Faculty Opinions recommendation of The role of vesicoureteral reflux in acute renal cortical scintigraphic lesion and ultimate scar formation.

Author(s):  
Anthony Caldamone
2008 ◽  
Vol 180 (5) ◽  
pp. 2167-2170 ◽  
Author(s):  
Mi Mi Oh ◽  
Myeong Heon Jin ◽  
Jae Hyun Bae ◽  
Hong Seok Park ◽  
Jeong Gu Lee ◽  
...  

PEDIATRICS ◽  
1981 ◽  
Vol 67 (3) ◽  
pp. 392-400 ◽  

The role of VUR in the development and progression of renal damage in children is universally acknowledged. The risk/benefit ratio of therapeutic intervention, whether medical or surgical, continues to be debated. This carefully controlled prospective, longitudinal, multispecialty, international trial aims to establish a rational basis for the treatment of VUR.


2014 ◽  
Vol 9 (3) ◽  
pp. 197-204
Author(s):  
Kathleen Kieran ◽  
Christopher S. Cooper

Author(s):  
Sima SHAHROKHZADEH ◽  
Azam SOLEIMANI ◽  
Dor-Mohammad KORDI-TAMANDANI ◽  
Mohammad Hossein SANGTARASH ◽  
Omid NEJATI ◽  
...  

Background: Vesicoureteral reflux (VUR) disease is the most common type of urinary tract anomalies in children. Genetic risk factors may be associated with the etiology of VUR. The role of the Glutathione S-transferases (GSTs) as multifunctional enzymes is cellular oxidative stress handling. This is the first study aimed at evaluating the relative risk of GSTP1, GSTM1, and GSTT1 polymorphisms in VUR susceptibility in children and provides new important insights into the genetics of affected children. Methods: The study was done in 2013 in Sistan and Baluchestan University, eastern Iran. Genotyping of three GSTP1, GSTM1, and GSTT1 genes were determined using the multiplex polymerase chain reaction assay in 216 reactions for 72 VUR children and 312 reactions for 104 healthy controls. Results: The presence of GSTT1 deletion was associated with high risk of VUR in children, whereas GSTP1 and GSTM1 genotypes did not show the same effect. Furthermore, the combination of GSTT1/GSTM1 and GSTT1/ GSTP1 genotypes showed a significant influence on lower risk of VUR in children. Conclusion: Deletion of GSTT1 functional gene is a genetic risk factor causing VUR in children. Interestingly, the combination of GSTM1 and GSTP1 null genotypes with GSTT1 has shown a protective role against risk of GSTT1 deletion.


2007 ◽  
Vol 17 (4) ◽  
pp. 252-256 ◽  
Author(s):  
William C Faust ◽  
Hans G Pohl

2020 ◽  
Vol 14 (8) ◽  
pp. 683-696
Author(s):  
Flávia C Valério ◽  
Renata D Lemos ◽  
Ana L de C Reis ◽  
Letícia P Pimenta ◽  
Érica LM Vieira ◽  
...  

Aim: This article aimed to review the role of cytokines, chemokines, growth factors and cellular adhesion molecules as biomarkers for vesicoureteral reflux (VUR) and reflux nephropathy (RN). Methods: We reviewed articles from 1979 onward by searching PubMed and Scopus utilizing the combination of words: ‘VUR’ or ‘RN’ and each one of the biomarkers. Results: Genetic, inflammatory, fibrogenic, environmental and epigenetic factors responsible for renal scarring need to be better understood. TGF-β, IL-10, IL-6, IL-8 and TNF seem to exert a role in VUR particularly in RN based on the current literature. Serum levels of procalcitonin have been also associated with high-grade VUR and RN. These molecules should be more intensively evaluated as potential biomarkers for renal scarring in VUR. Conclusion: Further studies are necessary to define which molecules will really be of utility in clinical decisions and as therapeutic targets for VUR and RN.


2020 ◽  
Vol 133 (18) ◽  
pp. 2236-2238
Author(s):  
Shi-Lu Yin ◽  
Ze-Lian Qin ◽  
Xin Yang

2019 ◽  
Vol 15 (5) ◽  
pp. 514.e1-514.e6 ◽  
Author(s):  
V. Capone ◽  
F. Taroni ◽  
M.A. Pavesi ◽  
M. Castellani ◽  
D. Consonni ◽  
...  

Burns ◽  
2007 ◽  
Vol 33 (1) ◽  
pp. S153-S154
Author(s):  
Suzanne Rea ◽  
Natalie Giles ◽  
Fiona Wood ◽  
Mark Fear

Sign in / Sign up

Export Citation Format

Share Document