scholarly journals Evaluation of anterior pituitary hormonal profile in patients with first seizure of tonic-clonic and temporal lobe epilepsies in Al-Zahra hospital of Isfahan, Iran, during 2014-2016: comparison of hormonal profiles in 2 types of epilepsy

2019 ◽  
Vol 21 (2) ◽  
pp. 70-74
Author(s):  
Maryam Ghasemi Aliabadi ◽  
Mohammad Reza Najafi ◽  
Rokhsareh Meamar ◽  
Shahrzad Nematollahi ◽  
Noushin Mehrbod ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Temporal Lobe ◽  
Anterior Pituitary ◽  
Pituitary Hormones ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
Anterior Pituitary Hormones ◽  
Significant Difference ◽  
Clonic Seizures ◽  
Stimulating Hormone

Background and aims: Temporal lobe and tonic-clonic seizures are the most common types of epilepsy. It is a disease that disrupts the regulation of the hypothalamic pituitary adrenal (HPA) axis. The disturbance in the regulation of this axis affects the secretion of hormones from the anterior pituitary. Due to the different origins of these 2 types of epilepsy listed above, this study aimed to examine their differences in the level of anterior pituitary hormones. Methods: This cross-sectional study was conducted in Al-Zahra hospital of Isfahan, Iran, from 2014 to 2016. A total of 36 patients with the idiopathic first seizure were selected for the examination including 20 patients with tonic-clonic seizure and 16 patients with temporal lobe seizure. The diagnosis of epilepsy was confirmed by a neurologist along with electroencephalogram (EEG) findings. The levels of anterior pituitary hormones including thyroid-stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), GH (growth hormone), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and PRL (prolactin) were measured and compared using ELISA method in both groups. Results: The results indicated that all the anterior pituitary hormones except TSH and ACTH had higher means in the temporal lobe epilepsy than in the tonic-clonic epilepsy, but a significant difference (mean ± SD) was reported only in GH (4.59±2.95) (2.55±1.87) (P<0.005) and FSH (19.4±14.06) (4.34±2.37) (P<0.033) respectively in the temporal lobe and tonic-clonic seizures. Meanwhile, there was a significant relationship between seizure, regardless of its type, and the level of growth hormone and FSH. Conclusion: In the future, hormonal changes may be used as an adjunct to diagnose the type of epilepsy. More studies are required to confirm the findings.

scholarly journals Machine-Learning Prediction of Postoperative Pituitary Hormonal Outcomes in Nonfunctioning Pituitary Adenomas: A Multicenter Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Yi Fang ◽  
He Wang ◽  
Ming Feng ◽  
Wentai Zhang ◽  
Lei Cao ◽  
...  
Keyword(s):  
Machine Learning ◽  
Anterior Pituitary ◽  
Characteristic Curve ◽  
Pituitary Hormones ◽  
Thyroid Stimulating Hormone ◽  
Subtotal Resection ◽  
Logistic Regression Models ◽  
Anterior Pituitary Hormones ◽  
Prognostic Assessment ◽  
Stimulating Hormone

ObjectiveNo accurate predictive models were identified for hormonal prognosis in non-functioning pituitary adenoma (NFPA). This study aimed to develop machine learning (ML) models to facilitate the prognostic assessment of pituitary hormonal outcomes after surgery.MethodsA total of 215 male patients with NFPA, who underwent surgery in four medical centers from 2015 to 2021, were retrospectively reviewed. The data were pooled after heterogeneity assessment, and they were randomly divided into training and testing sets (172:43). Six ML models and logistic regression models were developed using six anterior pituitary hormones.ResultsOnly thyroid-stimulating hormone (p &lt; 0.001), follicle-stimulating hormone (p &lt; 0.001), and prolactin (PRL; p &lt; 0.001) decreased significantly following surgery, whereas growth hormone (GH) (p &lt; 0.001) increased significantly. The postoperative GH (p = 0.07) levels were slightly higher in patients with gross total resection, but the PRL (p = 0.03) level was significantly lower than that in patients with subtotal resection. The optimal model achieved area-under-the-receiver-operating-characteristic-curve values of 0.82, 0.74, and 0.85 in predicting hormonal hypofunction, new deficiency, and hormonal recovery following surgery, respectively. According to feature importance analyses, the preoperative levels of the same type and other hormones were all important in predicting postoperative individual hormonal hypofunction.ConclusionFluctuation in anterior pituitary hormones varies with increases and decreases because of transsphenoidal surgery. The ML models could accurately predict postoperative pituitary outcomes based on preoperative anterior pituitary hormones in NFPA.

ELECTROPHORETIC SEPARATION OF HORMONES ASSOCIATED WITH SECRETORY GRANULES FROM RAT ANTERIOR PITUITARY GLANDS

1970 ◽  
Vol 63 (2) ◽  
pp. 378-384 ◽  
Author(s):  
D. R. Hodges ◽  
W. H. McShan
Keyword(s):  
Growth Hormone ◽  
Anterior Pituitary ◽  
Secretory Granules ◽  
Follicle Stimulating Hormone ◽  
Pituitary Hormones ◽  
Thyroid Stimulating Hormone ◽  
Disc Electrophoresis ◽  
Hormone Activity ◽  
Pituitary Glands ◽  
Stimulating Hormone

ABSTRACT Electrophoretic analyses of rat, mouse, human and cow anterior pituitary homogenates with subsequent bioassays for hormonal activity have been reported. Comparison of the behaviour of the hormonal activities from rat anterior pituitary secretory granules and that reported for pituitary homogenates was made following disc electrophoresis on polyacrylamide gels. Bioassays of gel segments for the six anterior pituitary hormones resulted in the localization of the activities of five of the six hormones. ACTH activity was not detected. Growth hormone and prolactin were associated with the major cathodal and anodal discs respectively. Luteinizing hormone and thyroid stimulating hormone activities had similar mobilities and were located in a zone just above growth hormone. The activity was not restricted to a discrete, stainable disc in either case. Follicle stimulating hormone activity was detected in a narrow segment containing only one disc a few millimeters below growth hormone. Comparison of the mobilities of the hormones from homogenates and secretory granule extracts suggests that they have essentially similar electrophoretic characteristics at basis pH.

Associated Hypersecretion of Anterior Pituitary Hormones other than Growth Hormone in Acromegaly

Acromegaly ◽  
1987 ◽  
pp. 179-191
Author(s):  
G. Faglia ◽  
M. Arosio ◽  
M. Bassetti ◽  
P. Beck-Peccoz ◽  
L. Guglielmino ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Anterior Pituitary ◽  
Pituitary Hormones ◽  
Anterior Pituitary Hormones

INFLUENCE OF HORMONES ON LOBULO-ALVEOLAR DIFFERENTIATION OF MOUSE MAMMARY GLANDS IN VITRO

1966 ◽  
Vol 35 (4) ◽  
pp. 331-NP ◽  
Author(s):  
RUBY R. ICHINOSE ◽  
S. NANDI
Keyword(s):  
Growth Hormone ◽  
Steroid Hormones ◽  
Anterior Pituitary ◽  
Steroid Hormone ◽  
Mammary Glands ◽  
Defined Medium ◽  
Pituitary Hormones ◽  
Anterior Pituitary Hormones

SUMMARY (1) To induce mammary differentiation in vitro, BALB/cCrgl mice were given hormones before incubation of their mammary glands in defined medium containing steroid hormones (oestradiol, progesterone and aldosterone), anterior pituitary hormones (prolactin and growth hormone), and insulin. The sequence of lobule development in vitro obtained in this way was determined by cultivation of tissues for 1, 2, 3, 4 and 5 days. Lobules appeared on the 3rd day of culture, although proliferation occurred throughout the 5-day period. (2) In two other sets of experiments, mammary glands were exposed to various combinations of hormones in culture. Survival of cultured tissues required the presence of insulin, whereas differentiation required the presence of steroid hormones, anterior pituitary hormones, and insulin. Of the steroid hormones used, aldosterone alone fulfilled the minimum steroid hormone requirement for lobule formation in vitro.

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