Faculty Opinions recommendation of The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis.

2016 ◽  
Author(s):  
Cesare Massone
Keyword(s):  
Pulmonary Fibrosis ◽  
Progenitor Cells ◽  
Mesenchymal Progenitor Cells

scholarly journals The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis

2009 ◽  
Vol 86 (5) ◽  
pp. 1111-1118 ◽  
Author(s):  
Robert M. Strieter ◽  
Ellen C. Keeley ◽  
Molly A. Hughes ◽  
Marie D. Burdick ◽  
Borna Mehrad
Keyword(s):  
Pulmonary Fibrosis ◽  
Progenitor Cells ◽  
Mesenchymal Progenitor Cells

Role of JAK/STAT3 Signaling in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine

2018 ◽  
Vol 165 (5) ◽  
pp. 665-668 ◽  
Author(s):  
G. N. Zyuz’kov ◽  
E. V. Udut ◽  
L. A. Miroshnichenko ◽  
T. Yu. Polyakova ◽  
E. V. Simanina ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Mesenchymal Progenitor Cells ◽  
Stat3 Signaling ◽  
Functional Stimulation ◽  
Stimulation Of

scholarly journals Role of the C-C Chemokine Receptor (CCR10) in Mesenchymal Progenitor Cells in IPF

2020 ◽  
Author(s):  
M. Hohmann ◽  
D.M. Habiel ◽  
M.S. Espindola ◽  
G. Huang ◽  
Y.A.P.J. Sa ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Chemokine Receptor ◽  
Mesenchymal Progenitor Cells

scholarly journals The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders

2009 ◽  
Vol 101 (04) ◽  
pp. 613-618 ◽  
Author(s):  
Ellen Keeley ◽  
Borna Mehrad ◽  
Robert Strieter
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Critical Role ◽  
Pivotal Role ◽  
Mesenchymal Progenitor Cells ◽  
Tissue Remodelling ◽  
Fibrotic Diseases ◽  
Fibrotic Disorders

SummaryFibrocytes are bone marrow-derived mesenchymal progenitor cells that express markers of leukocytes, haematopoietic progenitor cells, and fibroblasts. They play a pivotal role in tissue remodelling and fibrosis in both physiologic and pathologic settings. Fibrocytes are unique in that they are capable of differentiating into fibroblasts and myofibroblasts, as well as adipocytes. In this review we will present data supporting the critical role they play in the pathogenesis of chronic inflammatory fibrotic diseases of the lungs, heart and vasculature.

scholarly journals PDZRN3 Negatively Regulates BMP-2–induced Osteoblast Differentiation through Inhibition of Wnt Signaling

2010 ◽  
Vol 21 (18) ◽  
pp. 3269-3277 ◽  
Author(s):  
Takeshi Honda ◽  
Hisato Yamamoto ◽  
Aiko Ishii ◽  
Makoto Inui
Keyword(s):  
Wnt Signaling ◽  
Progenitor Cells ◽  
Osteoblast Differentiation ◽  
Pdz Domain ◽  
Ring Finger ◽  
C2c12 Cells ◽  
Mesenchymal Progenitor Cells ◽  
Alp Activity ◽  
Morphogenetic Protein

PDZRN3 is a member of the PDZ domain–containing RING finger family of proteins. We previously showed that PDZRN3 is essential for the differentiation of C2C12 mouse mesenchymal progenitor cells into myotubes. Mesenchymal progenitor cells differentiate into osteoblasts, chondrocytes, and adipocytes in addition to myotubes, and we have now examined the potential role of PDZRN3 in the differentiation of C2C12 cells into osteoblasts. The abundance of PDZRN3 in C2C12 cells was increased after the induction of osteoblast differentiation by exposure to bone morphogenetic protein (BMP)-2 in low-serum medium. Depletion of PDZRN3 in C2C12 cells by RNA interference resulted in marked enhancement of the BMP-2–induced up-regulation of alkaline phosphatase (ALP) activity. Dkk1, an inhibitor of Wnt signaling, markedly attenuated the enhancement of the BMP-2–induced increase in ALP activity by PDZRN3 depletion. The up-regulation of ALP activity by Wnta3a was also promoted by depletion of PDZRN3. Furthermore, the expression and Wnt3a-induced phosphorylation of LRP6 as well as the increase in the cytosolic abundance of β-catenin induced by Wnt3a were potentiated in PDZRN3-depleted cells. These results indicate that PDZRN3 plays an important role in negative feedback control of BMP-2–induced osteoblast differentiation in C2C12 cells through inhibition of Wnt–β-catenin signaling.

Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro

2015 ◽  
Vol 159 (2) ◽  
pp. 245-247 ◽  
Author(s):  
G. N. Zyuz’kov ◽  
V. V. Zhdanov ◽  
E. V. Udut ◽  
L. A. Miroshnichenko ◽  
M. G. Danilets ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Growth Potential ◽  
Mesenchymal Progenitor Cells
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