scholarly journals Is Less Invasive Surfactant Administration a Beneficial Method for Late Preterm Infants?

2021 ◽  
Vol 24 (10) ◽  
pp. 759-764
Author(s):  
Mehmet Tekin ◽  
Musa Silahli ◽  
Zeynel Gokmen
Keyword(s):  
Respiratory Distress ◽  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Late Preterm ◽  
Reliable Technique ◽  
Very Preterm Infants ◽  
Late Preterm Infants ◽  
Less Invasive ◽  
Study Results ◽  
Surfactant Administration

Background: Late preterm infants (LPIs) have increased steadily in all newborns delivery and they are the largest patient group requiring admission to the neonatal intensive care unit. Surfactant treatment is frequently used in LPIs in case of respiratory distress, but the procedure and the timing of surfactant administration are not well-known. Objective: We aimed to evaluate the effect of surfactant administration techniques on pulmonary outcomes in LPIs with respiratory distress. Methods: In this retrospective study, we compared the effects of the less invasive surfactant administration (LISA) technique and conventional treatment on respiratory and other morbidities in LPIs who have respiratory difficulties. We named these two groups as the LISA group and the conventional group (CG). Comparison of the mechanical ventilation (MV) rates between the groups was the primary outcome of our study. Results: There were 25 LPIs in each group. The duration of nasal continuous positive airway pressure (CPAP) and oxygenation were similar in both groups. The rate of MV and the duration of MV (P=0.004 and P=0.02) were lower in the LISA group. Also, the need for more than 1 dose of surfactant was higher in the MV requiring group, although it was not statistically significant between the groups (P=0.21). Conclusion: Using the LISA technique for surfactant instillation reduces any MV requirement. LISA is a very useful and reliable technique in experienced hands in LPIs as in very preterm infants.

Surfactant Treatment of Late Preterm Infants during Emergency Transport: A Retrospective, Observational Study

Neonatology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Francesco Cavallin ◽  
Giorgia Carlone ◽  
Nicoletta Doglioni ◽  
Paolo Ernesto Villani ◽  
Luca Vecchiato ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Outcome Measures ◽  
Late Preterm ◽  
Stabilization Time ◽  
Late Preterm Infants ◽  
Transport Team ◽  
Emergency Transport ◽  
Surfactant Administration

<b><i>Background:</i></b> In late preterm infants born in nontertiary hospitals, the occurrence of respiratory distress syndrome requires postnatal transport. This study aimed to investigate the impact of the timing of surfactant administration in late preterm infants needing postnatal transport. <b><i>Methods:</i></b> This is a retrospective study evaluating surfactant administration in late preterm infants during emergency transports by the Eastern Veneto Neonatal Emergency Transport Service between January 2005 and December 2019. The outcome measures included short-term clinical complications, stabilization time, oxygen concentration, duration of mechanical ventilation and noninvasive respiratory support, length of hospital stay, bronchopulmonary dysplasia, intraventricular hemorrhage, and sepsis. <b><i>Results:</i></b> Surfactant was administered to 155/303 neonates (51.1%) at 3 different time points: at a referring hospital (50 neonates), when the transport team arrived (25 neonates), or at a referral hospital (80 neonates). Stabilization time was longer in neonates receiving surfactant by the transport team (adjusted mean difference 17 min, 95% confidence interval, 4–29 min; <i>p</i> = 0.01). Decrease in oxygen concentrations during the transport was larger in neonates receiving surfactant at a referring hospital (adjusted mean difference −11%, 95% confidence interval, −15 to −3%; <i>p</i> = 0.01). The other outcome measures were not statistically different according to the timing of surfactant administration. <b><i>Conclusions:</i></b> In late preterm infants with respiratory distress needing postnatal transfer, stabilization time was longer when the first surfactant was administered by the transport team, but such delay did not affect safety and clinical outcomes.

scholarly journals Lung ultrasound features predict admission to the neonatal intensive care unit in infants with transient neonatal tachypnoea or respiratory distress syndrome born by caesarean section

2020 ◽  
Author(s):  
Antonio Poerio ◽  
Silvia Galletti ◽  
Michelangelo Baldazzi ◽  
Silvia Martini ◽  
Alessandra Rollo ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Neonatal Intensive Care Unit ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Distress Syndrome ◽  
Lung Ultrasound ◽  
Late Preterm ◽  
Late Preterm Infants ◽  
Nicu Admission

Abstract We aimed to evaluate the reliability of lung ultrasound (LU) to predict admission to the neonatal intensive care unit (NICU) for transient neonatal tachypnoea or respiratory distress syndrome in infants born by caesarean section (CS). A prospective, observational, single-centre study was performed in the delivery room and NICU of Sant’Orsola-Malpighi Hospital in Bologna, Italy. Term and late-preterm infants born by CS were included. LU was performed at 30’ and 4 h after birth. LU appearance was graded according to a previously validated three-point scoring system (3P-LUS: type-1, white lung; type-2, black/white lung; type-3, normal lung). Full LUS was also calculated. One hundred infants were enrolled, and seven were admitted to the NICU. The 5 infants with bilateral type-1 lung at birth were all admitted to the NICU. Infants with type-2 and/or type-3 lung were unlikely to be admitted to the NICU. Mean full-LUS was 17 in infants admitted to the NICU, and 8 in infants not admitted. In two separate binary logistic regression models, both the 3P- and the full LUS proved to be independently associated with NICU admission (OR [95% CI] 0.001 [0.000–0.058], P = .001, and 2.890 [1.472–5.672], P = .002, respectively). The ROC analysis for the 3P-LUS yielded an AUC of 0.942 (95%CI, 0.876–0.979; P<.001), while ROC analysis for the full LUS yielded an AUC of 0.978 (95%CI, 0.926–0.997; P<.001). The AUCs for the two LU scores were not significantly different (p = .261). Conclusion: the 3P-LUS performed 30 min after birth proved to be a reliable tool to identify, among term and late preterm infants born to CS, those who will require NICU admission for transient neonatal tachypnoea or respiratory distress syndrome. What is known• Lung ultrasound (LU) has become an attractive diagnostic tool in neonatal settings, and guidelines on point-of-care LU in the neonatal intensive care unit (NICU) have been recently issued.• LU is currently used for diagnosing several neonatal respiratory morbidities and has been also proposed for predicting further intervention, such as NICU admission, need for surfactant treatment or mechanical ventilation in preterm infants. What is new• LU performed 30′ after birth and evaluated through a simple three-point scoring system represents a reliable tool to identify, among term and late preterm infants born to caesarean section, those with transient neonatal tachypnoea or respiratory distress syndrome who will require NICU admission.• LU performed in the neonatal period confirms its potential role in ameliorating routine neonatal clinical management.

Respiratory distress management in moderate and late preterm infants: The NEOBS Study

2021 ◽  
Author(s):  
T. Debillon ◽  
P. Tourneux ◽  
I. Guellec ◽  
P.-H. Jarreau ◽  
C. Flamant
Keyword(s):  
Respiratory Distress ◽  
Preterm Infants ◽  
Late Preterm ◽  
Late Preterm Infants

"COMPARATIVE STUDY OF EARLY NEONATAL MORBIDITIES OF LATE PRETERM AND TERM NEONATES"

2021 ◽  
pp. 23-25
Author(s):  
Jatin Manocha ◽  
Kusum Mahajan ◽  
Anuj Kumar
Keyword(s):  
Preterm Infants ◽  
Prospective Observational Study ◽  
Neonatal Period ◽  
Newborn Infants ◽  
Late Preterm ◽  
Preterm Neonates ◽  
Feeding Problems ◽  
Term Neonates ◽  
Late Preterm Infants ◽  
Study Results

Background- Newborn infants are unique in their physiology and the health problems that they experience. Neonatal period is dened from birth to under four weeks of age. Late preterm infants may physiologically and physically appear like infants born at term, but most late preterm infants may undergo complications like respiratory distress, apnea, hypothermia, feeding problems, hypoglycemia, hyperbilirubinemia, sepsis, and mortality. AIM-To compare the clinical prole of late preterm neonates with term neonates. MATERIALAND METHODS: This prospective observational study was carried out in neonatal division of department of pediatrics MMIMSR, Mullana. Eligible neonates delivered at MMIMSR, Mullana born from 34 weeks up to 42 weeks gestation were included. All infants enrolled in the study was followed daily till rst 7 days of life for any morbidity by clinical evaluation and review of hospital records.104 preterms included in the study and 226 term neonates were included in the study. Results- Preterms born via LSCS and NVD were(58%vs.42%).Morbidities in late preterms were Hypoglycemia (21.2% vs. 9.3%), Hypothermia (15.4%vs5.7%), hypocalcaemia (38.4% vs. 5.3%), neonatal hyperbilirubinemia(67.3% vs. 30.5%), feeding difculties(44.2% vs. 14.6%), sepsis(40.4% vs. 19.5%), respiratory support(53% vs. 47%)

Short-Term Outcomes following Standardized Admission of Late Preterm Infants to Family-Centered Care

2019 ◽  
Author(s):  
Jonathan Reiss ◽  
Pavan S. Upadhyayula ◽  
Hyeri You ◽  
Ronghui Xu ◽  
Lisa M. Stellwagen
Keyword(s):  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Transitions Of Care ◽  
Late Preterm ◽  
Family Centered Care ◽  
Short Term ◽  
Late Preterm Infants ◽  
Car Seat ◽  
Centered Care ◽  
Family Centered

Abstract Objective The study compares the short-term outcomes of late preterm infants (LPI) at an academic center in San Diego, California after a change in protocol that eliminated a previously mandatory 12-hour neonatal intensive care unit (NICU) observation period after birth. Study Design This is a retrospective observational study examining all LPI born with gestational age 35 to 366/7 weeks between October 1, 2016 and October 31, 2017. A total of 189 infants were included in the review. Short-term outcomes were analyzed before and after the protocol change. Results Transfers to the NICU from family-centered care (FCC) were considerably higher (23.2%) following the protocol change, compared to before (8.2%). More infants were transferred to the NICU for failed car seat tests postprotocol compared to preprotocol. Length of stay before the protocol change was 5.13 days compared to 4.80 days after. Conclusion LPI are vulnerable to morbidities after delivery and through discharge. We found an increase in failed car seat tests in LPI cared for in FCC after elimination of a mandatory NICU observation after birth. The transitions of care from delivery to discharge are key checkpoints in minimizing complications.

A survey on criteria for intubation in moderate to late preterm infants with respiratory distress

2020 ◽  
Vol 55 (11) ◽  
pp. 2970-2982
Author(s):  
Susan Y. S. Feng ◽  
Shripada Rao ◽  
Sanjay Patole
Keyword(s):  
Respiratory Distress ◽  
Preterm Infants ◽  
Late Preterm ◽  
Late Preterm Infants

scholarly journals Behavioural outcomes at 3 years of age among late preterm infants admitted to neonatal intensive care: a cohort study

2014 ◽  
Vol 99 (5) ◽  
pp. F359-F365 ◽  
Author(s):  
Jackie Boylan ◽  
Fiona A Alderdice ◽  
Jennifer E McGowan ◽  
Stanley Craig ◽  
Oliver Perra ◽  
...  
Keyword(s):  
Cohort Study ◽  
Intensive Care ◽  
Preterm Infants ◽  
Neonatal Intensive Care ◽  
Late Preterm ◽  
Late Preterm Infants
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