scholarly journals Chemical Structure and Biological Activities of Porphyromonas gingivalis Lipid A.

1997 ◽  
Vol 52 (2) ◽  
pp. 475-483
Author(s):  
Toshio UMEMOTO ◽  
Hidefumi KUMADA ◽  
Kiyoko WATANABE
Keyword(s):  
Porphyromonas Gingivalis ◽  
Chemical Structure ◽  
Lipid A ◽  
Biological Activities

Chemical structure and immunobiological activity of lipid A from Serratia marcescens LPS

2007 ◽  
Vol 56 (11) ◽  
pp. 1440-1446 ◽  
Author(s):  
Yutaka Makimura ◽  
Yasuyuki Asai ◽  
Akiko Sugiyama ◽  
Tomohiko Ogawa
Keyword(s):  
Serratia Marcescens ◽  
Chemical Structure ◽  
Lipid A ◽  
Biological Activities ◽  
Gel Filtration ◽  
Peritoneal Macrophages ◽  
Weak Acid ◽  
Active Centre ◽  
Necrosis Factor Alpha ◽  
Phenol Water

The chemical structure and immunobiological activities of Serratia marcescens lipid A, an active centre of LPS, were investigated. LPS preparations of S. marcescens were extracted using a hot phenol/water method, after which purified lipid A specimens were prepared by weak acid hydrolysis, followed by normal phase and gel filtration chromatographic separation. The lipid A structure was determined by MS to be a diglucosamine backbone with diphosphates and five C14 normal chain acyl groups, including two acyloxyacyl groups at the 2 and 3 positions of the non-reducing side. S. marcescens lipid A and Escherichia coli-type synthetic lipid A (compound 506) exhibited definite reactivity in Limulus amoebocyte lysate assays. The lethal toxicity of S. marcescens lipid A was nearly comparable to that of compound 506, and both induced nuclear factor-κB activation in murine cells via Toll-like receptor (TLR)4/MD-2 but not TLR2, as well as various inflammatory cytokines in peritoneal macrophages of C3H/HeN mice but not C3H/HeJ mice. Furthermore, S. marcescens lipid A induced nearly the same amounts of tumour necrosis factor alpha, interleukin-6, and nitric oxide production by the murine alveolar macrophage cell line MH-S as compared with compound 506. These results indicate that S. marcescens possesses a penta-acylated lipid A, which is nearly identical to E. coli lipid A in regard to biological activities, while it also may be a crucial virulence factor of the bacterium.

scholarly journals A Further Comprehensive Review on the Phytoconstituents from the Genus Erythrina

2020 ◽  
Vol 23 (1) ◽  
pp. 65-77 ◽  
Author(s):  
Mohammad Musarraf Hussain
Keyword(s):  
Chemical Structure ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Pharmaceutical Journal ◽  
Significant Source ◽  
Comprehensive Review ◽  
Chemical Structures ◽  
Previous Review

Erythrina is a significant source of phytoconstituents. The aim of this review is to solicitude of classification, synthesis, and phytochemicals with biological activities of Erythrina. In our previous review on this genus (Hussain et. al., 2016a) fifteen species (Erythrina addisoniae, E. caribeae, E. indica, E. lattisima, E. melanacantha, E. mildbraedii, E. poeppigiama, E. stricta, E. subumbrans, E. veriagata, E. vespertilio, E. velutina, E. zeberi, E. zeyheri and E. americana) have been studied and 155 molecules with chemical structures were reported. A further comprehensive review was done upon continuation on the same genus and thirteen species (E. abyssinica, E. arborescens, E. berteroana, E. burttii, E. caffra, E. coralloids, E. crista-galli, E. fusca, E. herbaceae, E. lysistemon, E. mulungu, E. speciosa and E. tahitensis) of Erythrina have been studied and 127 compounds are reported as phytoconstituents with their chemical structure in this review. Erythrina crista-galli and E. lysistemon consist of highest number of chemical constituents. Bangladesh Pharmaceutical Journal 23(1): 65-77, 2020

scholarly journals Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4

2008 ◽  
Vol 6 (18) ◽  
pp. 3371 ◽  
Author(s):  
Yanghui Zhang ◽  
Jidnyasa Gaekwad ◽  
Margreet A. Wolfert ◽  
Geert-Jan Boons
Keyword(s):  
Porphyromonas Gingivalis ◽  
Lipid A ◽  
Derivatives Of

scholarly journals 3-O-Acetyl-narcissidine, a Bioactive Alkaloid from Hippeastrum puniceum Lam. (Amaryllidaceae)

2008 ◽  
Vol 63 (9-10) ◽  
pp. 639-643 ◽  
Author(s):  
Omar Santana ◽  
Matías Reina ◽  
Ana Luisa Anaya ◽  
Fidel Hernández ◽  
M. Elena Izquierdo ◽  
...  
Keyword(s):  
Leptinotarsa Decemlineata ◽  
Chemical Structure ◽  
Spectroscopic Analysis ◽  
Biological Activities ◽  
Protective Role ◽  
Panicum Maximum ◽  
Amaranthus Hypochondriacus ◽  
Plant Defensive Compounds ◽  
Polyphagous Insect ◽  
Rottboellia Cochinchinensis

In the context of the study on plant defensive compounds we have isolated the main alkaloid from Hippeastrum puniceum (Amaryllidaceae), 3-O-acetyl-narcissidine (1), and its biological activities tested against two divergent insect species and several plant species. 1 was isolated from the bioactive alkaloidal fraction of H. puniceum. Its chemical structure was established by spectroscopic analysis. The biological activity tests showed that 1 is an antifeedant against the polyphagous insect Spodoptera littoralis but not against the olyphage Leptinotarsa decemlineata. Furthermore, the root growth of Amaranthus hypochondriacus, Rottboellia cochinchinensis, Panicum maximum and Solanum lycopersicum was significantly affected by 1. These results suggest a plant protective role for H. puniceum alkaloids.

Sign in / Sign up

Export Citation Format

Share Document