scholarly journals Genetic screening for multiple endocrine neoplasia syndrome type 1 (MEN-1): when and how

10.3410/m2-14 ◽  
2010 ◽  
Vol 2 ◽  
Author(s):  
Alberto Falchetti
Keyword(s):  
Genetic Screening ◽  
Multiple Endocrine Neoplasia ◽  
Syndrome Type ◽  
Men 1 ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Syndrome

scholarly journals The role of non-coding RNAs in the pathogenesis of multiple endocrine neoplasia syndrome type 1

2020 ◽  
Vol 66 (2) ◽  
pp. 4-12
Author(s):  
Elizaveta O. Mamedova ◽  
Diana A. Dimitrova ◽  
Zhanna E. Belaya ◽  
Galina A. Melnichenko
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Endocrine Tumors ◽  
Syndrome Type ◽  
Gene Encoding ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Men1 Gene ◽  
Men 1 ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Syndrome

Changes in the expression of non-coding ribonucleic acids (ncRNAs) takes part in the formation of various tumors. Multiple endocrine neoplasia syndrome type 1 (MEN1) is a rare autosomal dominant disease caused by mutations of the MEN1 gene encoding the Menin protein. Syndrome is characterized by the occurrence of parathyroid tumors, gastroenteropancreatic neuroendocrine tumors, pituitary adenoma, as well as other endocrine and non-endocrine tumors. The mechanisms for the formation of MEN1-related tumors due to mutations in the MEN1 gene are not . In the absence of mutations of the MEN1 gene in patients with phenotypically similar features, this condition is regarded as a phenocopy of this syndrome. The cause of the combination of several MEN-1-related tumors in these patients remains unknown. The possible cause is that changes in the expression of ncRNAs affect the regulation of signaling pathways in which Menin participates and may contribute to the development of MEN-1-related tumors. The identification of even a small number of agents interacting with Menin makes a significant contribution to the improvement of knowledge about its pathophysiological influence and ways of developing tumors within the MEN-1 syndrome and its phenocopies.

Optimal extent of initial parathyroid resection in patients with multiple endocrine neoplasia syndrome type 1: A meta-analysis

Surgery ◽  
2020 ◽  
Author(s):  
Constantinos Nastos ◽  
Dimitrios Papaconstantinou ◽  
Efstratios Kofopoulos-Lymperis ◽  
Melpomeni Peppa ◽  
Andreas Pikoulis ◽  
...  
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Meta Analysis ◽  
Syndrome Type ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Syndrome

scholarly journals Simultaneous transoral parathyroidectomy and laparoscopic pancreatic resection in type 1 Multiple Endocrine Neoplasia syndrome

2021 ◽  
Vol 26 (4) ◽  
pp. 126-132
Author(s):  
S. E. Gryaznov ◽  
I. M. Buriev ◽  
G. G. Melkonyan ◽  
N. S. Malyuga ◽  
B. K. Laypanov
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Pancreatic Head ◽  
Original Solution ◽  
Men 1 ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Syndrome ◽  
Laparoscopic Pancreatic Resection ◽  
Pancreatic Head Tumor

The article presents a clinical observation of a patient with type 1 Multiple Endocrine Neoplasia syndrome (MEN 1). During the diagnostic search, a combination of primary hyperparathyroidism, parathyroid adenoma and hormonally inactive pancreatic head tumor was found. Simultaneous transoral parathyroidectomy and laparoscopic resection of the pancreatic head was performed. We haven`t found the literature data describing such kind of operations for MEN 1 syndrome. An original solution was applied to perform intraoperative ultrasonography monitoring. The results of 1-year postoperative follow-up are presented. This observation demonstrates the possibilities of endoscopic technologies in the treatment of MEN 1 syndrome.

scholarly journals Multiple endocrine neoplasia syndrome type 1: institution, management, and data analysis of a nationwide multicenter patient database

Endocrine ◽  
2017 ◽  
Vol 58 (2) ◽  
pp. 349-359 ◽  
Author(s):  
Francesca Giusti ◽  
Luisella Cianferotti ◽  
Francesca Boaretto ◽  
Filomena Cetani ◽  
Federica Cioppi ◽  
...  
Keyword(s):  
Data Analysis ◽  
Multiple Endocrine Neoplasia ◽  
Syndrome Type ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Syndrome ◽  
Patient Database

scholarly journals Cinacalcet therapy in patients affected by primary hyperparathyroidism associated to Multiple Endocrine Neoplasia Syndrome type 1 (MEN1)

Endocrine ◽  
2015 ◽  
Vol 52 (3) ◽  
pp. 495-506 ◽  
Author(s):  
Francesca Giusti ◽  
Luisella Cianferotti ◽  
Giorgio Gronchi ◽  
Federica Cioppi ◽  
Laura Masi ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Multiple Endocrine Neoplasia ◽  
Syndrome Type ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Syndrome
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