Faculty Opinions recommendation of Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers.

2006 ◽  
Author(s):  
Klaus Bielefeldt
Keyword(s):  
Healthy Volunteers ◽  
Chloride Channel ◽  
Gastrointestinal Transit ◽  
Motor Functions ◽  
Channel Activator

Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers

2006 ◽  
Vol 290 (5) ◽  
pp. G942-G947 ◽  
Author(s):  
Michael Camilleri ◽  
Adil E. Bharucha ◽  
Ryuji Ueno ◽  
Duane Burton ◽  
George M. Thomforde ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Chloride Channel ◽  
Chloride Channels ◽  
Gastrointestinal Transit ◽  
Intestinal Secretion ◽  
Gastric Volume ◽  
Colonic Transit ◽  
Controlled Study ◽  
Double Blind

Chloride channels modulate gastrointestinal neuromuscular functions in vitro. Lubiprostone, a selective type 2 chloride channel (ClC-2) activator, induces intestinal secretion and has been shown to relieve constipation in clinical trials; however, the effects of lubiprostone on gastric function and whole gut transit in humans are unclear. Our aim was to compare the effects of the selective ClC-2 activator lubiprostone on maximum tolerated volume (MTV) of a meal, postprandial symptoms, gastric volumes, and gastrointestinal and colonic transit in humans. We performed a randomized, parallel-group, double-blind, placebo-controlled study evaluating the effects of lubiprostone (24 μg bid) in 30 healthy volunteers. Validated methods were used: scintigraphic gastrointestinal and colonic transit, SPECT to measure gastric volumes, and the nutrient drink (“satiation”) test to measure MTV and postprandial symptoms. Lubiprostone accelerated small bowel and colonic transit, increased fasting gastric volume, and retarded gastric emptying. MTV values were reduced compared with placebo; however, the MTV was within the normal range for healthy adults in 13 of 14 participants, and there was no significant change compared with baseline measurements. Lubiprostone had no significant effect on postprandial gastric volume or aggregate symptoms but did decrease fullness 30 min after the fully satiating meal. Thus the ClC-2 activator lubiprostone accelerates small intestinal and colonic transit, which confers potential in the treatment of constipation.

scholarly journals Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects

2009 ◽  
Vol 296 (2) ◽  
pp. G295-G301 ◽  
Author(s):  
Seth Sweetser ◽  
Irene A. Busciglio ◽  
Michael Camilleri ◽  
Adil E. Bharucha ◽  
Lawrence A. Szarka ◽  
...  
Keyword(s):  
Chloride Channel ◽  
Controlled Trial ◽  
Colonic Transit ◽  
Double Blind ◽  
Motor Functions ◽  
Pain Thresholds ◽  
Colonic Motor ◽  
Irritable Bowel ◽  
Motor Effects ◽  
Channel Activator

Lubiprostone, a bicyclic fatty acid chloride channel activator, is efficacious in treatment of chronic constipation and constipation-predominant irritable bowel syndrome. The study aim was to compare effects of lubiprostone and placebo on colonic sensory and motor functions in humans. In double-blind, randomized fashion, 60 healthy adults received three oral doses of placebo or 24 μg lubiprostone per day in a parallel-group, placebo-controlled trial. A barostat-manometry tube was placed in the left colon by flexible sigmoidoscopy and fluoroscopy. We measured treatment effects on colonic sensation and motility with validated methods, with the following end points: colonic compliance, fasting and postprandial tone and motility indexes, pain thresholds, and sensory ratings to distensions. Among participants receiving lubiprostone or placebo, 26 of 30 and 28 of 30, respectively, completed the study. There were no overall effects of lubiprostone on compliance, fasting tone, motility indexes, or sensation. However, there was a treatment-by-sex interaction effect for compliance ( P = 0.02), with lubiprostone inducing decreased fasting compliance in women ( P = 0.06) and an overall decreased colonic tone contraction after a standard meal relative to fasting tone ( P = 0.014), with greater effect in women ( P < 0.01). Numerical differences of first sensation and pain thresholds ( P = 0.11 in women) in the two groups were not significant. We concluded that oral lubiprostone 24 μg does not increase colonic motor function. The findings of decreased colonic compliance and decreased postprandial colonic tone in women suggest that motor effects are unlikely to cause accelerated colonic transit with lubiprostone, although they may facilitate laxation. Effects of lubiprostone on sensitivity deserve further study.

scholarly journals Effects of ghrelin receptor agonist, relamorelin, on gastric motor functions and satiation in healthy volunteers

2016 ◽  
Vol 28 (11) ◽  
pp. 1705-1713 ◽  
Author(s):  
A. D. Nelson ◽  
M. Camilleri ◽  
A. Acosta ◽  
I. Busciglio ◽  
S. Linker Nord ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Receptor Agonist ◽  
Motor Functions ◽  
Ghrelin Receptor ◽  
Ghrelin Receptor Agonist
Sign in / Sign up

Export Citation Format

Share Document