Faculty Opinions recommendation of Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease.

2006 ◽  
Author(s):  
Pascal Derkinderen
Keyword(s):  
Parkinson Disease ◽  
Alpha Synuclein ◽  
Inclusion Formation ◽  
Drosophila Model

Aplp1 and the Aplp1-Lag3 Complex facilitates transmission of pathologic alpha-synuclein

2021 ◽  
Author(s):  
Xiaobo Mao ◽  
Hao Gu ◽  
Donghoon Kim ◽  
Yasuyoshi Kimura ◽  
Ning Wang ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Molecular Mechanism ◽  
Amyloid Beta ◽  
Dopaminergic Neurons ◽  
Lymphocyte Activation ◽  
Alpha Synuclein ◽  
Therapeutic Strategies ◽  
Behavioral Deficits ◽  
Lymphocyte Activation Gene

Pathologic alpha-synuclein (alpha-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid beta precursor-like protein 1 (Aplp1) forms a complex with Lag3 that facilitates the binding, internalization, transmission, and toxicity of pathologic alpha-syn. Deletion of both Aplp1 and Lag3 eliminates the loss of dopaminergic neurons and the accompanying behavioral deficits induced by alpha-syn preformed fibrils (PFF). Anti-Lag3 prevents the internalization of alpha-syn PFF by disrupting the interaction of Aplp1 and Lag3, and blocks the neurodegeneration induced by alpha-syn PFF in vivo. The identification of Aplp1 and the interplay with Lag3 for alpha-syn PFF induced pathology advances our understanding of the molecular mechanism of cell-to-cell transmission of pathologic alpha-syn and provides additional targets for therapeutic strategies aimed at preventing neurodegeneration in Parkinson disease and related alpha-synucleinopathies.

Alpha-synuclein staining in non-neural structures of the gastrointestinal tract is non-specific in Parkinson disease

2018 ◽  
Vol 55 ◽  
pp. 15-17 ◽  
Author(s):  
Chaewon Shin ◽  
Sung-Hye Park ◽  
Ji Young Yun ◽  
Jung Hwan Shin ◽  
Han-Kwang Yang ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Parkinson Disease ◽  
Alpha Synuclein

2.313 Alcoholism, alpha-synuclein, and Parkinson disease: A case-control study

2007 ◽  
Vol 13 ◽  
pp. S125
Author(s):  
L. Brighina ◽  
N.K. Schneider ◽  
T.G. Lesnick ◽  
M. de Andrade ◽  
J.M. Cunningham ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Case Control Study ◽  
Case Control ◽  
Alpha Synuclein ◽  
Control Study
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