Faculty Opinions recommendation of Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients.

2006 ◽  
Author(s):  
Kiat Ruxrungtham
Keyword(s):  
Immune Restoration

Baseline CD4/CD8 T-Cell Ratio Predicts Prompt Immune Restoration Upon cART Initiation

2016 ◽  
Vol 14 (6) ◽  
pp. 491-496 ◽  
Author(s):  
Francesco Bellissimo ◽  
Marilia Rita Pinzone ◽  
Benedetto Maurizio Celesia ◽  
Bruno Cacopardo ◽  
Giuseppe Nunnari
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Immune Restoration ◽  
Cell Ratio ◽  
Cart Initiation

scholarly journals Immune Restoration Diseases Reflect Diverse Immunopathological Mechanisms

2009 ◽  
Vol 22 (4) ◽  
pp. 651-663 ◽  
Author(s):  
Patricia Price ◽  
David M. Murdoch ◽  
Upasna Agarwal ◽  
Sharon R. Lewin ◽  
Julian H. Elliott ◽  
...  
Keyword(s):  
T Cell ◽  
Immune Responses ◽  
T Cell Activation ◽  
Cell Activation ◽  
De Novo ◽  
Granulomatous Inflammation ◽  
T Cell Response ◽  
Immune Restoration ◽  
Immunological Parameters ◽  
Varicella Zoster

SUMMARY Up to one in four patients infected with human immunodeficiency virus type 1 and given antiretroviral therapy (ART) experiences inflammatory or cellular proliferative disease associated with a preexisting opportunistic infection, which may be subclinical. These immune restoration diseases (IRD) appear to result from the restoration of immunocompetence. IRD associated with intracellular pathogens are characterized by cellular immune responses and/or granulomatous inflammation. Mycobacterial and cryptococcal IRD are attributed to a pathological overproduction of Th1 cytokines. Clinicopathological characteristics of IRD associated with viral infections suggest different pathogenic mechanisms. For example, IRD associated with varicella-zoster virus or JC polyomavirus infection correlate with a CD8 T-cell response in the central nervous system. Exacerbations or de novo presentations of hepatitis associated with hepatitis C virus (HCV) infection following ART may also reflect restoration of pathogen-specific immune responses as titers of HCV-reactive antibodies rise in parallel with liver enzymes and plasma markers of T-cell activation. Correlations between immunological parameters assessed in longitudinal sample sets and clinical presentations are required to illuminate the diverse immunological scenarios described collectively as IRD. Here we present salient clinical features and review progress toward understanding their pathogeneses.

TLR2-induced cytokine responses may characterize HIV-infected patients experiencing mycobacterial immune restoration disease

AIDS ◽  
2011 ◽  
Vol 25 (12) ◽  
pp. 1455-1460 ◽  
Author(s):  
Dino B.A. Tan ◽  
Andrew Lim ◽  
Yean K. Yong ◽  
Sasheela Ponnampalavanar ◽  
Sharifah Omar ◽  
...  
Keyword(s):  
Immune Restoration ◽  
Immune Restoration Disease ◽  
Cytokine Responses

scholarly journals Clinically Indicated Corticosteroids Do Not Affect Bone Turnover During Immune Restoration of Severely Lymphopenic HIV-Infected Patients

2015 ◽  
Vol 31 (7) ◽  
pp. 739-744
Author(s):  
Philip M. Grant ◽  
Virginia Sheikh ◽  
Rebecca DerSimonian ◽  
Adam Rupert ◽  
Gregg Roby ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Immune Restoration

Immune restoration of mice immunosuppressed by a graft-vs.-host reaction

1974 ◽  
Vol 11 (1-3) ◽  
pp. 419-426 ◽  
Author(s):  
Wayne S. Lapp ◽  
Ann Wechsler ◽  
Patricia A.L. Kongshavn
Keyword(s):  
Host Reaction ◽  
Immune Restoration

Gene therapy and immune restoration for HIV disease

The Lancet ◽  
1995 ◽  
Vol 345 (8947) ◽  
pp. 427-432 ◽  
Author(s):  
N Sarver ◽  
S.H Bridges
Keyword(s):  
Gene Therapy ◽  
Hiv Disease ◽  
Immune Restoration

Immune restoration and onset of new AIDS-defining events with combination antiretroviral therapy in HIV type-1-infected immigrants in the Netherlands

2010 ◽  
Vol 15 (6) ◽  
pp. 871-879 ◽  
Author(s):  
Anouk M Kesselring ◽  
Luuk Gras ◽  
Ferdinand W Wit ◽  
Colette Smit ◽  
Suzanne E Geerlings ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
The Netherlands ◽  
Combination Antiretroviral Therapy ◽  
Immune Restoration ◽  
Hiv Type 1
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