scholarly journals An Update of Helicobacter pylori Prevalence and Associated Risk Factors in Southern Iran: A Population-Based Study

2020 ◽  
Vol 23 (10) ◽  
pp. 665-671
Author(s):  
Fateme Ziyaee ◽  
Abdolvahab Alborzi ◽  
Gholamreza Pouladfar ◽  
Bahman Pourabbas ◽  
Sadaf Asaee ◽  
...  
Keyword(s):  
Developing Countries ◽  
Helicobacter Pylori ◽  
Parental Education ◽  
Population Based ◽  
Current Status ◽  
Preventive Strategies ◽  
Prevalence Rates ◽  
Population Based Study ◽  
Southern Iran ◽  
H Pylori

Background: The childhood period is considered to be the primary period for acquisition of the Helicobacter pylori. The high prevalence rates from developing countries are associated with gastric cancer. A decreasing trend of its prevalence has been reported from different parts of the world. Determining the prevalence rate could be important in choosing preventive strategies. This study aimed to determine the prevalence of H. pylori among a group of children from southern Iran to provide an update on the current status of the disease. Methods: This is a cross-sectional population-based study conducted in Shiraz, southern Iran, from January 2014 to December 2015. Four groups including neonates, children aged 6 months to 3 years, 10- and 15-year-old children were included. Multi-monoclonal stool antibody test was used for diagnosis. Results: Among 436 participants, 24.8% (95% CI: 20.8–29.1) had a positive test for H. pylori: 25% in neonates (95% CI: 16.2–36.1), 22% in children aged 6 months to 3 years (95% CI: 15.2–30.2), 19.5% in the 10-year-old (95% CI: 12.3–29.4), and 29.2% in 15-year-old children (95% CI: 21–39). Sex, age, number of siblings, owning a pet, parents’ smoking status, parental education, residential area, birth weight, and feeding status were not found to be statistically significant predictors of H. pylori antigen positivity (P > 0.05). Conclusion: The prevalence of H. pylori was estimated to be low in southern Iran in comparison with previous reports or other developing countries. Preventive strategies with respect to low prevalence rates may be considered in the childhood period.

scholarly journals Reliability of Helicobacter pylori and CagA Serological Assays

2002 ◽  
Vol 9 (2) ◽  
pp. 412-416 ◽  
Author(s):  
James E. Everhart ◽  
Deanna Kruszon-Moran ◽  
Guillermo Perez-Perez
Keyword(s):  
Helicobacter Pylori ◽  
Mexican Americans ◽  
Odds Ratio ◽  
Serological Test ◽  
Population Based ◽  
Immune Serum ◽  
Serological Tests ◽  
Population Based Study ◽  
Health And Nutrition ◽  
H Pylori

ABSTRACT Background serological assays for Helicobacter pylori are commonly used without knowledge of reliability. This information is needed to define the ability of serological tests to determine either new cases of infection or loss of infection in longitudinal studies. We evaluated the reproducibility and the interrelationships of serological test results for H. pylori and cytotoxin-associated gene product A (CagA) enzyme-linked immunoassays within a subset of participants in a population-based study. Stored samples from 1,229 participants in the third U.S. National Health and Nutrition Examination Survey were replicate serologically tested for H. pylori and CagA. Overall disagreement was 3.4% between duplicate tests for H. pylori (or 2.3% if equivocal results were disregarded). Six percent of samples positive on the first test had an immune serum ratio at least 30% lower on repeat testing. The odds ratio for H. pylori seropositivity on retesting was 2.8 (95% confidence interval [CI] = 1.8 to 4.5) when CagA serology was positive versus when it was negative. CagA antibody was found among 47.8% of H. pylori-equivocal and 7.0% of H. pylori-negative samples. CagA-positive yet H. pylori-negative samples were more likely to occur among Mexican Americans (odds ratio, 5.2; 95% CI = 2.4 to 11.4) and non-Hispanic blacks (odds ratio, 5.5; 95% CI = 2.3 to 13.0) than among non-Hispanic whites. Relying on repeated H. pylori serological tests over time to determine infection rates may result in misinterpretation due to limits in test reproducibility. CagA testing may have a role in verifying infection.

Helicobacter pylori infection, peptic ulceration, and Meckel's diverticulum

2011 ◽  
Author(s):  
R. Mark Beattie ◽  
Anil Dhawan ◽  
John W.L. Puntis
Keyword(s):  
Developing Countries ◽  
Helicobacter Pylori ◽  
Meckel’S Diverticulum ◽  
Meckel's Diverticulum ◽  
Peptic Ulceration ◽  
Helicobacter Pylori Infection ◽  
Prevalence Rates ◽  
Gram Negative ◽  
H Pylori ◽  
Common Infection

Helicobacter pylori194Other causes of antral gastritis and peptic (gastric and duodenal) ulceration 196Meckel's diverticulum 197•H. pylori is a Gram-negative organism. It is a very common infection worldwide. Infection is usually acquired in childhood, but prevalence rates are variable, being highest in developing countries. Most individuals infected with ...

scholarly journals Helicobacter pylori Infection Mass Screening for Children and Adolescents: a Systematic Review of Observational Studies

2021 ◽  
Author(s):  
Hiroaki Saito ◽  
Yoshitaka Nishikawa ◽  
Yuko Masuzawa ◽  
Masaharu Tsubokura ◽  
Yasuhiro Mizuno
Keyword(s):  
Systematic Review ◽  
Helicobacter Pylori ◽  
Young People ◽  
Breath Test ◽  
Screening Method ◽  
Population Based ◽  
Current Status ◽  
Cochrane Library ◽  
H Pylori ◽  
Potential Methods

Abstract Purpose Population-based Helicobacter pylori (H. pylori) screening and eradication for adults in areas with a high incidence of gastric cancer have been shown to be effective. The current status of H. pylori screening for young people, however, has not been sufficiently evaluated. Methods A systematic review of population-based H. pylori screening of young people was performed using four databases (MEDLINE, EMBASE, the Cochrane Library, and ICHUSHI) and independently evaluated by two investigators. Studies were evaluated with regard to the country, region, screening method, target age, number of screened people, and rate of positive screening. Results From 3231 studies, 39 studies were included (14 English original studies published in peer-review journals, 6 Japanese original studies, and 19 conference reports). These studies originated from 10 countries, with the largest number stemming from Japan (29 studies) followed by Germany (2 studies). Screening was performed using the urea breath test, blood antibodies, stool antigens, and urine antibodies. Five countries used the breath test as the first screening method, five used blood samples, two used stool antigens, and only Japan used urinary tests. Conclusion Screening for H. pylori in young people was reviewed based on reports from several countries, and findings suggest that local authorities considering screening for H. pylori in young people need to scrutinize the age and potential methods. Further research is required to determine the effectiveness of mid- to long-term H. pylori screening for young people.

A population-based study of gastric cancer and Barrett's Esophagus in a rural population in Colombia: Lack of protection by H. Pylori

2000 ◽  
Vol 118 (4) ◽  
pp. A1382
Author(s):  
Hector Cardona ◽  
Oscar Gutierrez ◽  
J. Becerra ◽  
William Otero ◽  
Antonia Sepulveda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Barrett’S Esophagus ◽  
Rural Population ◽  
Barrett's Esophagus ◽  
Population Based ◽  
Population Based Study ◽  
H Pylori

scholarly journals Non Alcoholic Fatty Liver Disease in Southern Iran: A Population Based Study

2013 ◽  
Vol 13 (5) ◽  
Author(s):  
Kamran Bagheri Lankarani ◽  
Fariborz Ghaffarpasand ◽  
Mojtaba Mahmoodi ◽  
Mehrzad Lotfi ◽  
Nima Zamiria ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Population Based ◽  
Population Based Study ◽  
Alcoholic Fatty Liver ◽  
Southern Iran ◽  
Alcoholic Fatty Liver Disease

scholarly journals Correlation between Quantitative 13C-Urea Breath Test and Helicobacter pylori Treatment Success in a Population-Based Cohort

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Doron Boltin ◽  
Zohar Levi ◽  
Tsachi Tsadok Perets ◽  
Hemda Schmilovitz-Weiss ◽  
Rachel Gingold-Belfer ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Treatment Success ◽  
Population Based ◽  
Urea Breath Test ◽  
First Line Therapy ◽  
13C Urea Breath Test ◽  
Helicobacter Pylori Treatment ◽  
H Pylori ◽  
First Time

Background. There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H. pylori) infection. The 13C-urea breath test result (C13-UBT) utilizes H. pylori urease activity and is a highly accurate diagnostic assay. We aimed to determine whether the magnitude of C13-UBT result is related to treatment success. Methods. Adult patients who underwent a first-time 13C-urea breath test between January 2010 and January 2016 were included. In order to isolate a naïve test-and-treat population who were unlikely to have undergone an initial endoscopy-based H. pylori test, we excluded patients > 45 years and those with a previous C13-UBT. Data were extracted from the Clalit Health Services laboratory database. Results. A total of 94,590 subjects (36.1% male, age 28.5 ± 6.0 years) who underwent a first-time C13-UBT during the study period were included. C13-UBT was positive in 48,509 (51.3%) subjects. A confirmatory posttreatment C13-UBT was performed in 18,375 (37.8%), and eradication was successful in 12,018 (65.4%). The mean C13-UBT recording was 20.6 ± 16.2 DOB in subjects with successful eradication and 19.5 ± 13.1 DOB in subjects with treatment failure (OR, 1.01; 95% CI 1.00-1.01, p<0.01). Among patients in the upper quintile of C13-UBT measurement, eradication was achieved in 67.6%, compared to 62.6% in the lower quintile (OR, 1.22; 95% CI 1.11-1.35, p<0.01). Subjects in the top 1 percentile (C13-UBT ≥ 70 DOB) achieved eradication in 75.0%, compared to 65.3% among subjects with C13-UBT < 70 DOB (OR, 1.59; 95% CI 1.05-2.41, p<0.01). Conclusions. The superiority in H. pylori eradication observed in subjects with a higher C13-UBT DOB is small but significant. Further studies should examine the physiological and microbiological basis for this finding.

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