scholarly journals Risk Factors, Clinical Symptoms, Laboratory Findings and Imaging of Pregnant Women Infected with COVID-19 in North of Iran

2020 ◽  
Vol 23 (12) ◽  
pp. 856-863
Author(s):  
Soudabeh Kazemi Aski ◽  
Seyedeh Hajar Sharami ◽  
Fatemeh Hosseinzadeh ◽  
Ezat Hesni ◽  
Seyedeh Fatemeh Dalil Heirati ◽  
...  

Background: Due to the physiological changes in the body during pregnancy, the increased susceptibility to viral infections during this period and also the high prevalence of coronavirus disease 2019 (COVID-19) in the Guilan province, Iran, this study aimed to evaluate risk factors, clinical symptoms, laboratory findings and imaging of pregnant mothers with COVID-19. Methods: In this descriptive study, 70 pregnant women aged 17–41 years with COVID-19 who were hospitalized from early March to late April 2020 were enrolled. Sampling was performed by census and from all hospitals in Guilan. The research instruments included a researcher-made questionnaire, including demographic characteristics, clinical symptoms, medical examinations, and paraclinical results. Data were analyzed with SPSS version 16. Frequency and percent were used to describe qualitative variables; for quantitative variables, if they were normally distributed, mean and standard deviation were used, and if they were non-normal, median and interquartile range (IQR) were used. Results: The most severe symptoms recorded in mothers at the time of hospitalization were fever (47%), shortness of breath (16%) and cough (15%), respectively. One of 68 (1%) was in the severe stage of the disease and two mothers (2%) were in critical condition and admitted to the intensive care unit and finally died. Fifty-five of 66 women (83%) had lymphopenia, 22 of 42 (52%) tested positive on PCR, and 30 of 33 (90%) had an increase in lactate dehydrogenase (LDH) levels.Results showed that 15 of 32 patients who gave birth had preterm delivery (46%). Conclusion: The most common manifestations of the disease in pregnant women were fever, cough and shortness of breath, and in some cases muscle pain. The most common laboratory finding in infected mothers was lymphopenia. Complications of pregnancy and childbirth in women included an increase in cesarean delivery.

2020 ◽  
Vol 17 (34) ◽  
pp. 656-666
Author(s):  
Akmaral K ZHUMALINA ◽  
Balash T TUSUPKALIEV ◽  
Yuliya A ZAME ◽  
Lyudmila V VOLOSHINA ◽  
Klara B DARZHANOVA

Today about 40 % of babies are infected with intrauterine infections. The immune statuses of children during the neonatal period are largely associated with the patterns of pregnancies in their mothers. This work aimed to study clinical and immunological features in newborns of mothers with intrauterine infection. 48 infants were observed. Neonates were divided into two groups: group 1 – 33 newborns from mothers infected with cytomegalovirus infection, group 2 – 15 children from healthy mothers. The diagnosis of intrauterine infection verifizierung the basis of survey questionnaire for pregnant women, outpatient data of pregnant women and neonates, serologic study, PCR, ELISA, and the cellular immunity and humoral immunity. Somatic and obstetric and gynecological history of mothers was thoroughly collected and the risk factors for the development of complications in the early period of adaptation were assessed. The result of the study revealed that the structure of risk factors in pregnant women with intrauterine infections is of great importance the age of 30 years, genital and extragenital pathology during pregnancy, spontaneous abortions and non-developing pregnancy, abortion. Associated viral infections (CMV, Cytomegalovirus) predominate in the structure of congenital infection. The analysis indicates significantly burdened perinatal anamnesis in children infectious factors and factors of perinatal hypoxia. The leading clinical symptoms for intrauterine infections among the examined children are in the early neonatal period prematurity asphyxia, urinary symptoms, late neonatal period differ polymorphism symptomatic. In this period reveals a specific organ of the Central nervous system. In newborns with intrauterine infections observed inhibition of immunological indicators (CD4+, Cd8+, Cd 19+).


Author(s):  
Natalie M. Bowman ◽  
Filemón Bucardo ◽  
Matthew H. Collins ◽  
Yaoska Reyes ◽  
Edwing Centeno Cuadra ◽  
...  

The American Zika virus (ZIKV) epidemic has highlighted the need to gain a better understanding of this emerging virus. The goal of this study was to describe the clinical symptoms, laboratory findings, and risk factors for symptomatic ZIKV infection in an area with ongoing transmission of other arboviral infections. We recruited patients at least 2 years of age seeking care at public health centers in León, Nicaragua, between January 2016 and August 2017, for fever, maculopapular rash, and/or nonsuppurative conjunctivitis with a duration of less than 1 week. A laboratory diagnosis of ZIKV was established using a combination of molecular and serological tests. Clinical and laboratory findings and potential risk factors were compared between participants with and without acute ZIKV infection. Fifty-eight (26%) of the 225 participants included in the analysis were found to have acute ZIKV infection. Pregnancy and reports of previous arboviral infection were associated with a higher risk of ZIKV infection. Rash, conjunctivitis, sore throat, and lower absolute neutrophil counts were associated with acute ZIKV infection. The clinical characteristics and risk factors identified were consistent with those identified by previous studies; however, we found sore throat to be a feature of ZIKV infection. We also found that neutrophil counts were lower in ZIKV-infected subjects. These clinical symptoms and laboratory data may help clinicians suspect ZIKV infection during future outbreaks.


2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Wahyu ja’far siddiq ◽  
Indah sulistiyowati

The Covid-19 pandemic that is currently spreading in Indonesia has claimed thousands of lives. Coronavirus Disease is characterized by the main clinical symptoms of fever >38 °C, coughing, to shortness of breath. In preventing its spread, the government conducts early detection by examining the main symptoms in the form of a fever and enforcing health protocols on each line. Therefore, we need an appropriate innovation that can make it easier for officers/guards to check human body temperature, especially in crowded places such as at airports, malls, or on the highway. Currently, body temperature measurement equipment is widely used, which allegedly made many errors in detecting it. Therefore, an innovative helmet was created that can be used by guards, security and even the police to detect body temperature based on the Arduino Pro Mini with the MLX90614-DCI sensor and the output is the real body temperature displayed on the LED screen. When the body temperature reads more than 38 °C, the helmet will turn on a buzzer and an LED to show that the target measurement is in a fever condition, and it is recommended going to the health center for further examination. This tool has been tested, and the sensor readings have an accuracy at a distance of 100 cm with several participants and the sensor readings are compared with the reading values from the alpha one thermometer and the measurement results have an accuracy level of 95%.


2019 ◽  
Vol 24 (1) ◽  
pp. 33-40
Author(s):  
Willy Ramos ◽  
Miguel Luna ◽  
Tania Alarcón ◽  
Gerardo Jiménez ◽  
Jesús Díaz ◽  
...  

This article aims to describe the cutaneous manifestations observed in the Zika epidemic in Peru during 2016 and 2017, as well as discuss the potential differential diagnoses. During the outbreak, the main reason for seeking medical advice was the development of a pruriginous maculopapular rash with a marked papular component, which started on the chest and later generalized to the rest of the body. Similar manifestations were noted in adults, children, and pregnant women. Other manifestations such as conjunctivitis, edema, or petechiae on the palate were rare. We suggest that in areas that are endemic for arboviral infections, in the differential diagnosis of a rash one must consider infections such as dengue, Zika, or chikungunya viruses. In nonendemic areas, the diagnosis is more difficult, as the rash may result from other viral infections not transmitted by arthropods and/or reactive or inflammatory diseases (urticaria, atopic dermatitis, systemic lupus erythematosus). We recommend that primary care health personnel are trained in the recognition of the mucocutaneous lesions caused by Zika virus infection, which could contribute to the identification of suspicious cases, particularly pregnant women.


2021 ◽  
pp. 96-101
Author(s):  
O. R. Trutiak ◽  
O. L. Lychkovska ◽  
R. R. Holovyn ◽  
M. I. Dats-Opoka

Bronchial asthma (BA) is a common chronic pathology of the lower respiratory tract in children. The first manifestations of the disease can begin at any age, but the clinical features, of the course, are different in different periods of childhood. Manifestations and course of asthma may disappear or progress with age. Therefore, it is likely that there are differences in the pathophysiology, inflammatory response of the body and the features of the clinic of asthma in children of different ages, which affects the diagnosis and treatment. The aim of the study was to determine the features of clinical symptoms and the influence of risk factors for asthma on its occurrence in children of different ages. Materials and methods. We analyzed the anamnesis and clinical symptoms of 57 children aged 3 to 18 years, who were treated from September 2020 to June 2021 in the Lviv Regional Children's Clinical Hospital “OHMATDYT” and in the Lviv Municipal City Children's Clinical Hospital. The age groups did not differ statistically in the severity of asthma (P> 0.05). Thus, in group 1 was 1 patient (9.09%) with mild form, 1 patient (9.09%) - moderate persistent form, 8 patients (72.73%) - with severe persistent form. Among patients of age group 2 was 1 patient (3.85%) with mild persistent form, 3 children (11.54%) - moderate and 21 children (80.77%) - with severe persistent form. In group 3 was 1 patient (5%) with a mild persistent form, 6 patients (30%) - moderate and 12 children (80%) - with a severe persistent form. The vast majority of patients were boys (84.21 ± 4.83%). All patients underwent general clinical examinations, spirometry, and allergy tests. We used the clinical-anamnestic method to perform the tasks of the work, which consisted in collecting a detailed somatic and genealogical anamnesis during the parents` questionnaire. Physical development of children was assessed using centile tables. Statistics were evaluated by calculating Student's t-test and Pearson's consistency test. Preschool children with asthma were more likely to experience shortness of breath during exercise and a wet low-yielding cough, and children of primary and secondary school age were more characterized by concomitant allergic rhinitis. Autumn was more unfavorable period for the exacerbation of clinical manifestations of asthma in children of Lviv region was period. We did not find correlation of birth weight on the timing of asthma. However, a burdensome obstetric history contributed to the early development of clinical manifestations of asthma. Preschool children were more likely to be exposed to nicotine during the antenatal period and had a shorter duration of breastfeeding, which may be a probable risk factor for asthma in preschool children. In 77% of children from different age groups were burdened with a history of allergies, with 66% of cases more pronounced in the maternal line. An analysis of physical development revealed that most preschool children were overweight. Conclusions. Asthma has features of clinical symptoms in children of different ages - shortness of breath during exercise and whooping cough are characteristic of preschool children, and concomitant chronic persistent rhinitis - for older age groups. Seasonal exacerbations are characteristic of asthma in children; in particular, the autumn period is more unfavorable, common for asthmatics in children of all ages among patients in Lviv region. Maternal smoking during pregnancy has a significant effect on the risk of developing asthma in children. Also, a burdened maternal allergy history and overweight child contributes to the development of asthma in children.


2019 ◽  
Vol 2 (1) ◽  
pp. 9
Author(s):  
Sulastri Sulastri ◽  
Arina Maliya ◽  
Ni'mah Mufidah ◽  
Eka Nurhayati

                             Introduction. Obstetric and neonatal emergencies are a condition that can be life threatening and can occur both during pregnancy and childbirth. One of the causes of emergency is the complication of pregnancy, where this complication can arise due to risk factors during pregnancy, one of which is the gravida. Pregnant women with primigravida and gravida = 4 are high-risk factors for pregnancy and childbirth. The purpose of this study was to determine the contribution of the number of pregnancies (gravida) to mothers who had complications of pregnancy and childbirth in the work area of the Gatak Health Center, Sukoharjo. Methods. This research is a quantitative descriptive with a retrospective approach, data collection using the record or other documents in the form of health information for pregnant women with pregnancy comorbidities taken based on data from January 1 to December 31, 2018, in total sampling. Result. Of the 224 data of pregnant women with comorbidities, among them experienced pre-eclampsia (67.1%). The characteristics of respondents were based on the most age at 20-35 years old (82.5%), multigravida status (84.8%), and SC delivery (67%). Discussion. The importance of regulating and monitoring the number of pregnancies (gravida) of mothers to prevent complications of pregnancy and childbirth and to improve the degree of life of a mother.


2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Annisa Meivira Budiman ◽  
Sumartini Dewi ◽  
Marietta Shanti Prananta

Background Systemic sclerosis is a chronic progressive multisystem autoimmune disease in connective tissue, characterized by its heterogeneous clinical manifestation. The purpose of this study is to give information regarding clinical manifestations and laboratory findings of systemic sclerosis patients to establish diagnosis of disease. Methods This study was conducted using descriptive quantitative design in September−October 2016. Data was collected from medical records of patients visiting Rheumatology Clinic Dr. Hasan Sadikin General Hospital from 1 July 2015−30 June 2016 using total sampling method. The collected data were expected to comprise patient’s clinical manifestation and laboratory finding. Results Most of patients had cutaneous 57 (100.0%) and musculoskeletal 40 (70.2%) involvement. Some of the disease manifestations were Raynaud’s phenomenon 38 (66.7%), fingertip lesion 33 (57.9%), stiffness in skin 34 (59.6%), and arthalgia 29 (50.9%). Gastrointestinal involvements were present in 29 (50.9%) patients. Renal involvement were determined from urinalysis result showed proteinuria 10 (17.5%) and hematuria 8 (14.0%), found in 24 (42.1%) patients, while pulmonary and cardiac involvements were found in 30 (52.6%) patients, acknowledged from clinical symptoms such as dyspnea 12 (21.1%). Identification of autoantibodies was found in 12 (21.1%) patients, with 10 (17.5%) patients had reactive ANA and 3 (3.5%) had positive anti-Scl70. Conclusion Most of systemic sclerosis patients had cutaneous involvement. Renal, pulmonary, and cardiac involvement were concluded based on laboratory findings. Keywords: Systemic sclerosis, clinical manifestation, laboratory finding


2019 ◽  
Author(s):  
Sulastri . ◽  
Arina Maliya ◽  
Ni’mah Mufidah ◽  
Eka Nurhayati

Background: Emergency obstetric and newborn is a condition that can be life-threatening and can occur during pregnancy and childbirth. The cause of such emergencies include comorbidities, complications of pregnancy and child birth in which this condition can arise because of risk factors during pregnancy,one of them is gravida. Pregnantwomenwithprimigravidaandgrandmultigravidaareoneoftheriskfactorsfor complications of pregnancy and childbirth. Objectives: The purpose of this study was to determine the contribution of the number of pregnancies (gravida) to women who experience complications of childbirth in Hospital Pandan Arang Boyolali Methods: The study was a retrospective descriptive quantitative approach, data collection using notes or other documents in the form of health information for pregnant women with gestationalcomorbiditiesaretakenbasedondatafromJanuary1toDecember31,2018, with total sampling. Results: From the data 224 pregnant women with comorbidities and complications of labor, based on the characteristics of the highest responder status occurs at age 20-35 years old in 185 (82.5%), multigravida status of 190 (84.8%), co-morbidities pregnancy Preeclampsia 124 (55.3%) and the handling of labor SC 152 (67%). The highest contribution to the multigravida gravida with the highest labor complication is bleeding 101 (53.2%). Conclusions: The importance of monitoring the mother’s pregnancy and regulating the number of pregnancies (gravida) to prevent complications of pregnancy and childbirth and to improve the degree of life of amother.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wen Shi ◽  
Xiao-ming Huang ◽  
Yun-lu Feng ◽  
Feng-dan Wang ◽  
Xiao-xing Gao ◽  
...  

Abstract Background Caroli syndrome (CS) is a rare congenital disorder without pathognomonic clinical symptoms or laboratory findings; therefore, the diagnosis is often delayed. The objective of this study was to investigate the diagnostic delay and associated risk factors in CS patients. Methods This was a retrospective analysis of 16 CS patients admitted to a single tertiary medical center on mainland China. The diagnostic timelines of CS patients were reviewed to demonstrate the initial findings of CS at diagnosis, the risk factors associated with diagnostic delay, and potential clues leading to early diagnosis. Results The median diagnostic delay was 1.75 years (range: 1 month to 29 years, interquartile range: 6.2 years) in 16 enrolled CS patients. Sex, age, and initial symptoms were not associated with diagnostic delay. 87.5% of CS patients were diagnosed by imaging, and the accuracies of ultrasonography, computed tomography (CT), and magnetic resonance cholangiopancreatography were 25, 69.2, and 83.3%, respectively. The median diagnostic delays for patients with or without CT performed at the first hospital visited according to physician and radiologist suspicion of the diagnosis were 7.4 months and 6 years, respectively (p = 0.021). Hepatic cysts with splenomegaly were detected by ultrasound in over half of CS patients. Conclusions The majority of CS patients were not diagnosed until complications of portal hypertension had already developed. Recognition and early suspicion of the disease were important factors influencing diagnostic delay of CS. Hepatic cysts plus splenomegaly detected by US might raise the clinical suspicion to include CS in the differential diagnosis.


2021 ◽  
Vol 8 (03) ◽  
pp. 5275-5281
Author(s):  
Faith Diorgu ◽  
Maynard Ehianu ◽  
Anacletus Francis

Associated Risk Factors for Bacterial Urinary Tract Infection among Internally Displaced Pregnant Women in Niger Delta Camps, Nigeria   Abstract This study investigated associated risk factors for bacterial urinary tract infection among internally displaced pregnant women in Niger Delta camps. The objectives of the study were to determine the association between age, parity, trimester of pregnancy, religion and the incidence of bacterial urinary tract infection among internally displaced pregnant women. The population of the study comprised 108 internally displaced pregnant women who also formed the study sample as no sampling method was adopted due to the limited number of study participants. The tools for data collection was midstream urine samples collected using sterile screw-capped universal containers, the instruments used in isolating the bacterial uropathogens, include Cysteine-Lactose Deficient (CLED) agar, MacConkey and Nutrient agar plates as well as a structured checklist in socio-demographic characteristics of the pregnant women. Descriptive statistics of frequency and percentage were used for data analysis and the Statistical Package for Social Sciences (SPSS) software was employed in the analytical process. Results from the study showed there was no significant association between age, parity, trimester of pregnancy, and the incidence of bacterial urinary tract infection among internally displaced pregnant women (P>0.05). However, religion was significantly associated with the incidence of bacterial urinary tract infection among internally displaced pregnant women (P<0.05).  The study concluded that there is an increasing incidence of bacterial urinary tract infections among internally displaced pregnant women linked to religious beliefs.  Based on the study findings, early routine screening of all internally pregnant women presenting or not presenting with clinical symptoms of urinary tract infection is recommended. The need for good personal and environmental hygiene to be encouraged in internally displaced persons’ camps. Keywords: Associated risk factors, Bacterial urinary tract infection, Internally Displaced Women, Camps, Niger Delta    


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