Faculty Opinions recommendation of Serotype distribution and antibiotic susceptibility of invasive and nasopharyngeal isolates of Streptococcus pneumoniae among children in rural Mozambique.

2006 ◽  
Author(s):  
Andy Hall
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antibiotic Susceptibility ◽  
Serotype Distribution

scholarly journals Serotype Distribution and Antibiotic Susceptibility of Streptococcus pneumoniae Isolates in Tehran, Iran: A Surveillance Study

2020 ◽  
Vol Volume 13 ◽  
pp. 333-340 ◽  
Author(s):  
Soheila Habibi Ghahfarokhi ◽  
Mehrdad Mosadegh ◽  
Ali Ahmadi ◽  
Mohammad Reza Pourmand ◽  
Mohammad Azarsa ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antibiotic Susceptibility ◽  
Surveillance Study ◽  
Serotype Distribution

Serotype distribution and antibiotic susceptibility of invasive Streptococcus pneumoniae disease isolates from children in Turkey, 2001–2004

2006 ◽  
Vol 165 (9) ◽  
pp. 654-657 ◽  
Author(s):  
Isık Yalçın ◽  
Nezahat Gürler ◽  
Emre Alhan ◽  
Akgün Yaman ◽  
Mehmet Turgut ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antibiotic Susceptibility ◽  
Serotype Distribution

Antibiotic Susceptibility and Serotype Distribution of Streptococcus pneumoniae in Malaysian Children

1988 ◽  
Vol 34 (4) ◽  
pp. 182-185 ◽  
Author(s):  
Y. M. Cheong ◽  
M. Jegathesan ◽  
J. Henrichsen ◽  
Y. H. Wong ◽  
A. J. Ng ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antibiotic Susceptibility ◽  
Serotype Distribution

scholarly journals Antibiotic Susceptibility in Relation to Penicillin-Binding Protein Genes and Serotype Distribution of Streptococcus pneumoniae Strains Responsible for Meningitis in Japan, 1999 to 2002

2004 ◽  
Vol 48 (5) ◽  
pp. 1488-1494 ◽  
Author(s):  
Kimiko Ubukata ◽  
Naoko Chiba ◽  
Keiko Hasegawa ◽  
Reiko Kobayashi ◽  
Satoshi Iwata ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antibiotic Susceptibility ◽  
Binding Protein ◽  
Penicillin Binding Protein ◽  
Serotype Distribution ◽  
Conjugate Vaccines ◽  
Pneumococcal Conjugate Vaccines ◽  
Early Introduction ◽  
Antibiotic Susceptibilities ◽  
Nationwide Surveillance

ABSTRACT The antibiotic susceptibilities, genotypes of penicillin (PEN)-binding protein genes (pbp), and serotype distributions of Streptococcus pneumoniae isolates from meningitis patients were investigated by a nationwide surveillance group in Japan between 1999 and 2002. We analyzed 146 isolates from children (≤17 years old) and 73 from adults (≥18 years old). Isolates with or without abnormal pbp1a, pbp2x, or pbp2b genes identified by PCR were classified into six genotype patterns and 90% MIC (MIC90) values for PEN: (i) strains with three normal genes (17.2% of isolates; MIC90, 0.031 μg/ml); (ii) strains with abnormal pbp2x (22.1%, 0.063 μg/ml); (iii) strains with abnormal pbp2b (1.0%, 0.125 μg/ml); (iv) strains with abnormal pbp2x and pbp2b (7.4%, 0.25 μg/ml); (v) strains with abnormal pbp1a and pbp2x (12.7%, 0.25 μg/ml); and (vi) strains with three abnormal PBP genes (39.7%, 4 μg/ml), which are termed genotypic PEN-resistant S. pneumoniae (gPRSP). Panipenem, a carbapenem, showed an excellent MIC90 (0.125 μg/ml) against gPRSP, followed by meropenem and vancomycin (0.5 μg/ml), cefotaxime and ceftriaxone (1 μg/ml), and ampicillin (4 μg/ml). Strains of gPRSP were significantly more prevalent in children (45.2%) than in adults (27.4%). The most frequent serotypes were 6B, 19F, 23F, 6A, and 14 in children and 23F, 22, 3, 10, 6B, and 19F in adults. Serotypes 6B, 6A, 19F, 23F, and 14 predominated among gPRSP. In children, 7- and 11-valent pneumococcal conjugate vaccines would cover 76.2 and 81.3% of isolates, respectively, although coverage would be lower in adults (43.9 and 56.0%, respectively). These findings suggest the need for early introduction of pneumococcal conjugate vaccines and continuous bacteriological surveillance for meningitis.

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