to result in marked attenuation of exercise-induced lipid peroxidation.

scholarly journals Age, but not short-term intensive swimming, affects chondrocyte turnover in zebrafish vertebral cartilage

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5739 ◽  
Author(s):  
Quan-Liang Jian ◽  
Wei-Chun HuangFu ◽  
Yen-Hua Lee ◽  
I-Hsuan Liu
Keyword(s):  
Critical Factor ◽  
The Body ◽  
Micro Computed Tomography ◽  
Mineral Density ◽  
Short Term ◽  
Cartilage Homeostasis ◽  
Intensive Exercise ◽  
Before And After ◽  
Two Factors ◽  
Brdu Labeling

Both age and intensive exercise are generally considered critical risk factors for osteoarthritis. In this work, we intend to establish zebrafish models to assess the role of these two factors on cartilage homeostasis. We designed a swimming device for zebrafish intensive exercise. The body measurements, bone mineral density (BMD) and the histology of spinal cartilages of 4- and 12-month-old zebrafish, as well the 12-month-old zebrafish before and after a 2-week exercise were compared. Our results indicate that both age and exercise affect the body length and body weight, and the micro-computed tomography reveals that both age and exercise affect the spinal BMD. However, quantitative analysis of immunohistochemistry and histochemistry indicate that short-term intensive exercise does not affect the extracellular matrix (ECM) of spinal cartilage. On the other hand, the cartilage ECM significantly grew from 4 to 12 months of age with an increase in total chondrocytes. dUTP nick end labeling staining shows that the percentages of apoptotic cells significantly increase as the zebrafish grows, whereas the BrdU labeling shows that proliferative cells dramatically decrease from 4 to 12 months of age. A 30-day chase of BrdU labeling shows some retention of labeling in cells in 4-month-old spinal cartilage but not in cartilage from 12-month-old zebrafish. Taken together, our results suggest that zebrafish chondrocytes are actively turned over, and indicate that aging is a critical factor that alters cartilage homeostasis. Zebrafish vertebral cartilage may serve as a good model to study the maturation and homeostasis of articular cartilage.

scholarly journals Exercise Induced Adipokine Changes and the Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Saeid Golbidi ◽  
Ismail Laher
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
The Body ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Before And After ◽  
Inflammatory State ◽  
Exercise Induced

The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of secreting many cytokines that are though to be involved in the pathophysiology of obesity, insulin resistance, and metabolic syndrome. Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. Lifestyle change in terms of increased physical activity and exercise is the best nonpharmacological treatment for obesity since these can reduce insulin resistance, counteract the inflammatory state, and improve the lipid profile. There is growing evidence that exercise exerts its beneficial effects partly through alterations in the adipokine profile; that is, exercise increases secretion of anti-inflammatory adipokines and reduces proinflammatory cytokines. In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.

scholarly journals Effect of 2-weeks Coenzyme Q10 Supplementation on Malondialdehyde and Catalase Serum Levels Following Moderate and Severe Acute Resistance Training in Inactive Female Students

2019 ◽  
Vol 25 (4) ◽  
pp. 256-269
Author(s):  
Yeganeh Feizi ◽  
◽  
Mohammad Esmaeil Afzalpur ◽  
Seyed-Hosein Abtahi-Eivary ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Resistance Training ◽  
Coenzyme Q10 ◽  
Serum Levels ◽  
Female Students ◽  
Moderate Intensity ◽  
Control Group ◽  
Short Term ◽  
Coenzyme Q10 Supplementation ◽  
And Oxidative Stress

Aims Physical activity is usually accompanied by free radicals’ production and oxidative stress. Moreover, to prevent adverse effects, coaches and athletes have to use proper supplementation. Therefore, the present study aimed to investigate the effect of short-term coenzyme Q10 supplementation on malondialdehyde and serum catalase enzyme activity following moderate and severe acute resistance training in inactive female students. Methods & Materials In total, 27 female students were randomly divided into three groups; the groups were homogeneous and equal (two groups of resistance training and one control group). The experimental groups were subjected to moderate-intensity acute (70% 1RM) acute and severe acute activity (85% 1RM) and supplemented with coenzyme Q10 (30 mg /d). CAT and MDA were measured in ELISA using a human kit. Findings Moderate and severe acute resistance activities did not alter MDA and catalytic activity (P>0.05); however, after 2 weeks of coenzyme Q10 supplementation, those resulted in a significant decrease in MDA (0.006 and 0.01, respectively) and CAT (0.04 and 0.007, respectively). There were no significant differences between the effects of two exercises (P>0.05). Conclusion Short-term (two weeks) supplementation of coenzyme Q10 and severe acute resistance activity could reduce two important oxidative stress indexes (MDA and CAT).

scholarly journals Comparison of GFAP and HSP27 concentrations in acute moderate-intensity aerobic exercise of different duration

2016 ◽  
Vol 25 (2) ◽  
pp. 112-7
Author(s):  
Robert Stefanus ◽  
Sophie Yolanda ◽  
Radiana D. Antarianto
Keyword(s):  
Aerobic Exercise ◽  
Sports Medicine ◽  
Plasma Concentrations ◽  
The Body ◽  
Moderate Intensity ◽  
Synapse Plasticity ◽  
Significant Difference ◽  
Single Bout ◽  
Before And After ◽  
Exercise Induced

Background: Glial fibrillary acidic protein (GFAP) and heat shock protein -27 (HSP27) plasma can be used as the parameters of exercise-induced astrocyte reactivity. The American College of Sports Medicine (ACSM) recommends an exercise of 30 minutes or 10 minutes duration (each performing bout accumulated toward 30 minutes). The aim of this study was to compare GFAP and HSP27 plasma concentrations in young adults undergoing acute moderate-intensity aerobic exercise of different durations (10 minutes vs 30 minutes).Methods: An experimental study with pre-post design was conducted on 22 participants assigned to either 10 minutes or 30 minutes duration of single bout exercise. Blood sampling was performed before and after the exercise. GFAP and HSP27 plasma levels were measured with ELISA methods. Plasma GFAP and HSP27 levels before and after exercise were analyzed using paired t -test, while GFAP and HSP27 levels after exercise between the two groups were processed using unpaired t-test.Results: Plasma GFAP concentration decreased significantly (0,45 ng/mL) after 30 minutes of aerobic exercise (p<0.05). Plasma HSP27 concentration decreased significantly (1,71 ng/mL) after 10 minutes of aerobic exercise (p<0.05). No significant difference in plasma GFAP and HSP27 concentrations between 10 minutes (GFAP=0.49 ng/mL; HSP27=2.09 ng/mL) and 30 minutes duration of exercise (GFAP=0.45 ng/mL; HSP27=1,71 ng/mL).Conclusion: Acute moderate-intensity aerobic exercise with 10- and 30-minutes duration reduces the reactivity of astrocytes indication the increase of the synapse plasticity. The decrease in GFAP concentration occurred after 30 minutes of exercise and the decrease in HSP27 occurred after 10 minutes of exercise. These results showed that the body responds differently to different treatment duration in order to obtain the same effect on the body.

scholarly journals PO-061 Differential expression of proteins in urea from male athletes after 30 km running evaluated by proteomics

2018 ◽  
Vol 1 (3) ◽  
Author(s):  
Wen Tao Lin ◽  
HaiQi Lin
Keyword(s):  
Differential Expression ◽  
Expression Profile ◽  
Specific Antigen ◽  
The Body ◽  
Urine Samples ◽  
Male Athletes ◽  
Target Proteins ◽  
Proteomic Approach ◽  
Before And After ◽  
Exercise Induced

Objective In order to elucidate the target proteins of exercise-induced stress, differential expression of proteins in urine from male athletes after 30 km running was evaluated by proteomics. Methods Urine samples were collected from ten male runners before and after 30 km running. The differential expression profile of urine proteins was investigated by using a proteomic approach based on two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) procedures. Results Totally 1011 ± 243 and 1737 ± 15 protein spots were detected from 2-DE of urine samples harvested from the subjects before and after 30 km running. In addition, 110 protein spots with differential expression were achieved. After exercise, 10 proteins with ≥5 fold up-regulation and 23 new proteins were observed; 18 protein spots with ≥5 fold down-regulation were observed and 6 proteins were disappeared. The target proteins were identified as zinc-α2-glycoprotein, albumin, vitamin D-binding protein, prostate-specific antigen, β-actin and Bence-Jones protein (BJP), which are correlated with the change of energy metabolism pathway, material transport and stress protection in the body. Conclusions An obviously differential protein expression profile in urine samples from the subjects after 30 km running is achieved, which provides a new idea for further exploring exercise-induced proteinuria. However, further studies need to develop urine protein profiles of athletes, which will benefit for monitoring sport competition and doping control as well as excessive exercise-induced diseases.

Overloaded Training Increases Exercise-Induced Oxidative Stress and Damage

2003 ◽  
Vol 28 (4) ◽  
pp. 588-604 ◽  
Author(s):  
Stephane Palazzetti ◽  
Marie-Jeanne Richard ◽  
Alain Favier ◽  
Irene Margaritis
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Defense Mechanism ◽  
Induced Response ◽  
Tbars Level ◽  
Sod Activity ◽  
Activity Increase ◽  
Before And After ◽  
Exercise Induced ◽  
Leukocyte Dna Damage

We hypothesized that overloaded training (OT) in triathlon would induce oxidative stress and damage on muscle and DNA. Nine male triathletes and 6 male sedentary subjects participated in this study. Before and after a 4-week OT, triathletes exercised for a duathlon. Blood ratio of reduced vs. oxidized glutathione (GSH/GSSG), plasma thiobarbituric acid reactive substances (TEARS), leukocyte DNA damage, creatine kinase (CK), and CK-MB mass in plasma, erythrocyte superoxide dismutase (SOD) activity, erythrocyte and plasma glutathione peroxidase (GSH-Px) activities, and plasma total antioxidant status (TAS) were measured before and after OT in pre- and postexercise situations. Triathletes were overloaded in response to OT. In rest conditions, OT induced plasma GSH-Px activity increase and plasma TAS decrease (both p < 0.05). In exercise conditions, OT resulted in higher exercise-induced variations of blood GSH/GSSG ratio, TBARS level (both p < 0.05), and CK-MB mass (p < 0.01) in plasma; and decreased TAS response (p < 0.05). OT could compromise the antioxidant defense mechanism with respect to exercise-induced response. The resulting increased exercise-induced oxidative stress and further cellular susceptibility to damage needs more study. Key words: lipid peroxidation, leukocyte DNA damage, antioxidant, triathlon

Conjugated Linoleic Acid’s Lack of Attenuation of Hyperpnea-Induced Bronchoconstriction in Asthmatic Individuals in the Short Term

2011 ◽  
Vol 21 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Jonathon L. Stickford ◽  
Timothy D. Mickleborough ◽  
Alyce D. Fly ◽  
Joel M. Stager
Keyword(s):  
Pulmonary Function Tests ◽  
Area Under The Curve ◽  
Airway Disease ◽  
Forced Expiratory Volume ◽  
Allergic Airway Disease ◽  
Short Term ◽  
Before And After ◽  
Eucapnic Voluntary Hyperventilation ◽  
Exercise Induced ◽  
Usual Diet

Purpose:Conjugated linoleic acid (CLA) has been reported to modify the inflammatory response associated with allergic airway disease, primarily in animal models. To extend these observations to humans, the effect of short-term CLA supplementation on the severity of exercise-induced bronchoconstriction (EIB) was investigated in asthmatics.Methods:Six subjects with physician-diagnosed asthma and EIB began the study on their usual diet, to which was added 4.8 g CLA/d for 8 wk. Pulmonary-function tests were administered before and after eucapnic voluntary hyperventilation (EVH) challenge at the commencement (Week 0) and conclusion of the treatment period (Week 8). Pre- and 90 min post-EVH challenge, urine was assayed for the presence of cysteinyl leukotrienes (LT) C4−E4 and 9α,11β-prostaglandin (PG) F2.Results:Pre- to post- EVH forced expiratory volume in 1 s (FEV1) did not significantly differ (p > .05) from Week 8 to Week 0. The pre- to post-EVH decline in FEV1 at Week 8 (–29.6% ± 6.6%) was not significantly different (p > .05) from that at Week 0 (–32.0% ± 5.5%). Area under the curve of FEV1 plotted against time from zero to 60 min (AUC0–60) was unaltered at Week 8 (–931% ± 350% change per minute) compared with Week 0 (−1,090% ± 270% change per minute). CLA supplementation did not alter forced midexpiratory flow, forced vital capacity (FVC), or FEV1/FVC. In addition, post-EVH urinary LTC4–E4 and 9α,11β-PGF2 were unchanged after CLA supplementation.Conclusion:Daily supplementation of 4.8 g CLA for 8 wk does not attenuate airway inflammation or hyperpnea-induced bronchoconstriction in asthmatic individuals.

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