Faculty Opinions recommendation of NADPH oxidase restrains the matrix metalloproteinase activity of macrophages.

2006 ◽  
Author(s):  
Caroline Owen
Keyword(s):  
Matrix Metalloproteinase ◽  
Nadph Oxidase ◽  
The Matrix ◽  
Metalloproteinase Activity

scholarly journals NADPH Oxidase Restrains the Matrix Metalloproteinase Activity of Macrophages

2005 ◽  
Vol 280 (34) ◽  
pp. 30201-30205 ◽  
Author(s):  
Sean Y. Kassim ◽  
Xiaoyun Fu ◽  
W. Conrad Liles ◽  
Steven D. Shapiro ◽  
William C. Parks ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Nadph Oxidase ◽  
The Matrix ◽  
Metalloproteinase Activity

Fluorescence imaging to assess the matrix metalloproteinase activity and its inhibitor in vivo

2008 ◽  
Vol 13 (1) ◽  
pp. 011006 ◽  
Author(s):  
Zhihong Zhang ◽  
Jie Yang ◽  
Jinling Lu ◽  
Juqiang Lin ◽  
Shaoqun Zeng ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Fluorescence Imaging ◽  
The Matrix ◽  
Metalloproteinase Activity

scholarly journals Structure and expression of the human gene for the matrix metalloproteinase matrilysin.

1994 ◽  
Vol 269 (3) ◽  
pp. 2032-2040
Author(s):  
M. Gaire ◽  
Z. Magbanua ◽  
S. McDonnell ◽  
L. McNeil ◽  
D.H. Lovett ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Human Gene ◽  
The Matrix

scholarly journals Long-Term Ethanol Consumption Leadsto Lung Tissue Oxidative Stress and Injury

2010 ◽  
Vol 3 (6) ◽  
pp. 414-420 ◽  
Author(s):  
Subir Kumar Das ◽  
Sukhes Mukherjee
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Matrix Metalloproteinase ◽  
Lung Tissue ◽  
Ethanol Consumption ◽  
Ethanol Exposure ◽  
Lung Homogenate ◽  
Ethanol Administration ◽  
Metalloproteinase Activity

Background: Alcohol abuse is a systemic disorder. The deleterious health effects of alcohol consumption may result in irreversible organ damage. By contrast, there currently is little evidence for the toxicity of chronic alcohol use on lung tissue. Hence, in this study we investigated long-term effects of ethanol in the lung.Results: Though body weight of rats increased significantly with duration of exposure compared to its initial weight, there was no significant change in relative weight (g/100 g body weight) of lung due to ethanol exposure. The levels of thiobarbituric acid reactive substances (TBARS), nitrite, protein carbonyl, oxidized glutathione (GSS G), redox ratio (GSS G/ GSH ) and GST activity elevated; while reduced glutathione (GSH ) level and activities of glutathione reductase (GR), glutathione peroxidase (GPx), catalase, superoxide dismutase (SOD) and Na+K+ATPase reduced significantly with duration of ethanol exposure in the lung homogenate compared to the control group. Total matrix metalloproteinase activity elevated in the lung homogenate with time of ethanol consumption. Histopathologic examination also demonstrated that severity of lung injury enhanced with duration of ethanol exposure.Methods: 16–18 week-old male albino Wistar strain rats weighing 200–220 g were fed with ethanol (1.6 g/kg body weight/day) up to 36 weeks. At the end of the experimental period, blood samples were collected from reteroorbital plexus to determine blood alcohol concentration and the animals were sacrificed. Various oxidative stress-related biochemical parameters, total matrix metalloproteinase activity and histopathologic examinations of the lung tissues were performed.Conclusions: Results of this study indicate that long-term ethanol administration aggravates systemic and local oxidative stress, which may be associated with lung tissue injury.

Matrix metalloproteinase activity relates to macrophages and plaque complications

1995 ◽  
Vol 115 ◽  
pp. S26
Author(s):  
A.C. van der Wal ◽  
M.M.H. Marijianowski ◽  
C.M. van der Loos ◽  
D.C. Jansen ◽  
V. Everts ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Metalloproteinase Activity
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