Faculty Opinions recommendation of Gastric acid inhibition for fat malabsorption or gastroesophageal reflux disease in cystic fibrosis: longitudinal effect on bacterial colonization and pulmonary function.

2010 ◽  
Author(s):  
Shruti Paranjape
Keyword(s):  
Cystic Fibrosis ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Pulmonary Function ◽  
Gastric Acid ◽  
Reflux Disease ◽  
Bacterial Colonization ◽  
Acid Inhibition ◽  
Gastric Acid Inhibition ◽  
Fat Malabsorption

scholarly journals Gastroesophageal Reflux Disease and Need for Antireflux Surgery in Children with Cystic Fibrosis: A Systematic Review on Incidence, Surgical Complications, and Postoperative Outcomes

2020 ◽  
Author(s):  
Jessica Ng ◽  
Florian Friedmacher ◽  
Caroline Pao ◽  
Paul Charlesworth
Keyword(s):  
Cystic Fibrosis ◽  
Postoperative Complications ◽  
Gastroesophageal Reflux Disease ◽  
Lung Function ◽  
Gastroesophageal Reflux ◽  
Nutritional Status ◽  
Reflux Disease ◽  
Antireflux Surgery ◽  
Published Data ◽  
Refractory Gerd

Abstract Introduction Gastroesophageal reflux disease (GERD) is associated with accelerated decline in lung health in children with cystic fibrosis (CF). Thus, antireflux surgery (ARS) is offered to a selected CF cohort with refractory GERD, but outcomes remain poorly investigated. This study aimed to determine the incidence of GERD in children with CF and to evaluate complications and outcomes of ARS. Materials and Methods A systematic literature-based search was conducted using various online databases according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The number of GERD cases in pediatric CF cohorts who underwent diagnostic investigation(s) was recorded. Data on postoperative complications and outcomes (including symptoms, lung function, and nutritional status) following ARS were analyzed. Results Ten articles (n = 289 patients) met the defined inclusion criteria (51% male; age range, 0.5 month–36 years). The overall incidence of GERD was 46% (range, 19–81%), derived from seven studies (n = 212 patients). Four publications (n = 82 patients) reported on ARS due to uncontrolled GERD. All ARSs were Nissen fundoplication (majority with gastrostomy placement). Major postoperative complications occurred in 15 (18%) patients, two required redo-ARS. Median follow-up time was 2 years (range, 3 months–6 years); 59% showed symptom improvement, and pulmonary exacerbations and decline in lung function were reduced. Nutritional status mainly improved in milder CF cases. There were no deaths related to ARS. Conclusion Approximately half of pediatric CF patients have GERD. Published data for children with CF are limited and heterogeneous in terms of GERD diagnosis and outcomes following ARS. However, ARS has shown to slow the deterioration of lung function in CF.

Postprandial proximal gastric acid pocket and gastroesophageal reflux disease

2011 ◽  
Vol 25 (7) ◽  
pp. 652-655 ◽  
Author(s):  
F. A. M. Herbella ◽  
F. P. P. Vicentine ◽  
L. C. Silva ◽  
M. G. Patti
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Gastric Acid ◽  
Reflux Disease ◽  
Acid Pocket
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